Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4385514819', 'doi': 'https://doi.org/10.1093/toxsci/kfad078', 'title': 'Identification of an adverse outcome pathway (AOP) for chemical-induced craniofacial anomalies using the transgenic zebrafish model', 'display_name': 'Identification of an adverse outcome pathway (AOP) for chemical-induced craniofacial anomalies using the transgenic zebrafish model', 'publication_year': 2023, 'publication_date': '2023-08-02', 'ids': {'openalex': 'https://openalex.org/W4385514819', 'doi': 'https://doi.org/10.1093/toxsci/kfad078', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37531284'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/toxsci/kfad078', 'pdf_url': 'https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfad078/51024160/kfad078.pdf', 'source': {'id': 'https://openalex.org/S186282544', 'display_name': 'Toxicological Sciences', 'issn_l': '1096-0929', 'issn': ['1096-0929', '1096-6080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfad078/51024160/kfad078.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034770439', 'display_name': 'Shujie Liu', 'orcid': 'https://orcid.org/0000-0003-0012-5199'}, 'institutions': [{'id': 'https://openalex.org/I207623266', 'display_name': 'Kao Corporation (Japan)', 'ror': 'https://ror.org/016t1kc57', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I207623266']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shujie Liu', 'raw_affiliation_strings': ['R&D, Safety Science Research, Kao Corporation, Tochigi, 321-3497, Japan'], 'affiliations': [{'raw_affiliation_string': 'R&D, Safety Science Research, Kao Corporation, Tochigi, 321-3497, Japan', 'institution_ids': ['https://openalex.org/I207623266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016841567', 'display_name': 'Toru Kawanishi', 'orcid': 'https://orcid.org/0000-0001-7038-9769'}, 'institutions': [{'id': 'https://openalex.org/I114531698', 'display_name': 'Tokyo Institute of Technology', 'ror': 'https://ror.org/0112mx960', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I114531698']}, {'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toru Kawanishi', 'raw_affiliation_strings': ['Department of Biological Sciences, Graduate School of Science, University of Tokyo , Tokyo 113-0033, Japan', 'School of Life Science and Technology, Tokyo Institute of Technology , Kanagawa 226-8501, Japan'], 'affiliations': [{'raw_affiliation_string': 'School of Life Science and Technology, Tokyo Institute of Technology , Kanagawa 226-8501, Japan', 'institution_ids': ['https://openalex.org/I114531698']}, {'raw_affiliation_string': 'Department of Biological Sciences, Graduate School of Science, University of Tokyo , Tokyo 113-0033, Japan', 'institution_ids': ['https://openalex.org/I161296585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108609297', 'display_name': 'Atsuko Shimada', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Atsuko Shimada', 'raw_affiliation_strings': ['Department of Biological Sciences, Graduate School of Science, University of Tokyo , Tokyo 113-0033, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Graduate School of Science, University of Tokyo , Tokyo 113-0033, Japan', 'institution_ids': ['https://openalex.org/I161296585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110647983', 'display_name': 'Naohiro Ikeda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I207623266', 'display_name': 'Kao Corporation (Japan)', 'ror': 'https://ror.org/016t1kc57', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I207623266']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naohiro Ikeda', 'raw_affiliation_strings': ['R&D, Safety Science Research, Kao Corporation, Kanagawa, 210-0821, Japan'], 'affiliations': [{'raw_affiliation_string': 'R&D, Safety Science Research, Kao Corporation, Kanagawa, 210-0821, Japan', 'institution_ids': ['https://openalex.org/I207623266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110890739', 'display_name': 'Masayuki Yamane', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I207623266', 'display_name': 'Kao Corporation (Japan)', 'ror': 'https://ror.org/016t1kc57', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I207623266']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masayuki Yamane', 'raw_affiliation_strings': ['R&D, Safety Science Research, Kao Corporation, Tochigi, 321-3497, Japan'], 'affiliations': [{'raw_affiliation_string': 'R&D, Safety Science Research, Kao Corporation, Tochigi, 321-3497, Japan', 'institution_ids': ['https://openalex.org/I207623266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086601107', 'display_name': 'Hiroyuki Takeda', 'orcid': 'https://orcid.org/0000-0002-7932-6358'}, 'institutions': [{'id': 'https://openalex.org/I168356945', 'display_name': 'Kyoto Sangyo University', 'ror': 'https://ror.org/05t70xh16', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I168356945']}, {'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Hiroyuki Takeda', 'raw_affiliation_strings': ['Department of Biological Sciences, Graduate School of Science, University of Tokyo , Tokyo 113-0033, Japan', 'Faculty of Life Sciences, Kyoto Sangyo University , Kyoto 603-8555, Japan'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Life Sciences, Kyoto Sangyo University , Kyoto 603-8555, Japan', 'institution_ids': ['https://openalex.org/I168356945']}, {'raw_affiliation_string': 'Department of Biological Sciences, Graduate School of Science, University of Tokyo , Tokyo 113-0033, Japan', 'institution_ids': ['https://openalex.org/I161296585']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028364525', 'display_name': 'Junichi Tasaki', 'orcid': 'https://orcid.org/0000-0003-1798-5160'}, 'institutions': [{'id': 'https://openalex.org/I207623266', 'display_name': 'Kao Corporation (Japan)', 'ror': 'https://ror.org/016t1kc57', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I207623266']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Junichi Tasaki', 'raw_affiliation_strings': ['R&D, Safety Science Research, Kao Corporation, Kanagawa, 210-0821, Japan'], 'affiliations': [{'raw_affiliation_string': 'R&D, Safety Science Research, Kao Corporation, Kanagawa, 210-0821, Japan', 'institution_ids': ['https://openalex.org/I207623266']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5086601107', 'https://openalex.org/A5028364525'], 'corresponding_institution_ids': ['https://openalex.org/I168356945', 'https://openalex.org/I161296585', 'https://openalex.org/I207623266'], 'apc_list': {'value': 4278, 'currency': 'USD', 'value_usd': 4278, 'provenance': 'doaj'}, 'apc_paid': {'value': 4278, 'currency': 'USD', 'value_usd': 4278, 'provenance': 'doaj'}, 'fwci': 1.419, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.638558, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 87}, 'biblio': {'volume': '196', 'issue': '1', 'first_page': '38', 'last_page': '51'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11374', 'display_name': 'Cleft Lip and Palate Research', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11374', 'display_name': 'Cleft Lip and Palate Research', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11679', 'display_name': 'Craniofacial Disorders and Treatments', 'score': 0.9755, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10978', 'display_name': 'Prenatal Screening and Diagnostics', 'score': 0.952, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/craniofacial-abnormality', 'display_name': 'Craniofacial abnormality', 'score': 0.8054187}, {'id': 'https://openalex.org/keywords/cranial-neural-crest', 'display_name': 'Cranial neural crest', 'score': 0.73432887}, {'id': 'https://openalex.org/keywords/adverse-outcome-pathway', 'display_name': 'Adverse Outcome Pathway', 'score': 0.7126067}, {'id': 'https://openalex.org/keywords/sox10', 'display_name': 'SOX10', 'score': 0.5442207}], 'concepts': [{'id': 'https://openalex.org/C2781245598', 'wikidata': 'https://www.wikidata.org/wiki/Q5182134', 'display_name': 'Craniofacial', 'level': 2, 'score': 0.9209629}, {'id': 'https://openalex.org/C2776878037', 'wikidata': 'https://www.wikidata.org/wiki/Q169444', 'display_name': 'Zebrafish', 'level': 3, 'score': 0.8870081}, {'id': 'https://openalex.org/C2778951934', 'wikidata': 'https://www.wikidata.org/wiki/Q5182137', 'display_name': 'Craniofacial abnormality', 'level': 3, 'score': 0.8054187}, {'id': 'https://openalex.org/C2780071072', 'wikidata': 'https://www.wikidata.org/wiki/Q5182130', 'display_name': 'Cranial neural crest', 'level': 4, 'score': 0.73432887}, {'id': 'https://openalex.org/C2910206359', 'wikidata': 'https://www.wikidata.org/wiki/Q18559532', 'display_name': 'Adverse Outcome Pathway', 'level': 2, 'score': 0.7126067}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6704612}, {'id': 'https://openalex.org/C126749454', 'wikidata': 'https://www.wikidata.org/wiki/Q1348455', 'display_name': 'Neural crest', 'level': 3, 'score': 0.6689973}, {'id': 'https://openalex.org/C40692019', 'wikidata': 'https://www.wikidata.org/wiki/Q815547', 'display_name': 'Morphogenesis', 'level': 3, 'score': 0.60433894}, {'id': 'https://openalex.org/C2777302934', 'wikidata': 'https://www.wikidata.org/wiki/Q18031655', 'display_name': 'SOX10', 'level': 4, 'score': 0.5442207}, {'id': 'https://openalex.org/C65290608', 'wikidata': 'https://www.wikidata.org/wiki/Q631521', 'display_name': 'Teratology', 'level': 4, 'score': 0.45316544}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.42778304}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41137204}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.35441124}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.30100477}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.24880487}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.22445199}, {'id': 'https://openalex.org/C172680121', 'wikidata': 'https://www.wikidata.org/wiki/Q26513', 'display_name': 'Fetus', 'level': 3, 'score': 0.21561417}, {'id': 'https://openalex.org/C2779234561', 'wikidata': 'https://www.wikidata.org/wiki/Q11995', 'display_name': 'Pregnancy', 'level': 2, 'score': 0.06468412}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06466514}], 'mesh': [{'descriptor_ui': 'D000073931', 'descriptor_name': 'Adverse Outcome Pathways', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008322', 'descriptor_name': 'Mammals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012886', 'descriptor_name': 'Skull', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013723', 'descriptor_name': 'Teratogens', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/toxsci/kfad078', 'pdf_url': 'https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfad078/51024160/kfad078.pdf', 'source': {'id': 'https://openalex.org/S186282544', 'display_name': 'Toxicological Sciences', 'issn_l': '1096-0929', 'issn': ['1096-0929', '1096-6080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37531284', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/toxsci/kfad078', 'pdf_url': 'https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfad078/51024160/kfad078.pdf', 'source': {'id': 'https://openalex.org/S186282544', 'display_name': 'Toxicological Sciences', 'issn_l': '1096-0929', 'issn': ['1096-0929', '1096-6080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1556198965', 'https://openalex.org/W1589250623', 'https://openalex.org/W164317671', 'https://openalex.org/W1871458241', 'https://openalex.org/W1969712562', 'https://openalex.org/W1973461367', 'https://openalex.org/W1978053825', 'https://openalex.org/W1981048058', 'https://openalex.org/W1991078032', 'https://openalex.org/W1994122604', 'https://openalex.org/W2000089305', 'https://openalex.org/W2005998762', 'https://openalex.org/W2006218994', 'https://openalex.org/W2011936682', 'https://openalex.org/W2015193409', 'https://openalex.org/W2020788680', 'https://openalex.org/W2026907845', 'https://openalex.org/W2051031547', 'https://openalex.org/W2057938155', 'https://openalex.org/W2069179564', 'https://openalex.org/W2070314600', 'https://openalex.org/W2071524798', 'https://openalex.org/W2075386924', 'https://openalex.org/W2077720819', 'https://openalex.org/W2084074518', 'https://openalex.org/W2086538740', 'https://openalex.org/W2094807249', 'https://openalex.org/W2095404170', 'https://openalex.org/W2099230193', 'https://openalex.org/W2105768185', 'https://openalex.org/W2108274213', 'https://openalex.org/W2119446332', 'https://openalex.org/W2122920636', 'https://openalex.org/W2123373545', 'https://openalex.org/W2134374915', 'https://openalex.org/W2135256472', 'https://openalex.org/W2138143005', 'https://openalex.org/W2146714906', 'https://openalex.org/W2154330374', 'https://openalex.org/W2163344736', 'https://openalex.org/W2167668539', 'https://openalex.org/W2169178447', 'https://openalex.org/W2232521592', 'https://openalex.org/W2313757172', 'https://openalex.org/W2326434969', 'https://openalex.org/W2410392235', 'https://openalex.org/W2413328216', 'https://openalex.org/W2425966091', 'https://openalex.org/W2520593528', 'https://openalex.org/W2559709990', 'https://openalex.org/W2564874325', 'https://openalex.org/W2780997838', 'https://openalex.org/W2896571296', 'https://openalex.org/W2915554805', 'https://openalex.org/W2980181133', 'https://openalex.org/W2981193446', 'https://openalex.org/W3017023309', 'https://openalex.org/W3022997872', 'https://openalex.org/W3106680822', 'https://openalex.org/W3112611560', 'https://openalex.org/W4212763591', 'https://openalex.org/W4214629368'], 'related_works': ['https://openalex.org/W4385514819', 'https://openalex.org/W3156499266', 'https://openalex.org/W2566467703', 'https://openalex.org/W2123140235', 'https://openalex.org/W2093118342', 'https://openalex.org/W2075386924', 'https://openalex.org/W2011889556', 'https://openalex.org/W1995581940', 'https://openalex.org/W1982192259', 'https://openalex.org/W1795745518'], 'abstract_inverted_index': {'Abstract': [0], 'Craniofacial': [1], 'anomalies': [2, 45, 112, 211], 'are': [3, 13], 'one': [4], 'of': [5, 63, 69, 120, 139, 150, 184], 'the': [6, 39, 41, 93, 101, 121, 140, 151, 181], 'most': [7], 'frequent': [8], 'birth': [9], 'defects': [10], 'worldwide': [11], 'and': [12, 18, 24, 67, 90, 117, 137, 194, 205], 'often': [14], 'caused': [15], 'by': [16], 'genetic': [17], 'environmental': [19], 'factors': [20], 'such': [21], 'as': [22, 55, 164], 'pharmaceuticals': [23], 'chemical': [25], 'agents.': [26], 'Although': [27], 'identifying': [28], 'adverse': [29], 'outcome': [30], 'pathways': [31], '(AOPs)': [32], 'is': [33, 189], 'a': [34, 165], 'central': [35], 'issue': [36], 'for': [37, 59, 72, 95, 168], 'evaluating': [38], 'teratogenicity,': [40], 'AOP': [42], 'causing': [43], 'craniofacial': [44, 96, 111, 170, 203, 210], 'has': [46, 52], 'not': [47], 'been': [48], 'identified.': [49], 'Recently,': [50], 'zebrafish': [51, 79, 193], 'gained': [53], 'interest': [54], 'an': [56], 'emerging': [57], 'model': [58, 167], 'predicting': [60, 209], 'teratogenicity': [61], 'because': [62], 'high': [64], 'throughput,': [65], 'cost-effectiveness': [66], 'availability': [68], 'various': [70], 'tools': [71], 'examining': [73], 'teratogenic': [74], 'mechanisms.': [75], 'Here,': [76], 'we': [77, 99, 156], 'established': [78], 'sox10-EGFP': [80, 160], 'reporter': [81, 161], 'lines': [82, 162], 'to': [83, 104, 109, 175, 201], 'visualize': [84], 'cranial': [85], 'neural': [86], 'crest': [87], 'cells': [88], '(CNCCs)': [89], 'have': [91], 'identified': [92], 'AOPs': [94], 'anomalies.': [97], 'When': [98], 'exposed': [100], 'transgenic': [102], 'embryos': [103], 'teratogens': [105], 'that': [106, 134, 158, 180], 'were': [107, 125, 143], 'reported': [108], 'cause': [110], 'in': [113, 208, 212], 'mammals,': [114, 195], 'CNCC': [115], 'migration': [116], 'subsequent': [118], 'morphogenesis': [119], 'first': [122], 'pharyngeal': [123], 'arch': [124], 'impaired': [126], 'at': [127], '24': [128], 'hours': [129], 'post-fertilization.': [130], 'We': [131], 'also': [132], 'found': [133], 'cell': [135], 'proliferation': [136], 'apoptosis': [138], 'migratory': [141], 'CNCCs': [142, 185], 'disturbed,': [144], 'which': [145], 'would': [146], 'be': [147, 199], 'key': [148], 'events': [149], 'AOP.': [152], 'From': [153], 'these': [154], 'results,': [155], 'propose': [157], 'our': [159, 196], 'serve': [163], 'valuable': [166], 'detecting': [169], 'skeletal': [171], 'abnormalities,': [172], 'from': [173], 'early': [174], 'late': [176], 'developmental': [177, 182], 'stages.': [178], 'Given': [179], 'process': [183], 'around': [186], 'this': [187], 'stage': [188], 'highly': [190], 'conserved': [191], 'between': [192], 'findings': [197], 'can': [198], 'extrapolated': [200], 'mammalian': [202], 'development': [204], 'thus': [206], 'help': [207], 'human.': [213]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4385514819', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}], 'updated_date': '2025-01-12T08:04:48.765626', 'created_date': '2023-08-04'}