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De-Rycke', 'raw_affiliation_strings': ['Assistance Publique Hôpitaux de Paris, CEPHEPI, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Assistance Publique Hôpitaux de Paris, CEPHEPI, Paris, France', 'institution_ids': ['https://openalex.org/I4210097159']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062315921', 'display_name': 'N. 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Costedoat-Chalumeau', 'raw_affiliation_strings': ['Cochin Hospital APHP, Internal Medicine, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Cochin Hospital APHP, Internal Medicine, Paris, France', 'institution_ids': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210092774']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028332108', 'display_name': 'E. Elefant', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'E. Elefant', 'raw_affiliation_strings': ['Trousseau Hospital APHP, CRAT, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Trousseau Hospital APHP, CRAT, Paris, France', 'institution_ids': ['https://openalex.org/I4210097159']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084857103', 'display_name': 'V. Tsatsaris', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092774', 'display_name': 'Hôpital Cochin', 'ror': 'https://ror.org/00ph8tk69', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092774', 'https://openalex.org/I4210097159', 'https://openalex.org/I4210124464']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'V. 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'https://openalex.org/W2950613016', 'https://openalex.org/W2415629051', 'https://openalex.org/W2401426098', 'https://openalex.org/W2326356712', 'https://openalex.org/W2185550546', 'https://openalex.org/W2146636017', 'https://openalex.org/W2098604002'], 'abstract_inverted_index': {'<h3>Background</h3>': [0], 'Continuation': [1, 200], 'of': [2, 51, 64, 135, 160, 180, 185, 201, 209, 216, 232, 273, 344, 397, 426], 'biologics': [3], 'during': [4, 12, 338, 403], 'pregnancy': [5, 13, 38, 62, 79, 117, 129, 137, 149, 173, 186, 211, 238, 322, 404], 'in': [6, 57, 101, 175, 229, 250, 277, 334], 'patients': [7, 233, 302, 335], 'with': [8, 22, 70, 104, 126, 206, 218, 303, 316, 319, 341], 'chronic': [9, 23], 'inflammatory': [10, 25, 52], 'diseases': [11, 26], 'is': [14, 39], 'still': [15], 'a': [16, 98, 115, 267, 270, 342], 'difficult': [17], 'medical': [18], 'decision.': [19], 'Many': [20], 'women': [21, 69, 181, 315], 'rheumatic': [24], '(CRID)': [27], 'decide': [28], 'to': [29, 41, 72, 96, 226, 300, 393, 418], 'stop': [30, 76], 'tumor': [31], 'necrosis': [32], 'factor': [33], 'inhibitors': [34], '(TNFi)': [35], 'treatment': [36, 66, 146, 169], 'once': [37], 'confirmed': [40], 'avoid': [42], 'potential': [43], 'adverse': [44], 'fetal': [45], 'events': [46], 'but': [47, 240], 'taking': [48], 'the': [49, 61, 82, 133, 145, 183, 214, 230, 235, 251, 278, 281, 419], 'risk': [50], 'flare.': [53], '<h3>Objectives</h3>': [54], 'To': [55], 'compare': [56], 'real': [58], 'life': [59], 'settings': [60], 'outcomes': [63, 138, 327], 'two': [65], 'strategies': [67, 147], 'among': [68, 166], 'CRID:': [71], 'continue': [73], 'TNFi': [74, 77, 127, 168, 202, 236, 282, 320, 337], 'vs.': [75, 247, 254, 285], 'upon': [78, 128], 'diagnosis.': [80, 130], '<h3>Methods</h3>': [81], 'French': [83, 420], 'nationwide': [84], 'health': [85], 'insurance': [86], 'database': [87], '(<i>Système': [88], 'National': [89], 'des': [90], 'Données': [91], 'de': [92], 'Santé</i>)': [93], 'was': [94, 170, 187, 196, 203, 266, 415], 'used': [95, 299], 'emulate': [97], 'target': [99], 'trial': [100], 'adult': [102], 'women,': [103], 'CRID': [105, 317], '(i.e.,': [106], 'rheumatoid': [107], 'arthritis,': [108], 'psoriatic': [109], 'arthritis': [110], 'or': [111], 'spondyloarthritis),': [112], 'having': [113], 'started': [114], 'singleton': [116], 'between': [118, 144], '2008': [119], 'and': [120, 122, 123, 142, 165, 191, 309, 402, 405], '2017,': [121], 'being': [124], 'treated': [125, 318], 'We': [131], 'compared': [132, 340], 'frequency': [134, 272], 'unfavorable': [136, 210, 222, 325], '(malformations,': [139], 'obstetrical': [140, 223, 306, 326], 'complications,': [141], 'infections)': [143], 'at': [148, 182, 219], 'diagnosis,': [150, 323], 'using': [151], 'inverse': [152], 'probability': [153], 'weighted': [154], 'marginal': [155], 'models.': [156], '<h3>Results</h3>': [157], 'A': [158], 'total': [159], '1466': [161], 'pregnancies': [162, 217], 'were': [163, 298, 331], 'included,': [164], 'them,': [167], 'discontinued': [171], 'after': [172, 237], 'diagnosis': [174, 239], '74%.': [176], 'Mean': [177], '(SD)': [178, 193], 'age': [179], 'start': [184], '31': [188], '(5)': [189, 198], 'years': [190], 'mean': [192], 'disease': [194], 'duration': [195], '4': [197], 'years.': [199], 'not': [204], 'associated': [205], 'increased': [207, 333], 'frequencies': [208], 'outcomes:': [212], 'interestingly,': [213], 'proportion': [215], 'least': [220], 'one': [221], 'outcome': [224], 'tended': [225], 'be': [227], 'lower': [228, 271], 'group': [231, 252, 279], 'continuing': [234, 253, 280, 336], 'without': [241], 'reaching': [242], 'statistical': [243], 'significance:': [244], '66': [245], '(17.3%)': [246], '201': [248], '(18.5%)': [249], 'discontinuing,': [255], 'respectively': [256], '(adjusted': [257], 'RR=': [258], '0.79': [259], '[95%': [260], 'CI,': [261], '0.57;': [262], '1.10]).': [263], 'Also,': [264], 'there': [265], 'trend': [268], 'for': [269, 395], 'severe': [274, 329], 'maternal': [275], 'infections': [276, 330], '(7': [283], '(1.8%)': [284], '36': [286], '(3.3%),': [287], '(aRR=0.43': [288], '[0.16;': [289], '1.14]).': [290], 'Table.': [291], '<b>Limitation:</b>': [292], 'Algorithms': [293], 'rather': [294], 'than': [295], 'clinical': [296], 'data': [297], 'identify': [301], 'CRID,': [304], 'pregnancies,': [305], 'outcomes,': [307], 'malformation': [308], 'serious': [310], 'infections.': [311], '<h3>Conclusion</h3>': [312], 'In': [313], 'pregnant': [314], 'until': [321], 'neither': [324], 'nor': [328], 'significantly': [332], 'pregnancy,': [339, 401], 'strategy': [343], 'stopping': [345], 'TNFi.': [346], '<h3>Reference</h3>': [347], '[1]Götestam': [348], 'Skorpen': [349], 'C,': [350, 360, 365, 387], 'Hoeltzenbein': [351], 'M,': [352, 375, 383], 'Tincani': [353], 'A,': [354, 379], 'Fischer-Betz': [355], 'R,': [356, 371], 'Elefant': [357], 'E,': [358], 'Chambers': [359], 'da': [361], 'Silva': [362], 'J,': [363, 381], 'Nelson-Piercy': [364], 'Cetin': [366], 'I,': [367], 'Costedoat-Chalumeau': [368], 'N,': [369, 385], 'Dolhain': [370], 'Förger': [372], 'F,': [373], 'Khamashta': [374], 'Ruiz-Irastorza': [376], 'G,': [377], 'Zink': [378], 'Vencovsky': [380], 'Cutolo': [382], 'Caeyers': [384], 'Zumbühl': [386], 'Østensen': [388], 'M.': [389], 'The': [390], 'EULAR': [391], 'points': [392], 'consider': [394], 'use': [396], 'antirheumatic': [398], 'drugs': [399], 'before': [400], 'lactation.': [406], 'Ann': [407], 'Rheum': [408], 'Dis.': [409], '2016': [410], 'May;75(5):795-810.': [411], '<h3>Acknowledgements</h3>': [412], 'This': [413], 'study': [414], 'conducted': [416], 'thanks': [417], 'national': [421], 'grant': [422], 'PHRC': [423], '2019.': [424], '<h3>Disclosure': [425], 'Interests</h3>': [427], 'Anna': [428], 'Moltó': [429], 'Consultant': [430], 'of:': [431], 'Abbvie,': [432], 'Biogen,': [433], 'BMS,': [434], 'Gilead,': [435], 'Lilly,': [436], 'MSD,': [437], 'Novartis,': [438], 'Pfizer,': [439], 'UCB,': [440, 445], 'Grant/research': [441], 'support': [442], 'from:': [443], 'Biogen': [444], 'Aya': [446], 'Ajrouche:': [447], 'None': [448, 452, 456, 460, 464, 468, 472, 476, 480, 484], 'declared,': [449, 453, 457, 461, 465, 469, 473, 477, 481], 'Diep': [450], 'Tran:': [451], 'yann': [454], 'de-rycke:': [455], 'Nathalie': [458], 'Costedoat-Chalumeau:': [459], 'Elisabeth': [462], 'Elefant:': [463], 'Vassilis': [466], 'Tsatsaris:': [467], 'Jeanne': [470], 'Fresson:': [471], 'Brigitte': [474], 'Bader-Meunier:': [475], 'Bruno': [478], 'Fautrel:': [479], 'Florence': [482], 'Tubach:': [483], 'declared.': [485]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4379523753', 'counts_by_year': [], 'updated_date': '2024-12-24T03:40:45.085594', 'created_date': '2023-06-07'}