Publication Information

{'id': 'https://openalex.org/W4379521544', 'doi': 'https://doi.org/10.1136/annrheumdis-2023-eular.1552', 'title': 'POS0308 LONG-TERM CLINICAL PROFILE OF FILGOTINIB (FIL) IN PATIENTS (PTS) WITH RHEUMATOID ARTHRITIS (RA) BY CARDIOVASCULAR (CV) RISK FACTORS: A POST HOC SUBGROUP ANALYSIS', 'display_name': 'POS0308 LONG-TERM CLINICAL PROFILE OF FILGOTINIB (FIL) IN PATIENTS (PTS) WITH RHEUMATOID ARTHRITIS (RA) BY CARDIOVASCULAR (CV) RISK FACTORS: A POST HOC SUBGROUP ANALYSIS', 'publication_year': 2023, 'publication_date': '2023-05-30', 'ids': {'openalex': 'https://openalex.org/W4379521544', 'doi': 'https://doi.org/10.1136/annrheumdis-2023-eular.1552'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/annrheumdis-2023-eular.1552', 'pdf_url': 'https://ard.bmj.com/content/annrheumdis/82/Suppl_1/397.1.full.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'proceedings-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://ard.bmj.com/content/annrheumdis/82/Suppl_1/397.1.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013618587', 'display_name': 'M. H. Buch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159460', 'display_name': 'NIHR Manchester Biomedical Research Centre', 'ror': 'https://ror.org/05njkjr15', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I34931013', 'https://openalex.org/I4210159460']}, {'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'M. H. Buch', 'raw_affiliation_strings': ['University of Manchester and NIHR Manchester Biomedical Research Centre, Division of Musculoskeletal & Dermatological Sciences, Manchester, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'University of Manchester and NIHR Manchester Biomedical Research Centre, Division of Musculoskeletal & Dermatological Sciences, Manchester, United Kingdom', 'institution_ids': ['https://openalex.org/I4210159460', 'https://openalex.org/I28407311']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048687810', 'display_name': 'J. A. Gómez-Puerta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115097', 'display_name': 'Hospital Clínic de Barcelona', 'ror': 'https://ror.org/02a2kzf50', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115097']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'J. A. Gómez-Puerta', 'raw_affiliation_strings': ['Hospital Clinic of Barcelona, Department of Rheumatology, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hospital Clinic of Barcelona, Department of Rheumatology, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I4210115097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076851275', 'display_name': 'Gerd R Burmester', 'orcid': 'https://orcid.org/0000-0001-7518-1131'}, 'institutions': [{'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'G. R. Burmester', 'raw_affiliation_strings': ['Charité – Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Charité – Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048584658', 'display_name': 'B. Combe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I19894307', 'display_name': 'Université de Montpellier', 'ror': 'https://ror.org/051escj72', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I19894307']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'B. Combe', 'raw_affiliation_strings': ['Montpellier University, Department of Rheumatology, Montpellier, France'], 'affiliations': [{'raw_affiliation_string': 'Montpellier University, Department of Rheumatology, Montpellier, France', 'institution_ids': ['https://openalex.org/I19894307']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041018063', 'display_name': 'V. Rajendran', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I85459889', 'display_name': 'Galapagos (Belgium)', 'ror': 'https://ror.org/04e4j5d46', 'country_code': 'BE', 'type': 'company', 'lineage': ['https://openalex.org/I85459889']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'V. Rajendran', 'raw_affiliation_strings': ['Galapagos NV, Clinical Research, Mechelen, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Galapagos NV, Clinical Research, Mechelen, Belgium', 'institution_ids': ['https://openalex.org/I85459889']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011229981', 'display_name': 'P. J. Stiers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I85459889', 'display_name': 'Galapagos (Belgium)', 'ror': 'https://ror.org/04e4j5d46', 'country_code': 'BE', 'type': 'company', 'lineage': ['https://openalex.org/I85459889']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'P. J. Stiers', 'raw_affiliation_strings': ['Galapagos NV, Biostatistics, Mechelen, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Galapagos NV, Biostatistics, Mechelen, Belgium', 'institution_ids': ['https://openalex.org/I85459889']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014361894', 'display_name': 'P. Van Hoek', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I85459889', 'display_name': 'Galapagos (Belgium)', 'ror': 'https://ror.org/04e4j5d46', 'country_code': 'BE', 'type': 'company', 'lineage': ['https://openalex.org/I85459889']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'P. Van Hoek', 'raw_affiliation_strings': ['Galapagos NV, Medical Safety, Mechelen, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Galapagos NV, Medical Safety, Mechelen, Belgium', 'institution_ids': ['https://openalex.org/I85459889']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090259206', 'display_name': 'Katrien Van Beneden', 'orcid': 'https://orcid.org/0009-0001-2004-7653'}, 'institutions': [{'id': 'https://openalex.org/I85459889', 'display_name': 'Galapagos (Belgium)', 'ror': 'https://ror.org/04e4j5d46', 'country_code': 'BE', 'type': 'company', 'lineage': ['https://openalex.org/I85459889']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'K. Van Beneden', 'raw_affiliation_strings': ['Galapagos NV, Medical Affairs, Mechelen, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Galapagos NV, Medical Affairs, Mechelen, Belgium', 'institution_ids': ['https://openalex.org/I85459889']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107869788', 'display_name': 'Jacques-Éric Gottenberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'J. E. Gottenberg', 'raw_affiliation_strings': ['Strasbourg University Hospital, Rheumatology Department, Strasbourg, France'], 'affiliations': [{'raw_affiliation_string': 'Strasbourg University Hospital, Rheumatology Department, Strasbourg, France', 'institution_ids': ['https://openalex.org/I68947357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075295962', 'display_name': 'Y. Tanaka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I188700360', 'display_name': 'University of Occupational and Environmental Health Japan', 'ror': 'https://ror.org/020p3h829', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I188700360']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Y. Tanaka', 'raw_affiliation_strings': ['University of Occupational and Environmental Health, Department of Internal Medicine, Kitakyushu, Japan'], 'affiliations': [{'raw_affiliation_string': 'University of Occupational and Environmental Health, Department of Internal Medicine, Kitakyushu, Japan', 'institution_ids': ['https://openalex.org/I188700360']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061411814', 'display_name': 'Daniel Aletaha', 'orcid': 'https://orcid.org/0000-0003-2108-0030'}, 'institutions': [{'id': 'https://openalex.org/I76134821', 'display_name': 'Medical University of Vienna', 'ror': 'https://ror.org/05n3x4p02', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I76134821']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'D. Aletaha', 'raw_affiliation_strings': ['Medical University of Vienna, Department of Medicine III (Division of Rheumatology), Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Medical University of Vienna, Department of Medicine III (Division of Rheumatology), Vienna, Austria', 'institution_ids': ['https://openalex.org/I76134821']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049908897', 'display_name': 'R. Westhovens', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'R. Westhovens', 'raw_affiliation_strings': ['KU Leuven, Skeletal Biology and Engineering Research Center, Department of Rheumatology, Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'KU Leuven, Skeletal Biology and Engineering Research Center, Department of Rheumatology, Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5069330674', 'display_name': 'R. Caporali', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I168537998', 'display_name': 'Eli Lilly (United States)', 'ror': 'https://ror.org/01qat3289', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I168537998']}, {'id': 'https://openalex.org/I182380053', 'display_name': 'University of Health Sciences and Pharmacy', 'ror': 'https://ror.org/01btzz102', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I182380053']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R. Caporali', 'raw_affiliation_strings': ['Eli Lilly and Company,', 'San Diego Clinical Services, San Diego, United States of America;', 'University of Health Sciences and Pharmacy, Pharmacy, St. Louis, United States of America;'], 'affiliations': [{'raw_affiliation_string': 'Eli Lilly and Company,', 'institution_ids': ['https://openalex.org/I168537998']}, {'raw_affiliation_string': 'San Diego Clinical Services, San Diego, United States of America;', 'institution_ids': []}, {'raw_affiliation_string': 'University of Health Sciences and Pharmacy, Pharmacy, St. Louis, United States of America;', 'institution_ids': ['https://openalex.org/I182380053']}]}], 'institution_assertions': [], 'countries_distinct_count': 8, 'institutions_distinct_count': 12, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.251, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.69718, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 84}, 'biblio': {'volume': None, 'issue': None, 'first_page': '397.1', 'last_page': '398'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.8498, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.8498, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.7574, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14108', 'display_name': 'Medical and Pharmaceutic Studies', 'score': 0.7065, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dyslipidemia', 'display_name': 'Dyslipidemia', 'score': 0.57893693}, {'id': 'https://openalex.org/keywords/post-hoc-analysis', 'display_name': 'Post-hoc analysis', 'score': 0.52196044}, {'id': 'https://openalex.org/keywords/subgroup-analysis', 'display_name': 'Subgroup analysis', 'score': 0.44401544}, {'id': 'https://openalex.org/keywords/pooled-analysis', 'display_name': 'Pooled analysis', 'score': 0.41749063}, {'id': 'https://openalex.org/keywords/rheumatoid-factor', 'display_name': 'Rheumatoid factor', 'score': 0.41501138}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.93432343}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.70559746}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.59818155}, {'id': 'https://openalex.org/C2778096610', 'wikidata': 'https://www.wikidata.org/wiki/Q1476525', 'display_name': 'Dyslipidemia', 'level': 3, 'score': 0.57893693}, {'id': 'https://openalex.org/C67761136', 'wikidata': 'https://www.wikidata.org/wiki/Q2105849', 'display_name': 'Post-hoc analysis', 'level': 2, 'score': 0.52196044}, {'id': 'https://openalex.org/C50440223', 'wikidata': 'https://www.wikidata.org/wiki/Q1475848', 'display_name': 'Risk factor', 'level': 2, 'score': 0.48666745}, {'id': 'https://openalex.org/C61511704', 'wikidata': 'https://www.wikidata.org/wiki/Q1671857', 'display_name': 'Incidence (geometry)', 'level': 2, 'score': 0.46342173}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.45228195}, {'id': 'https://openalex.org/C187960798', 'wikidata': 'https://www.wikidata.org/wiki/Q7631152', 'display_name': 'Subgroup analysis', 'level': 3, 'score': 0.44401544}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.43430173}, {'id': 'https://openalex.org/C3017906399', 'wikidata': 'https://www.wikidata.org/wiki/Q48973845', 'display_name': 'Pooled analysis', 'level': 3, 'score': 0.41749063}, {'id': 'https://openalex.org/C2776232647', 'wikidata': 'https://www.wikidata.org/wiki/Q702883', 'display_name': 'Rheumatoid factor', 'level': 3, 'score': 0.41501138}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.28168166}, {'id': 'https://openalex.org/C44249647', 'wikidata': 'https://www.wikidata.org/wiki/Q208498', 'display_name': 'Confidence interval', 'level': 2, 'score': 0.19441888}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/annrheumdis-2023-eular.1552', 'pdf_url': 'https://ard.bmj.com/content/annrheumdis/82/Suppl_1/397.1.full.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/annrheumdis-2023-eular.1552', 'pdf_url': 'https://ard.bmj.com/content/annrheumdis/82/Suppl_1/397.1.full.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4252079945', 'https://openalex.org/W4246826797', 'https://openalex.org/W3211880015', 'https://openalex.org/W3112743285', 'https://openalex.org/W3041461385', 'https://openalex.org/W2973124766', 'https://openalex.org/W2869651365', 'https://openalex.org/W2136725827', 'https://openalex.org/W2035351580', 'https://openalex.org/W1500340015'], 'abstract_inverted_index': {'<h3>Background</h3>': [0], 'FIL': [1, 29, 34, 191], 'is': [2, 333, 477], 'an': [3, 478], 'oral': [4], 'Janus': [5], 'kinase': [6], '1': [7], 'preferential': [8], 'inhibitor': [9], 'for': [10, 28, 108, 187, 214, 252, 259, 343, 415, 429], 'the': [11, 303, 381, 483, 486, 496, 527], 'treatment': [12], 'of': [13, 56, 114, 156, 160, 176, 198, 201, 208, 221, 320, 356, 397, 410, 413, 438, 485, 499, 564, 586], 'moderate': [14], 'to': [15, 326, 370, 454, 494, 501, 595, 608, 616], 'severe': [16], 'active': [17], 'RA.': [18], 'A': [19, 620], 'previous': [20], 'pooled': [21, 87], 'analysis': [22, 86, 183, 463], 'reported': [23], 'long-term': [24, 49, 109], 'safety': [25, 50, 488], 'and': [26, 42, 51, 70, 97, 120, 134, 206, 255, 276, 323, 367, 431, 452, 529, 538, 551, 580], 'efficacy': [27, 52, 509], '200': [30], 'mg': [31, 36], '(FIL200)': [32], 'vs': [33, 80, 131, 142, 272, 288, 328, 402], '100': [35], '(FIL100)': [37], 'in': [38, 53, 228, 267, 278, 443, 482, 512, 533], 'pts': [39, 57, 188, 209, 268, 279, 289, 350, 403, 465], 'aged': [40, 269, 280, 290, 298, 351, 388, 404], '≥65': [41, 63, 71, 132, 143, 270, 281, 299, 311, 352, 389, 405, 423, 466], '&lt;65': [43, 61, 65, 273, 291, 418], 'y.<sup>[1]</sup>': [44], '<h3>Objectives</h3>': [45], 'To': [46], 'report': [47], 'updated': [48], '4': [54], 'subgroups': [55, 416, 445], 'with': [58, 74, 78, 217, 284, 306, 374, 384, 450, 469], 'RA': [59], '(aged': [60, 417], 'y,': [62, 64, 300, 353, 406], 'y': [66, 72, 137, 144, 274, 282, 292, 312, 390, 419, 424, 467], 'without': [67, 138, 293, 420], 'CV': [68, 75, 139, 147, 150, 157, 165, 247, 285, 294, 307, 315, 340, 393, 421, 427, 471, 503], 'risk,': [69], 'or': [73, 145, 164, 178, 223, 246, 283, 313, 391, 425, 441, 468], 'risk),': [76], 'treated': [77], 'FIL200': [79, 377, 430, 453, 487], 'FIL100.': [81], '<h3>Methods</h3>': [82], 'This': [83, 460], '<i>post': [84, 461], 'hoc</i>': [85, 462], 'data': [88, 186], 'from': [89], 'phase': [90, 98], '2': [91], '(DARWIN': [92, 118], '1–3;': [93], 'NCT01888874,': [94], 'NCT01894516,': [95], 'NCT02065700)': [96], '3': [99], '(FINCH': [100, 124, 446], '1–4;': [101], 'NCT02889796,': [102], 'NCT02873936,': [103], 'NCT02886728,': [104], 'NCT03025308)': [105], 'trials.': [106], 'Data': [107], 'extensions': [110], '(LTEs)': [111], 'were': [112, 127, 250, 264, 372, 399, 448, 541], 'as': [113], 'May': [115, 121], '2,': [116], '2022': [117, 123], '3),': [119], '6,': [122], '4).': [125], 'Analyses': [126], 'by': [128, 236, 244, 302, 543, 560, 572, 582], 'age': [129, 237, 245, 332, 476, 500], '(&lt;65': [130, 136], 'y)': [133], 'subgroup': [135, 305, 383], 'risk': [140, 148, 151, 248, 286, 295, 308, 336, 341, 385, 394, 472, 480, 504], 'factor': [141, 249, 337, 481], '≥1': [146, 190, 314, 392, 426, 470], 'factor).': [149], 'factors': [152, 309, 342, 386], 'were:': [153], 'family': [154], 'history': [155, 159], 'disease;': [158, 166], 'dyslipidemia,': [161], 'diabetes': [162], 'mellitus': [163], 'hypertension,': [167], 'ischemic': [168], 'vascular': [169, 172], 'conditions,': [170], 'peripheral': [171], 'disease,': [173], 'extra-articular': [174], 'manifestations': [175], 'RA;': [177], 'ever': [179], 'smoked.': [180], 'The': [181, 536], 'as-treated': [182], 'set': [184], 'included': [185], 'receiving': [189], 'dose.': [192], 'Exposure-adjusted': [193], 'incidence': [194], 'rates': [195], '(EAIRs)/100': [196], 'patient-years': [197], 'exposure': [199], '(PYE)': [200], 'selected': [202], 'adverse': [203], 'events': [204], '(AEs),': [205], '%': [207], 'achieving': [210], 'Disease': [211], 'Activity': [212], 'Score': [213], '28': [215], 'joints': [216], 'C-reactive': [218], 'protein': [219], '(DAS28-CRP)': [220], '&lt;2.6': [222, 440], '≤3.2': [224, 442], 'through': [225], 'Week': [226, 455], '156': [227, 456], 'FINCH': [229, 507, 537], '4,': [230, 508], 'are': [231, 433, 492], 'reported.': [232], '<h3>Results</h3>': [233], 'Baseline': [234, 241], 'characteristics': [235, 243], 'have': [238], 'been': [239], 'reported.<sup>[1]</sup>': [240], 'disease': [242, 253], 'similar': [251], 'severity': [254], 'concurrent': [256], 'treatment.': [257], 'EAIRs': [258, 319, 396, 412], 'any': [260], 'treatment-emergent': [261], 'AEs': [262, 345, 398, 414], '(TEAEs)': [263], 'generally': [265, 400], 'higher': [266, 277, 318], '(120.40)': [271], '(97.86),': [275], '(120.45)': [287], '(81.83).': [296], 'Pts': [297], 'followed': [301], 'broader': [304, 382], '(i.e.': [310, 387], 'risk)': [316, 428], 'had': [317], 'serious': [321], 'TEAEs': [322, 324, 368], 'leading': [325, 369], 'discontinuation': [327], 'other': [329, 339], 'subgroups,': [330], 'indicating': [331, 407], 'a': [334], 'key': [335], 'alongside': [338], 'developing': [344], '(data': [346], 'not': [347], 'shown).': [348], 'In': [349, 380, 506], 'lower': [354, 401], 'incidences': [355], 'malignancies': [357], '(excluding': [358], 'non-melanoma': [359], 'skin': [360], 'cancer': [361], '[NMSC]),': [362], 'NMSC,': [363], 'herpes': [364], 'zoster': [365], '(HZ)': [366], 'death': [371], 'observed': [373], 'FIL100': [375, 432, 451], 'than': [376], '(<b>Figure': [378, 435], '1</b>).': [379, 436, 458], 'factor),': [395], 'greater': [408], 'influence': [409], 'age.': [411], 'risk;': [422], 'shown': [434], 'Rates': [437], 'DAS28-CRP': [439], 'all': [444, 513], '4)': [447], 'maintained': [449, 511], '(<b>Table': [457], '<h3>Conclusion</h3>': [459], '(in': [464], 'factor)': [473], 'suggests': [474], 'that': [475], 'important': [479], 'evaluation': [484], 'profile.': [489], 'Future': [490], 'studies': [491, 540], 'needed': [493], 'address': [495], 'relative': [497], 'contribution': [498], 'traditional': [502], 'factors.': [505], 'was': [510, 558, 570], 'subgroups.': [514], '<h3>Reference</h3>': [515], '[1]Buch': [516], 'M,': [517], 'et': [518], 'al.': [519], 'Arthritis': [520], 'Rheumatol': [521], '2022;74(Suppl': [522], '9):0281.': [523], '<h3>Acknowledgements</h3>': [524], 'We': [525], 'thank': [526], 'physicians': [528], 'patients': [530], 'who': [531], 'participated': [532], 'these': [534], 'studies.': [535], 'DARWIN': [539], 'co-funded': [542], 'Gilead': [544, 614], 'Sciences': [545], 'Inc.': [546], '(Foster': [547], 'City,': [548], 'CA,': [549], 'USA)': [550], 'Galapagos': [552, 565, 583], 'NV': [553], '(Mechelen,': [554], 'Belgium).': [555], 'Publication': [556], 'coordination': [557], 'provided': [559, 571], 'Fabien': [561], 'Debailleul,': [562], 'PhD,': [563], 'NV.': [566, 584], 'Medical': [567], 'writing': [568], 'support': [569, 612, 727, 750, 789], 'Stephanie': [573], 'Rippon,': [574], 'MBio': [575], '(Aspire': [576], 'Scientific,': [577], 'Bollington,': [578], 'UK),': [579], 'funded': [581], '<h3>Disclosure': [585], 'Interests</h3>': [587], 'Maya': [588], 'H': [589], 'Buch': [590], 'Speakers': [591, 622, 636, 657, 733, 762, 804, 816], 'bureau:': [592, 623, 637, 658, 734, 763, 805, 817], 'AbbVie': [593], '(paid': [594, 615], 'host': [596, 609, 617], 'institution),': [597, 610, 618], 'Consultant': [598, 630, 646, 666, 691, 716, 775, 809, 829], 'of:': [599, 631, 647, 667, 678, 681, 686, 692, 701, 709, 712, 717, 776, 810, 830], 'AbbVie,': [600, 638, 648, 659, 668, 718, 735, 752, 764, 777, 791, 818, 831], 'CESAS': [601], 'Medical,': [602], 'Galapagos,': [603, 625, 642, 651, 661, 669, 679, 682, 687, 698, 710, 713, 720, 767, 780, 794, 807, 812, 823, 833], 'Gilead,': [604, 670, 721, 745, 768, 781, 795, 808, 813], 'Pfizer': [605], '(all': [606], 'paid': [607], 'Grant/research': [611, 726, 749, 788], 'from:': [613, 728, 751, 790], 'José': [619], 'Gómez-Puerta': [621], 'AstraZeneca,': [624, 736], 'GSK,': [626, 746], 'Janssen,': [627, 662, 671, 702, 769, 782, 796, 824], 'Lilly,': [628, 643, 652, 663, 672, 722, 744, 766, 779, 793, 825, 834], 'Pfizer,': [629, 644, 653, 664, 725, 730, 748, 772, 785, 799, 827, 836], 'Sanofi,': [632, 645, 654, 774, 787, 801], 'Gerd': [633], 'Rüdiger': [634], 'Burmester': [635], 'Amgen,': [639, 649, 819], 'BMS,': [640, 650, 719, 729, 737, 820], 'Chugai,': [641, 740, 756], 'Bernard': [655], 'Combe': [656], 'Celltrion,': [660, 806, 811, 821], 'Roche-Chugai,': [665, 674], 'Novartis,': [673, 724, 771, 784, 798, 826, 835], 'Vijay': [675], 'Rajendran': [676], 'Shareholder': [677, 708], 'Employee': [680, 685, 700, 711], 'Pieter-Jan': [683], 'Stiers': [684], 'Paul': [688], 'Van': [689, 706], 'Hoek': [690], 'AOP': [693], 'Health,': [694], 'Aspen,': [695], 'Astellas': [696], 'Pharma,': [697], 'Sanofi-Genzyme,': [699], 'MSD,': [703, 723], 'Schering-Plough,': [704], 'Katrien': [705], 'Beneden': [707], 'Jacques-Eric': [714], 'Gottenberg': [715], 'Yoshiya': [731], 'Tanaka': [732], 'Boehringer': [738, 754], 'Ingelheim,': [739, 755], 'Daiichi-Sankyo,': [741, 757], 'Eisai,': [742, 758], 'Eli': [743, 765, 778, 792], 'Mitsubishi-Tanabe,': [747], 'Asahi-Kasei,': [753], 'Takeda,': [759], 'Daniel': [760], 'Aletaha': [761], 'Merck,': [770, 783, 797], 'Sandoz,': [773, 786, 800], 'Rene': [802], 'Westhovens': [803], 'Roberto': [814], 'Caporali': [815], 'Fresenius,': [822, 832], 'UCB,': [828], 'UCB.': [837]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4379521544', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}], 'updated_date': '2024-12-27T21:49:02.763717', 'created_date': '2023-06-07'}