Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4384438281', 'doi': 'https://doi.org/10.1101/2023.07.14.549007', 'title': 'Genetic dissection of BDNF and TrkB expression in glial cells', 'display_name': 'Genetic dissection of BDNF and TrkB expression in glial cells', 'publication_year': 2023, 'publication_date': '2023-07-15', 'ids': {'openalex': 'https://openalex.org/W4384438281', 'doi': 'https://doi.org/10.1101/2023.07.14.549007', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37503044'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2023.07.14.549007', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/07/25/2023.07.14.549007.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/07/25/2023.07.14.549007.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112960698', 'display_name': 'Changran Niu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I33213144', 'display_name': 'University of Florida', 'ror': 'https://ror.org/02y3ad647', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I33213144']}, {'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Changran Niu', 'raw_affiliation_strings': ['Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, 33458, FL', 'Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, 9037, CA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, 33458, FL', 'institution_ids': ['https://openalex.org/I33213144']}, {'raw_affiliation_string': 'Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, 9037, CA', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012546500', 'display_name': 'Xinpei Yue', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}, {'id': 'https://openalex.org/I33213144', 'display_name': 'University of Florida', 'ror': 'https://ror.org/02y3ad647', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I33213144']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xinpei Yue', 'raw_affiliation_strings': ['Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, 33458, FL', 'Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, 9037, CA'], 'affiliations': [{'raw_affiliation_string': 'Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, 9037, CA', 'institution_ids': ['https://openalex.org/I123431417']}, {'raw_affiliation_string': 'Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, 33458, FL', 'institution_ids': ['https://openalex.org/I33213144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111009576', 'display_name': 'Juan Ji An', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I33213144', 'display_name': 'University of Florida', 'ror': 'https://ror.org/02y3ad647', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I33213144']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Juan Ji An', 'raw_affiliation_strings': ['Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, 33458, FL'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, 33458, FL', 'institution_ids': ['https://openalex.org/I33213144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100809700', 'display_name': 'Haifei Xu', 'orcid': 'https://orcid.org/0000-0002-0962-7702'}, 'institutions': [{'id': 'https://openalex.org/I33213144', 'display_name': 'University of Florida', 'ror': 'https://ror.org/02y3ad647', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I33213144']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Haifei Xu', 'raw_affiliation_strings': ['Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, 33458, FL'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, 33458, FL', 'institution_ids': ['https://openalex.org/I33213144']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035599351', 'display_name': 'Baoji Xu', 'orcid': 'https://orcid.org/0000-0002-2416-6633'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}, {'id': 'https://openalex.org/I33213144', 'display_name': 'University of Florida', 'ror': 'https://ror.org/02y3ad647', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I33213144']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Baoji Xu', 'raw_affiliation_strings': ['Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, 33458, FL', 'Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, 9037, CA'], 'affiliations': [{'raw_affiliation_string': 'Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, 9037, CA', 'institution_ids': ['https://openalex.org/I123431417']}, {'raw_affiliation_string': 'Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, 33458, FL', 'institution_ids': ['https://openalex.org/I33213144']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5035599351'], 'corresponding_institution_ids': ['https://openalex.org/I123431417', 'https://openalex.org/I33213144'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 67}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Neuroinflammation and Neurodegeneration Mechanisms', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/trk-receptor', 'display_name': 'Trk receptor', 'score': 0.43065703}], 'concepts': [{'id': 'https://openalex.org/C97124661', 'wikidata': 'https://www.wikidata.org/wiki/Q14897782', 'display_name': 'Tropomyosin receptor kinase B', 'level': 4, 'score': 0.9944824}, {'id': 'https://openalex.org/C2778790584', 'wikidata': 'https://www.wikidata.org/wiki/Q123045', 'display_name': 'Brain-derived neurotrophic factor', 'level': 4, 'score': 0.7548366}, {'id': 'https://openalex.org/C160539049', 'wikidata': 'https://www.wikidata.org/wiki/Q3064187', 'display_name': 'Neurotrophic factors', 'level': 3, 'score': 0.66758317}, {'id': 'https://openalex.org/C2779830541', 'wikidata': 'https://www.wikidata.org/wiki/Q1622829', 'display_name': 'Microglia', 'level': 3, 'score': 0.53690267}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.51404893}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.5060112}, {'id': 'https://openalex.org/C134139212', 'wikidata': 'https://www.wikidata.org/wiki/Q24719927', 'display_name': 'Trk receptor', 'level': 4, 'score': 0.43065703}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4280485}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.27085996}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.14198121}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.087044}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2023.07.14.549007', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/07/25/2023.07.14.549007.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biom14010091', 'pdf_url': 'https://www.mdpi.com/2218-273X/14/1/91/pdf?version=1704966165', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370033', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37503044', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2023.07.14.549007', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/07/25/2023.07.14.549007.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1592387428', 'https://openalex.org/W1600123087', 'https://openalex.org/W1963539721', 'https://openalex.org/W1980374113', 'https://openalex.org/W1983559498', 'https://openalex.org/W1995290481', 'https://openalex.org/W2021497853', 'https://openalex.org/W2047804311', 'https://openalex.org/W2074264738', 'https://openalex.org/W2077113617', 'https://openalex.org/W2080402262', 'https://openalex.org/W2083817323', 'https://openalex.org/W2088844842', 'https://openalex.org/W2091995911', 'https://openalex.org/W2096500024', 'https://openalex.org/W2104823419', 'https://openalex.org/W2118238385', 'https://openalex.org/W2119871070', 'https://openalex.org/W2122127855', 'https://openalex.org/W2128994172', 'https://openalex.org/W2133172346', 'https://openalex.org/W2152832272', 'https://openalex.org/W2159965706', 'https://openalex.org/W2164003508', 'https://openalex.org/W2206278845', 'https://openalex.org/W2273567156', 'https://openalex.org/W2324202603', 'https://openalex.org/W2369050436', 'https://openalex.org/W2512350562', 'https://openalex.org/W2520969273', 'https://openalex.org/W2530121292', 'https://openalex.org/W2563147358', 'https://openalex.org/W2581435615', 'https://openalex.org/W2708579841', 'https://openalex.org/W2904459349', 'https://openalex.org/W2907357165', 'https://openalex.org/W2912162449', 'https://openalex.org/W2915299452', 'https://openalex.org/W2939463158', 'https://openalex.org/W2946168453', 'https://openalex.org/W2949740574', 'https://openalex.org/W2953794169', 'https://openalex.org/W2969472499', 'https://openalex.org/W3031463389', 'https://openalex.org/W3148401583', 'https://openalex.org/W3184874058', 'https://openalex.org/W3203835685', 'https://openalex.org/W3216353063', 'https://openalex.org/W4225284443', 'https://openalex.org/W4225287891', 'https://openalex.org/W4312174098'], 'related_works': ['https://openalex.org/W56018094', 'https://openalex.org/W4308531319', 'https://openalex.org/W4280574736', 'https://openalex.org/W4255543363', 'https://openalex.org/W3026620415', 'https://openalex.org/W2895910948', 'https://openalex.org/W2623953495', 'https://openalex.org/W2588481612', 'https://openalex.org/W2024625433', 'https://openalex.org/W2020667484'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'brain-derived': [2], 'neurotrophic': [3], 'factor': [4], '(BDNF)': [5], 'and': [6, 31, 35, 55, 66, 76, 108, 135, 140, 153, 177, 204, 219, 235], 'its': [7], 'high-affinity': [8], 'receptor': [9, 12], 'tropomyosin-related': [10], 'kinase': [11], 'B': [13], '(TrkB)': [14], 'are': [15, 171], 'widely': [16], 'expressed': [17, 96], 'in': [18, 78, 81, 91, 97, 137, 150, 165, 206, 221, 237], 'the': [19, 58, 72, 82, 98, 131, 151, 166, 182, 207, 215], 'central': [20], 'nervous': [21], 'system.': [22], 'It': [23], 'is': [24, 95, 186], 'well': [25], 'documented': [26], 'that': [27, 179, 193], 'neurons': [28], 'express': [29, 53, 163, 180, 201], 'BDNF': [30, 54, 75, 134, 218, 234], 'full-length': [32], 'TrkB': [33, 41, 77, 106, 136, 220, 236], '(TrkB.FL),': [34], 'a': [36, 63, 172], 'lower': [37], 'level': [38], 'of': [39, 74, 133, 175, 184, 217, 233], 'truncated': [40], '(TrkB.T).': [42], 'With': [43], 'conflicting': [44], 'results,': [45], 'glial': [46, 79, 126, 222, 238], 'cells': [47, 80, 100], 'also': [48, 191, 225], 'have': [49], 'been': [50], 'reported': [51], 'to': [52, 70, 111, 116, 129, 187, 228], 'TrkB.': [56], 'In': [57], 'current': [59], 'study,': [60], 'we': [61, 143], 'employed': [62], 'more': [64], 'sensitive': [65], 'reliable': [67], 'genetic': [68], 'method': [69], 'characterize': [71], 'expression': [73, 132, 216], 'mouse': [83, 89], 'brain.': [84, 168, 209], 'We': [85, 122, 190], 'utilized': [86], 'three': [87], 'Cre': [88, 93], 'strains': [90], 'which': [92, 185], 'recombinase': [94], 'same': [99], 'as': [101], 'BDNF,': [102, 181], 'TrkB.FL,': [103], 'or': [104, 119, 147], 'all': [105], 'isoforms,': [107], 'crossed': [109], 'them': [110], 'Cre-dependent': [112], 'EGFP': [113], 'reporter': [114], 'mice': [115], 'label': [117], 'BDNF-': [118, 146], 'TrkB-expressing': [120, 148], 'cells.': [121, 239], 'performed': [123], 'immunohistochemistry': [124], 'with': [125, 157], 'cell': [127], 'markers': [128], 'examine': [130], 'microglia,': [138], 'astrocytes,': [139], 'oligodendrocytes.': [141], 'Surprisingly,': [142], 'found': [144, 192], 'no': [145], 'microglia': [149], 'brain': [152], 'spinal': [154], 'cord.': [155], 'Consistent': [156], 'previous': [158], 'studies,': [159], 'most': [160], 'astrocytes': [161, 176], 'only': [162, 213], 'TrkB.T': [164, 205], 'adult': [167, 208], 'Moreover,': [169], 'there': [170], 'small': [173], 'number': [174], 'oligodendrocytes': [178], 'function': [183], 'be': [188], 'determined.': [189], 'oligodendrocyte': [194], 'precursor': [195], 'cells,': [196, 223], 'but': [197, 224], 'not': [198, 212], 'mature': [199], 'oligodendrocytes,': [200], 'both': [202], 'TrkB.FL': [203], 'These': [210], 'results': [211], 'clarify': [214], 'open': [226], 'opportunities': [227], 'investigate': [229], 'previously': [230], 'unidentified': [231], 'roles': [232]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4384438281', 'counts_by_year': [], 'updated_date': '2025-01-05T09:57:30.309451', 'created_date': '2023-07-16'}