Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4386305241', 'doi': 'https://doi.org/10.1128/mbio.00332-23', 'title': 'Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3', 'display_name': 'Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3', 'publication_year': 2023, 'publication_date': '2023-10-31', 'ids': {'openalex': 'https://openalex.org/W4386305241', 'doi': 'https://doi.org/10.1128/mbio.00332-23', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37650650'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mbio.00332-23', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210201176', 'display_name': 'mBio', 'issn_l': '2150-7511', 'issn': ['2150-7511', '2161-2129'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1128/mbio.00332-23', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100370519', 'display_name': 'Jian Wang', 'orcid': 'https://orcid.org/0000-0002-9482-5227'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian Wang', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University , Suzhou, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University , Suzhou, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077457004', 'display_name': 'Hui Zheng', 'orcid': 'https://orcid.org/0000-0002-4325-4946'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui Zheng', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University , Suzhou, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University , Suzhou, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102026067', 'display_name': 'Chunsheng Dong', 'orcid': 'https://orcid.org/0000-0003-4184-6398'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunsheng Dong', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University , Suzhou, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University , Suzhou, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101445508', 'display_name': 'Sidong Xiong', 'orcid': 'https://orcid.org/0000-0002-0321-5635'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Sidong Xiong', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University , Suzhou, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University , Suzhou, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3900, 'currency': 'USD', 'value_usd': 3900, 'provenance': 'doaj'}, 'apc_paid': {'value': 3900, 'currency': 'USD', 'value_usd': 3900, 'provenance': 'doaj'}, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 71}, 'biblio': {'volume': '14', 'issue': '5', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11668', 'display_name': 'Innate Immunity to Viral Infection', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11668', 'display_name': 'Innate Immunity to Viral Infection', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/irf3', 'display_name': 'IRF3', 'score': 0.9869209}, {'id': 'https://openalex.org/keywords/irf7', 'display_name': 'IRF7', 'score': 0.80516684}, {'id': 'https://openalex.org/keywords/deubiquitinating-enzyme', 'display_name': 'Deubiquitinating enzyme', 'score': 0.76281667}, {'id': 'https://openalex.org/keywords/tlr3', 'display_name': 'TLR3', 'score': 0.53573036}, {'id': 'https://openalex.org/keywords/gene-expression-regulation', 'display_name': 'Gene Expression Regulation', 'score': 0.510755}, {'id': 'https://openalex.org/keywords/interferon-type-i', 'display_name': 'Interferon type I', 'score': 0.50480354}], 'concepts': [{'id': 'https://openalex.org/C2780209191', 'wikidata': 'https://www.wikidata.org/wiki/Q14914339', 'display_name': 'IRF3', 'level': 4, 'score': 0.9869209}, {'id': 'https://openalex.org/C2776966659', 'wikidata': 'https://www.wikidata.org/wiki/Q18028003', 'display_name': 'IRF7', 'level': 4, 'score': 0.80516684}, {'id': 'https://openalex.org/C9173399', 'wikidata': 'https://www.wikidata.org/wiki/Q6046461', 'display_name': 'Interferon regulatory factors', 'level': 4, 'score': 0.7859812}, {'id': 'https://openalex.org/C102658986', 'wikidata': 'https://www.wikidata.org/wiki/Q5266092', 'display_name': 'Deubiquitinating enzyme', 'level': 4, 'score': 0.76281667}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.7102803}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.7096584}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.5841855}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.5556387}, {'id': 'https://openalex.org/C2778420691', 'wikidata': 'https://www.wikidata.org/wiki/Q14866230', 'display_name': 'TLR3', 'level': 5, 'score': 0.53573036}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.5229034}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.50583553}, {'id': 'https://openalex.org/C2778278966', 'wikidata': 'https://www.wikidata.org/wiki/Q6046488', 'display_name': 'Interferon type I', 'level': 3, 'score': 0.50480354}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45845288}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.38101828}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3167675}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.21544534}, {'id': 'https://openalex.org/C2776709828', 'wikidata': 'https://www.wikidata.org/wiki/Q408004', 'display_name': 'Toll-like receptor', 'level': 4, 'score': 0.15982631}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.11419195}], 'mesh': [{'descriptor_ui': 'D007370', 'descriptor_name': 'Interferon Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050838', 'descriptor_name': 'Interferon Regulatory Factor-3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050838', 'descriptor_name': 'Interferon Regulatory Factor-3', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007370', 'descriptor_name': 'Interferon Type I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mbio.00332-23', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210201176', 'display_name': 'mBio', 'issn_l': '2150-7511', 'issn': ['2150-7511', '2161-2129'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653906', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-2249253/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-2249253/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37650650', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mbio.00332-23', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210201176', 'display_name': 'mBio', 'issn_l': '2150-7511', 'issn': ['2150-7511', '2161-2129'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.46, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '32170148'}], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1617606969', 'https://openalex.org/W1776950904', 'https://openalex.org/W1812905037', 'https://openalex.org/W1971128251', 'https://openalex.org/W1994647589', 'https://openalex.org/W1994826332', 'https://openalex.org/W2000390166', 'https://openalex.org/W2006928776', 'https://openalex.org/W2008458519', 'https://openalex.org/W2021912464', 'https://openalex.org/W2060441844', 'https://openalex.org/W2074654296', 'https://openalex.org/W2090116519', 'https://openalex.org/W2096109794', 'https://openalex.org/W2124651203', 'https://openalex.org/W2137303998', 'https://openalex.org/W2154190189', 'https://openalex.org/W2161995310', 'https://openalex.org/W2367101210', 'https://openalex.org/W2477973757', 'https://openalex.org/W2548101052', 'https://openalex.org/W2556750995', 'https://openalex.org/W2557071123', 'https://openalex.org/W2598294330', 'https://openalex.org/W2613065881', 'https://openalex.org/W2613997270', 'https://openalex.org/W2800469433', 'https://openalex.org/W2887119856', 'https://openalex.org/W2900128053', 'https://openalex.org/W2912309278', 'https://openalex.org/W2991331878', 'https://openalex.org/W2995171541', 'https://openalex.org/W3004963086', 'https://openalex.org/W3007012676', 'https://openalex.org/W3007658484', 'https://openalex.org/W3020485810', 'https://openalex.org/W3023846908', 'https://openalex.org/W3026999446', 'https://openalex.org/W3032631374', 'https://openalex.org/W3038485477', 'https://openalex.org/W3042820456', 'https://openalex.org/W3081601130', 'https://openalex.org/W3115414062', 'https://openalex.org/W3125796414', 'https://openalex.org/W3134635250', 'https://openalex.org/W3160690163', 'https://openalex.org/W3169279273', 'https://openalex.org/W3174078272', 'https://openalex.org/W3180569188', 'https://openalex.org/W3190205340'], 'related_works': ['https://openalex.org/W4386305241', 'https://openalex.org/W4307210675', 'https://openalex.org/W3123689060', 'https://openalex.org/W2927551315', 'https://openalex.org/W2739766559', 'https://openalex.org/W2538848459', 'https://openalex.org/W2160045547', 'https://openalex.org/W2159995523', 'https://openalex.org/W2137303998', 'https://openalex.org/W2123026728'], 'abstract_inverted_index': {'Interferon': [0], '(IFN)': [1], 'regulatory': [2, 38], 'factor': [3], '(IRF3)': [4], 'is': [5, 27], 'one': [6], 'of': [7, 33, 104], 'the': [8, 37, 46, 64, 89, 97, 121], 'key': [9], 'factors': [10], 'for': [11, 123], 'type': [12, 19, 115], 'I': [13, 20, 116], 'IFN': [14, 21, 117], 'transcription.': [15], 'To': [16], 'sophisticatedly': [17], 'regulate': [18], 'antiviral': [22, 58, 98, 124], 'immune': [23, 59], 'response,': [24], 'IRF3': [25, 65, 105], 'activity': [26], 'closely': [28], 'controlled': [29], 'by': [30, 100], 'a': [31], 'variety': [32], 'post-translational': [34], 'modifications.': [35], 'However,': [36], 'mechanisms': [39], 'are': [40], 'still': [41], 'not': [42], 'fully': [43], 'elucidated.': [44], 'In': [45], 'present': [47], 'study,': [48], 'we': [49, 108], 'found': [50], 'that': [51, 92, 110], 'human': [52, 111], 'deubiquitinase': [53], 'OTUD6B': [54, 61, 78, 94, 112], 'positively': [55], 'regulates': [56, 96], 'IRF3-mediated': [57], 'response.': [60], 'can': [62], 'stabilize': [63], 'protein': [66], 'level': [67], 'via': [68], 'hydrolyzing': [69], '(Lys33)-linked': [70], 'polyubiquitin': [71], 'at': [72], 'Lys315.': [73], 'More': [74], 'importantly,': [75], 'mice': [76], 'with': [77], 'overexpression': [79], 'exhibited': [80], 'more': [81], 'resistance': [82], 'to': [83], 'RNA': [84], 'virus': [85], 'infection.': [86], 'Thus,': [87], 'unlike': [88], 'previous': [90], 'report': [91], 'zebrafish': [93], 'negatively': [95], 'response': [99, 118], 'suppressing': [101], 'K63-linked': [102], 'ubiquitination': [103], 'and': [106, 119], 'IRF7,': [107], 'demonstrate': [109], 'actually': [113], 'enhances': [114], 'has': [120], 'potential': [122], 'therapy.': [125]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4386305241', 'counts_by_year': [], 'updated_date': '2024-09-12T12:43:02.298159', 'created_date': '2023-09-01'}