Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4377104832', 'doi': 'https://doi.org/10.3390/ijms24108903', 'title': 'Functional Role of Arrestin-1 Residues Interacting with Unphosphorylated Rhodopsin Elements', 'display_name': 'Functional Role of Arrestin-1 Residues Interacting with Unphosphorylated Rhodopsin Elements', 'publication_year': 2023, 'publication_date': '2023-05-17', 'ids': {'openalex': 'https://openalex.org/W4377104832', 'doi': 'https://doi.org/10.3390/ijms24108903', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37240250'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms24108903', 'pdf_url': 'https://www.mdpi.com/1422-0067/24/10/8903/pdf?version=1684323479', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1422-0067/24/10/8903/pdf?version=1684323479', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5044103642', 'display_name': 'Sergey A. Vishnivetskiy', 'orcid': 'https://orcid.org/0000-0001-8619-4157'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sergey A. Vishnivetskiy', 'raw_affiliation_strings': ['Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010021060', 'display_name': 'Liana D. Weinstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Liana D. Weinstein', 'raw_affiliation_strings': ['Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101639918', 'display_name': 'Chen Zheng', 'orcid': 'https://orcid.org/0000-0002-3610-5715'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chen Zheng', 'raw_affiliation_strings': ['Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055148764', 'display_name': 'Eugenia V. Gurevich', 'orcid': 'https://orcid.org/0000-0002-0563-8295'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eugenia V. Gurevich', 'raw_affiliation_strings': ['Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049089914', 'display_name': 'Vsevolod V. Gurevich', 'orcid': 'https://orcid.org/0000-0002-3950-5351'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vsevolod V. Gurevich', 'raw_affiliation_strings': ['Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA;', 'institution_ids': ['https://openalex.org/I200719446']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 0.521, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.499258, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 84}, 'biblio': {'volume': '24', 'issue': '10', 'first_page': '8903', 'last_page': '8903'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12236', 'display_name': 'Photoreceptor and optogenetics research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10683', 'display_name': 'Mass Spectrometry Techniques and Applications', 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/arrestin', 'display_name': 'Arrestin', 'score': 0.9678854}], 'concepts': [{'id': 'https://openalex.org/C202033177', 'wikidata': 'https://www.wikidata.org/wiki/Q423107', 'display_name': 'Rhodopsin', 'level': 3, 'score': 0.97805107}, {'id': 'https://openalex.org/C2777503648', 'wikidata': 'https://www.wikidata.org/wiki/Q905671', 'display_name': 'Arrestin', 'level': 4, 'score': 0.9678854}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.6670318}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5517348}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.48014754}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.44424808}, {'id': 'https://openalex.org/C16318435', 'wikidata': 'https://www.wikidata.org/wiki/Q149299', 'display_name': 'Mutagenesis', 'level': 4, 'score': 0.43010107}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40116146}, {'id': 'https://openalex.org/C135285700', 'wikidata': 'https://www.wikidata.org/wiki/Q38173', 'display_name': 'G protein-coupled receptor', 'level': 3, 'score': 0.36501735}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3462224}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.32443833}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.16709918}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.078092575}, {'id': 'https://openalex.org/C2780827179', 'wikidata': 'https://www.wikidata.org/wiki/Q422001', 'display_name': 'Retinal', 'level': 2, 'score': 0.068852246}], 'mesh': [{'descriptor_ui': 'D019393', 'descriptor_name': 'Arrestin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012243', 'descriptor_name': 'Rhodopsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019393', 'descriptor_name': 'Arrestin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012243', 'descriptor_name': 'Rhodopsin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012243', 'descriptor_name': 'Rhodopsin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms24108903', 'pdf_url': 'https://www.mdpi.com/1422-0067/24/10/8903/pdf?version=1684323479', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219436', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.20944/preprints202304.0476.v1', 'pdf_url': 'https://www.preprints.org/manuscript/202304.0476/v1/download', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37240250', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms24108903', 'pdf_url': 'https://www.mdpi.com/1422-0067/24/10/8903/pdf?version=1684323479', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1498831674', 'https://openalex.org/W1521219614', 'https://openalex.org/W1528353095', 'https://openalex.org/W1603105681', 'https://openalex.org/W193979248', 'https://openalex.org/W1981561980', 'https://openalex.org/W1982690891', 'https://openalex.org/W1986048756', 'https://openalex.org/W1994539207', 'https://openalex.org/W2009742151', 'https://openalex.org/W2013596647', 'https://openalex.org/W2015590113', 'https://openalex.org/W2017875329', 'https://openalex.org/W2021607480', 'https://openalex.org/W2023661096', 'https://openalex.org/W2030222651', 'https://openalex.org/W2033688302', 'https://openalex.org/W2038863418', 'https://openalex.org/W2038890593', 'https://openalex.org/W2040130844', 'https://openalex.org/W2040368565', 'https://openalex.org/W2040727774', 'https://openalex.org/W2061109953', 'https://openalex.org/W2061534502', 'https://openalex.org/W2067482553', 'https://openalex.org/W2068003883', 'https://openalex.org/W2079311820', 'https://openalex.org/W2087085101', 'https://openalex.org/W2090858556', 'https://openalex.org/W2140038371', 'https://openalex.org/W2142866188', 'https://openalex.org/W2165726219', 'https://openalex.org/W2165775221', 'https://openalex.org/W2340675996', 'https://openalex.org/W2470669072', 'https://openalex.org/W2617686703', 'https://openalex.org/W2727595407', 'https://openalex.org/W2739933313', 'https://openalex.org/W2767610564', 'https://openalex.org/W2781662777', 'https://openalex.org/W2921758355', 'https://openalex.org/W2989686935', 'https://openalex.org/W2999487242', 'https://openalex.org/W3000145087', 'https://openalex.org/W3035794825', 'https://openalex.org/W3037696572', 'https://openalex.org/W3085998057', 'https://openalex.org/W3095552437', 'https://openalex.org/W4294316928', 'https://openalex.org/W4295136939', 'https://openalex.org/W4309009624', 'https://openalex.org/W4322744441', 'https://openalex.org/W74249497'], 'related_works': ['https://openalex.org/W4310038632', 'https://openalex.org/W3211321159', 'https://openalex.org/W2923284938', 'https://openalex.org/W2619724621', 'https://openalex.org/W2595602881', 'https://openalex.org/W2225689975', 'https://openalex.org/W2148247699', 'https://openalex.org/W2114487805', 'https://openalex.org/W2033688302', 'https://openalex.org/W1981995076'], 'abstract_inverted_index': {'Arrestin-1,': [0], 'or': [1, 124], 'visual': [2], 'arrestin,': [3], 'exhibits': [4], 'an': [5], 'exquisite': [6], 'selectivity': [7, 19, 160], 'for': [8, 161, 165], 'light-activated': [9, 108], 'phosphorylated': [10, 55], 'rhodopsin': [11, 42, 50, 56, 110], '(P-Rh*)': [12], 'over': [13], 'its': [14], 'other': [15], 'functional': [16, 91], 'forms.': [17], 'That': [18], 'is': [20], 'believed': [21], 'to': [22, 48, 75, 81, 105, 122, 128, 133, 154], 'be': [23], 'mediated': [24], 'by': [25, 87], 'two': [26], 'well-established': [27], 'structural': [28], 'elements': [29], 'in': [30, 61, 96, 142], 'the': [31, 34, 38, 44, 49, 62, 66, 90, 119, 126, 139, 151, 166, 174], 'arrestin-1': [32, 71, 99, 152, 159], 'molecule,': [33], 'activation': [35], 'sensor': [36, 46], 'detecting': [37], 'active': [39, 54], 'conformation': [40], 'of': [41, 65, 93, 168, 173], 'and': [43, 107, 156], 'phosphorylation': [45], 'responsive': [47], 'phosphorylation,': [51], 'which': [52, 77], 'only': [53, 121], 'can': [57], 'engage': [58], 'simultaneously.': [59], 'However,': [60], 'crystal': [63], 'structure': [64], 'arrestin-1–rhodopsin': [67], 'complex': [68], 'there': [69], 'are': [70], 'residues': [72, 95, 141], 'located': [73], 'close': [74], 'rhodopsin,': [76], 'do': [78], 'not': [79], 'belong': [80], 'either': [82, 117], 'sensor.': [83], 'Here': [84], 'we': [85], 'tested': [86], 'site-directed': [88], 'mutagenesis': [89], 'role': [92], 'these': [94, 143], 'wild': [97], 'type': [98], 'using': [100], 'a': [101, 169], 'direct': [102], 'binding': [103, 120, 127, 147, 153], 'assay': [104], 'P-Rh*': [106], 'unphosphorylated': [109], '(Rh*).': [111], 'We': [112], 'found': [113], 'that': [114, 138], 'many': [115], 'mutations': [116], 'enhanced': [118], 'Rh*': [123, 129, 155], 'increased': [125], 'much': [130], 'more': [131], 'than': [132], 'P-Rh*.': [134, 162], 'The': [135], 'data': [136], 'suggest': [137], 'native': [140], 'positions': [144], 'act': [145], 'as': [146], 'suppressors,': [148], 'specifically': [149], 'inhibiting': [150], 'thereby': [157], 'increasing': [158], 'This': [163], 'calls': [164], 'modification': [167], 'widely': [170], 'accepted': [171], 'model': [172], 'arrestin–receptor': [175], 'interactions.': [176]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4377104832', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}], 'updated_date': '2024-12-23T08:34:36.667965', 'created_date': '2023-05-20'}