Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4379374925', 'doi': 'https://doi.org/10.20944/preprints202306.0263.v1', 'title': 'Cellular and Molecular Mechanisms of the Colorectal Cancer Tumor Stroma: Insights into Disease Progression and Therapeutic Targets', 'display_name': 'Cellular and Molecular Mechanisms of the Colorectal Cancer Tumor Stroma: Insights into Disease Progression and Therapeutic Targets', 'publication_year': 2023, 'publication_date': '2023-06-05', 'ids': {'openalex': 'https://openalex.org/W4379374925', 'doi': 'https://doi.org/10.20944/preprints202306.0263.v1'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.20944/preprints202306.0263.v1', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.20944/preprints202306.0263.v1', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024266815', 'display_name': 'Nikolay K. Shakhpazyan', 'orcid': 'https://orcid.org/0000-0003-3386-7746'}, 'institutions': [{'id': 'https://openalex.org/I4210145101', 'display_name': 'Research Institute of Human Morphology', 'ror': 'https://ror.org/042k8ng80', 'country_code': 'RU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210145101']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Nikolay Shakhpazyan', 'raw_affiliation_strings': ['Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210145101']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040838582', 'display_name': 'Л.М. Михалева', 'orcid': 'https://orcid.org/0000-0003-2052-914X'}, 'institutions': [{'id': 'https://openalex.org/I4210145101', 'display_name': 'Research Institute of Human Morphology', 'ror': 'https://ror.org/042k8ng80', 'country_code': 'RU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210145101']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Liudmila Mikhaleva', 'raw_affiliation_strings': ['Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210145101']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062778661', 'display_name': 'A L Bedzhanyan', 'orcid': 'https://orcid.org/0000-0002-4377-0035'}, 'institutions': [{'id': 'https://openalex.org/I4210164220', 'display_name': 'Russian Scientific Center of Surgery', 'ror': 'https://ror.org/05pnsh228', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210164220']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Arcady L. Bedzhanyan', 'raw_affiliation_strings': ['Department of Abdominal Surgery and Oncology II (Coloproctology and Uro-Gynecology), Petrovsky National Research Center of Surgery, 119435, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Department of Abdominal Surgery and Oncology II (Coloproctology and Uro-Gynecology), Petrovsky National Research Center of Surgery, 119435, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210164220']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053281043', 'display_name': 'Z.V. Gioeva', 'orcid': 'https://orcid.org/0000-0002-5456-8692'}, 'institutions': [{'id': 'https://openalex.org/I4210145101', 'display_name': 'Research Institute of Human Morphology', 'ror': 'https://ror.org/042k8ng80', 'country_code': 'RU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210145101']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Zarina Gioeva', 'raw_affiliation_strings': ['Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210145101']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019319211', 'display_name': 'Nikolay K. Sadykhov', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145101', 'display_name': 'Research Institute of Human Morphology', 'ror': 'https://ror.org/042k8ng80', 'country_code': 'RU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210145101']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Nikolay Sadykhov', 'raw_affiliation_strings': ['Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210145101']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077374686', 'display_name': 'A Mikhalev', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I337778094', 'display_name': 'Pirogov Russian National Research Medical University', 'ror': 'https://ror.org/018159086', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I337778094', 'https://openalex.org/I4210117042']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Alexander Mikhalev', 'raw_affiliation_strings': ['Pirogov Russian National Research Medical University, 117997, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Pirogov Russian National Research Medical University, 117997, Moscow, Russia', 'institution_ids': ['https://openalex.org/I337778094']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061817158', 'display_name': 'Dmitri Atiakshin', 'orcid': 'https://orcid.org/0000-0002-8347-4556'}, 'institutions': [{'id': 'https://openalex.org/I3129897247', 'display_name': 'Russian New University', 'ror': 'https://ror.org/00gj2kk32', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I3129897247']}, {'id': 'https://openalex.org/I126527374', 'display_name': "Peoples' Friendship University of Russia", 'ror': 'https://ror.org/02dn9h927', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I126527374']}, {'id': 'https://openalex.org/I2800247874', 'display_name': 'Voronezh State Medical Academy named after N.N. Burdenko', 'ror': 'https://ror.org/05kce7016', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I2800247874']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Dmitri Atiakshin', 'raw_affiliation_strings': ['RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation', 'Research Institute of Experimental Biology and Medicine, Burdenko Voronezh State Medical University, 394036 Voronezh, Russia.'], 'affiliations': [{'raw_affiliation_string': 'RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation', 'institution_ids': ['https://openalex.org/I3129897247', 'https://openalex.org/I126527374']}, {'raw_affiliation_string': 'Research Institute of Experimental Biology and Medicine, Burdenko Voronezh State Medical University, 394036 Voronezh, Russia.', 'institution_ids': ['https://openalex.org/I2800247874']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011657635', 'display_name': 'Igor Buchwalow', 'orcid': 'https://orcid.org/0000-0003-1142-7483'}, 'institutions': [{'id': 'https://openalex.org/I3129897247', 'display_name': 'Russian New University', 'ror': 'https://ror.org/00gj2kk32', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I3129897247']}, {'id': 'https://openalex.org/I126527374', 'display_name': "Peoples' Friendship University of Russia", 'ror': 'https://ror.org/02dn9h927', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I126527374']}, {'id': 'https://openalex.org/I4210098441', 'display_name': 'Institut für Hämatopathologie Hamburg', 'ror': 'https://ror.org/00y9hdv35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098441']}], 'countries': ['DE', 'RU'], 'is_corresponding': False, 'raw_author_name': 'Igor Buchwalow', 'raw_affiliation_strings': ['Institute for Hematopathology, 22547 Hamburg, Germany.', 'RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation'], 'affiliations': [{'raw_affiliation_string': 'RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation', 'institution_ids': ['https://openalex.org/I3129897247', 'https://openalex.org/I126527374']}, {'raw_affiliation_string': 'Institute for Hematopathology, 22547 Hamburg, Germany.', 'institution_ids': ['https://openalex.org/I4210098441']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039102985', 'display_name': 'Markus Tiemann', 'orcid': 'https://orcid.org/0000-0002-6499-4855'}, 'institutions': [{'id': 'https://openalex.org/I4210098441', 'display_name': 'Institut für Hämatopathologie Hamburg', 'ror': 'https://ror.org/00y9hdv35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098441']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Markus Tiemann', 'raw_affiliation_strings': ['Institute for Hematopathology, 22547 Hamburg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Institute for Hematopathology, 22547 Hamburg, Germany.', 'institution_ids': ['https://openalex.org/I4210098441']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5105411377', 'display_name': 'Alexander N. Orekhov', 'orcid': 'https://orcid.org/0000-0002-3318-4681'}, 'institutions': [{'id': 'https://openalex.org/I4210145101', 'display_name': 'Research Institute of Human Morphology', 'ror': 'https://ror.org/042k8ng80', 'country_code': 'RU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210145101']}, {'id': 'https://openalex.org/I4210131054', 'display_name': 'Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences', 'ror': 'https://ror.org/03jmc9t23', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210110862', 'https://openalex.org/I4210131054']}, {'id': 'https://openalex.org/I4210152246', 'display_name': 'Institute for Atherosclerosis Research', 'ror': 'https://ror.org/05wdzq856', 'country_code': 'RU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210152246']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Alexander Orekhov', 'raw_affiliation_strings': ['Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435, Moscow, Russia', 'Institute for Atherosclerosis Research, Moscow 121096, Russia', 'Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow 125315, Russia'], 'affiliations': [{'raw_affiliation_string': 'Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210145101']}, {'raw_affiliation_string': 'Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow 125315, Russia', 'institution_ids': ['https://openalex.org/I4210131054']}, {'raw_affiliation_string': 'Institute for Atherosclerosis Research, Moscow 121096, Russia', 'institution_ids': ['https://openalex.org/I4210152246']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 9, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.981939, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 71, 'max': 82}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Stem Cells and Tumor Metastasis', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Stem Cells and Tumor Metastasis', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10066', 'display_name': 'Diversity and Function of Gut Microbiome', 'score': 0.9853, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tumor-progression', 'display_name': 'Tumor progression', 'score': 0.69954216}, {'id': 'https://openalex.org/keywords/tumor-microenvironment', 'display_name': 'Tumor Microenvironment', 'score': 0.587483}, {'id': 'https://openalex.org/keywords/tumor-budding', 'display_name': 'Tumor budding', 'score': 0.57518256}], 'concepts': [{'id': 'https://openalex.org/C52124034', 'wikidata': 'https://www.wikidata.org/wiki/Q557179', 'display_name': 'Stroma', 'level': 3, 'score': 0.8923697}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.70125556}, {'id': 'https://openalex.org/C2779256057', 'wikidata': 'https://www.wikidata.org/wiki/Q16909647', 'display_name': 'Tumor progression', 'level': 3, 'score': 0.69954216}, {'id': 'https://openalex.org/C16930146', 'wikidata': 'https://www.wikidata.org/wiki/Q4381253', 'display_name': 'Stromal cell', 'level': 2, 'score': 0.6870282}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.6594829}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.65124875}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.58483905}, {'id': 'https://openalex.org/C2779188454', 'wikidata': 'https://www.wikidata.org/wiki/Q16948689', 'display_name': 'Tumor budding', 'level': 5, 'score': 0.57518256}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.56470317}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.49423864}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.47467375}, {'id': 'https://openalex.org/C143121216', 'wikidata': 'https://www.wikidata.org/wiki/Q1330402', 'display_name': 'Microbiome', 'level': 2, 'score': 0.4473266}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.4216565}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.28682214}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.2638027}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.24677402}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.24173439}, {'id': 'https://openalex.org/C3020616263', 'wikidata': 'https://www.wikidata.org/wiki/Q1216998', 'display_name': 'Tumor cells', 'level': 2, 'score': 0.23265767}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.20845118}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.108492225}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.058244407}, {'id': 'https://openalex.org/C2992571226', 'wikidata': 'https://www.wikidata.org/wiki/Q170758', 'display_name': 'Lymph node metastasis', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.20944/preprints202306.0263.v1', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biomedicines11092361', 'pdf_url': 'https://www.mdpi.com/2227-9059/11/9/2361/pdf?version=1692863451', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.20944/preprints202306.0263.v1', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.57}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 99, 'referenced_works': ['https://openalex.org/W2012550268', 'https://openalex.org/W2145199081', 'https://openalex.org/W2148129217', 'https://openalex.org/W2429678950', 'https://openalex.org/W2540633756', 'https://openalex.org/W2724914948', 'https://openalex.org/W2751802280', 'https://openalex.org/W2768799378', 'https://openalex.org/W2796331245', 'https://openalex.org/W2802421303', 'https://openalex.org/W2804478743', 'https://openalex.org/W2805309434', 'https://openalex.org/W2885190696', 'https://openalex.org/W2899828884', 'https://openalex.org/W2919427816', 'https://openalex.org/W2932225899', 'https://openalex.org/W2936221430', 'https://openalex.org/W2941641153', 'https://openalex.org/W2946663348', 'https://openalex.org/W2951541824', 'https://openalex.org/W2957585395', 'https://openalex.org/W2965300169', 'https://openalex.org/W2972734154', 'https://openalex.org/W2976533954', 'https://openalex.org/W2978077164', 'https://openalex.org/W2989425431', 'https://openalex.org/W2998084909', 'https://openalex.org/W3005687797', 'https://openalex.org/W3006122165', 'https://openalex.org/W3006819220', 'https://openalex.org/W3010011098', 'https://openalex.org/W3011825303', 'https://openalex.org/W3012695604', 'https://openalex.org/W3019294197', 'https://openalex.org/W3028510355', 'https://openalex.org/W3035748750', 'https://openalex.org/W3035953791', 'https://openalex.org/W3042800367', 'https://openalex.org/W3049761941', 'https://openalex.org/W3079850087', 'https://openalex.org/W3093166388', 'https://openalex.org/W3095058622', 'https://openalex.org/W3107234799', 'https://openalex.org/W3108389912', 'https://openalex.org/W3108919818', 'https://openalex.org/W3112064419', 'https://openalex.org/W3117886022', 'https://openalex.org/W3125898497', 'https://openalex.org/W3127536399', 'https://openalex.org/W3129009728', 'https://openalex.org/W3129667909', 'https://openalex.org/W3130224122', 'https://openalex.org/W3132331925', 'https://openalex.org/W3134865079', 'https://openalex.org/W3134972904', 'https://openalex.org/W3136248491', 'https://openalex.org/W3147142721', 'https://openalex.org/W3151963551', 'https://openalex.org/W3153284035', 'https://openalex.org/W3165801417', 'https://openalex.org/W3180882235', 'https://openalex.org/W3194796309', 'https://openalex.org/W3200378278', 'https://openalex.org/W3201013965', 'https://openalex.org/W3204442371', 'https://openalex.org/W3212249097', 'https://openalex.org/W3214871787', 'https://openalex.org/W4200155765', 'https://openalex.org/W4205961267', 'https://openalex.org/W4206413922', 'https://openalex.org/W4206819725', 'https://openalex.org/W4214495282', 'https://openalex.org/W4214852440', 'https://openalex.org/W4220769578', 'https://openalex.org/W4221016108', 'https://openalex.org/W4221088758', 'https://openalex.org/W4221096865', 'https://openalex.org/W4224987914', 'https://openalex.org/W4225266727', 'https://openalex.org/W4280531356', 'https://openalex.org/W4280562196', 'https://openalex.org/W4281871476', 'https://openalex.org/W4283644123', 'https://openalex.org/W4285009376', 'https://openalex.org/W4285088579', 'https://openalex.org/W4285391272', 'https://openalex.org/W4285391705', 'https://openalex.org/W4286504955', 'https://openalex.org/W4291114109', 'https://openalex.org/W4291720780', 'https://openalex.org/W4295749214', 'https://openalex.org/W4306247683', 'https://openalex.org/W4307338693', 'https://openalex.org/W4308633899', 'https://openalex.org/W4315796832', 'https://openalex.org/W4319985495', 'https://openalex.org/W4322774389', 'https://openalex.org/W4360607627', 'https://openalex.org/W4379374925'], 'related_works': ['https://openalex.org/W4386869142', 'https://openalex.org/W4386142372', 'https://openalex.org/W4379374925', 'https://openalex.org/W4313416302', 'https://openalex.org/W2911184935', 'https://openalex.org/W2593769346', 'https://openalex.org/W2198389860', 'https://openalex.org/W2050605814', 'https://openalex.org/W2032175417', 'https://openalex.org/W1897293598'], 'abstract_inverted_index': {'This': [0], 'review': [1, 74, 119], 'systematically': [2], 'examines': [3], 'the': [4, 8, 25, 43, 92, 103, 110, 121], 'multifaceted': [5], 'relationship': [6], 'between': [7, 124], 'tumor': [9, 49, 64, 107], 'microenvironment,': [10, 129], 'stromal': [11], 'interactions,': [12], 'and': [13, 18, 66, 84, 94, 109, 127], 'colorectal': [14], 'cancer': [15], '(CRC)': [16], 'progression': [17], 'metastasis.': [19], 'The': [20, 40, 73], 'analysis': [21], 'begins': [22], 'by': [23], 'assessing': [24], 'gut': [26], 'microbiome's': [27], 'influence': [28], 'on': [29, 56, 63], 'CRC': [30, 48, 82, 125], 'development,': [31], 'emphasizing': [32], 'its': [33, 54, 61], 'association': [34], 'with': [35], 'gut-associated': [36], 'lymphoid': [37], 'tissue': [38], '(GALT).': [39], 'role': [41], 'of': [42, 105], 'Wnt': [44], 'signaling': [45], 'pathway': [46], 'in': [47, 113], 'stroma': [50, 83, 112], 'is': [51, 97], 'scrutinized,': [52], 'elucidating': [53], 'impact': [55], 'disease': [57], 'progression.': [58], 'Tumor': [59], 'budding,': [60], 'effect': [62], 'stroma,': [65], 'implications': [67], 'for': [68], 'patient': [69], 'prognosis': [70], 'are': [71], 'investigated.': [72], 'also': [75], 'identifies': [76], 'conserved': [77], 'oncogenic': [78], 'signatures': [79], '(COS)': [80], 'within': [81], 'explores': [85], 'their': [86, 128], 'potential': [87], 'as': [88], 'therapeutic': [89, 135], 'targets.': [90], 'Lastly,': [91], 'seed': [93], 'soil': [95], 'hypothesis': [96], 'employed': [98], 'to': [99], 'contextualize': [100], 'metastasis,': [101], 'accentuating': [102], 'significance': [104], 'both': [106], 'cells': [108, 126], 'surrounding': [111], 'metastatic': [114], 'propensity.': [115], 'In': [116], 'summary,': [117], 'this': [118], 'highlights': [120], 'intricate': [122], 'interdependence': [123], 'providing': [130], 'valuable': [131], 'insights': [132], 'into': [133], 'prospective': [134], 'approaches': [136], 'targeting': [137], 'tumor-stroma': [138], 'interactions.': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4379374925', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-09-15T07:41:18.725014', 'created_date': '2023-06-06'}