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2097, 2107, 2124, 2144, 2148, 2155, 2198, 2237, 2328, 2352, 2406, 2433, 2440, 2564, 2660, 2770, 2802, 2852, 2867, 2994, 3103, 3181, 3289, 3339, 3435, 3464, 3481, 3505, 3509, 3541, 3637, 3777, 3834, 3974, 4002, 4029, 4032, 4050, 4318, 4487, 4655, 4706, 4775], 'treating': [112], 'mental': [113, 198, 930, 1270, 4051], 'health': [114, 199, 1271], 'conditions': [115, 266, 399, 779], 'described.': [117], 'Are': [118], 'we': [119, 123, 2938, 4182], 'clear': [120, 1554], 'on': [121, 231, 651, 667, 675, 1019, 1144, 1252, 1401, 1412, 1422, 1436, 1502, 1544, 1823, 1840, 1878, 2134, 2424, 2666, 2760, 2789, 2810, 3235, 3272, 3306, 3998, 4057, 4232, 4288, 4347, 4699, 4726], 'what': [122, 2322], 'are': [124, 281, 317, 716, 1164, 2289, 2454, 2729, 2751, 3736], 'trying': [125], 'describe?': [127], 'Take': [128], 'definition': [130], 'psychedelic-assisted': [132, 3323, 3365], 'therapy': [133, 356, 2122, 2181, 2201, 2229, 3633, 3689, 4079, 4231, 4317], 'offered': [134], 'new': [137, 4671], 'European': 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1313, 1882, 1901, 1947, 2167, 2273, 2498, 2641, 3001, 3461, 3836, 3888, 4140, 4672], 'itself.…': [173], 'In': [174, 876, 1074, 1136, 1769, 2054, 2764, 2931, 3013], 'words,': [176], 'psychedelics’': [177], 'novel': [178, 3322], 'value': [180, 1255], 'stems': [181], 'role': [184, 849, 1274, 1994, 2816], 'enhancements': [186], 'psychotherapeutic': [189, 1124, 3884], 'process,': [190], 'grounded': [191, 219], 'relationship-centered': [194], 'approach,': [195], 'that': [196, 205, 243, 264, 294, 793, 823, 872, 912, 1031, 1039, 1161, 1405, 1476, 1617, 1707, 1948, 2061, 2086, 2138, 2160, 2313, 2582, 2958], 'views': [197], 'through': [200, 2318], 'biopsychosocial': [202], 'lens.The': [203], 'statement': [204, 290], 'itself,': [217], 'an': [221, 360, 375, 1002, 1154, 1355, 1584, 1620, 1765, 2010, 2235, 2579, 2952, 3578, 4411], 'odd': [222], 'dualism.': [223], 'medication': [228], 'presumably': [229], 'works': [230], 'brain': [233, 2409, 2425, 2855, 3734], '(as': [234], '“catalyst”),': [236], 'but': [237, 372, 1744, 1787, 1967, 2474, 2841, 2912], 'there': [238, 260, 1026, 1406, 1708, 1927, 2861], 'separate': [241], 'psychotherapy': [242, 247, 348, 665, 813, 851, 920, 1328, 2001, 2173, 2371, 2628, 2636, 2715, 3553, 3831, 4114, 4629], 'it': [244, 350, 373, 913, 1745, 2365, 2373, 2400, 2621, 2643, 2707, 2720, 2831, 2920, 2934], 'facilitates.': [245], 'That': [246], '“relationship': [249], 'centered,”': [250], 'which': [251, 333, 2853], 'has': [252, 834, 1281, 1715, 2072, 2510, 2605, 2708, 2819, 2838, 3108, 3169, 3186, 3193, 3233], 'usually': [253, 352, 1165, 1987], 'meant': [254, 1404], 'nondirective': [255, 285, 1982, 2836], 'counseling': [256], '(Table': [257, 2531], '1).': [258, 2532], 'Ironically,': [259], 'no': [262, 640, 645, 662, 2765], 'evidence': [263], 'being': [267, 1570, 2629, 2808], 'targeted': [268], 'psychedelics': [270, 4620], '(severe': [271], 'depression,': [272, 1680], 'posttraumatic': [273, 433, 702], 'stress': [274, 434, 703], 'disorder': [275, 419, 427, 435, 688, 696, 704, 1360], '[PTSD],': [276], 'substance': [278, 1072], 'disorders)': [280], 'effectively': [282], 'treated': [283], 'counseling.': [286], 'More': [287], 'importantly,': [288], 'fails': [291], 'recognize': [293], 'psychological': [296, 391, 638, 643, 648, 658, 739, 1276, 1575, 2205, 2755, 3573, 3707, 4207], 'support': [297, 649, 740, 1277, 1292, 1576, 1735, 1786, 2206, 2689, 2756, 2777, 3152, 3189, 3574, 3711, 4208], 'provided': [298], 'recent': [300, 2185, 2566], 'studies': [301, 412, 681, 1371, 1675, 1860, 1935, 2159, 2804, 2998, 4056], 'primarily': [305], 'directed': [306], 'safety—specifically,': [308], 'preparation': [310, 1659, 1685], 'safeguarding': [312, 1705], 'vulnerable': [314, 2613], 'people': [315], 'who': [316, 2071], 'submitting': [318], 'potentially': [321, 1294], 'disorienting': [322], 'They': [324, 342, 2288], 'will': [325, 2905, 2935], 'also': [326, 1427, 1893, 2430], 'be': [327, 359, 403, 735, 809, 844, 916, 945, 1142, 1496, 1588, 1646, 1687, 1709, 1831, 2018, 2554, 2702, 2713, 2758, 2793, 2844, 2863, 2892, 2906, 2917, 2922, 2951, 3003], 'participating': [328], 'clinical': [331, 629, 1232, 2259, 2885, 3388, 3638, 3846, 3925, 4055, 4238, 4326], 'trial,': [332], 'requires': [334, 1706, 2684], 'informed': [335, 2686], 'consent': [336], 'measure': [339], 'equipoise.': [341], 'do': [343], 'typically': [345], 'receive': [346], 'evidence-based': [347, 2172, 2272], 'understood.': [353, 2718], 'Staff': [354], 'with': [355, 510, 721, 761, 1047, 1054, 1354, 1374, 1489, 1513, 1525, 1553, 1567, 1640, 2292, 2395, 2403, 2413, 2443, 2527, 2578, 2732, 2747, 2908, 3438, 3466, 3511, 3572, 3840, 3947, 4206, 4619], 'backgrounds': [357], 'may': [358, 807, 860, 2017, 2268, 2314, 2842, 2862, 2890, 2915], 'excellent': [361], 'choice': [362, 1440], 'personnel': [364], 'provide': [366, 929, 2723], 'necessary': [368, 2253], 'essential': [370, 981], 'support,': [371], 'open': [376, 1356, 1662, 1832, 2011], 'question': [377], 'how': [378, 1632, 2266, 2829], 'far': [379, 2297, 2993], 'efforts': [381], 'enhance': [382], 'efficacy': [383, 724, 2091, 2170, 2218, 2277, 3341, 3432, 4111], 'rather': [384, 2968], 'than': [385, 2104, 2969, 4602], 'simply': [386, 2645, 3023], 'ensuring,': [387], 'intended,': [390], 'physical': [393], 'safety.': [394, 2696], 'Such': [395, 2595], 'safety': [396, 746, 2023, 2279, 3343, 4109, 4137], 'creates': [397], 'optimal': [398], 'patients': [401, 802, 1373, 1403, 1443, 1488, 1524, 2027, 2064, 3437, 3465, 3510, 3839], 'immersed': [404], 'experience.TABLE': [408], '1.': [409, 678], 'major': [411, 417, 680, 686, 1679, 1938, 2051, 3604, 4142, 4233, 4285, 4319], 'depressive': [418, 687, 1871, 1919, 2790, 4143, 4234, 4320, 4692], '(MDD),': [420, 689], 'treatment-resistant': [421, 690, 1452, 1526, 1862, 2441, 3576, 3601, 3635, 4210, 4282], 'depression': [422, 691, 1453, 1493, 1527, 1863, 2442, 2470, 3506, 3636, 4290], '(TRD),': [423, 692], 'alcohol': [425, 694, 2190, 2238, 3841], '(AUD),': [428, 697], 'MDMA': [431, 700, 2603], '(PTSD)Imperial': [436], 'College': [437, 444, 1457], 'London': [438, 445, 1458, 3059], '(12,': [439], '35)Johns': [440], 'Hopkins': [441], '(32,': [442], '36)Imperial': [443], '(37)COMPASS': [446], 'Pathways': [447, 3057], '(13,': [448, 1774], '38)University': [449], 'Zurich': [451], '(39)NYU': [452], '(21,': [453, 2195], '23)Multidisciplinary': [454], 'Association': [455, 3245], 'Psychedelic': [457, 1338, 2304, 3312, 3942, 4462, 4488], 'Studies': [458], '(30)Disorder': [459], 'NTRD': [461], '(N=20)MDD': [462], '(N=24)MDD': [463], '(N=59)TRD': [464], '(N=232)MDD': [465], '(N=52)AUD': [466], '(N=95)PTSD': [467], '(N=90)DesignOpen-labelRandomizedRandomized,': [468], 'double-blind,': [469, 471, 473, 475, 480, 4085, 4324], 'placebo-controlledRandomized,': [470, 472, 474], 'active': [476, 481, 766, 1585, 1792, 1801, 2571], 'placebo-controlled': [477, 482, 4086], 'plus': [478, 483], 'psychotherapyRandomized,': [479], 'psychotherapyDosePsilocybin:': [484], 'first': [485, 493, 503, 532, 551], 'dose,': [486, 490, 494, 499, 518, 526, 533, 538], '10': [487, 523, 1482, 1532, 1568], 'mg;': [488, 508], 'second': [489, 498, 505, 537, 559], '25': [491, 507, 520, 534, 952, 1485], 'mgPsilocybin:': [492, 524], '20': [495], 'mg/70': [496, 501, 528, 535, 540], 'kg;': [497, 536], '30': [500], 'kgPsilocybin:': [502], 'doses,': [506, 1580], 'compared': [509, 4115], '6': [511], 'weeks': [512, 1923], 'daily': [514], 'oral': [515], 'escitalopramPsilocybin;': [516], 'one': [517, 525, 572, 2851, 3740], 'either': [519], 'mg': [521, 1483, 1569], '14.98': [527], 'kg': [529], '(0.215': [530], 'mg/kg)Psilocybin:': [531], '25–40': [539], 'kgMDMA:': [541], 'variable': [542], 'dosingPreparationOne': [543], '4-hour': [544, 569], 'session8': [545], 'hours': [546, 563, 567, 577, 601, 614, 616, 626, 1692, 1698, 1962, 2227], 'totalOne': [547, 602], '3-hour': [548], 'session': [549, 557, 603], 'before': [550, 558, 1885], 'administration': [552, 1478, 2692], '1-hour': [555, 573], 'telephone': [556, 579, 608], 'administrationTwo': [560], 'sessions,': [561, 565, 575], '∼2': [562], 'totalTwo': [564, 568, 617], '2': [566, 1509, 1697], 'sessions': [570, 609, 620, 1599, 2526], 'sessionThree': [574], '4.5': [576], 'totalIntegrationBy': [578], 'day': [581, 588, 1702, 1880], 'after': [582, 589, 597, 604, 611, 1847, 2128, 3742], 'low-dose': [583], 'administration;': [584, 592, 606], 'person': [586, 1638, 1712], 'high-dose': [591, 599], 'another': [593], 'visit': [594], '1': [595, 2233, 4745, 4777], 'week': [596], 'administration2–3': [600], 'each': [605, 612], 'three': [607], 'weekly': [610, 955], 'administration∼2.5': [613], 'total3': [615], '2-hour': [618], 'sessionsNine': [619], '(three': [621], 'per': [622, 2543], 'administration),': [624], '13.5': [625], 'totalTherapy': [627], 'supportTwo': [628], 'psychiatristsTwo': [630], 'therapistsTwo': [631, 632, 635], 'therapistsOne': [633], 'therapistTwo': [634], 'therapistsModel': [636], 'specifiedNondirective': [637, 642, 647], 'support;': [639, 644, 659], 'manual': [641, 646, 663, 2562], 'based': [650, 666], '“accept,': [653], 'connect,': [654], 'embody”': [655], '(ACE)': [656], 'modelNondirective': [657], 'manualizedPsychological': [660], 'counseling;': [661], 'specifiedManualized': [664], 'components': [668], 'addiction': [670], 'treatmentManualized': [671], 'treatment;': [672], 'strong': [673, 2822], 'emphasis': [674, 1121, 1139, 2771, 2824], 'therapist': [676, 763, 775, 1777, 1805, 2600, 3628], 'interactionTABLE': [677], '(PTSD)Enlarge': [705], 'tableIt': [706], 'important': [708, 1674], 'get': [710], 'right,': [712], 'because': [713, 982, 2248, 2465, 2610], 'regulatory': [714, 2286, 2300], 'bodies': [715], 'asked': [717], 'approve': [719], 'drugs': [720, 871, 1100, 1242, 2746, 4181], 'defined': [723], 'safety,': [726, 2761], 'psychotherapies.': [728, 1959], 'Indeed,': [729, 2158, 2726], 'effect': [732, 1939, 2542, 2593, 3917], 'only': [734], 'established': [736], 'unambiguously': [737], 'if': [738, 2347, 2372, 2634], 'available': [742, 905, 1784], 'largely': [743, 1315, 1539, 2679, 2730], 'ensure': [745], 'applied': [749], 'stereotyped': [752], 'way,': [753], 'whatever': [754], 'dose.': [757], 'Any': [758], 'complex': [759], 'interaction': [760, 1046, 1125, 1953, 2572, 2596], 'during': [764, 803, 2601, 2690], 'experience': [768, 806, 1265, 1300, 1344, 1825, 1850, 2057, 2131, 2350, 2384, 2559, 2604, 2674, 2683, 2699, 2788], 'clearly': [769, 1973, 2534, 2568, 3054], 'complicates': [770], 'interpretation': [771], 'outcomes;': [774], 'expectations': [776], 'could': [777, 826, 1633, 1686], 'create': [778], 'ripe': [780], 'mutual': [782], 'unblinding': [783], 'amplification': [786], 'demand': [788], 'characteristics.': [789], 'Additionally,': [790], 'harms': [792, 3360], 'result': [795], 'interactions': [798, 2734], 'between': [799, 1308, 2408, 2503, 2573, 2597], 'therapists': [800, 2085], 'fully': [810, 1874, 3910], 'appreciated.': [811], 'Unregulated': [812], 'practice': [814, 825], 'regularly': [815], 'leads': [816], 'ethical': [818, 2608], 'violations': [819], '(2).': [820], 'risk': [822], 'become': [827], 'natural': [829], 'partner': [830], 'been': [835, 1282, 1318, 2281, 2431, 2514, 2710, 2800], 'highlighted': [836], 'recently': [837], '(3).': [838, 1768], 'There': [839, 1368], 'therefore': [841], 'nothing': [842], 'gained': [845], 'exaggerating': [847], 'deriving': [853], 'experience.The': [858, 1838], 'confusion': [859], 'lie': [861], 'large': [863, 1434], 'part': [864], 'medical': [867, 1022, 1738], 'history': [868], 'effects.': [875], '1950s,': [878], 'virtually': [879], 'all': [880], 'influential': [881, 1187], 'psychiatrists': [882], 'United': [885], 'States': [886], 'had': [887, 1058, 1118, 1888], 'undergone': [888], 'psychoanalysis': [889], 'spoke': [891], 'language': [893], 'psychodynamic': [895], 'psychotherapy.': [896, 2333, 2518, 2737, 3012, 3345], 'When': [897], 'Sandoz': [898], 'Laboratories': [899], 'made': [900, 1444, 1748], 'lysergic': [901], 'acid': [902], 'diethylamide': [903], '(LSD)': [904], 'them,': [907], 'package': [909], 'insert': [910], 'stated': [911, 936], 'was': [914, 935, 973, 979, 992, 1027, 1219, 1778, 1806, 1817, 1854, 1873, 2213], '“used': [917], 'analytical': [919], 'elicit': [922], 'release': [923], 'repressed': [925], 'material': [926, 2585], 'relaxation.”': [931], 'recommended': [933], 'dose': [934, 1559, 2676, 3746, 3766, 3997], 'vary': [938], 'greatly': [939], 'patient': [941, 1351, 1611, 1763, 2574, 2598, 2617], 'patient,': [943, 1631], 'built': [946], 'up': [947, 3738], 'small': [949], 'steps': [950], '(from': [951], 'micrograms)': [953], 'at': [954, 1105, 1379, 1528, 1902, 2283, 3033, 3047, 3071, 3095], 'visits': [956, 962], 'anticipate': [959], '7–10': [960], 'milder': [964], 'cases': [965, 1985], '14–15': [967], 'severe': [970, 1492, 4081, 4674], 'cases.': [971], 'What': [972], 'described': [974, 1183, 1980, 2432, 2515, 2893], '“proper': [976], 'psychiatric': [977, 3310], 'supervision”': [978], 'deemed': [980], 'potential': [985, 1758, 4688], 'adverse': [987], 'reactions.': [988], 'Thus,': [989, 1926], 'recommendation': [991], 'explicitly': [993, 1788], 'relatively': [996, 1380, 1855], 'low': [997], 'doses': [998, 1035, 1364, 1382, 1471, 2653, 2898, 2901, 2914], 'LSD': [1000], 'aid': [1003], 'psychotherapy,': [1005, 2911], 'psycholytic,': [1009], 'terminology': [1013], 'time.However,': [1016], 'early': [1018, 1169], 'LSD,': [1025, 3537, 4058], 'competing': [1029], 'tradition': [1030], 'used': [1032, 2563], 'much': [1033, 1651, 2101, 2806, 2830], 'higher': [1034], 'produced': [1037, 1095, 1383, 2386], 'states': [1038, 2661, 2728], 'were': [1040, 1079, 1407, 1426, 1538, 1546, 1577], 'intrinsically': [1041], 'less': [1042], 'amenable': [1043], 'formal': [1045], 'therapist.': [1049], 'psychiatrist': [1051], 'Humphry': [1052], 'Osmond,': [1053], 'collaborator': [1055], 'Abram': [1056], 'Hoffer,': [1057], 'intended': [1059], 'simulate': [1061], 'negative': [1063], 'impact': [1064, 1842, 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1402, 1442, 1742, 3483], 'diagnoses': [1376], '(7–9).': [1377], 'high': [1381, 3745], 'typical': [1384], 'effects,': [1386], 'including': [1387], 'increased': [1388, 2550], 'connectedness,': [1389], 'visual': [1390], 'restructuration,': [1391], 'emotional': [1393, 1622, 1896, 1908, 2319, 3662], 'reexperiencing': [1394], 'past': [1396], 'events': [1397], '(10).': [1398, 2560], 'focus': [1400, 1465], 'particular': [1408], 'claims': [1409], 'demoralization': [1414], 'wrought': [1415], 'imminent': [1417], 'death.': [1418], 'However,': [1419, 2241, 2334, 2547], 'mood': [1423, 1545], 'anxiety': [1425, 3463, 3508], 'striking': [1428], 'rapid': [1431, 4022], 'onset': [1432], 'size': [1435], 'standard': [1437], 'scales.While': [1438], 'generalization': [1445], 'difficult': [1446], '(11),': [1447], 'pilot': [1449], 'Imperial': [1456], 'group': [1459, 1726], '(12)': [1460], 'brought': [1461], 'conventional': [1464, 2271, 2736, 2877, 2910], 'application': [1468], 'psilocybin.': [1473, 3748], 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