POS0753 TIF1-GAMMA IGG2 ISOTYPE IS ASSOCIATED WITH ETHNICITY IN JDM PATIENTS

Name: Work Video:
Duration: 3 min 30 s
Huong D. Nguyen; F. Jouen; B. Déchelotte; N. Cordel; Cyril Gitiaux; Christine Bodemer; Pierre Quartier; Alexandre Bélot; Kerry O’Brien; Isabelle Melki; Nicole Fabien; Sarah Tansley; Lucy R. Wedderburn; Olivier Boyer; Brigitte Bader‐Meunier
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'JDM': [28, 288, 312, 496], 'adult': [30, 71, 97, 105, 274, 303, 479, 542], 'DM,': [31, 275, 480], 'including': [32, 196], 'skin': [33], 'rashes': [34], 'proximal': [36], 'muscle': [37], 'weakness,': [38], 'however,': [39], 'the': [40, 83, 173, 290, 349, 372], 'manifestations': [41, 143, 489], 'prevalence': [43], 'associated': [45, 93, 484, 538], 'autoantibodies': [46], 'vary,': [47], 'depending': [48], 'on': [49, 127], 'age': [50], 'onset.': [52], 'Myositis': [53], 'specific': [54], 'antibodies': [55], '(MSA)': [56], 'have': [57, 101, 110, 650], 'been': [58, 263], 'used': [59], 'as': [60, 137, 491], 'a': [61, 138, 149, 205, 267, 420, 462, 474, 618], 'prognostic': [62], 'tool': [63], 'to': [64, 152, 236, 265, 652], 'aid': [65], 'management': [66], 'both': [70, 315, 321], 'JDM.': [74, 131, 145], 'In': [75, 286], 'JDM,': [76], 'anti-TIF1γ': [77, 118, 128, 135, 157, 183, 192, 194, 255, 261, 335, 405, 417, 432, 465], 'highly': [79], 'prevalent,': [80], 'most': [84], 'common': [85], 'MSA': [86, 91], 'Caucasian': [88, 346, 362], 'patients.': [89, 159, 497], 'This': [90, 160], 'with': [94, 108, 191, 485, 539], 'malignancy': [95, 270, 281, 494], '[1].': [99], 'We': [100, 147, 401, 638], 'previously': [102], 'shown': [103, 264], 'patients': [107, 164, 171, 243, 347, 414, 645], 'cancer': [109, 477, 540], 'significantly': [111], 'higher': [112], 'frequency': [113], 'serological': [115, 429], 'level': [116], 'IgG2': [119, 258, 332, 356, 385, 444, 466, 472, 535, 609], 'isotype': [120, 253, 259, 333, 467, 536], '[2].': [121, 215, 307], 'However,': [122], 'there': [123, 276, 327, 459], 'limited': [125], 'data': [126], 'isotypes': [129, 136, 195, 406, 418], '<h3>Objectives</h3>': [132], 'To': [133], 'investigate': [134], 'potential': [139], 'biomarker': [140, 268, 475], 'for': [141, 182, 269, 318, 324, 416, 443, 452, 476], 'clinical': [142, 154], '<h3>Methods</h3>': [146], 'conducted': [148], 'retrospective': [150], 'study': [151, 456], 'evaluate': [153], 'features': [155], 'positive': [158, 317, 357, 386, 441, 450], 'cohort': [161, 313], 'includes': [162], '20': [163], 'from': [165, 172], 'French': [166], 'healthcare': [167, 175], 'centres': [168], '11': [170], 'UK': [174], 'centres.': [176], 'Serum': [177], 'samples': [178], 'were': [179, 202, 223, 277, 316, 322, 328, 348, 368, 387], 'first': [180], 'tested': [181, 415], 'using': [184, 204], 'either': [185], 'lineblot': [186], 'or': [187, 488, 493], 'immunoprecipitation.': [188], 'Within': [189], 'those': [190], 'antibodies,': [193], 'IgG1,': [197], 'IgG2,': [198], 'IgG3': [199], 'IgG4': [201], 'measured': [203], 'multiplex': [206], 'ALBIA': [207], 'assay': [208], 'developed': [209], 'by': [210, 226], 'Aussy': [211], 'et': [212], 'al.': [213], '(2019)': [214], '<h3>Results</h3>': [216], 'Out': [217], '31': [219, 242], '54.8%': [221], '(17)': [222], 'Caucasian,': [224], 'followed': [225], 'North': [227, 390], 'African': [228, 391], '(25.8%,': [229], 'n=7),': [230], 'other': [232], 'minority': [233], 'groups.': [234], 'Male': [235], 'female': [237], 'ratio': [238], 'was': [239, 294, 359], '14/17.': [240], 'All': [241], 'had': [244, 249, 426, 435], 'IgG1': [245], 'isotype,': [246], '14': [248], 'more': [250], 'than': [251, 300], 'one': [252], 'antibody.': [256], 'Although': [257], 'has': [262], 'be': [266, 461], 'mortality': [272, 492], 'no': [278], 'reports': [279], 'this': [283, 311, 398, 653], 'paediatric': [284], 'cohort.': [285], 'our': [287], 'cohort,': [289], 'rate': [291], 'IgG2-positive': [293], '25.8%': [295], '(8/31)': [296], 'which': [297], 'lower': [299, 436], 'observed': [301, 369], '55%': [306], 'Two': [308], 'cases': [309, 358, 425], 'died:': [314], 'IgG4,': [319], 'but': [320], 'negative': [323], 'IgG2.': [325], 'Interestingly,': [326], 'significant': [329, 366], 'differences': [330, 367], 'regarding': [331], 'antibody': [336], 'presence': [337], 'ethnic': [339, 399], 'groups': [340], '(p': [341, 375, 380], '=': [342, 376, 381], '0.008).': [343], 'Specifically,': 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