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1574, 1586, 1603, 1632, 1767, 1775], 'target': [902, 1045, 1052, 1305], 'vessel': [903, 1053, 1306], 'failure': [904], '(TVF).1': [905], 'prespecified': [907], 'substudy': [908, 1721], 'focused': [911], 'on': [912, 956, 2339], 'patients': [913, 930, 964, 1082, 1097, 1232, 1343, 1359, 1392, 1403, 1421, 1511, 1529, 1581, 1590, 1614, 1622, 1638, 1646, 1656, 1771, 2229], 'undergoing': [914, 931], 'CTO': [915, 932, 1124, 1190, 1345, 1367, 1394, 1405, 1538, 1557, 1592, 1616, 1677, 1712, 1733, 1737, 1753, 1798], 'evaluated': [918], 'prognostic': [920], 'impact': [921, 2171], 'over': [926], 'intervention.CTO': [933], 'defined': [935, 1004, 1038], 'as': [936, 1005, 1039, 1180, 2335], 'a': [937, 1040, 1093, 1278, 1299, 1720, 1723, 1730, 2238, 2261, 2361], 'major': [938, 1010], 'obstruction': [941], 'with': [942, 1098, 1344, 1393, 1404, 1449, 1582, 1591, 1615, 1623, 1639, 1647, 1657, 1701, 1765, 1772, 1806, 1825, 2086, 2179, 2230], 'Thrombolysis': [943], 'Myocardial': [945], 'Infarction': [946], 'flow': [947], 'grade': [948], '0': [949], 'least': [952], '3': [953], 'months': [954], 'duration': [955], 'basis': [958], "patient's": [961], 'history.2,3': [962], 'In': [963, 1564, 1629, 2358], 'assigned': [965, 1128, 1233], 'PCI,': [969, 1125, 1547], 'choice': [971], 'device': [975], 'between': [976, 1157, 1211, 1274, 1342, 1509, 1589], 'ultrasound': [978, 1243], 'optical': [980, 1247, 2427], 'coherence': [981, 1248], 'tomography': [982], 'left': [984], 'operator': [986], 'discretion.': [987], 'Standard': [988], 'protocols': [989], 'image': [991], 'acquisition': [992], 'optimization': [995, 1002, 1017, 1257, 1471, 1675, 1683, 1781, 1796], 'were': [996, 1103, 1127, 1150, 1179, 1360, 1611, 1822], 'during': [998], 'trial': [999, 1071, 1738, 1803, 2077, 2082, 2128], 'enrollment.': [1000], 'Stent': [1001], 'sufficient': [1006], 'expansion': [1008], 'without': [1009, 1460], 'malapposition': [1011], 'edge': [1013], 'dissection.': [1014], 'If': [1015], 'not': [1019, 1155, 1209, 1272, 1597, 1666, 1731, 1823, 2260, 2279, 2292, 2299], 'achieved,': [1020], 'additional': [1021, 1025], 'dilatation': [1023], 'or': [1024, 1049, 1110, 1134, 1304, 1829, 1839, 2042], 'implantation': [1027, 2227], 'recommended': [1029], 'both': [1031, 1515], 'groups.': [1032, 1138, 1164], 'primary': [1034, 1506], 'outcome': [1035], 'TVF,': [1037], 'composite': [1041, 1300], 'cardiac': [1043, 1302], 'death,': [1044], 'vessel–related': [1046], 'myocardial': [1047], 'infarction,': [1048], 'clinically': [1050], 'driven': [1051], 'revascularization.1': [1054], 'Deidentified': [1055], 'data': [1056, 1837], 'will': [1057, 2312, 2330], 'be': [1058, 1709, 2305, 2314, 2331, 2346], 'provided': [1059, 1083], 'upon': [1060], 'reasonable': [1061], 'request': [1062], 'after': [1063], 'discussion': [1064], 'by': [1065, 1075, 1396, 1407, 1607, 1685, 1782], 'Executive': [1067], 'Committee': [1068, 2353], 'members.': [1069], 'protocol': [1072, 1827], 'approved': [1074], 'institutional': [1077, 1849, 1869, 1901], 'review': [1078], 'boards': [1079], 'all': [1081], 'informed': [1084], 'consent': [1085], 'before': [1086], 'enrollment.From': [1087], 'May': [1088, 1091], '2018': [1089], '2021,': [1092], '1639': [1096], 'randomized': [1104, 1724, 2080, 2185], 'either': [1106, 1130], '(n=1092)': [1109], '(n=547)': [1113], 'groups': [1114, 1214, 1534], 'RENOVATE-COMPLEX-PCI.': [1116], 'Among': [1117, 1231], 'these': [1118], 'patients,': [1119], '319': [1120], '(343': [1121], 'vessels)': [1122], 'underwent': [1123, 1241, 1246], '(n=220)': [1133], '(n=99)': [1137], 'Mean': [1139], 'age': [1140], 'study': [1143, 1175, 1714, 1830, 1835], 'population': [1144, 1176], '63.7': [1146], 'years': [1147], '82.4%': [1149], 'men.': [1151], 'Baseline': [1152], 'did': [1154, 1208, 1271, 1596], 'differ': [1156, 1210, 1273], 'components': [1166], 'J-CTO': [1168, 1206], 'score': [1169, 1207], 'proportion': [1172], 'satisfying': [1177], 'them': [1178], 'follows:': [1181], 'blunt': [1182], 'stump': [1183], 'entry,': [1185], '55.5%;': [1186], 'calcification': [1187], 'within': [1188], 'segment,': [1191], '27.6%;': [1192], 'bending': [1193], '>45°,': [1194], '45.1%;': [1195], 'length': [1197], '≥20': [1198], 'mm,': [1199], '71.2%;': [1200], 're-attempted': [1202], 'procedure,': [1203], '7.8%.': [1204], '2': [1213, 1276], '(2.0': [1215], '[Q1': [1216, 1224], 'Q3,': [1218], '1.0': [1219, 1227], '3.0]': [1221], '2.0': [1223], 'Q3': [1226], '3.0];': [1229], 'P=0.755).': [1230], 'group,': [1239, 1446], '80.4%': [1240], '19.6%': [1245], 'tomography,': [1249], '34.5%': [1251], '(76/220)': [1252], 'met': [1253], 'predefined': [1255], 'criteria.': [1258], 'incidence': [1260, 1503], 'overall': [1262], 'procedure-related': [1263], 'complications': [1264], '(5.0%': [1265, 1287, 1308, 1617], '[n=11]': [1266], '5.1%': [1268], '[n=5];': [1269], 'P=0.999)': [1270], 'groups.During': [1277], 'follow-up': [1279], '2.1': [1281], 'years,': [1282], 'TVF': [1286, 1341, 1375, 1387, 1413, 1477, 1576, 1588, 1606, 1634, 1769, 1777], '13.5%;': [1289, 1452, 1463], 'hazard': [1290, 1544], 'ratio': [1291], '[HR],': [1292], '0.30;': [1293], '95%': [1294, 1313, 1354, 1455, 1466], 'CI,': [1295, 1314, 1355, 1456, 1467], '0.13–0.71;': [1296], 'P=0.006)': [1297], 'death': [1303], 'MI': [1307], '11.1%;': [1310], 'HR,': [1311, 1352, 1453, 1464, 1543], '0.36;': [1312], '0.15–0.87;': [1315], 'P=0.024)': [1316], 'significantly': [1318, 1377, 1473, 1572], 'lower': [1319, 1474, 1573], 'group': [1325, 1427, 1482], 'than': [1326, 1478, 1577, 1620, 1816, 2308], 'group.': [1331], 'There': [1332], 'no': [1334, 1652, 1918, 2306], 'significant': [1335], 'difference': [1336], 'non-CTO': [1347, 1594, 1624], '(7.6%': [1349], '9.6%;': [1351], '0.80;': [1353], '0.51–1.26;': [1356], 'P=0.331).': [1357], 'When': [1358], 'classified': [1361, 1512, 1530], 'according': [1362, 1490, 1513, 1531, 1778], 'presence': [1365, 1492, 1517], 'guidance,': [1371], 'different': [1378], 'among': [1379], '4': [1381], 'groups,': [1382, 1498], 'highest': [1390], 'treated': [1395, 1406], 'lowest': [1401], '(Figure': [1411, 1483], '[A]).': [1412], 'occurred': [1414], '1.3%,': [1416], '6.8%,': [1417], '13.5%': [1419], 'who': [1428, 1434], 'had': [1429, 1472], 'optimized': [1430, 1438], 'results,': [1431, 1439], 'those': [1433], 'failed': [1435], 'achieve': [1437], 'angiography': [1443], 'guided': [1444], 'respectively.': [1447], 'Patients': [1448], '(1.3%': [1450], '0.14;': [1454], '0.02–0.56;': [1457], 'P=0.003)': [1458], '(6.8%': [1461], '0.41;': [1465], '0.17–0.99;': [1468], 'P=0.049)': [1469], '[B]).Download': [1484], 'figureDownload': [1485], 'PowerPointFigure.': [1486], 'Primary': [1487], 'end': [1488, 1507], 'point': [1489, 1508], 'occlusion,': [1496], 'treatment': [1497, 1533, 2092, 2135], 'Cumulative': [1502], '(A)': [1510], '(CTO)': [1522], 'guidance': [1526], '(B)': [1528], 'indicates': [1539], 'occlusion;': [1542], 'ratio;': [1545], 'intervention.Despite': [1550], 'potential': [1551], 'advantages': [1552], 'intervention,': [1558], 'previous': [1559], 'trials': [1560], 'presented': [1561], 'conflicting': [1562], 'results.4,5': [1563], 'current': [1566], 'study,': [1567], 'CTO.': [1583, 1773], 'Although': [1584], 'differ,': [1598], 'absolute': [1600], 'relative': [1602], 'reductions': [1604], 'using': [1608, 1668, 1739], 'greater': [1612], '13.5%)': [1619], '(8.3%': [1626], '12.0%).': [1628], 'addition,': [1630], 'gradually': [1635], 'increased': [1636], 'from': [1637, 1809, 1852, 1872, 1904, 2237], 'optimization,': [1645, 1654], 'but': [1651, 1671], 'PCI.': [1659], 'These': [1660], 'results': [1661, 2236], 'suggest': [1662, 1690], 'importance': [1664, 1787], 'only': [1667, 2313], 'also': [1672], 'achieving': [1673], 'lesions.': [1678], 'relatively': [1680], 'low': [1681], 'procedural': [1682], 'rates': [1684], 'devices': [1688, 1742, 1751], '(34.5%)': [1689], 'there': [1692, 1916], 'room': [1694], 'improvement.': [1696], 'Therefore,': [1697], 'meticulous': [1698], 'step-by-step': [1699], 'evaluation': [1700], 'subsequent': [1705], 'adjunctive': [1706], 'procedures': [1707], 'should': [1708, 2248, 2304, 2345], 'encouraged': [1710], 'intervention.Our': [1713], 'has': [1715], 'limitations.': [1716], 'First,': [1717], 'this': [1718], 'controlled': [1725], 'trial.': [1726, 1734], 'Second,': [1727], 'dedicated': [1732, 1736], 'A': [1735, 2079], 'needed': [1744], 'explain': [1746], 'further': [1747], 'how': [1748], 'could': [1755], 'result': [1756], 'improvement': [1758], 'prognosis.Intravascular': [1760], 'associated': [1764], 'reduced': [1766], 'Graded': [1774], 'supports': [1785], 'achievement': [1793], 'intervention.ARTICLE': [1799], 'INFORMATIONSources': [1800], 'FundingThis': [1802], 'investigator-initiated': [1805], 'grant': [1807], 'support': [1808], 'Abbott': [1810, 1853, 1884], 'Boston': [1813, 1855, 1887, 1905], 'Scientific.': [1814], 'Other': [1815], 'providing': [1817, 2264], 'financial': [1818], 'support,': [1819], 'sponsors': [1821], 'involved': [1824], 'development': 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2283, 2291, 2298, 2318], 'competing': [1919], 'interests': [1920], 'declare.Footnotes*D.': [1922], 'S.M.': [1925], 'contributed': [1927, 1933], 'equally.†S.Y.': [1928], 'J.M.': [1931], 'equally.For': [1934], 'Sources': [1935], 'Funding': [1937], 'Disclosures,': [1939], 'see': [1940], 'page': [1941], '905.Circulation': [1942], 'available': [1944], 'www.ahajournals.org/journal/circRegistration:': [1946], 'URL:': [1947], 'https://www.clinicaltrials.gov;': [1948], 'Unique': [1949], 'identifier:': [1950], 'NCT03381872.Correspondence': [1951], '[email protected]': [1984], '[email protected].': [2017], 'JM,': [2019, 2110], 'KH,': [2021, 2033], 'YB,': [2023], 'J-Y,': [2025], 'S-J,': [2027], 'SY,': [2029], 'SM,': [2031], 'JY,': [2035], 'CJ,': [2037], 'et': [2038, 2074, 2125, 2165, 2214], 'al.': [2039, 2126, 2215], 'PCI.N': [2045], 'Engl': [2046], 'J': [2047, 2380, 2383], 'Med.': [2048], '2023;': [2049], '388:1668–1679.': [2050], 'doi:': [2051, 2102, 2142, 2191, 2244], 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