Abstract: Research into various means and methods, including physical activity, is necessary for scientists to comprehensively study the serious disturbances in men's comfort caused by disorders in the genitourinary system, with the aim of improving the quality of life indicators.The aim of this research is to investigate the correlation between the level of regular physical activity of men and their quality of life after a transurethral removal of prostate adenoma.Materials and methods.The research was conducted in medical institutions located in four cities of the Republic of Kazakhstan.The research evaluated 205 men, between the ages of 40 and 90 who had undergone transurethral resection of prostate adenoma.To compare the quality of life, a survey was performed using the SF-36 questionnaire.This questionnaire consists of 8 scales assessing the physical and mental condition of a person.The researchers categorized all participants into two different observation groups, depending on the volume and intensity of their regular physical activity.Group "O" (n = 68 men) was classified as those who had achieved the WHO-recommended optimal level of non-weekly physical activity, which was a minimum of 2.5hrs./week of moderate physical activity.A group of 136 men (Group "H") with a low level of physical activity, less than 2.5hrs./week,was included in the study.The weekly physical activity of the participants was measured by the International Physical Activity Questionnaire-Short Form (IPAQ-SF).Research results.The study findings are as follows: Men in group "O" exhibited a cumulative value of 234 mins/week for moderate physical activity, indicating an 86.1% increase compared to men in group "H", who had recorded only 125.7 mins/week (p < 0.05).Men in group "O" engaged in non-weekly moderate physical activity with a mean of 149.This index was 1 minute per week and was 84.5% higher in men of group "O" compared to group "H", where it was 80.8 minutes per week (p < 0.05).Patients in group "O" had a 27.5% higher frequency of walking per week compared to men in group "H".The group of patients with optimal regular activity had a mean of 85.6 minutes of walking time per week, which was 90.6% higher than the mean among men in group "H" (44.9 minutes per week) (p < 0.05).Conclusions.In men who engage in regular physical activity at an optimal level, the values of indicators in all scales of quality of life were notably higher than those of men with low physical activity (p < 0.05).In conclusion, to alleviate discomfort caused by prostate adenoma in middleaged, elderly and senile men, promoting regular physical activity should be actively promoted in addition to medical measures.