Title: Trends in the Burden of Obesity-Related Cancers in SADC Countries, 1990-2019: Findings from the Global Burden of Disease Study
Abstract: Background: The burden of obesity-related cancers in the 16 Southern African Development Community (SADC) countries is quite prominent but the time trends are unknown.Methods: Data from the 2019 Global Burden of Diseases (GBD) Study was analysed. Mortality was estimated from vital registration, verbal autopsies and ICD codes. Prevalence and mortality rates for each cancer type were calculated using the Cause of Death Ensemble model (CODEm) and Spatio-Temporal Gaussian process. Annual rates of change (AROC) from 1990-2019 were calculated.Findings: The leading mortality rates per 100,000 population for males in 2019 for SADC were leukaemia, 20.1 (95% Uncertainty Intervals [UIs]: (14.4-26.4), oesophageal cancer, 15.1(11.2-19.1), and colon/rectum cancer, 10.3(8.6-12.6). For females in 2019, breast, 20.6(16.6-25.0), leukaemia, 17.1(11.4-23.7), and oesophageal, 8.3(5.5-10.7) cancers had the top mortality rates. For males AROC showed statistically significant (p<0.05) linear increase for kidney cancer for 11 countries (0.41 to 1.24%), colon/rectum cancer for eight countries (0.39-0.92%), and pancreatic cancer for seven countries (0.26-1.01%). For females AROC showed statistically significant linear increase in pancreatic cancer for 13 countries (0.34-1.67%), nine countries for kidney cancer (0.27-1.02%), seven countries each for breast cancer (0.35-1.13%), and ovarian cancer (0.33-1.21%).Interpretation: There is need for location-specific and culturally appropriate strategies for better nutrition and weight control and improved screening for all cancers in the SADC. Health promotion messaging in SADC should target kidney, colon/rectum, pancreatic and breast cancers and encourage clinically tested methods of reducing BMI such as increasing personal levels of physical activity that produce results and adoption of dietary regimes that are equally effective.Funding: There was no funding associated with this work.Declaration of Interest: We report no conflict of interest.
Publication Year: 2023
Publication Date: 2023-01-01
Language: en
Type: preprint
Indexed In: ['crossref']
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