Development, Synthesis and Antiprotozoal Assessment of New Substituted Diquinolinyl-Pyridine Derivatives as Antiparasitic Agents by Potential G-4 Binding

Name: Work Video:
Duration: 3 min 30 s
Rabindra Nath Das; Anita Cohen; Clotilde Boudot; Solène Savrimoutou; Sandra Albenque-Rubio; Stéphane Moreau; Jean‐Louis Mergny; Luisa Ronga; Ioannis Kanavos; Charles Descamps; Valentin Verdier; Patrice Agnamey; Catherine Mullié; Bertrand Courtioux; Pascal Sonne; Jean Guillon
{'id': 'https://openalex.org/W4382789800', 'doi': 'https://doi.org/10.31080/asps.2023.07.0965', 'title': 'Development, Synthesis and Antiprotozoal Assessment of New Substituted Diquinolinyl-Pyridine Derivatives as Antiparasitic Agents by Potential G-4 Binding', 'display_name': 'Development, Synthesis and Antiprotozoal Assessment of New Substituted Diquinolinyl-Pyridine Derivatives as Antiparasitic Agents by Potential G-4 Binding', 'publication_year': 2023, 'publication_date': '2023-06-30', 'ids': {'openalex': 'https://openalex.org/W4382789800', 'doi': 'https://doi.org/10.31080/asps.2023.07.0965'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.31080/asps.2023.07.0965', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210199804', 'display_name': 'Acta Scientific Pharmaceutical Sciences', 'issn_l': '2581-5423', 'issn': ['2581-5423'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.31080/asps.2023.07.0965', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080407325', 'display_name': 'Rabindra Nath Das', 'orcid': 'https://orcid.org/0000-0001-6347-2169'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I15057530', 'display_name': 'Université de Bordeaux', 'ror': 'https://ror.org/057qpr032', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I15057530']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I145286018', 'display_name': 'SRM Institute of Science and Technology', 'ror': 'https://ror.org/050113w36', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I145286018']}], 'countries': ['FR', 'IN'], 'is_corresponding': False, 'raw_author_name': 'Rabindra Nath Das', 'raw_affiliation_strings': ['Department of Chemistry, College of Engineering and Technology, Kattankulathur -Chennai, Tamil Nadu, India', 'University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France'], 'affiliations': [{'raw_affiliation_string': 'University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I15057530', 'https://openalex.org/I1294671590']}, {'raw_affiliation_string': 'Department of Chemistry, College of Engineering and Technology, Kattankulathur -Chennai, Tamil Nadu, India', 'institution_ids': ['https://openalex.org/I145286018']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071896697', 'display_name': 'Anita Cohen', 'orcid': 'https://orcid.org/0000-0003-2432-7342'}, 'institutions': [{'id': 'https://openalex.org/I4210166444', 'display_name': 'Institut de Recherche pour le Développement', 'ror': 'https://ror.org/05q3vnk25', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2802818602', 'https://openalex.org/I4210090127', 'https://openalex.org/I4210131494', 'https://openalex.org/I4210166444']}, {'id': 'https://openalex.org/I21491767', 'display_name': 'Aix-Marseille Université', 'ror': 'https://ror.org/035xkbk20', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I21491767']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Anita Cohen', 'raw_affiliation_strings': ['University of Aix-Marseille, IRD, AP-HM, SSA, VITROME, France'], 'affiliations': [{'raw_affiliation_string': 'University of Aix-Marseille, IRD, AP-HM, SSA, VITROME, France', 'institution_ids': ['https://openalex.org/I4210166444', 'https://openalex.org/I21491767']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068348623', 'display_name': 'Clotilde Boudot', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210152337', 'display_name': 'Institut d’Epidémiologie Neurologique et de Neurologie Tropicale', 'ror': 'https://ror.org/0529q4s79', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210145734', 'https://openalex.org/I4210152337', 'https://openalex.org/I65806277']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I65806277', 'display_name': 'Université de Limoges', 'ror': 'https://ror.org/02cp04407', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I65806277']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Clotilde Boudot', 'raw_affiliation_strings': ['University of Limoges, INSERM U1094, Tropical Neuroepidemiology, Limoges, France; Institute of Neuroepidemiology and Tropical Neurology, France'], 'affiliations': [{'raw_affiliation_string': 'University of Limoges, INSERM U1094, Tropical Neuroepidemiology, Limoges, France; Institute of Neuroepidemiology and Tropical Neurology, France', 'institution_ids': ['https://openalex.org/I4210152337', 'https://openalex.org/I154526488', 'https://openalex.org/I65806277']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017082381', 'display_name': 'Solène Savrimoutou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I15057530', 'display_name': 'Université de Bordeaux', 'ror': 'https://ror.org/057qpr032', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I15057530']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Solène Savrimoutou', 'raw_affiliation_strings': ['University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France'], 'affiliations': [{'raw_affiliation_string': 'University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I1294671590', 'https://openalex.org/I15057530']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027120032', 'display_name': 'Sandra Albenque-Rubio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I15057530', 'display_name': 'Université de Bordeaux', 'ror': 'https://ror.org/057qpr032', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I15057530']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Sandra Albenque-Rubio', 'raw_affiliation_strings': ['University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France'], 'affiliations': [{'raw_affiliation_string': 'University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I15057530', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061700845', 'display_name': 'Stéphane Moreau', 'orcid': 'https://orcid.org/0000-0002-9306-8375'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I15057530', 'display_name': 'Université de Bordeaux', 'ror': 'https://ror.org/057qpr032', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I15057530']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Stéphane Moreau', 'raw_affiliation_strings': ['University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France'], 'affiliations': [{'raw_affiliation_string': 'University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I15057530', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050850407', 'display_name': 'Jean‐Louis Mergny', 'orcid': 'https://orcid.org/0000-0003-3043-8401'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I142476485', 'display_name': 'École Polytechnique', 'ror': 'https://ror.org/05hy3tk52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I142476485', 'https://openalex.org/I4210145102']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-Louis Mergny', 'raw_affiliation_strings': ["Ecole Polytechnique, Laboratoire d'Optique et Biosciences, CNRS, INSERM, Institut Polytechnique de Paris, France"], 'affiliations': [{'raw_affiliation_string': "Ecole Polytechnique, Laboratoire d'Optique et Biosciences, CNRS, INSERM, Institut Polytechnique de Paris, France", 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I1294671590', 'https://openalex.org/I142476485']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112220667', 'display_name': 'Luisa Ronga', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092492', 'display_name': "Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux", 'ror': 'https://ror.org/00222yk13', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I144889574', 'https://openalex.org/I4210092492', 'https://openalex.org/I4210128300']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I144889574', 'display_name': "Université de Pau et des Pays de l'Adour", 'ror': 'https://ror.org/01frn9647', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I144889574']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Luisa Ronga', 'raw_affiliation_strings': ["Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM, France"], 'affiliations': [{'raw_affiliation_string': "Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM, France", 'institution_ids': ['https://openalex.org/I4210092492', 'https://openalex.org/I1294671590', 'https://openalex.org/I144889574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036453633', 'display_name': 'Ioannis Kanavos', 'orcid': 'https://orcid.org/0009-0006-6310-6242'}, 'institutions': [{'id': 'https://openalex.org/I4210092492', 'display_name': "Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux", 'ror': 'https://ror.org/00222yk13', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I144889574', 'https://openalex.org/I4210092492', 'https://openalex.org/I4210128300']}, {'id': 'https://openalex.org/I144889574', 'display_name': "Université de Pau et des Pays de l'Adour", 'ror': 'https://ror.org/01frn9647', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I144889574']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Ioannis Kanavos', 'raw_affiliation_strings': ["Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM, France"], 'affiliations': [{'raw_affiliation_string': "Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM, France", 'institution_ids': ['https://openalex.org/I4210092492', 'https://openalex.org/I144889574', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110549795', 'display_name': 'Charles Descamps', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I15057530', 'display_name': 'Université de Bordeaux', 'ror': 'https://ror.org/057qpr032', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I15057530']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Charles Descamps', 'raw_affiliation_strings': ['University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France'], 'affiliations': [{'raw_affiliation_string': 'University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I15057530', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029611263', 'display_name': 'Valentin Verdier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I15057530', 'display_name': 'Université de Bordeaux', 'ror': 'https://ror.org/057qpr032', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I15057530']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Valentin Verdier', 'raw_affiliation_strings': ['University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France'], 'affiliations': [{'raw_affiliation_string': 'University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I15057530']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009647802', 'display_name': 'Patrice Agnamey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4401200328', 'display_name': 'Agents infectieux, résistance et chimiothérapie', 'ror': 'https://ror.org/04mywez65', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I4401200328', 'https://openalex.org/I4647051']}, {'id': 'https://openalex.org/I4210111259', 'display_name': 'AGroecologies, Innovations & Ruralities', 'ror': 'https://ror.org/01sjmsj73', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I205747304', 'https://openalex.org/I2802818602', 'https://openalex.org/I4210088668', 'https://openalex.org/I4210090127', 'https://openalex.org/I4210103063', 'https://openalex.org/I4210111259', 'https://openalex.org/I4210131494', 'https://openalex.org/I4210166444']}, {'id': 'https://openalex.org/I4647051', 'display_name': 'Université de Picardie Jules Verne', 'ror': 'https://ror.org/01gyxrk03', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4647051']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Patrice Agnamey', 'raw_affiliation_strings': ['University of Picardie Jules Verne, Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, UFR de Pharmacie, France'], 'affiliations': [{'raw_affiliation_string': 'University of Picardie Jules Verne, Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, UFR de Pharmacie, France', 'institution_ids': ['https://openalex.org/I4401200328', 'https://openalex.org/I4210111259', 'https://openalex.org/I4647051']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060029531', 'display_name': 'Catherine Mullié', 'orcid': 'https://orcid.org/0000-0001-8986-9666'}, 'institutions': [{'id': 'https://openalex.org/I4210111259', 'display_name': 'AGroecologies, Innovations & Ruralities', 'ror': 'https://ror.org/01sjmsj73', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I205747304', 'https://openalex.org/I2802818602', 'https://openalex.org/I4210088668', 'https://openalex.org/I4210090127', 'https://openalex.org/I4210103063', 'https://openalex.org/I4210111259', 'https://openalex.org/I4210131494', 'https://openalex.org/I4210166444']}, {'id': 'https://openalex.org/I4647051', 'display_name': 'Université de Picardie Jules Verne', 'ror': 'https://ror.org/01gyxrk03', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4647051']}, {'id': 'https://openalex.org/I4401200328', 'display_name': 'Agents infectieux, résistance et chimiothérapie', 'ror': 'https://ror.org/04mywez65', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I4401200328', 'https://openalex.org/I4647051']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Catherine Mullié', 'raw_affiliation_strings': ['University of Picardie Jules Verne, Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, UFR de Pharmacie, France'], 'affiliations': [{'raw_affiliation_string': 'University of Picardie Jules Verne, Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, UFR de Pharmacie, France', 'institution_ids': ['https://openalex.org/I4210111259', 'https://openalex.org/I4647051', 'https://openalex.org/I4401200328']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073543158', 'display_name': 'Bertrand Courtioux', 'orcid': 'https://orcid.org/0000-0002-0841-2240'}, 'institutions': [{'id': 'https://openalex.org/I4210152337', 'display_name': 'Institut d’Epidémiologie Neurologique et de Neurologie Tropicale', 'ror': 'https://ror.org/0529q4s79', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210145734', 'https://openalex.org/I4210152337', 'https://openalex.org/I65806277']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I65806277', 'display_name': 'Université de Limoges', 'ror': 'https://ror.org/02cp04407', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I65806277']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Bertrand Courtioux', 'raw_affiliation_strings': ['University of Limoges, INSERM U1094, Tropical Neuroepidemiology, Limoges, France; Institute of Neuroepidemiology and Tropical Neurology, France'], 'affiliations': [{'raw_affiliation_string': 'University of Limoges, INSERM U1094, Tropical Neuroepidemiology, Limoges, France; Institute of Neuroepidemiology and Tropical Neurology, France', 'institution_ids': ['https://openalex.org/I4210152337', 'https://openalex.org/I154526488', 'https://openalex.org/I65806277']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5092374342', 'display_name': 'Pascal Sonne', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210111259', 'display_name': 'AGroecologies, Innovations & Ruralities', 'ror': 'https://ror.org/01sjmsj73', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I205747304', 'https://openalex.org/I2802818602', 'https://openalex.org/I4210088668', 'https://openalex.org/I4210090127', 'https://openalex.org/I4210103063', 'https://openalex.org/I4210111259', 'https://openalex.org/I4210131494', 'https://openalex.org/I4210166444']}, {'id': 'https://openalex.org/I4401200328', 'display_name': 'Agents infectieux, résistance et chimiothérapie', 'ror': 'https://ror.org/04mywez65', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I4401200328', 'https://openalex.org/I4647051']}, {'id': 'https://openalex.org/I4647051', 'display_name': 'Université de Picardie Jules Verne', 'ror': 'https://ror.org/01gyxrk03', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4647051']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Pascal Sonne', 'raw_affiliation_strings': ['University of Picardie Jules Verne, Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, UFR de Pharmacie, France'], 'affiliations': [{'raw_affiliation_string': 'University of Picardie Jules Verne, Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, UFR de Pharmacie, France', 'institution_ids': ['https://openalex.org/I4210111259', 'https://openalex.org/I4401200328', 'https://openalex.org/I4647051']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028441333', 'display_name': 'Jean Guillon', 'orcid': 'https://orcid.org/0000-0001-8577-3894'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I15057530', 'display_name': 'Université de Bordeaux', 'ror': 'https://ror.org/057qpr032', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I15057530']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean Guillon', 'raw_affiliation_strings': ['University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France'], 'affiliations': [{'raw_affiliation_string': 'University of Bordeaux, Faculty of Pharmacy, CNRS, INSERM, ARNA, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I15057530', 'https://openalex.org/I1294671590']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 14, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 68}, 'biblio': {'volume': '7', 'issue': '7', 'first_page': '15', 'last_page': '33'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11281', 'display_name': 'Asymmetric Hydrogenation and Catalysis', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1604', 'display_name': 'Inorganic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/antiprotozoal', 'display_name': 'Antiprotozoal', 'score': 0.92448723}, {'id': 'https://openalex.org/keywords/antiparasitic', 'display_name': 'Antiparasitic', 'score': 0.7613708}, {'id': 'https://openalex.org/keywords/antiparasitic-agent', 'display_name': 'Antiparasitic agent', 'score': 0.7158469}], 'concepts': [{'id': 'https://openalex.org/C2776635100', 'wikidata': 'https://www.wikidata.org/wiki/Q582559', 'display_name': 'Antiprotozoal', 'level': 3, 'score': 0.92448723}, {'id': 'https://openalex.org/C2781421772', 'wikidata': 'https://www.wikidata.org/wiki/Q581102', 'display_name': 'Antiparasitic', 'level': 2, 'score': 0.7613708}, {'id': 'https://openalex.org/C2911037157', 'wikidata': 'https://www.wikidata.org/wiki/Q581102', 'display_name': 'Antiparasitic agent', 'level': 2, 'score': 0.7158469}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5317159}, {'id': 'https://openalex.org/C2779485729', 'wikidata': 'https://www.wikidata.org/wiki/Q210385', 'display_name': 'Pyridine', 'level': 2, 'score': 0.5311526}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5295523}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.43670815}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.4003768}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2575909}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22348925}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.21970728}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.17252687}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.09972033}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.31080/asps.2023.07.0965', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210199804', 'display_name': 'Acta Scientific Pharmaceutical Sciences', 'issn_l': '2581-5423', 'issn': ['2581-5423'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.31080/asps.2023.07.0965', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210199804', 'display_name': 'Acta Scientific Pharmaceutical Sciences', 'issn_l': '2581-5423', 'issn': ['2581-5423'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.63, 'display_name': 'Zero hunger', 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1489752972', 'https://openalex.org/W1935711444', 'https://openalex.org/W1996356451', 'https://openalex.org/W2014456408', 'https://openalex.org/W2018104916', 'https://openalex.org/W2049133776', 'https://openalex.org/W2105668259', 'https://openalex.org/W2114918609', 'https://openalex.org/W2114971505', 'https://openalex.org/W2131232496', 'https://openalex.org/W2170646500', 'https://openalex.org/W2402321437', 'https://openalex.org/W2488347478', 'https://openalex.org/W2502173429', 'https://openalex.org/W2510725391', 'https://openalex.org/W2561473308', 'https://openalex.org/W2590403341', 'https://openalex.org/W2738277744', 'https://openalex.org/W2780667525', 'https://openalex.org/W2782475976', 'https://openalex.org/W2979381900', 'https://openalex.org/W2997619704', 'https://openalex.org/W3047196252', 'https://openalex.org/W3199798576', 'https://openalex.org/W3214489906', 'https://openalex.org/W4311023235', 'https://openalex.org/W4318592271'], 'related_works': ['https://openalex.org/W4382789800', 'https://openalex.org/W3088329562', 'https://openalex.org/W2594183909', 'https://openalex.org/W2580410898', 'https://openalex.org/W2572322481', 'https://openalex.org/W2414880193', 'https://openalex.org/W2101092227', 'https://openalex.org/W1995087214', 'https://openalex.org/W1992122072', 'https://openalex.org/W1991265839'], 'abstract_inverted_index': {'In': [0], 'order': [1], 'to': [2, 48, 134, 232], 'fight': [3], 'malaria,': [4], 'a': [5, 22, 67, 130, 158, 242], 'public': [6], 'health': [7], 'problem': [8], 'for': [9, 31], 'which': [10, 32], 'nearly': [11], 'half': [12], 'of': [13, 36, 69, 108, 132, 137, 162, 190, 207, 219, 222, 228], 'the': [14, 33, 59, 64, 100, 124, 140, 152, 171, 180, 205, 226, 234], "world's": [15], 'population': [16], 'is': [17, 47], 'at': [18, 39], 'risk': [19], 'and': [20, 30, 50, 76, 87, 102, 174, 192, 211], 'responsible': [21], 'lifethreatening': [23], 'disease': [24], 'primarily': [25], 'found': [26, 122], 'in': [27, 42, 63, 78, 99, 105], 'tropical': [28], 'countries': [29], 'estimated': [34], 'number': [35], 'deaths': [37], 'stood': [38], '619': [40], '000': [41], '2021,': [43], 'an': [44], 'original': [45], 'strategy': [46], 'design': [49], 'synthesize': [51], 'quinoline-based': [52], 'drugs': [53, 185], 'that': [54, 204], 'are': [55], 'not': [56], 'recognized': [57], 'by': [58], 'protein': [60], 'system': [61], 'involved': [62], 'drug': [65], 'efflux.Thus,': [66], 'series': [68], 'new': [70, 110, 230], '2,6-di-(carbamoyl-2-quinolinyl)pyridine': [71], 'derivatives': [72, 112, 231], 'was': [73, 113, 121, 148], 'considered,': [74], 'synthesized,': [75], 'evaluated': [77, 114], 'vitro': [79, 106], 'against': [80, 139], 'three': [81], 'parasites': [82, 208], '(Plasmodium': [83], 'falciparum,': [84], 'Leishmania': [85], 'donovani': [86], 'Trypanosoma': [88, 212], 'brucei': [89, 197, 198], 'brucei).Pharmacological': [90], 'results': [91], 'showed': [92], 'antiparasitic': [93, 155], 'activity': [94], 'with': [95, 129, 157, 186], 'IC': [96], '50': [97], 'values': [98], 'sub': [101], 'µM': [103], 'range.The': [104], 'cytotoxicity': [107], 'these': [109, 229], 'diquinolinyl-pyridine': [111, 119], 'on': [115, 164, 195], 'human': [116], 'HepG2': [117], 'cells.The': [118], '1e': [120], 'as': [123, 151, 179, 216], 'most': [125, 153, 181], 'potent': [126, 154], 'antimalarial': [127], 'candidate': [128, 184], 'ratio': [131], 'cytotoxic': [133], 'antiprotozoal': [135], 'activities': [136], '73.5': [138], 'P.': [141, 166, 209], 'falciparum': [142, 167, 210], 'CQ-resistant': [143], 'strain': [144], 'W2.Moreover,': [145], 'derivative': [146], '3b': [147, 175], 'also': [149, 177], 'identified': [150, 178], 'compound': [156], 'selectivity': [159, 187], 'index': [160, 188], '(SI)': [161, 189], '21.48': [163], '3D7': [165], 'CQsensitive': [168], 'strain.In': [169], 'addition,': [170], '2,6-di-(carbamoyl-2-quinolinyl)pyridines': [172], '2c': [173], 'were': [176], 'interesting': [182], 'antitrypanosomal': [183], '75.9': [191], '38.94,': [193], 'respectively': [194], 'T.': [196], 'strain.It': [199], 'has': [200], 'been': [201, 239], 'previously': [202], 'described': [203], 'telomeres': [206], 'could': [213], 'be': [214], 'considered': [215], 'potential': [217], 'targets': [218], 'this': [220], 'kind': [221], 'nitrogen': [223], 'heterocycles,': [224], 'thus': [225], 'ability': [227], 'stabilize': [233], 'parasitic': [235], 'telomeric': [236], 'G-quadruplexes': [237], 'have': [238], 'measured': [240], 'through': [241], 'FRET': [243], 'melting': [244], 'assay.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4382789800', 'counts_by_year': [], 'updated_date': '2024-12-15T04:53:10.748637', 'created_date': '2023-07-02'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
