Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4386439623', 'doi': 'https://doi.org/10.3390/ph16091252', 'title': 'Recent Advances in the Treatment of Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases', 'display_name': 'Recent Advances in the Treatment of Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases', 'publication_year': 2023, 'publication_date': '2023-09-05', 'ids': {'openalex': 'https://openalex.org/W4386439623', 'doi': 'https://doi.org/10.3390/ph16091252', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37765060'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ph16091252', 'pdf_url': 'https://www.mdpi.com/1424-8247/16/9/1252/pdf?version=1693904338', 'source': {'id': 'https://openalex.org/S16322639', 'display_name': 'Pharmaceuticals', 'issn_l': '1424-8247', 'issn': ['1424-8247'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1424-8247/16/9/1252/pdf?version=1693904338', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056471587', 'display_name': 'Anna Smukowska-Gorynia', 'orcid': 'https://orcid.org/0000-0002-0738-7952'}, 'institutions': [{'id': 'https://openalex.org/I120230055', 'display_name': 'Poznan University of Medical Sciences', 'ror': 'https://ror.org/02zbb2597', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I120230055']}], 'countries': ['PL'], 'is_corresponding': True, 'raw_author_name': 'Anna Smukowska-Gorynia', 'raw_affiliation_strings': ['1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland'], 'affiliations': [{'raw_affiliation_string': '1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland', 'institution_ids': ['https://openalex.org/I120230055']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009950796', 'display_name': 'Weronika Gościniak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I120230055', 'display_name': 'Poznan University of Medical Sciences', 'ror': 'https://ror.org/02zbb2597', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I120230055']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Weronika Gościniak', 'raw_affiliation_strings': ['1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland'], 'affiliations': [{'raw_affiliation_string': '1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland', 'institution_ids': ['https://openalex.org/I120230055']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003478984', 'display_name': 'Patrycja Woźniak', 'orcid': 'https://orcid.org/0000-0002-0833-6196'}, 'institutions': [{'id': 'https://openalex.org/I120230055', 'display_name': 'Poznan University of Medical Sciences', 'ror': 'https://ror.org/02zbb2597', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I120230055']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Patrycja Woźniak', 'raw_affiliation_strings': ['1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland'], 'affiliations': [{'raw_affiliation_string': '1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland', 'institution_ids': ['https://openalex.org/I120230055']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088511142', 'display_name': 'Sylwia Iwańczyk', 'orcid': 'https://orcid.org/0000-0003-0509-6075'}, 'institutions': [{'id': 'https://openalex.org/I120230055', 'display_name': 'Poznan University of Medical Sciences', 'ror': 'https://ror.org/02zbb2597', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I120230055']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Sylwia Iwańczyk', 'raw_affiliation_strings': ['1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland'], 'affiliations': [{'raw_affiliation_string': '1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland', 'institution_ids': ['https://openalex.org/I120230055']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5092634252', 'display_name': 'Karolina Jaxa-Kwiatkowska', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I120230055', 'display_name': 'Poznan University of Medical Sciences', 'ror': 'https://ror.org/02zbb2597', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I120230055']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Karolina Jaxa-Kwiatkowska', 'raw_affiliation_strings': ['1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland'], 'affiliations': [{'raw_affiliation_string': '1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland', 'institution_ids': ['https://openalex.org/I120230055']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056717999', 'display_name': 'Sylwia Sławek-Szmyt', 'orcid': 'https://orcid.org/0000-0003-1143-2485'}, 'institutions': [{'id': 'https://openalex.org/I120230055', 'display_name': 'Poznan University of Medical Sciences', 'ror': 'https://ror.org/02zbb2597', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I120230055']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Sylwia Sławek-Szmyt', 'raw_affiliation_strings': ['1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland'], 'affiliations': [{'raw_affiliation_string': '1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland', 'institution_ids': ['https://openalex.org/I120230055']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064828818', 'display_name': 'Magdalena Janus', 'orcid': 'https://orcid.org/0000-0002-9500-6776'}, 'institutions': [{'id': 'https://openalex.org/I120230055', 'display_name': 'Poznan University of Medical Sciences', 'ror': 'https://ror.org/02zbb2597', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I120230055']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Magdalena Janus', 'raw_affiliation_strings': ['1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland'], 'affiliations': [{'raw_affiliation_string': '1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland', 'institution_ids': ['https://openalex.org/I120230055']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052241279', 'display_name': 'Jerzy Paluszkiewicz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I120230055', 'display_name': 'Poznan University of Medical Sciences', 'ror': 'https://ror.org/02zbb2597', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I120230055']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Jerzy Paluszkiewicz', 'raw_affiliation_strings': ['1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland'], 'affiliations': [{'raw_affiliation_string': '1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland', 'institution_ids': ['https://openalex.org/I120230055']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5053122058', 'display_name': 'Tatiana Mularek‐Kubzdela', 'orcid': 'https://orcid.org/0000-0001-5282-1570'}, 'institutions': [{'id': 'https://openalex.org/I120230055', 'display_name': 'Poznan University of Medical Sciences', 'ror': 'https://ror.org/02zbb2597', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I120230055']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Tatiana Mularek-Kubzdela', 'raw_affiliation_strings': ['1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland'], 'affiliations': [{'raw_affiliation_string': '1st Department of Cardiology, Poznan University of Medical Sciences, Długa 1/2 Street, 61-848 Poznan, Poland', 'institution_ids': ['https://openalex.org/I120230055']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5056471587'], 'corresponding_institution_ids': ['https://openalex.org/I120230055'], 'apc_list': {'value': 2000, 'currency': 'CHF', 'value_usd': 2165, 'provenance': 'doaj'}, 'apc_paid': {'value': 2000, 'currency': 'CHF', 'value_usd': 2165, 'provenance': 'doaj'}, 'fwci': 0.249, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.464716, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 71, 'max': 82}, 'biblio': {'volume': '16', 'issue': '9', 'first_page': '1252', 'last_page': '1252'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10728', 'display_name': 'Diagnosis and Treatment of Pulmonary Hypertension', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10728', 'display_name': 'Diagnosis and Treatment of Pulmonary Hypertension', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10870', 'display_name': 'Idiopathic Pulmonary Fibrosis: Diagnosis and Management', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12199', 'display_name': 'Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia', 'score': 0.9833, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/riociguat', 'display_name': 'Riociguat', 'score': 0.9508669}, {'id': 'https://openalex.org/keywords/treprostinil', 'display_name': 'Treprostinil', 'score': 0.8543066}, {'id': 'https://openalex.org/keywords/iloprost', 'display_name': 'Iloprost', 'score': 0.64207596}, {'id': 'https://openalex.org/keywords/ctd', 'display_name': 'CTD', 'score': 0.62838155}, {'id': 'https://openalex.org/keywords/pulmonary-hypertension', 'display_name': 'Pulmonary Hypertension', 'score': 0.560442}, {'id': 'https://openalex.org/keywords/ambrisentan', 'display_name': 'Ambrisentan', 'score': 0.46705425}], 'concepts': [{'id': 'https://openalex.org/C2776304953', 'wikidata': 'https://www.wikidata.org/wiki/Q2154494', 'display_name': 'Riociguat', 'level': 4, 'score': 0.9508669}, {'id': 'https://openalex.org/C2781109936', 'wikidata': 'https://www.wikidata.org/wiki/Q419769', 'display_name': 'Bosentan', 'level': 4, 'score': 0.88892275}, {'id': 'https://openalex.org/C2776768464', 'wikidata': 'https://www.wikidata.org/wiki/Q191521', 'display_name': 'Sildenafil', 'level': 2, 'score': 0.8714826}, {'id': 'https://openalex.org/C2776432619', 'wikidata': 'https://www.wikidata.org/wiki/Q3495231', 'display_name': 'Treprostinil', 'level': 3, 'score': 0.8543066}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.83410347}, {'id': 'https://openalex.org/C2780930700', 'wikidata': 'https://www.wikidata.org/wiki/Q1128595', 'display_name': 'Pulmonary hypertension', 'level': 2, 'score': 0.74067014}, {'id': 'https://openalex.org/C2780816001', 'wikidata': 'https://www.wikidata.org/wiki/Q424156', 'display_name': 'Tadalafil', 'level': 3, 'score': 0.7242062}, {'id': 'https://openalex.org/C2781103887', 'wikidata': 'https://www.wikidata.org/wiki/Q20817139', 'display_name': 'Iloprost', 'level': 3, 'score': 0.64207596}, {'id': 'https://openalex.org/C125533998', 'wikidata': 'https://www.wikidata.org/wiki/Q1024499', 'display_name': 'CTD', 'level': 2, 'score': 0.62838155}, {'id': 'https://openalex.org/C2776670291', 'wikidata': 'https://www.wikidata.org/wiki/Q1779300', 'display_name': 'Connective tissue disease', 'level': 4, 'score': 0.54067}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5205463}, {'id': 'https://openalex.org/C2780263000', 'wikidata': 'https://www.wikidata.org/wiki/Q410789', 'display_name': 'Ambrisentan', 'level': 5, 'score': 0.46705425}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.4481154}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.39996773}, {'id': 'https://openalex.org/C144980905', 'wikidata': 'https://www.wikidata.org/wiki/Q24721308', 'display_name': 'Endothelin receptor', 'level': 3, 'score': 0.3988022}, {'id': 'https://openalex.org/C2781128415', 'wikidata': 'https://www.wikidata.org/wiki/Q412050', 'display_name': 'Prostacyclin', 'level': 2, 'score': 0.33016384}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.22238186}, {'id': 'https://openalex.org/C2777428986', 'wikidata': 'https://www.wikidata.org/wiki/Q1958249', 'display_name': 'Chronic thromboembolic pulmonary hypertension', 'level': 3, 'score': 0.094908446}, {'id': 'https://openalex.org/C111368507', 'wikidata': 'https://www.wikidata.org/wiki/Q43518', 'display_name': 'Oceanography', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2779075594', 'wikidata': 'https://www.wikidata.org/wiki/Q8084905', 'display_name': 'Autoimmune disease', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C127313418', 'wikidata': 'https://www.wikidata.org/wiki/Q1069', 'display_name': 'Geology', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ph16091252', 'pdf_url': 'https://www.mdpi.com/1424-8247/16/9/1252/pdf?version=1693904338', 'source': {'id': 'https://openalex.org/S16322639', 'display_name': 'Pharmaceuticals', 'issn_l': '1424-8247', 'issn': ['1424-8247'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534675', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.20944/preprints202308.0951.v1', 'pdf_url': 'https://www.preprints.org/manuscript/202308.0951/v1/download', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37765060', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ph16091252', 'pdf_url': 'https://www.mdpi.com/1424-8247/16/9/1252/pdf?version=1693904338', 'source': {'id': 'https://openalex.org/S16322639', 'display_name': 'Pharmaceuticals', 'issn_l': '1424-8247', 'issn': ['1424-8247'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.54, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 73, 'referenced_works': ['https://openalex.org/W114168622', 'https://openalex.org/W1840736932', 'https://openalex.org/W1974227996', 'https://openalex.org/W1979770196', 'https://openalex.org/W1994680391', 'https://openalex.org/W1997446782', 'https://openalex.org/W1997983291', 'https://openalex.org/W2029788843', 'https://openalex.org/W2048443661', 'https://openalex.org/W2051069436', 'https://openalex.org/W2070897020', 'https://openalex.org/W2080605484', 'https://openalex.org/W2090213540', 'https://openalex.org/W2091428762', 'https://openalex.org/W2100422140', 'https://openalex.org/W2107011819', 'https://openalex.org/W2118156816', 'https://openalex.org/W2120335078', 'https://openalex.org/W2121376498', 'https://openalex.org/W2126563759', 'https://openalex.org/W2132978366', 'https://openalex.org/W2135510321', 'https://openalex.org/W2142699072', 'https://openalex.org/W2143132974', 'https://openalex.org/W2143819380', 'https://openalex.org/W2148038451', 'https://openalex.org/W2158862125', 'https://openalex.org/W2160071709', 'https://openalex.org/W2170779936', 'https://openalex.org/W2254626740', 'https://openalex.org/W2278696749', 'https://openalex.org/W2465789506', 'https://openalex.org/W2524823759', 'https://openalex.org/W2621360946', 'https://openalex.org/W2626098699', 'https://openalex.org/W2736062315', 'https://openalex.org/W2745759236', 'https://openalex.org/W2750529301', 'https://openalex.org/W2804765270', 'https://openalex.org/W2909006646', 'https://openalex.org/W2911671206', 'https://openalex.org/W2935133347', 'https://openalex.org/W2938865688', 'https://openalex.org/W2942931819', 'https://openalex.org/W2947560919', 'https://openalex.org/W2999142710', 'https://openalex.org/W3010651527', 'https://openalex.org/W3012847302', 'https://openalex.org/W3017187965', 'https://openalex.org/W3039093989', 'https://openalex.org/W3127813230', 'https://openalex.org/W3133955216', 'https://openalex.org/W3136356001', 'https://openalex.org/W3140644472', 'https://openalex.org/W3152050105', 'https://openalex.org/W3182435702', 'https://openalex.org/W3202093461', 'https://openalex.org/W3206212741', 'https://openalex.org/W3210217027', 'https://openalex.org/W4225159676', 'https://openalex.org/W4255412302', 'https://openalex.org/W4282937720', 'https://openalex.org/W4283698815', 'https://openalex.org/W4292870157', 'https://openalex.org/W4293217384', 'https://openalex.org/W4306672998', 'https://openalex.org/W4308687689', 'https://openalex.org/W4310137383', 'https://openalex.org/W4310661445', 'https://openalex.org/W4312095670', 'https://openalex.org/W4323293924', 'https://openalex.org/W4381248594', 'https://openalex.org/W4385564309'], 'related_works': ['https://openalex.org/W4386439623', 'https://openalex.org/W4386299924', 'https://openalex.org/W4385791471', 'https://openalex.org/W3127400092', 'https://openalex.org/W2890873445', 'https://openalex.org/W2806314961', 'https://openalex.org/W2522928291', 'https://openalex.org/W2469613225', 'https://openalex.org/W2184784963', 'https://openalex.org/W2099464507'], 'abstract_inverted_index': {'Pulmonary': [0], 'hypertension': [1, 26, 49], '(PH)': [2], 'is': [3, 65, 84], 'a': [4, 66], 'severe': [5], 'vascular': [6], 'complication': [7], 'of': [8, 101, 147, 158, 160], 'connective': [9], 'tissue': [10], 'diseases': [11], '(CTD).': [12], 'Patients': [13], 'with': [14, 149], 'CTD': [15], 'may': [16], 'develop': [17], 'PH': [18, 29, 37], 'belonging': [19], 'to': [20, 31, 39, 134], 'diverse': [21], 'groups:': [22], '(1)': [23], 'pulmonary': [24, 48], 'arterial': [25], '(PAH),': [27], '(2)': [28], 'due': [30, 38], 'left': [32], 'heart': [33], 'disease,': [34], '(3)': [35], 'secondary': [36], 'lung': [40], 'disease': [41, 68], 'and/or': [42], 'hypoxia': [43], 'and': [44, 87, 97, 107, 145, 163, 166], '(4)': [45], 'chronic': [46], 'thromboembolic': [47], '(CTEPH).': [50], 'PAH': [51], 'most': [52], 'often': [53], 'develops': [54], 'in': [55, 60, 129, 141], 'systemic': [56], 'scleroderma': [57], '(SSc),': [58], 'mostly': [59], 'its': [61], 'limited': [62], 'variant.': [63], 'PAH-CTD': [64, 83, 172], 'progressive': [67], 'characterized': [69], 'by': [70], 'poor': [71], 'prognosis.': [72], 'Therefore,': [73], 'early': [74], 'diagnosis': [75], 'should': [76], 'be': [77], 'established.': [78], 'A': [79], 'specific': [80], 'treatment': [81, 143], 'for': [82], 'currently': [85], 'available': [86], 'recommended:': [88], 'prostacyclin': [89], 'derivative': [90], '(treprostinil,': [91], 'epoprostenol,': [92], 'iloprost,': [93], 'selexipag),': [94], 'nitric': [95], 'oxide': [96], 'natriuretic': [98], 'pathway:': [99], 'stimulators': [100], 'soluble': [102], 'guanylate': [103], 'cyclase': [104], '(sGC:': [105], 'riociguat)': [106], 'phosphodiesterase-five': [108], 'inhibitors': [109], '(PDE5i:': [110], 'sildenafil,': [111], 'tadalafil),': [112], 'endothelin': [113], 'receptor': [114], 'antagonists': [115], '(ERA:': [116], 'bosentan,': [117], 'macitentan,': [118], 'ambrisentan).': [119], 'Moreover,': [120], 'novel': [121], 'drugs,': [122], 'e.g.,': [123], 'sotatercept,': [124], 'have': [125], 'been': [126], 'intensively': [127], 'investigated': [128], 'clinical': [130], 'trials.': [131], 'We': [132], 'aim': [133], 'review': [135], 'the': [136, 142, 156, 167], 'literature': [137], 'on': [138, 171], 'recent': [139], 'advances': [140], 'strategy': [144], 'prognosis': [146], 'patients': [148], 'PAH-CTD.': [150], 'In': [151], 'this': [152], 'manuscript,': [153], 'we': [154], 'discuss': [155], 'mechanism': [157], 'action': [159], 'PAH-specific': [161], 'drugs': [162], 'new': [164], 'agents': [165], 'latest': [168], 'research': [169], 'conducted': [170], 'patients.': [173]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4386439623', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-09-13T17:28:07.650276', 'created_date': '2023-09-06'}