Title: Unifocal Type-3 Mixed Histiocytosis in a 10-Years Old Child
Abstract: AbstractBackground Histiocytoses patients present with highly heterogeneous clinical and histopathological pictures requiring multidisciplinary management. Mixed histiocytosis is a recently described group of syndromes defined by the histological overlap of Langerhans cell histiocytosis and other histiocytic proliferations that include three clinically and prognostically different conditions (i.e., Type-1–3 mixed histiocytosis).Case report We describe a 10 year-old boy with unifocal (type-3) mixed histiocytosis – Langerhans cell histiocytosis combined with a lesion with features intermediate between Rosai-Dorfman disease and reticulohistiocytosis. Sixty months after excision, the child is disease free.Discussion Cutaneous type-3 mixed histiocytosis (Langerhans cell histiocytosis with Rosai-Dorfman disease/reticulohistiocytosis) may occur in older childhood, be unifocal, and be cured by surgical excision.Keywords: HistiocytosisLangerhans cell histiocytosisdifferential diagnosisprognosissurgerycutaneous pathology Disclosure statementNo potential conflict of interest was reported by the authors.Ethics approval statementThe study was conducted following local ethical guidelines and the Helsinki declaration.Patient consent statementThe patient’s informed consent was gathered.Permission to reproduce material from other sourcesN/A.Data availability statementData are fully available upon the author’s requestAdditional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Publication Year: 2023
Publication Date: 2023-08-22
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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