Publication Information

{'id': 'https://openalex.org/W4383104678', 'doi': 'https://doi.org/10.1101/2023.07.03.547593', 'title': 'Structure and engineering of miniature<i>Acidibacillus sulfuroxidans</i>Cas12f1', 'display_name': 'Structure and engineering of miniature<i>Acidibacillus sulfuroxidans</i>Cas12f1', 'publication_year': 2023, 'publication_date': '2023-07-03', 'ids': {'openalex': 'https://openalex.org/W4383104678', 'doi': 'https://doi.org/10.1101/2023.07.03.547593'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2023.07.03.547593', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/07/03/2023.07.03.547593.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/07/03/2023.07.03.547593.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051900529', 'display_name': 'Zhaowei Wu', 'orcid': 'https://orcid.org/0000-0001-8952-0181'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhaowei Wu', 'raw_affiliation_strings': ['School of Physical Science and Technology, ShanghaiTech University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'School of Physical Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100323866', 'display_name': 'Dongliang Liu', 'orcid': 'https://orcid.org/0000-0002-8055-1157'}, 'institutions': [{'id': 'https://openalex.org/I3133055985', 'display_name': 'Westlake University', 'ror': 'https://ror.org/05hfa4n20', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3133055985']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dongliang Liu', 'raw_affiliation_strings': ['Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China', 'Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China', 'institution_ids': ['https://openalex.org/I3133055985']}, {'raw_affiliation_string': 'Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China', 'institution_ids': ['https://openalex.org/I3133055985']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062231929', 'display_name': 'Deng Pan', 'orcid': 'https://orcid.org/0000-0002-9007-0744'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Deng Pan', 'raw_affiliation_strings': ['School of Physical Science and Technology, ShanghaiTech University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'School of Physical Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077790956', 'display_name': 'Haopeng Yu', 'orcid': 'https://orcid.org/0000-0002-5184-2430'}, 'institutions': [{'id': 'https://openalex.org/I100288624', 'display_name': 'John Innes Centre', 'ror': 'https://ror.org/055zmrh94', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I100288624', 'https://openalex.org/I2799693246', 'https://openalex.org/I4210087105']}, {'id': 'https://openalex.org/I2799300731', 'display_name': 'Norwich Research Park', 'ror': 'https://ror.org/0062dz060', 'country_code': 'GB', 'type': 'archive', 'lineage': ['https://openalex.org/I2799300731']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Haopeng Yu', 'raw_affiliation_strings': ['Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, UK', 'institution_ids': ['https://openalex.org/I100288624', 'https://openalex.org/I2799300731']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034906860', 'display_name': 'Jin Shi', 'orcid': 'https://orcid.org/0000-0002-1677-791X'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jin Shi', 'raw_affiliation_strings': ['School of Physical Science and Technology, ShanghaiTech University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'School of Physical Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102852739', 'display_name': 'Jiacheng Ma', 'orcid': 'https://orcid.org/0009-0005-4656-392X'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiacheng Ma', 'raw_affiliation_strings': ['School of Physical Science and Technology, ShanghaiTech University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'School of Physical Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091640013', 'display_name': 'Wenhan Fu', 'orcid': 'https://orcid.org/0000-0002-1109-4861'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenhan Fu', 'raw_affiliation_strings': ['School of Physical Science and Technology, ShanghaiTech University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'School of Physical Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087950075', 'display_name': 'Z Wang', 'orcid': 'https://orcid.org/0000-0002-7544-4293'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhipeng Wang', 'raw_affiliation_strings': ['School of Physical Science and Technology, ShanghaiTech University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'School of Physical Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005347513', 'display_name': 'Zijie Zheng', 'orcid': 'https://orcid.org/0000-0001-7622-0470'}, 'institutions': [{'id': 'https://openalex.org/I3133055985', 'display_name': 'Westlake University', 'ror': 'https://ror.org/05hfa4n20', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3133055985']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zijie Zheng', 'raw_affiliation_strings': ['Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China', 'Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China', 'institution_ids': ['https://openalex.org/I3133055985']}, {'raw_affiliation_string': 'Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China', 'institution_ids': ['https://openalex.org/I3133055985']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109627000', 'display_name': 'Yannan Qu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3133055985', 'display_name': 'Westlake University', 'ror': 'https://ror.org/05hfa4n20', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3133055985']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yannan Qu', 'raw_affiliation_strings': ['Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China', 'Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China', 'institution_ids': ['https://openalex.org/I3133055985']}, {'raw_affiliation_string': 'Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China', 'institution_ids': ['https://openalex.org/I3133055985']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100373589', 'display_name': 'Fan Li', 'orcid': 'https://orcid.org/0000-0002-9338-3295'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fan Li', 'raw_affiliation_strings': ['School of Physical Science and Technology, ShanghaiTech University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'School of Physical Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025013285', 'display_name': 'Weizhong Chen', 'orcid': 'https://orcid.org/0000-0003-2234-2258'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weizhong Chen', 'raw_affiliation_strings': ['School of Physical Science and Technology, ShanghaiTech University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'School of Physical Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057361452', 'display_name': 'Xingxu Huang', 'orcid': 'https://orcid.org/0000-0001-8934-1247'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xingxu Huang', 'raw_affiliation_strings': ['Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China', 'Guangzhou Laboratory, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Guangzhou Laboratory, Guangzhou, China', 'institution_ids': []}, {'raw_affiliation_string': 'Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088224156', 'display_name': 'Huaizong Shen', 'orcid': 'https://orcid.org/0000-0002-1216-5393'}, 'institutions': [{'id': 'https://openalex.org/I3133055985', 'display_name': 'Westlake University', 'ror': 'https://ror.org/05hfa4n20', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3133055985']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Huaizong Shen', 'raw_affiliation_strings': ['Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China', 'Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China', 'institution_ids': ['https://openalex.org/I3133055985']}, {'raw_affiliation_string': 'Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China', 'institution_ids': ['https://openalex.org/I3133055985']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052855859', 'display_name': 'Quanjiang Ji', 'orcid': 'https://orcid.org/0000-0002-2321-8462'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Quanjiang Ji', 'raw_affiliation_strings': ['Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China', 'School of Physical Science and Technology, ShanghaiTech University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'School of Physical Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}, {'raw_affiliation_string': 'Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China', 'institution_ids': ['https://openalex.org/I30809798']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5088224156', 'https://openalex.org/A5052855859'], 'corresponding_institution_ids': ['https://openalex.org/I3133055985', 'https://openalex.org/I30809798'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 68}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9889, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12610', 'display_name': 'RNA regulation and disease', 'score': 0.9881, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nuclease', 'display_name': 'Nuclease', 'score': 0.87371576}, {'id': 'https://openalex.org/keywords/subgenomic-mrna', 'display_name': 'Subgenomic mRNA', 'score': 0.8600929}, {'id': 'https://openalex.org/keywords/guide-rna', 'display_name': 'Guide RNA', 'score': 0.7876854}, {'id': 'https://openalex.org/keywords/genome-engineering', 'display_name': 'Genome Engineering', 'score': 0.7116826}, {'id': 'https://openalex.org/keywords/toolbox', 'display_name': 'Toolbox', 'score': 0.4200403}], 'concepts': [{'id': 'https://openalex.org/C2777271071', 'wikidata': 'https://www.wikidata.org/wiki/Q422529', 'display_name': 'Nuclease', 'level': 3, 'score': 0.87371576}, {'id': 'https://openalex.org/C189819185', 'wikidata': 'https://www.wikidata.org/wiki/Q384283', 'display_name': 'Subgenomic mRNA', 'level': 4, 'score': 0.8600929}, {'id': 'https://openalex.org/C98108389', 'wikidata': 'https://www.wikidata.org/wiki/Q412563', 'display_name': 'CRISPR', 'level': 3, 'score': 0.8343685}, {'id': 'https://openalex.org/C144501496', 'wikidata': 'https://www.wikidata.org/wiki/Q5533489', 'display_name': 'Genome editing', 'level': 4, 'score': 0.8134451}, {'id': 'https://openalex.org/C97702854', 'wikidata': 'https://www.wikidata.org/wiki/Q4039747', 'display_name': 'Guide RNA', 'level': 5, 'score': 0.7876854}, {'id': 'https://openalex.org/C132455925', 'wikidata': 'https://www.wikidata.org/wiki/Q16965677', 'display_name': 'Cas9', 'level': 4, 'score': 0.76506597}, {'id': 'https://openalex.org/C145290725', 'wikidata': 'https://www.wikidata.org/wiki/Q5533489', 'display_name': 'Genome engineering', 'level': 5, 'score': 0.7116826}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.70061904}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44908}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.44562143}, {'id': 'https://openalex.org/C2777655017', 'wikidata': 'https://www.wikidata.org/wiki/Q1501161', 'display_name': 'Toolbox', 'level': 2, 'score': 0.4200403}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.31078854}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.2832384}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18726572}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.07757047}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2023.07.03.547593', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/07/03/2023.07.03.547593.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2023.07.03.547593', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/07/03/2023.07.03.547593.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W2003797386', 'https://openalex.org/W2045435533', 'https://openalex.org/W2054770020', 'https://openalex.org/W2105329815', 'https://openalex.org/W2124026197', 'https://openalex.org/W2148941629', 'https://openalex.org/W2152562710', 'https://openalex.org/W2157328664', 'https://openalex.org/W2160378127', 'https://openalex.org/W2165869860', 'https://openalex.org/W2336828812', 'https://openalex.org/W2480829753', 'https://openalex.org/W2566705644', 'https://openalex.org/W2587625522', 'https://openalex.org/W2593511418', 'https://openalex.org/W2766599608', 'https://openalex.org/W2786390877', 'https://openalex.org/W2897700601', 'https://openalex.org/W2902246058', 'https://openalex.org/W2911354827', 'https://openalex.org/W2915459742', 'https://openalex.org/W2943335541', 'https://openalex.org/W2950967305', 'https://openalex.org/W2981137429', 'https://openalex.org/W2990692474', 'https://openalex.org/W2995081665', 'https://openalex.org/W2996883039', 'https://openalex.org/W3014278982', 'https://openalex.org/W3042599313', 'https://openalex.org/W3083245676', 'https://openalex.org/W3088092039', 'https://openalex.org/W3093089676', 'https://openalex.org/W3103257049', 'https://openalex.org/W3108495343', 'https://openalex.org/W3111085913', 'https://openalex.org/W3119803887', 'https://openalex.org/W3137249078', 'https://openalex.org/W3156458251', 'https://openalex.org/W3169602398', 'https://openalex.org/W3177445623', 'https://openalex.org/W3183969621', 'https://openalex.org/W3188582333', 'https://openalex.org/W3198162943', 'https://openalex.org/W3198344223', 'https://openalex.org/W3198740632', 'https://openalex.org/W3203405076', 'https://openalex.org/W3210235422', 'https://openalex.org/W4214518133', 'https://openalex.org/W4214867556', 'https://openalex.org/W4239521868', 'https://openalex.org/W4280501739', 'https://openalex.org/W4280544078', 'https://openalex.org/W4281564380', 'https://openalex.org/W4282975571', 'https://openalex.org/W4296941685', 'https://openalex.org/W4310075481', 'https://openalex.org/W4316494493', 'https://openalex.org/W4316810847'], 'related_works': ['https://openalex.org/W4383104678', 'https://openalex.org/W3085130654', 'https://openalex.org/W2952896068', 'https://openalex.org/W2950422347', 'https://openalex.org/W2949907681', 'https://openalex.org/W2805979811', 'https://openalex.org/W2804028787', 'https://openalex.org/W2795639748', 'https://openalex.org/W2794852126', 'https://openalex.org/W2529558541'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1, 102], 'miniature': [2], 'CRISPR-Cas12f': [3], 'nucleases': [4], 'allow': [5], 'for': [6, 19, 66, 94, 105, 160], 'efficient': [7], 'delivery': [8, 13], 'via': [9], 'cargo-size-limited': [10], 'adeno-associated': [11], 'virus': [12], 'vehicles,': [14], 'thereby': [15], 'showing': [16, 40], 'promising': [17], 'potential': [18], 'in': [20, 47, 131, 142], 'vivo': [21], 'therapeutic': [22, 161], 'applications.': [23, 162], 'Acidibacillus': [24], 'sulfuroxidans': [25], 'Cas12f1': [26], '(AsCas12f1,': [27], '422': [28], 'amino': [29], 'acids)': [30], 'is': [31, 64], 'the': [32, 56, 77, 81, 117, 123, 156], 'most': [33], 'compact': [34, 62, 151], 'Cas12f': [35], 'nuclease': [36, 63, 125], 'identified': [37], 'to': [38, 51], 'date,': [39], 'a': [41, 61], 'moderate': [42], 'level': [43], 'of': [44, 58, 80, 150], 'genome-editing': [45], 'activity': [46, 141], 'human': [48, 143], 'cells': [49], 'compared': [50], 'Cas9': [52], 'and': [53, 85, 99, 110, 126, 154], 'Cas12a.': [54], 'Understanding': [55], 'mechanisms': [57, 104], 'why': [59], 'such': [60], 'active': [65], 'genome': [67, 139], 'editing': [68, 140], 'would': [69], 'facilitate': [70], 'its': [71, 127], 'rational': [72], 'engineering.': [73], 'Here,': [74], 'we': [75, 120], 'report': [76], 'cryo-EM': [78], 'structure': [79], 'AsCas12f1-sgRNA-dsDNA': [82], 'ternary': [83], 'complex,': [84], 'reveal': [86], 'that': [87], 'AsCas12f1': [88, 124], 'functions': [89], 'as': [90], 'an': [91, 132], 'asymmetric': [92], 'dimer': [93, 106], 'single-guide': [95], 'RNA': [96], '(sgRNA)': [97], 'binding': [98], 'DNA': [100], 'targeting.': [101], 'detailed': [103], 'formation,': [107], 'PAM': [108], 'recognition,': [109], 'sgRNA': [111], 'accommodation': [112], 'are': [113], 'elucidated.': [114], 'Leading': [115], 'by': [116], 'structural': [118], 'knowledge,': [119], 'extensively': [121], 'engineer': [122], 'corresponding': [128], 'sgRNA,': [129], 'resulting': [130], 'evolved': [133], 'AsCas12f1-sgRNA': [134], 'combination': [135], 'with': [136], 'drastically': [137], 'enhanced': [138], 'cells.': [144], 'These': [145], 'results': [146], 'provide': [147], 'further': [148], 'understanding': [149], 'CRISPR': [152, 158], 'systems': [153], 'expand': [155], 'mini': [157], 'toolbox': [159]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4383104678', 'counts_by_year': [], 'updated_date': '2024-12-15T17:49:29.417650', 'created_date': '2023-07-05'}