Publication Information

{'id': 'https://openalex.org/W4382404422', 'doi': 'https://doi.org/10.1101/2023.06.27.546434', 'title': 'LPCAT2 Regulates CD14 Expression During Macrophage Inflammatory Response to E. coli O111:B4', 'display_name': 'LPCAT2 Regulates CD14 Expression During Macrophage Inflammatory Response to E. coli O111:B4', 'publication_year': 2023, 'publication_date': '2023-06-27', 'ids': {'openalex': 'https://openalex.org/W4382404422', 'doi': 'https://doi.org/10.1101/2023.06.27.546434'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2023.06.27.546434', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/06/27/2023.06.27.546434.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/06/27/2023.06.27.546434.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010410820', 'display_name': 'Victory Ibigo Poloamina', 'orcid': 'https://orcid.org/0000-0001-7675-9708'}, 'institutions': [{'id': 'https://openalex.org/I897542642', 'display_name': 'University of Plymouth', 'ror': 'https://ror.org/008n7pv89', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I897542642']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Victory Ibigo Poloamina', 'raw_affiliation_strings': ['University of Plymouth, Faculty of Health, Plymouth, UK PL4 8AA'], 'affiliations': [{'raw_affiliation_string': 'University of Plymouth, Faculty of Health, Plymouth, UK PL4 8AA', 'institution_ids': ['https://openalex.org/I897542642']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048807889', 'display_name': 'Wondwossen Abate', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I23923803', 'display_name': 'University of Exeter', 'ror': 'https://ror.org/03yghzc09', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I23923803']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Wondwossen Abate', 'raw_affiliation_strings': ['University of Exeter, College of Medicine and Health, Exeter, UK EX1 HZ'], 'affiliations': [{'raw_affiliation_string': 'University of Exeter, College of Medicine and Health, Exeter, UK EX1 HZ', 'institution_ids': ['https://openalex.org/I23923803']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040973230', 'display_name': 'György Fejér', 'orcid': 'https://orcid.org/0000-0001-6761-0506'}, 'institutions': [{'id': 'https://openalex.org/I897542642', 'display_name': 'University of Plymouth', 'ror': 'https://ror.org/008n7pv89', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I897542642']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gyorgy Fejer', 'raw_affiliation_strings': ['University of Plymouth, Faculty of Health, Plymouth, UK PL4 8AA'], 'affiliations': [{'raw_affiliation_string': 'University of Plymouth, Faculty of Health, Plymouth, UK PL4 8AA', 'institution_ids': ['https://openalex.org/I897542642']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102725408', 'display_name': 'Simon K. Jackson', 'orcid': 'https://orcid.org/0000-0002-5475-7637'}, 'institutions': [{'id': 'https://openalex.org/I897542642', 'display_name': 'University of Plymouth', 'ror': 'https://ror.org/008n7pv89', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I897542642']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Simon K Jackson', 'raw_affiliation_strings': ['University of Plymouth, Faculty of Health, Plymouth, UK PL4 8AA'], 'affiliations': [{'raw_affiliation_string': 'University of Plymouth, Faculty of Health, Plymouth, UK PL4 8AA', 'institution_ids': ['https://openalex.org/I897542642']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5010410820'], 'corresponding_institution_ids': ['https://openalex.org/I897542642'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 68}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11313', 'display_name': 'Immune cells in cancer', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lipid-raft', 'display_name': 'Lipid raft', 'score': 0.5653276}], 'concepts': [{'id': 'https://openalex.org/C2778513237', 'wikidata': 'https://www.wikidata.org/wiki/Q419553', 'display_name': 'CD14', 'level': 3, 'score': 0.9055574}, {'id': 'https://openalex.org/C2776070231', 'wikidata': 'https://www.wikidata.org/wiki/Q14914098', 'display_name': 'TLR4', 'level': 3, 'score': 0.8401676}, {'id': 'https://openalex.org/C2778754761', 'wikidata': 'https://www.wikidata.org/wiki/Q421804', 'display_name': 'Lipopolysaccharide', 'level': 2, 'score': 0.78199244}, {'id': 'https://openalex.org/C2779244956', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'Macrophage', 'level': 3, 'score': 0.70105255}, {'id': 'https://openalex.org/C79266657', 'wikidata': 'https://www.wikidata.org/wiki/Q424178', 'display_name': 'Lipid raft', 'level': 3, 'score': 0.5653276}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.50250864}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.4695167}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46289104}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.44211283}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.4334362}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.41187972}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.4105855}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.38362777}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3391955}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3282905}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.28445584}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19100282}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.17056248}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.15038404}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.09810883}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2023.06.27.546434', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/06/27/2023.06.27.546434.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2023.06.27.546434', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2023/06/27/2023.06.27.546434.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1476543482', 'https://openalex.org/W1519600901', 'https://openalex.org/W1550722396', 'https://openalex.org/W1562927520', 'https://openalex.org/W1881367260', 'https://openalex.org/W1954660491', 'https://openalex.org/W1969039333', 'https://openalex.org/W1969175670', 'https://openalex.org/W1973617509', 'https://openalex.org/W1982930427', 'https://openalex.org/W1993691455', 'https://openalex.org/W1999286245', 'https://openalex.org/W2002715153', 'https://openalex.org/W2006697711', 'https://openalex.org/W2015665561', 'https://openalex.org/W2015704296', 'https://openalex.org/W2017579409', 'https://openalex.org/W2018306937', 'https://openalex.org/W2019676172', 'https://openalex.org/W2024646097', 'https://openalex.org/W2065053912', 'https://openalex.org/W2076822925', 'https://openalex.org/W2077280564', 'https://openalex.org/W2077369999', 'https://openalex.org/W2100788479', 'https://openalex.org/W2107277218', 'https://openalex.org/W2107385964', 'https://openalex.org/W2109531607', 'https://openalex.org/W2110883977', 'https://openalex.org/W2142337464', 'https://openalex.org/W2142788310', 'https://openalex.org/W2147802195', 'https://openalex.org/W2166108529', 'https://openalex.org/W2166812872', 'https://openalex.org/W2199197455', 'https://openalex.org/W2338928007', 'https://openalex.org/W2528398213', 'https://openalex.org/W2602293693', 'https://openalex.org/W2771472591', 'https://openalex.org/W2786438865', 'https://openalex.org/W2805063019', 'https://openalex.org/W2906815767', 'https://openalex.org/W2976604399', 'https://openalex.org/W3005875457', 'https://openalex.org/W3083862721', 'https://openalex.org/W3113581523', 'https://openalex.org/W4230932305', 'https://openalex.org/W4283324595'], 'related_works': ['https://openalex.org/W4382404422', 'https://openalex.org/W4232966056', 'https://openalex.org/W4225264326', 'https://openalex.org/W2752431893', 'https://openalex.org/W2150722710', 'https://openalex.org/W2134577175', 'https://openalex.org/W2129350953', 'https://openalex.org/W2007747723', 'https://openalex.org/W1974055405', 'https://openalex.org/W1973010363'], 'abstract_inverted_index': {'Abstract': [0], 'LPCAT2': [1, 41, 48, 84, 90, 100], 'is': [2, 24], 'a': [3, 28], 'lipid-modifying': [4], 'enzyme': [5], 'that': [6, 67, 89, 99], 'co-localises': [7], 'in': [8, 49, 80], 'lipid': [9], 'rafts': [10], 'with': [11, 59, 83], 'TLR4': [12, 22], 'and': [13, 57, 94], 'regulates': [14, 91], 'macrophage': [15, 31], 'inflammatory': [16], 'response;': [17], 'however,': [18], 'its': [19], 'effect': [20, 39], 'on': [21, 42], 'co-receptor–CD14': [23], 'unknown.': [25], 'RAW264.7': [26, 50, 81], 'cells,': [27], 'common': [29], 'murine': [30], 'experimental': [32], 'model,': [33], 'were': [34], 'used': [35], 'to': [36], 'study': [37, 87], 'the': [38], 'of': [40, 47, 61], 'CD14': [43, 68, 92], 'expression.': [44, 96], 'The': [45], 'expression': [46, 69], 'cells': [51], 'was': [52, 74], 'silenced': [53], 'using': [54], 'RNA': [55], 'interference': [56], 'treated': [58], '100ng/ml': [60], 'various': [62], 'lipopolysaccharide': [63, 73], 'chemotypes.': [64], 'We': [65], 'found': [66], 'induced': [70], 'by': [71], 'smooth': [72], 'significantly': [75], 'decreased': [76], '(p': [77], '<': [78], '0.05)': [79], 'macrophages': [82], 'silenced.': [85], 'This': [86, 97], 'suggests': [88], 'gene': [93], 'protein': [95], 'implies': [98], 'can': [101], 'regulate': [102], 'CD14-dependent': [103], 'cellular': [104], 'activities.': [105]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4382404422', 'counts_by_year': [], 'updated_date': '2024-12-14T18:58:25.201518', 'created_date': '2023-06-29'}