Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4382359549', 'doi': 'https://doi.org/10.1016/j.ecoenv.2023.115198', 'title': 'Cytotoxicity induced by abamectin in hepatopancreas cells of Chinese mitten crab, Eriocheir sinensis: An in vitro assay', 'display_name': 'Cytotoxicity induced by abamectin in hepatopancreas cells of Chinese mitten crab, Eriocheir sinensis: An in vitro assay', 'publication_year': 2023, 'publication_date': '2023-06-28', 'ids': {'openalex': 'https://openalex.org/W4382359549', 'doi': 'https://doi.org/10.1016/j.ecoenv.2023.115198', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37390728'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ecoenv.2023.115198', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13733787', 'display_name': 'Ecotoxicology and Environmental Safety', 'issn_l': '0147-6513', 'issn': ['0147-6513', '1090-2414'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1016/j.ecoenv.2023.115198', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037472163', 'display_name': 'Yuhang Hong', 'orcid': 'https://orcid.org/0000-0003-2036-2554'}, 'institutions': [{'id': 'https://openalex.org/I4210119012', 'display_name': 'Xichang University', 'ror': 'https://ror.org/02h3fyk31', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210119012']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuhang Hong', 'raw_affiliation_strings': ['Key Laboratory of Animal Disease Detection and Prevention in Panxi District, Xichang University, Xichang 415000, China', 'Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China', 'institution_ids': ['https://openalex.org/I4210119012']}, {'raw_affiliation_string': 'Key Laboratory of Animal Disease Detection and Prevention in Panxi District, Xichang University, Xichang 415000, China', 'institution_ids': ['https://openalex.org/I4210119012']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101664867', 'display_name': 'Yi Huang', 'orcid': 'https://orcid.org/0000-0002-2311-0195'}, 'institutions': [{'id': 'https://openalex.org/I4210119012', 'display_name': 'Xichang University', 'ror': 'https://ror.org/02h3fyk31', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210119012']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi Huang', 'raw_affiliation_strings': ['Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China', 'institution_ids': ['https://openalex.org/I4210119012']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102203356', 'display_name': 'Yanzhen Dong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119012', 'display_name': 'Xichang University', 'ror': 'https://ror.org/02h3fyk31', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210119012']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanzhen Dong', 'raw_affiliation_strings': ['Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China', 'institution_ids': ['https://openalex.org/I4210119012']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112947766', 'display_name': 'Dayong Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119012', 'display_name': 'Xichang University', 'ror': 'https://ror.org/02h3fyk31', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210119012']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dayong Xu', 'raw_affiliation_strings': ['Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China', 'institution_ids': ['https://openalex.org/I4210119012']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100698197', 'display_name': 'Qiang Huang', 'orcid': 'https://orcid.org/0000-0003-0731-3176'}, 'institutions': [{'id': 'https://openalex.org/I4210119012', 'display_name': 'Xichang University', 'ror': 'https://ror.org/02h3fyk31', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210119012']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiang Huang', 'raw_affiliation_strings': ['Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China', 'institution_ids': ['https://openalex.org/I4210119012']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045705008', 'display_name': 'Zhiqiu Huang', 'orcid': 'https://orcid.org/0000-0001-9092-3893'}, 'institutions': [{'id': 'https://openalex.org/I4210119012', 'display_name': 'Xichang University', 'ror': 'https://ror.org/02h3fyk31', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210119012']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Zhiqiu Huang', 'raw_affiliation_strings': ['Key Laboratory of Animal Disease Detection and Prevention in Panxi District, Xichang University, Xichang 415000, China', 'Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Animal Disease Detection and Prevention in Panxi District, Xichang University, Xichang 415000, China', 'institution_ids': ['https://openalex.org/I4210119012']}, {'raw_affiliation_string': 'Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan, China', 'institution_ids': ['https://openalex.org/I4210119012']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5045705008'], 'corresponding_institution_ids': ['https://openalex.org/I4210119012'], 'apc_list': {'value': 2600, 'currency': 'USD', 'value_usd': 2600, 'provenance': 'doaj'}, 'apc_paid': {'value': 2600, 'currency': 'USD', 'value_usd': 2600, 'provenance': 'doaj'}, 'fwci': 0.573, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.652781, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 68, 'max': 79}, 'biblio': {'volume': '262', 'issue': None, 'first_page': '115198', 'last_page': '115198'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10450', 'display_name': 'Aquaculture Nutrition and Growth', 'score': 0.9926, 'subfield': {'id': 'https://openalex.org/subfields/1104', 'display_name': 'Aquatic Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10450', 'display_name': 'Aquaculture Nutrition and Growth', 'score': 0.9926, 'subfield': {'id': 'https://openalex.org/subfields/1104', 'display_name': 'Aquatic Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10447', 'display_name': 'Environmental Toxicology and Ecotoxicology', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10423', 'display_name': 'Neurobiology and Insect Physiology Research', 'score': 0.9598, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hepatopancreas', 'display_name': 'Hepatopancreas', 'score': 0.95165277}, {'id': 'https://openalex.org/keywords/chinese-mitten-crab', 'display_name': 'Chinese mitten crab', 'score': 0.85906035}, {'id': 'https://openalex.org/keywords/abamectin', 'display_name': 'Abamectin', 'score': 0.6224833}], 'concepts': [{'id': 'https://openalex.org/C2778914303', 'wikidata': 'https://www.wikidata.org/wiki/Q2324189', 'display_name': 'Eriocheir', 'level': 2, 'score': 0.9808371}, {'id': 'https://openalex.org/C2780710107', 'wikidata': 'https://www.wikidata.org/wiki/Q384912', 'display_name': 'Hepatopancreas', 'level': 2, 'score': 0.95165277}, {'id': 'https://openalex.org/C2776408259', 'wikidata': 'https://www.wikidata.org/wiki/Q823941', 'display_name': 'Chinese mitten crab', 'level': 3, 'score': 0.85906035}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.6702749}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.64050716}, {'id': 'https://openalex.org/C2781092779', 'wikidata': 'https://www.wikidata.org/wiki/Q305345', 'display_name': 'Abamectin', 'level': 3, 'score': 0.6224833}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48128003}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37887198}, {'id': 'https://openalex.org/C33070731', 'wikidata': 'https://www.wikidata.org/wiki/Q7218', 'display_name': 'Toxicology', 'level': 1, 'score': 0.32640815}, {'id': 'https://openalex.org/C505870484', 'wikidata': 'https://www.wikidata.org/wiki/Q180538', 'display_name': 'Fishery', 'level': 1, 'score': 0.3156608}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21437612}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.19604522}, {'id': 'https://openalex.org/C161176658', 'wikidata': 'https://www.wikidata.org/wiki/Q131656', 'display_name': 'Pesticide', 'level': 2, 'score': 0.12521547}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ecoenv.2023.115198', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13733787', 'display_name': 'Ecotoxicology and Environmental Safety', 'issn_l': '0147-6513', 'issn': ['0147-6513', '1090-2414'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37390728', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ecoenv.2023.115198', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13733787', 'display_name': 'Ecotoxicology and Environmental Safety', 'issn_l': '0147-6513', 'issn': ['0147-6513', '1090-2414'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1771937481', 'https://openalex.org/W1775749144', 'https://openalex.org/W1978285517', 'https://openalex.org/W1980898034', 'https://openalex.org/W1982959255', 'https://openalex.org/W1988912732', 'https://openalex.org/W1996315467', 'https://openalex.org/W1997370471', 'https://openalex.org/W2002015567', 'https://openalex.org/W2015122068', 'https://openalex.org/W2016658436', 'https://openalex.org/W2017481569', 'https://openalex.org/W2030328776', 'https://openalex.org/W2031033283', 'https://openalex.org/W2036190641', 'https://openalex.org/W2044217881', 'https://openalex.org/W2053568529', 'https://openalex.org/W2056149721', 'https://openalex.org/W2076134807', 'https://openalex.org/W2078388509', 'https://openalex.org/W2089496505', 'https://openalex.org/W2156257249', 'https://openalex.org/W2162328940', 'https://openalex.org/W2320600141', 'https://openalex.org/W2497981584', 'https://openalex.org/W2519786994', 'https://openalex.org/W2555179538', 'https://openalex.org/W2619468678', 'https://openalex.org/W2741043926', 'https://openalex.org/W2753396693', 'https://openalex.org/W2759555117', 'https://openalex.org/W2803771093', 'https://openalex.org/W2951397983', 'https://openalex.org/W2986719078', 'https://openalex.org/W2990598515', 'https://openalex.org/W3005202068', 'https://openalex.org/W3015300278', 'https://openalex.org/W3017071451', 'https://openalex.org/W3035057592', 'https://openalex.org/W3112917795', 'https://openalex.org/W3116610174', 'https://openalex.org/W4200381096', 'https://openalex.org/W4213132206', 'https://openalex.org/W4243574300', 'https://openalex.org/W4290964169', 'https://openalex.org/W4306790744'], 'related_works': ['https://openalex.org/W3122254251', 'https://openalex.org/W3097919871', 'https://openalex.org/W2392810933', 'https://openalex.org/W2386250335', 'https://openalex.org/W2378598117', 'https://openalex.org/W2325042865', 'https://openalex.org/W2065330682', 'https://openalex.org/W2014661161', 'https://openalex.org/W1985278332', 'https://openalex.org/W1587041068'], 'abstract_inverted_index': {'Toxic': [0], 'effects': [1, 43], 'of': [2, 25, 44, 49, 101, 113, 127, 144, 156, 174, 184, 203, 216, 221, 237], 'abamectin': [3, 27, 45, 64, 97, 204, 217], 'on': [4, 46, 205, 218], 'non-target': [5], 'aquatic': [6], 'organisms': [7], 'have': [8], 'been': [9], 'well': [10], 'documented': [11], 'due': [12], 'to': [13], 'its': [14], 'extensive': [15], 'use': [16], 'in': [17, 30, 57, 78, 121, 178, 226], 'both': [18, 128], 'agricultural': [19], 'and': [20, 74, 88, 110, 130, 150, 162, 191, 224], 'aquacultural': [21], 'areas.': [22], 'However,': [23], 'knowledge': [24], 'the': [26, 41, 93, 102, 111, 125, 142, 172, 175, 179, 201, 210, 214], 'induced': [28], 'cytotoxicity': [29, 215], 'crustacean': [31], 'hepatopancreas': [32, 47, 122, 219], 'is': [33], 'still': [34], 'incomplete.': [35], 'In': [36, 137, 208], 'this': [37, 225], 'study,': [38], 'we': [39], 'investigated': [40], 'cytotoxic': [42], 'cells': [48, 220], 'Chinese': [50], 'mitten': [51], 'crab,': [52], 'Eriocheir': [53], 'sinensis': [54, 223], 'by': [55], 'an': [56], 'vitro': [58, 227], 'assay.': [59], 'The': [60, 99, 153, 182], 'results': [61, 140], 'showed': [62, 141], 'that': [63], 'inhibited': [65], 'cell': [66, 115, 228], 'viability': [67], 'with': [68], 'elevated': [69], 'reactive': [70], 'oxygen': [71], 'species': [72], '(ROS)': [73], 'malondialdehyde': [75], '(MDA)': [76], 'levels': [77], 'a': [79], 'dose-dependent': [80], 'manner.': [81], 'Increased': [82], 'olive': [83], 'tail': [84], 'moment': [85], '(OTM)': [86], 'values': [87], "8-hydroxy-2'-deoxyguanosine": [89], '(8-OHdG)': [90], 'contents': [91], 'indicate': [92], 'DNA': [94], 'damage': [95], 'under': [96], 'exposure.': [98], 'up-regulation': [100, 143], 'typical': [103], 'apoptosis-related': [104], 'protein': [105, 108], 'BCL2-associated': [106], 'X': [107], '(Bax)': [109], 'down-regulation': [112], 'B': [114], 'leukemia/lymphoma': [116], '2': [117], '(Bcl-2)': [118], 'demonstrate': [119], 'apoptosis': [120], 'cells.': [123], 'Meanwhile,': [124], 'activities': [126], 'caspase-3': [129], 'caspase-9': [131], 'were': [132], 'increased,': [133, 170], 'indicating': [134], 'caspase-mediated': [135], 'apoptosis.': [136], 'addition,': [138], 'qRT-PCR': [139], 'antioxidant': [145], 'genes': [146, 187], 'superoxide': [147], 'dismutase': [148], '(SOD)': [149], 'catalase': [151], '(CAT).': [152], 'mRNA': [154], 'expression': [155], 'Cap': [157], "'n'": [158], 'Collar': [159], 'isoform-C': [160], '(CncC)': [161], 'c-Jun': [163], 'NH2-terminal': [164], 'kinases': [165], '(JNK)': [166], 'was': [167], 'also': [168, 199], 'significantly': [169], 'implying': [171], 'involvement': [173], 'Nrf2/MAPK': [176], 'pathway': [177], 'antioxidative': [180], 'response.': [181], 'alteration': [183], 'innate': [185], 'immune-associated': [186], 'Toll-like': [188], 'receptor': [189], '(TLR)': [190], 'myeloid': [192], 'differentiation': [193], 'primary': [194], 'response': [195], 'gene': [196], '88': [197], '(Myd88)': [198], 'indicates': [200], 'influence': [202], 'immune': [206], 'status.': [207], 'summary,': [209], 'present': [211], 'study': [212], 'reveals': [213], 'E.': [222], 'culture': [229], 'model': [230], 'could': [231], 'be': [232], 'used': [233], 'for': [234], 'further': [235], 'assessment': [236], 'pesticide': [238], 'toxicity.': [239]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4382359549', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-12-17T00:55:31.834935', 'created_date': '2023-06-29'}