Title: Medicinal potential of anandamide as a representative endocannabinoid and its effect at the cellular level in skin
Abstract: Various cellular processes such as proliferation, metabolism, differentiation, melanogenesis, or apoptosis depend on a proper functioning of the endocannabinoid system (ECS). The current ECS research is focused not only on investigating its individual components (endogenous cannabinoids (eCB), cannabinoid receptors, and enzymes responsible for the synthesis/degradation of endocannabinoids), but also on determining their interactions and influence on various physiological and pathological processes occurring in the organism. One of the first identified endocannabinoids was anandamide (AEA), which has a high affinity toward many receptors. Several endocannabinoids were confirmed to possess mostly beneficial properties on a cellular level, as well as in the whole tissue. As the skin is a multicell type tissue, the occurrence of most receptors for which endocannabinoids show high affinities is guaranteed. Within this review, we would like to summarize all known effects of anandamide on the normal and cancerous skin cells.
Publication Year: 2023
Publication Date: 2023-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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