Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4379929728', 'doi': 'https://doi.org/10.2957/kanzo.64.270', 'title': 'Two cases of acute liver failure complicated by COVID-19 remarkably responded to anticoagulant therapy', 'display_name': 'Two cases of acute liver failure complicated by COVID-19 remarkably responded to anticoagulant therapy', 'publication_year': 2023, 'publication_date': '2023-06-01', 'ids': {'openalex': 'https://openalex.org/W4379929728', 'doi': 'https://doi.org/10.2957/kanzo.64.270'}, 'language': 'ja', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2957/kanzo.64.270', 'pdf_url': 'https://www.jstage.jst.go.jp/article/kanzo/64/6/64_270/_pdf', 'source': {'id': 'https://openalex.org/S194384443', 'display_name': 'Kanzo', 'issn_l': '0451-4203', 'issn': ['0451-4203', '1881-3593'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4322764925', 'host_organization_name': 'The Japan Society of Hepatology', 'host_organization_lineage': ['https://openalex.org/P4322764925'], 'host_organization_lineage_names': ['The Japan Society of Hepatology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.jstage.jst.go.jp/article/kanzo/64/6/64_270/_pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112932624', 'display_name': 'Hiromitsu Oobo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiromitsu Oobo', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030283533', 'display_name': 'Hiroki Inada', 'orcid': 'https://orcid.org/0000-0002-3456-6921'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroki Inada', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024681830', 'display_name': 'Hiroko Setoyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroko Setoyama', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004634738', 'display_name': 'Satoshi Narahara', 'orcid': 'https://orcid.org/0000-0001-8647-9486'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Satoshi Narahara', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101526122', 'display_name': 'Kentaro Tanaka', 'orcid': 'https://orcid.org/0000-0003-4602-4465'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kentaro Tanaka', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5092119710', 'display_name': 'Soutaro Kurano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Soutaro Kurano', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049936220', 'display_name': 'Takayuki Tokunaga', 'orcid': 'https://orcid.org/0000-0002-3631-4525'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takayuki Tokunaga', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077530077', 'display_name': 'Etsuko Iio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Etsuko Iio', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084538267', 'display_name': 'Yoko Yoshimaru', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoko Yoshimaru', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005875682', 'display_name': 'Katsuya Nagaoka', 'orcid': 'https://orcid.org/0000-0002-7152-6101'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Katsuya Nagaoka', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027469624', 'display_name': 'Takehisa Watanabe', 'orcid': 'https://orcid.org/0000-0001-8990-9496'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takehisa Watanabe', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109138629', 'display_name': 'Motohiko Tanaka', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Motohiko Tanaka', 'raw_affiliation_strings': ['Public Health and Welfare Bureau, City of Kumamoto'], 'affiliations': [{'raw_affiliation_string': 'Public Health and Welfare Bureau, City of Kumamoto', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103196368', 'display_name': 'Masakuni Tateyama', 'orcid': 'https://orcid.org/0000-0003-1935-2797'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masakuni Tateyama', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009887722', 'display_name': 'Yasuhito Tanaka', 'orcid': 'https://orcid.org/0000-0002-2473-6966'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuhito Tanaka', 'raw_affiliation_strings': ['Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University', 'institution_ids': ['https://openalex.org/I96036126']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.396, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.598845, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 68, 'max': 79}, 'biblio': {'volume': '64', 'issue': '6', 'first_page': '270', 'last_page': '279'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10041', 'display_name': 'COVID-19 Clinical Research Studies', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10041', 'display_name': 'COVID-19 Clinical Research Studies', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11368', 'display_name': 'Long-Term Effects of COVID-19', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/d-dimer', 'display_name': 'D-dimer', 'score': 0.60136586}, {'id': 'https://openalex.org/keywords/anticoagulant-therapy', 'display_name': 'Anticoagulant Therapy', 'score': 0.48136097}], 'concepts': [{'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.64828694}, {'id': 'https://openalex.org/C2779519742', 'wikidata': 'https://www.wikidata.org/wiki/Q198526', 'display_name': 'D-dimer', 'level': 2, 'score': 0.60136586}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.57275826}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.54251325}, {'id': 'https://openalex.org/C2994427840', 'wikidata': 'https://www.wikidata.org/wiki/Q970208', 'display_name': 'Liver failure', 'level': 2, 'score': 0.5283267}, {'id': 'https://openalex.org/C3007834351', 'wikidata': 'https://www.wikidata.org/wiki/Q82069695', 'display_name': 'Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)', 'level': 5, 'score': 0.5197858}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.49928355}, {'id': 'https://openalex.org/C2993316766', 'wikidata': 'https://www.wikidata.org/wiki/Q215118', 'display_name': 'Anticoagulant therapy', 'level': 2, 'score': 0.48136097}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2957/kanzo.64.270', 'pdf_url': 'https://www.jstage.jst.go.jp/article/kanzo/64/6/64_270/_pdf', 'source': {'id': 'https://openalex.org/S194384443', 'display_name': 'Kanzo', 'issn_l': '0451-4203', 'issn': ['0451-4203', '1881-3593'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4322764925', 'host_organization_name': 'The Japan Society of Hepatology', 'host_organization_lineage': ['https://openalex.org/P4322764925'], 'host_organization_lineage_names': ['The Japan Society of Hepatology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2957/kanzo.64.270', 'pdf_url': 'https://www.jstage.jst.go.jp/article/kanzo/64/6/64_270/_pdf', 'source': {'id': 'https://openalex.org/S194384443', 'display_name': 'Kanzo', 'issn_l': '0451-4203', 'issn': ['0451-4203', '1881-3593'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4322764925', 'host_organization_name': 'The Japan Society of Hepatology', 'host_organization_lineage': ['https://openalex.org/P4322764925'], 'host_organization_lineage_names': ['The Japan Society of Hepatology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W3001118548', 'https://openalex.org/W3002108456', 'https://openalex.org/W3007940623', 'https://openalex.org/W3010637630', 'https://openalex.org/W3011516015', 'https://openalex.org/W3013486442', 'https://openalex.org/W3013727805', 'https://openalex.org/W3014067025', 'https://openalex.org/W3015256585', 'https://openalex.org/W3016362201', 'https://openalex.org/W3018741526', 'https://openalex.org/W3030475429', 'https://openalex.org/W3034561954', 'https://openalex.org/W3041205809', 'https://openalex.org/W3042066663', 'https://openalex.org/W3048705942', 'https://openalex.org/W3091912890', 'https://openalex.org/W3163367789', 'https://openalex.org/W4220666274', 'https://openalex.org/W4220854789', 'https://openalex.org/W4286499737'], 'related_works': ['https://openalex.org/W4292098121', 'https://openalex.org/W4224279380', 'https://openalex.org/W4206669628', 'https://openalex.org/W4206651655', 'https://openalex.org/W4206548596', 'https://openalex.org/W4205810683', 'https://openalex.org/W4205317059', 'https://openalex.org/W3198183218', 'https://openalex.org/W3176864053', 'https://openalex.org/W3081785542'], 'abstract_inverted_index': {'症例1は83歳男性.前医でSARS-CoV-2陽性判明後,AST': [0], '4276': [1], 'U/L,ALT': [2, 12], '2247': [3], 'U/Lと急激な肝酵素上昇を認めたため当院へ転院となった.PT': [4], '36': [5], '%,D-dimer': [6], '30.1': [7], 'μg/mL,FDP': [8], '43.8': [9], 'μg/mLと凝固異常を伴う急性肝不全非昏睡型で,未分画ヘパリンを開始したところ肝不全ならびに凝固異常は速やかに改善した.症例2は29歳男性.前医でSARS-CoV-2陽性判明後,AST': [10], '3027': [11], '2599': [13], 'U/Lと急激な肝酵素上昇を認め,第7病日に昏睡に至りPT': [14], '11': [15], '%と急性肝不全昏睡型の診断で当院へ転院となった.未分画ヘパリン投与および,持続的血液濾過透析と血漿交換による人工肝補助療法を開始後,肝不全の改善を認めた.COVID-19による急性肝不全に対し,早期の抗凝固療法含めた内科的治療によって救命し得た貴重な2症例を経験したので,報告する.': [16]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4379929728', 'counts_by_year': [], 'updated_date': '2024-12-09T20:10:06.593841', 'created_date': '2023-06-09'}