Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4380354488', 'doi': 'https://doi.org/10.1073/pnas.2220922120', 'title': 'Engineered gut symbiont inhibits microsporidian parasite and improves honey bee survival', 'display_name': 'Engineered gut symbiont inhibits microsporidian parasite and improves honey bee survival', 'publication_year': 2023, 'publication_date': '2023-06-12', 'ids': {'openalex': 'https://openalex.org/W4380354488', 'doi': 'https://doi.org/10.1073/pnas.2220922120', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37307477'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.2220922120', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1073/pnas.2220922120', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5031741220', 'display_name': 'Qiang Huang', 'orcid': 'https://orcid.org/0000-0001-5528-5099'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}, {'id': 'https://openalex.org/I74837319', 'display_name': 'Jiangxi Agricultural University', 'ror': 'https://ror.org/00dc7s858', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I74837319']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Qiang Huang', 'raw_affiliation_strings': ['Department of Integrative Biology, The University of Texas at Austin, Austin, TX 78712', 'Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Integrative Biology, The University of Texas at Austin, Austin, TX 78712', 'institution_ids': ['https://openalex.org/I86519309']}, {'raw_affiliation_string': 'Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China', 'institution_ids': ['https://openalex.org/I74837319']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016474935', 'display_name': 'Patrick J. Lariviere', 'orcid': 'https://orcid.org/0000-0002-8427-3879'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patrick J. Lariviere', 'raw_affiliation_strings': ['Department of Integrative Biology, The University of Texas at Austin, Austin, TX 78712', 'Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712'], 'affiliations': [{'raw_affiliation_string': 'Department of Integrative Biology, The University of Texas at Austin, Austin, TX 78712', 'institution_ids': ['https://openalex.org/I86519309']}, {'raw_affiliation_string': 'Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000217238', 'display_name': 'J. Elijah Powell', 'orcid': 'https://orcid.org/0000-0002-2758-6174'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. Elijah Powell', 'raw_affiliation_strings': ['Department of Integrative Biology, The University of Texas at Austin, Austin, TX 78712'], 'affiliations': [{'raw_affiliation_string': 'Department of Integrative Biology, The University of Texas at Austin, Austin, TX 78712', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013005155', 'display_name': 'Nancy A. Moran', 'orcid': 'https://orcid.org/0000-0003-2983-9769'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nancy A. Moran', 'raw_affiliation_strings': ['Department of Integrative Biology, The University of Texas at Austin, Austin, TX 78712'], 'affiliations': [{'raw_affiliation_string': 'Department of Integrative Biology, The University of Texas at Austin, Austin, TX 78712', 'institution_ids': ['https://openalex.org/I86519309']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.819, 'has_fulltext': False, 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.999827, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '120', 'issue': '25', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11641', 'display_name': 'Impact of Pesticides on Honey Bee Health', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11641', 'display_name': 'Impact of Pesticides on Honey Bee Health', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10702', 'display_name': 'Genomic Insights into Social Insects and Symbiosis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12134', 'display_name': 'Insect Symbiosis and Microbial Interactions', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nosema-ceranae', 'display_name': 'Nosema ceranae', 'score': 0.91741335}, {'id': 'https://openalex.org/keywords/honey-bees', 'display_name': 'Honey Bees', 'score': 0.55414}, {'id': 'https://openalex.org/keywords/rna-silencing', 'display_name': 'RNA silencing', 'score': 0.5266747}], 'concepts': [{'id': 'https://openalex.org/C2781375616', 'wikidata': 'https://www.wikidata.org/wiki/Q2700718', 'display_name': 'Nosema ceranae', 'level': 5, 'score': 0.91741335}, {'id': 'https://openalex.org/C2777308519', 'wikidata': 'https://www.wikidata.org/wiki/Q2708701', 'display_name': 'Nosema', 'level': 4, 'score': 0.904819}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.89899874}, {'id': 'https://openalex.org/C2777907900', 'wikidata': 'https://www.wikidata.org/wiki/Q102857', 'display_name': 'Honey bee', 'level': 2, 'score': 0.79997706}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.77896065}, {'id': 'https://openalex.org/C2780827966', 'wikidata': 'https://www.wikidata.org/wiki/Q132652', 'display_name': 'Microsporidia', 'level': 3, 'score': 0.6935309}, {'id': 'https://openalex.org/C71928629', 'wikidata': 'https://www.wikidata.org/wiki/Q804206', 'display_name': 'Parasite hosting', 'level': 2, 'score': 0.58242077}, {'id': 'https://openalex.org/C2191507', 'wikidata': 'https://www.wikidata.org/wiki/Q7277185', 'display_name': 'RNA silencing', 'level': 5, 'score': 0.5266747}, {'id': 'https://openalex.org/C2779711295', 'wikidata': 'https://www.wikidata.org/wiki/Q2441993', 'display_name': 'Mite', 'level': 2, 'score': 0.5247281}, {'id': 'https://openalex.org/C102789151', 'wikidata': 'https://www.wikidata.org/wiki/Q1141466', 'display_name': 'Pollinator', 'level': 4, 'score': 0.51633894}, {'id': 'https://openalex.org/C2778944004', 'wikidata': 'https://www.wikidata.org/wiki/Q91703', 'display_name': 'Caenorhabditis elegans', 'level': 3, 'score': 0.4579119}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.36995772}, {'id': 'https://openalex.org/C90856448', 'wikidata': 'https://www.wikidata.org/wiki/Q431', 'display_name': 'Zoology', 'level': 1, 'score': 0.35494322}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.23234653}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.22998211}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20348734}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16240922}, {'id': 'https://openalex.org/C168197293', 'wikidata': 'https://www.wikidata.org/wiki/Q134624', 'display_name': 'Pollination', 'level': 3, 'score': 0.10278323}, {'id': 'https://openalex.org/C2780618852', 'wikidata': 'https://www.wikidata.org/wiki/Q79932', 'display_name': 'Pollen', 'level': 2, 'score': 0.08741361}, {'id': 'https://openalex.org/C174618031', 'wikidata': 'https://www.wikidata.org/wiki/Q177332', 'display_name': 'Spore', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C136764020', 'wikidata': 'https://www.wikidata.org/wiki/Q466', 'display_name': 'World Wide Web', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006722', 'descriptor_name': 'Honey', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010271', 'descriptor_name': 'Parasites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014581', 'descriptor_name': 'Urticaria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000383', 'descriptor_name': 'Agriculture', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001516', 'descriptor_name': 'Bees', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020043', 'descriptor_name': 'Genes, Essential', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012330', 'descriptor_name': 'RNA, Double-Stranded', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.2220922120', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288570', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37307477', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.2220922120', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'score': 0.64, 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '32260862'}, {'funder': 'https://openalex.org/F4320337354', 'funder_display_name': 'National Institute of General Medical Sciences', 'award_id': 'R35GM131738'}], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1613387898', 'https://openalex.org/W1971522926', 'https://openalex.org/W1984609511', 'https://openalex.org/W2000560385', 'https://openalex.org/W2000682768', 'https://openalex.org/W2000900407', 'https://openalex.org/W2002952387', 'https://openalex.org/W2003519966', 'https://openalex.org/W2006874204', 'https://openalex.org/W2017576154', 'https://openalex.org/W2025245425', 'https://openalex.org/W2030764530', 'https://openalex.org/W2036721177', 'https://openalex.org/W2054363760', 'https://openalex.org/W2071957358', 'https://openalex.org/W2078471894', 'https://openalex.org/W2096339276', 'https://openalex.org/W2102119799', 'https://openalex.org/W2107810840', 'https://openalex.org/W2121440246', 'https://openalex.org/W2144693286', 'https://openalex.org/W2146533535', 'https://openalex.org/W2147995945', 'https://openalex.org/W2149853764', 'https://openalex.org/W2166396538', 'https://openalex.org/W2169555805', 'https://openalex.org/W2195228700', 'https://openalex.org/W2259600638', 'https://openalex.org/W2298413610', 'https://openalex.org/W2345386454', 'https://openalex.org/W2356986436', 'https://openalex.org/W2606201618', 'https://openalex.org/W2767577579', 'https://openalex.org/W2771995180', 'https://openalex.org/W2777887555', 'https://openalex.org/W2782966146', 'https://openalex.org/W2796055314', 'https://openalex.org/W2888072630', 'https://openalex.org/W2889348094', 'https://openalex.org/W2908967282', 'https://openalex.org/W2912895624', 'https://openalex.org/W2916919566', 'https://openalex.org/W2969343929', 'https://openalex.org/W2981847929', 'https://openalex.org/W3003740439', 'https://openalex.org/W3044937232', 'https://openalex.org/W3064621671', 'https://openalex.org/W3130243934', 'https://openalex.org/W3170389254', 'https://openalex.org/W4223454827', 'https://openalex.org/W4295537147', 'https://openalex.org/W4310640858'], 'related_works': ['https://openalex.org/W4380354488', 'https://openalex.org/W3134386759', 'https://openalex.org/W3085354933', 'https://openalex.org/W2990215913', 'https://openalex.org/W2888072630', 'https://openalex.org/W2739340686', 'https://openalex.org/W2513654735', 'https://openalex.org/W2147995945', 'https://openalex.org/W2104176716', 'https://openalex.org/W1964510698'], 'abstract_inverted_index': {'Honey': [0, 61], 'bees': [1, 62], '(': [2], 'Apis': [3], 'mellifera': [4], ')': [5], 'are': [6, 69], 'critical': [7], 'agricultural': [8], 'pollinators': [9], 'as': [10, 12], 'well': [11], 'model': [13], 'organisms': [14], 'for': [15], 'research': [16], 'on': [17], 'development,': [18], 'behavior,': [19], 'memory,': [20], 'and': [21, 132, 148], 'learning.': [22], 'The': [23, 125], 'parasite': [24, 138], 'Nosema': [25, 48, 130], 'ceranae': [26, 118], ',': [27], 'a': [28, 58, 105], 'common': [29], 'cause': [30], 'of': [31, 93, 116], 'honey': [32, 106], 'bee': [33, 107, 134], 'colony': [34], 'collapse,': [35], 'has': [36], 'developed': [37], 'resistance': [38], 'to': [39, 46, 78, 110, 165], 'small-molecule': [40], 'therapeutics.': [41], 'An': [42], 'alternative': [43], 'long-term': [44], 'strategy': [45], 'combat': [47], 'infection': [49], 'is': [50], 'therefore': [51], 'urgently': [52], 'needed,': [53], 'with': [54], 'synthetic': [55], 'biology': [56], 'offering': [57], 'potential': [59], 'solution.': [60], 'harbor': [63], 'specialized': [64], 'bacterial': [65], 'gut': [66, 108], 'symbionts': [67, 154, 164], 'that': [68, 161], 'transmitted': [70, 156], 'within': [71], 'hives.': [72], 'Previously,': [73], 'these': [74], 'have': [75], 'been': [76], 'engineered': [77, 104, 126, 153, 163], 'inhibit': [79], 'ectoparasitic': [80], 'mites': [81], 'by': [82], 'expressing': [83], 'double-stranded': [84], 'RNA': [85, 96], '(dsRNA)': [86], 'targeting': [87, 113], 'essential': [88, 114], 'mite': [89, 95], 'genes,': [90], 'via': [91, 119], 'activation': [92], 'the': [94, 120, 137], 'interference': [97], '(RNAi)': [98], 'pathway.': [99], 'In': [100], 'this': [101], 'study,': [102], 'we': [103], 'symbiont': [109, 127], 'express': [111], 'dsRNA': [112], 'genes': [115], 'N.': [117], 'parasite’s': [121], 'own': [122], 'RNAi': [123], 'machinery.': [124], 'sharply': [128], 'reduced': [129], 'proliferation': [131], 'improved': [133], 'survival': [135], 'following': [136], 'challenge.': [139], 'This': [140], 'protection': [141], 'was': [142], 'observed': [143], 'in': [144, 169], 'both': [145], 'newly': [146], 'emerged': [147], 'older': [149], 'forager': [150], 'bees.': [151], 'Furthermore,': [152], 'were': [155], 'among': [157], 'cohoused': [158], 'bees,': [159], 'suggesting': [160], 'introducing': [162], 'hives': [166], 'could': [167], 'result': [168], 'colony-level': [170], 'protection.': [171]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4380354488', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 3}], 'updated_date': '2024-09-12T11:19:07.389746', 'created_date': '2023-06-13'}