Plasmodium parasitophorous vacuole membrane protein Pfs16 promotes malaria transmission by silencing mosquito immunity

Name: Work Video:
Duration: 3 min 30 s
Julian Ramelow; Yacob Keleta; Guodong Niu; Xiaohong Wang; Jun Li
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2169, 2267, 2473, 2620, 2848, 2858, 2879, 3330, 3485, 3553, 3606, 3614, 3743, 3777, 3813, 4012, 4061, 4171], 'significant': [12, 224, 427, 2964, 3322], 'public': [13, 225], 'health': [14, 226], 'burden.': [15, 227], 'The': [16, 228, 536, 602, 1046, 1138, 1321, 1457, 1519, 1766, 1934, 2096, 2110, 2159, 2178, 2203, 2220, 2251, 2334, 2348, 2559, 2583, 2629, 2656, 2680, 2905, 2936, 3244, 3269, 3279, 3948], 'sexual': [17, 57, 229, 269, 649, 667, 914, 1011, 1088, 4162], 'stage': [18, 230, 915, 2325, 4163], 'of': [19, 73, 138, 152, 162, 231, 285, 350, 364, 374, 449, 454, 478, 481, 505, 518, 539, 584, 630, 750, 877, 907, 977, 998, 1027, 1048, 1056, 1083, 1090, 1111, 1127, 1160, 1202, 1252, 1257, 1306, 1371, 1407, 1464, 1483, 1505, 1560, 1595, 1666, 1728, 1771, 1818, 1864, 1920, 1949, 1998, 2023, 2124, 2205, 2279, 2337, 2354, 2447, 2555, 2609, 2638, 2726, 2809, 2818, 2830, 2896, 3048, 3054, 3152, 3155, 3164, 3198, 3365, 3402, 3440, 3547, 3770, 3809, 3951, 3979, 4026, 4059, 4127, 4134, 4173], 'parasite': [22, 234, 527, 578, 608, 612, 618, 640, 666, 811, 824, 847, 858, 1094, 1304, 1444, 1761, 1941, 2126, 3529, 3952], 'infects': [23, 235], 'mosquitoes': [24, 236, 861, 979, 1188, 1225, 1654, 2435, 2575, 2958, 3090, 3228, 3326, 3335, 3549], 'to': [25, 30, 63, 94, 122, 183, 208, 237, 242, 275, 306, 334, 395, 420, 439, 567, 592, 710, 802, 832, 854, 860, 888, 1008, 1038, 1146, 1186, 1191, 1273, 1442, 1479, 1653, 1677, 1704, 1709, 1718, 1733, 1851, 1871, 1883, 1932, 2034, 2071, 2091, 2266, 2362, 2410, 2415, 2434, 2458, 2524, 2528, 2574, 2576, 2591, 2648, 2661, 2685, 2737, 2768, 2772, 2793, 2860, 2917, 2982, 3209, 3226, 3260, 3343, 3382, 3392, 3451, 3462, 3491, 3508, 3583, 3587, 3963, 3990, 4001, 4021, 4150, 4153], 'transmit': [26, 238], 'from': [28, 240, 715, 786, 1363, 1868, 1880, 1929, 2256, 2408, 2413, 2544, 3018, 3176, 3236, 3345, 3494, 3527, 3662, 4137], 'host': [29, 241, 586, 4097], 'host.': [31, 243], 'Hence,': [32, 244], 'an': [33, 37, 84, 245, 249, 296, 580, 1974, 3610], 'infected': [34, 246, 743, 3022, 3088, 3099, 4138], 'mosquito': [35, 141, 163, 172, 185, 247, 353, 375, 384, 397, 741, 808, 826, 845, 920, 1308, 1447, 1499, 1756, 1764, 2286, 2801, 2855, 2934, 2942, 2974, 3058, 3126, 3143, 3156, 3237, 3249, 3348, 3664, 3779, 3955, 3966], 'plays': [36, 248, 2472], 'essential': [38, 250], 'role': [39, 251, 1688, 1997, 2475], 'transmission.': [42, 77, 211, 254, 289, 423, 2582], 'Plasmodium': [43, 255, 489, 492, 494, 496, 498, 501, 782, 882, 916, 1032, 1095, 1130, 1161, 1203, 1258, 1274, 1496, 1671, 2028, 2452, 2497, 2522, 2731, 2766, 3203, 3445, 3581, 3682, 3771, 3938, 3984, 4027, 4062, 4102], 'falciparum': [44, 256, 513, 917, 974, 1113, 1131, 1162, 1204, 1275, 1497, 1651, 2064, 2283, 2432, 2791, 3140, 3147, 3544, 3772, 3939, 4063, 4103], 'is': [45, 204, 257, 416, 485, 524, 604, 1003, 1050, 1105, 1460, 1790, 1937, 1973, 2139, 2225, 2246, 2469, 2540, 3133, 3174, 3405, 3418, 3641, 3708, 3861, 3999, 4158], 'most': [47, 259, 936, 4036], 'dominant': [48, 260], 'and': [49, 115, 261, 327, 444, 456, 462, 500, 508, 523, 609, 651, 655, 757, 760, 779, 797, 825, 852, 913, 939, 1066, 1170, 1212, 1302, 1368, 1375, 1392, 1438, 1532, 1597, 1610, 1633, 1779, 1830, 1876, 1942, 1984, 2083, 2098, 2105, 2128, 2200, 2211, 2234, 2301, 2328, 2394, 2400, 2412, 2505, 2572, 2611, 2643, 2666, 2675, 2783, 2812, 2836, 2872, 2881, 2893, 2954, 2977, 3013, 3077, 3101, 3113, 3231, 3247, 3253, 3299, 3355, 3424, 3516, 3525, 3638, 3658, 3660, 3705, 3807, 3865, 3914, 3941, 4095], 'dangerous': [50, 262], 'pathogen.': [52, 264], 'Previous': [53, 265, 1644], 'studies': [54, 266, 1645, 3498, 3837], 'identified': [55, 81, 267, 293, 851, 2425, 3872], 'stage-specific': [58, 270, 1012], 'protein': [59, 88, 271, 300, 1013, 1166, 1208, 1344, 1361, 1566, 1822, 1843, 1889, 1907, 1936, 1977, 2116, 2147, 2253, 2295, 2595, 2785, 2814, 2880, 3378, 4038], '16': [60, 272, 1014], '(Pfs16)': [61, 273, 1015, 1167, 1209], 'localized': [62, 274, 4000], 'parasitophorous': [65, 98, 277, 310, 595, 627, 1163, 1205, 1982, 4023], 'vacuole': [66, 99, 278, 311, 596, 1164, 1206, 1983, 4024, 4090], 'membrane.': [67, 100, 279, 312], 'Here,': [68, 280], 'we': [69, 281, 1741, 2002, 2045, 2305, 2387, 2551, 2795, 2805, 3001, 3470], 'elucidate': [70, 282], 'function': [72, 284, 2748], 'Pfs16': [74, 82, 108, 133, 158, 180, 203, 286, 294, 320, 345, 370, 392, 415, 1049, 1139, 1182, 1696, 1744, 1781, 1789, 1862, 1923, 1935, 1972, 2000, 2011, 2049, 2115, 2138, 2146, 2160, 2280, 2429, 2471, 2565, 2711, 2746, 2798, 2989, 3148, 3160, 3182, 3460, 3960, 3998, 4037], 'during': [75, 287, 617, 781, 827, 1168, 1210, 1410, 1776], 'Our': [78, 290], 'structural': [79, 291], 'analysis': [80, 155, 292, 367, 1159, 1201], 'as': [83, 295, 830, 935, 947, 1009, 1389, 1540, 1782, 2345, 2476, 2847, 2857, 2878, 3286, 3522, 3609, 4170], 'alpha-helical': [85, 297], 'integral': [86, 298], 'membrane': [87, 299, 588, 597, 629, 777, 1165, 1207, 1976, 2094, 2099, 2122, 2141, 2299, 4025, 4042], 'with': [89, 111, 197, 301, 323, 409, 982, 1524, 1845, 1946, 1978, 2068, 2089, 2215, 2248, 2314, 2374, 2568, 2932, 3009, 3071, 3129, 3135, 3170, 3184, 3221, 3229, 3267, 3282, 3353, 3357, 3367, 3420, 3552, 3965, 4004, 4011], 'one': [90, 302, 1331, 1926, 2375], 'transmembrane': [91, 303, 1842, 1878], 'domain': [92, 304, 1879], 'connecting': [93, 305], 'two': [95, 307, 2372, 4005], 'regions': [96, 308, 4006], 'across': [97, 309, 4007], 'ELISA': [101, 313, 3262, 3289, 3422], 'assays': [102, 127, 314, 339, 2332, 2547, 3290], 'showed': [103, 315, 1143, 1646, 2112, 2222, 2350, 2601, 2786, 3060, 3291, 3374], 'that': [104, 118, 129, 157, 179, 316, 330, 341, 369, 391, 1743, 1861, 1924, 2113, 2137, 2172, 2197, 2223, 2351, 2396, 2426, 2470, 2602, 2708, 2797, 2985, 3003, 3029, 3061, 3117, 3138, 3180, 3292, 3340, 3375, 3409, 4160], 'insect': [105, 317], 'cell-expressed': [106, 318], 'recombinant': [107, 319, 2145, 2170], '(rPfs16)': [109, 321, 2148], 'interacted': [110, 322], 'Anopheles': [112, 324, 909, 1224, 1253, 1309, 1364, 1465, 2827, 3843], 'gambiae': [113, 325, 910, 1254, 1466, 2828, 2997, 3106, 3388], 'midguts,': [114, 326, 2975, 3107, 3127], 'microscopy': [116, 328], 'found': [117, 329, 1742, 2395, 4039], 'rPfs16': [119, 148, 331, 360, 2174, 2206, 2224, 2252, 2294, 2545, 2784, 2813, 3004, 3062, 3271, 3295, 3341, 3354, 3366, 3377], 'was': [120, 332, 2087, 2117, 2161, 2213, 2254, 2343, 2659, 2845, 2962, 2987, 3045, 3272, 3304, 3320, 3369, 3961], 'bound': [121, 333, 3294, 3381, 3461], 'midgut': [123, 164, 199, 335, 376, 411, 828, 911, 985, 1507, 1713, 1720, 2357, 2494, 2627, 3165, 3301, 3317, 3349, 3389, 3555, 3679, 3780], 'epithelial': [124, 200, 336, 412, 3171, 3403, 3466], 'cells.': [125, 201, 337, 413, 2158, 2177, 3172], 'Transmission-blocking': [126, 338], 'demonstrated': [128, 340], 'polyclonal': [130, 342, 2006, 2055, 2562, 2587, 3276], 'antibodies': [131, 343, 1647, 2007, 2427, 2563, 2588, 2604, 2709, 2782, 2811, 3775], 'against': [132, 344, 1648, 2008, 2428, 2564, 2710, 3776], 'significantly': [134, 346, 2358, 2406, 2605, 2652, 2683, 3063, 3082, 3121, 3305, 3406], 'reduced': [135, 159, 347, 371, 3005, 3064], 'number': [137, 151, 349, 363, 2336, 2353, 2608], 'oocysts': [139, 351, 1762, 2355, 2610], 'midguts.': [142, 354, 1765, 2935], 'However,': [143, 355, 1685], 'on': [144, 356, 1108, 2271, 2281, 2580, 2789, 2815, 3505, 4131], 'contrary,': [146, 358], 'feeding': [147, 359, 2289, 2546], 'increased': [149, 361, 435, 2359, 2407, 2928, 3083, 3122], 'oocysts.': [153, 365], 'Further': [154, 366], 'revealed': [156, 368, 3116], 'activity': [161, 373, 3040, 3151], 'caspase': [165, 377, 1475, 2819, 2863, 2897, 2929, 2937, 2968, 3006, 3039, 3065, 3084, 3123, 3162], '3/7,': [166, 378, 2820], 'key': [168, 380, 1462, 1537, 2821, 3519], 'enzyme': [169, 381], 'Jun-N-terminal': [173, 385, 1322], 'kinase': [174, 386, 1323, 1544], 'immune': [175, 387, 932, 1235, 1412, 1526, 1530, 1571, 1757, 3157, 4182], 'pathway.': [176, 388], 'We': [177, 389, 2143, 2275, 2366, 2618, 2850, 3217, 3223], 'conclude': [178, 390], 'facilitates': [181, 393], 'parasites': [182, 394, 865, 1065, 1142, 1184, 1193, 1711, 2507, 3493, 4136, 4147, 4164], 'invade': [184, 396], 'midguts': [186, 398, 809, 1448, 2287, 2829, 2856, 2886, 2900, 2943, 2998, 3044, 3059, 3238, 3250, 3956, 3967], 'by': [187, 399, 436, 542, 606, 611, 980, 1172, 1214, 1232, 1342, 1395, 1501, 1535, 1562, 1748, 1939, 2057, 2103, 2107, 2185, 2192, 2218, 2288, 2698, 3108, 3265, 3274, 3550, 3646, 3713, 3774, 3858], 'actively': [188, 400], 'silencing': [189, 401], "mosquito's": [191, 403, 1730], 'innate': [192, 404, 1234, 1411, 1731, 2802], 'immunity': [193, 405, 976, 1251, 1500, 1732, 3546], 'through': [194, 406, 614], 'its': [195, 407, 1686, 1699, 2297, 4093], 'interaction': [196, 408, 880, 918, 941, 1030, 1669, 1708, 2026, 2450, 2729, 3201, 3220, 3443, 3982], 'Therefore,': [202, 414, 474, 2745, 2804], 'potential': [206, 418, 1692], 'target': [207, 419], 'control': [209, 421, 2364, 2687, 3309, 3395], 'Malaria': [424, 679, 3483], 'global': [428, 3888], 'disease.': [429, 511, 3487], 'In': [430, 841, 1738, 2061, 2385, 2993], '2021,': [431], 'case': [433], 'rates': [434], '6%': [437], 'compared': [438, 1190, 2361, 2684, 2931, 3008, 3070, 3128, 3391], '2020': [441], 'report': [442, 2424, 2707, 3179, 4014], '(https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2021),': [443], 'Africa': [445, 522], 'epicenter': [448], 'occurrence,': [451], 'reporting': [452], '94%': [453], 'deaths.': [457], 'About': [458], '241': [459], 'million': [460], '627,000': [463], 'deaths': [464], 'were': [465, 2066, 2101, 2180, 2190, 2548, 2566, 2589, 2646, 2876, 2887, 2901, 2909, 2944, 3251, 3258, 3284, 3351], 'officially': [466], 'reported;': [467], 'undocumented': [469], 'numbers': [470], 'are': [471, 503, 1477, 4148], 'presumably': [472], 'higher.': [473], 'better': [476], 'understanding': [477], 'pathogenesis': [480], 'this': [482, 1739, 2054, 3219, 3337], 'devastating': [483], 'disease': [484], 'still': [486], 'needed.': [487], 'Several': [488, 1691], 'species,': [490], 'including': [491, 753, 1528], 'falciparum,': [493], 'vivax,': [495], 'malaria,': [497], 'ovale,': [499], 'knowlesi,': [502], 'capable': [504], 'infecting': [506, 3495], 'humans': [507], 'causing': [509], 'P.': [512, 1112, 1650, 2063, 2282, 2317, 2431, 2569, 2790, 2833, 3118, 3139, 3146], 'accounts': [514], 'approximately': [516], '99.7%': [517], 'deadliest': [526], '(1Cowman': [528], 'A.F.': [529], 'Tonkin': [530], 'C.J.': [531], 'Tham': [532], 'W.H.': [533], 'Duraisingh': [534], 'M.T.': [535, 3628, 3695], 'molecular': [537, 3949], 'basis': [538], 'erythrocyte': [540, 1988, 4098], 'invasion': [541, 829, 1055, 3141, 3953], 'parasites.Cell': [544], 'Host': [545], 'Microbe.': [546], '2017;': [547, 1434, 4111], '22:': [548, 1914, 3753], '232-245Google': [549], 'Scholar,': [550, 691, 728, 895, 959, 1263, 1283, 1420, 1579, 3566, 3594, 3622, 3689, 3724, 3755, 3791, 3821, 3896, 3919, 4114], '2Alonso': [551], 'P.L.': [552], 'Brown': [553], 'G.': [554, 867, 899, 1017, 1269, 1454, 1656, 1838, 2013, 2437, 2481, 2483, 2509, 2511, 2716, 2753, 2755, 3188, 3430, 3568, 3570, 3666, 3668, 3827, 3831, 3874, 3884, 3898, 3921, 3929, 3969, 4082], 'Arevalo-Herrera': [555], 'M.': [556, 764, 1241, 1357, 1400, 1587], 'Binka': [557], 'F.': [558, 562, 1799, 4080], 'Chitnis': [559], 'C.': [560, 770, 945, 1239, 1291, 1456, 1495, 3604, 3634, 3701, 4085], 'Collins': [561], 'et': [563, 704, 775, 972, 1296, 1358, 1558, 1592, 1628, 1811, 2492, 2520, 2764, 3542, 3579, 3635, 3677, 3702, 3737, 3768, 3805, 3885, 3932, 4088], 'al.A': [564, 3886, 3933], 'research': [565], 'agenda': [566], 'underpin': [568], 'eradication.PLoS': [570], 'Med.': [571, 687, 955], '2011;': [572, 1380, 4030], '8e1000406Google': [573], 'Scholar).': [574, 637, 738, 795, 840, 996, 1045, 1102, 1137, 1181, 1223, 1320, 1472, 1518, 1607, 1643, 1684, 1967, 2041, 2535, 2744, 2779, 3216, 3854, 3947, 3997, 4033, 4144], 'When': [575, 3312], 'invades': [579], 'erythrocyte,': [581], 'portion': [583], 'cell': [587, 1060, 1393, 1431, 1962, 2194, 3467], 'will': [589], 'be': [590, 685, 855, 2662, 4151, 4154], 'invaginated': [591], 'form': [593, 800], '(PVM)': [598], 'around': [599], 'parasite.': [601], 'PVM': [603, 756, 761, 1110, 1892, 1945, 2303, 4003], 'modified': [605], 'integrated': [610, 1943, 1975], 'proteins': [613, 848, 883, 912, 1033, 1672, 2029, 2100, 2453, 2732, 3204, 3446, 3985], 'secretory': [615], 'organelles': [616], 'development': [619, 641, 684, 1256, 3507, 3773], '(3Goldberg': [620], 'D.E.': [621, 3759], 'Zimmerberg': [622, 4123], 'J.': [623, 724, 816, 820, 875, 905, 953, 1025, 1073, 1122, 1625, 1664, 1910, 2021, 2445, 2517, 2724, 2761, 3196, 3438, 3576, 3632, 3653, 3699, 3720, 3823, 3906, 3977, 4054, 4118, 4124], 'Hardly': [624], 'vacuous:': [625], 'vacuolar': [628], 'parasites.Trends': [632], 'Parasitol.': [633, 1098, 1177, 1219], '2020;': [634, 927, 993, 3563, 3654, 3721, 3894, 3916], '36:': [635], '138-146Google': [636], 'During': [638], 'at': [642, 1333, 1958, 2182, 2231, 2597, 3464, 3648, 3715], 'intraerythrocytic': [644], 'stage,': [645], 'some': [646, 1440, 3518], 'trophozoites': [647], 'experience': [648], 'differentiation': [650, 1089], 'develop': [652], 'into': [653, 1944, 2163, 4072], 'male': [654, 798], 'female': [656], 'gametocytes,': [657], 'which': [658, 2167, 2245, 2478, 3034, 3132, 3475, 4070], 'can': [659, 682, 1226, 1697], 'infect': [660, 803, 1187], 'anopheline': [661, 978, 1278, 3548], 'mosquitoes,': [662, 2794, 2926], 'definitive': [663], 'hosts': [664], 'reproduction': [668], '(4Carter': [669], 'R.': [670, 697, 730, 1583], 'Mendis': [671], 'K.N.': [672], 'Miller': [673], 'L.H.': [674], 'Molineaux': [675], 'L.': [676, 818, 971, 1351, 3541, 3596], 'Saul': [677], 'A.': [678, 943, 961, 992, 1316, 1355, 1491, 1514, 1833, 2996, 3105, 3387, 3531, 3562, 3602, 3630, 3697, 3767, 3787, 3850, 4110], 'transmission-blocking': [680, 707, 950, 1787, 3514, 3617, 3746], 'vaccines--how': [681], 'their': [683], 'supported?.Nat.': [686], '2000;': [688], '6:': [689, 838], '241-244Google': [690], '5McCoy': [692], 'K.D.': [693, 1810], 'Weldon': [694], 'C.T.': [695], 'Ansumana': [696], 'Lamin': [698], 'J.M.': [699, 1547, 3904, 4078], 'Stenger': [700], 'D.A.': [701, 1116, 4048], 'Ryan': [702], 'S.J.': [703, 1557], 'al.Are': [705], 'vaccines': [708, 3490], 'acceptable': [709], 'high': [711, 2401], 'burden': [712], 'communities?': [713], 'Results': [714, 2600, 3027, 3373], 'mixed': [717, 2306, 2567], 'methods': [718], 'study': [719], 'Bo,': [721], 'Sierra': [722], 'Leone.Malar.': [723], '2021;': [725, 837, 893, 1043, 1682, 1913, 1965, 2039, 2463, 2742, 3214, 3456, 3819, 3944, 3995], '20:': [726], '183Google': [727], '6Carter': [729], 'Transmission': [731], 'blocking': [732], 'vaccines.Vaccine.': [734], '2001;': [735, 1856], '19:': [736, 3655, 3722], '2309-2314Google': [737], 'After': [739, 2076, 4034], 'takes': [742], 'blood,': [744, 3020, 3131], 'gametocyte': [745, 784, 1132, 4064], 'egress': [746, 785], 'comprises': [747], 'set': [749], 'sequential': [751], 'events': [752], 'rapturing': [754], 'releasing': [758], 'gametes': [759, 799], 'pieces': [762], '(7Andreadaki': [763], 'Hanssen': [765], 'E.': [766, 768, 1589, 4122], 'Deligianni': [767], 'Claudet': [769], 'Wengelnik': [771], 'K.': [772, 3800], 'Mollard': [773], 'V.': [774], 'al.Sequential': [776], 'rupture': [778, 4094], 'vesiculation': [780], 'berghei': [783], 'red': [788, 1058], 'blood': [789, 1059, 2319, 2571, 3023, 3120, 3230, 3234, 3242], 'cell.Sci.': [790], 'Rep.': [791, 926, 3619], '2018;': [792], '8:': [793, 1435], '3543Google': [794], 'Female': [796], 'ookinetes': [801], 'mosquitoes.': [804, 2838, 3080, 3096], 'Many': [805], 'factors': [806, 1632], 'inside': [807, 1981, 3385, 3954], 'affect': [810], 'transmission': [812, 859, 887, 1037, 1652, 1676, 1703, 1747, 1778, 2033, 2433, 2457, 2527, 2714, 2736, 2771, 2792, 3208, 3450, 3586, 3857, 3940, 3989], '(8Keleta': [813], 'Y.': [814, 869, 873, 897, 1019, 1023, 1267, 1627, 1658, 1662, 2015, 2019, 2439, 2443, 2487, 2718, 2722, 3190, 3194, 3432, 3436, 3672, 3900, 3925, 3971, 3975], 'Ramelow': [815, 2516, 2760, 3575], 'Cui': [817, 868, 1018, 1657, 2014, 2438, 2717, 3189, 3431, 3970], 'Li': [819, 874, 900, 904, 1024, 1292, 1663, 2020, 2444, 2723, 3195, 3437, 3879, 3905, 3976], 'Molecular': [821], 'interactions': [822], 'between': [823], 'targets': [831, 3520], 'block': [833, 2525, 2769, 3509, 3584], 'transmission.NPJ': [835], 'Vaccines.': [836], '140Google': [839], 'particular,': [842], 'several': [843, 1000, 1228, 3866], 'interactive': [844, 3473], 'or': [846, 930, 1725, 4176], 'have': [849, 3329, 3870], 'been': [850, 3871], 'linked': [853], 'crucial': [856], 'either': [863], 'anchoring': [864, 2751], '(9Niu': [866, 1016, 1655, 2012, 2436, 2715, 3187, 3429, 3968], 'Wang': [870, 902, 1020, 1348, 1659, 2016, 2440, 2488, 2518, 2719, 2762, 3191, 3433, 3577, 3673, 3824, 3877, 3901, 3922, 3972], 'X.': [871, 903, 1021, 1660, 2017, 2441, 2489, 2519, 2720, 2763, 3192, 3434, 3578, 3674, 3825, 3878, 3902, 3923, 3973], 'Keleta': [872, 1022, 1661, 2018, 2442, 2721, 3193, 3435, 3974], 'Studies': [876, 1026, 1665, 2022, 2446, 2725, 3197, 3439, 3978], 'parasite-midgut': [879, 1029, 1668, 2025, 2449, 2728, 3200, 3442, 3981], 'reveal': [881, 1031, 1670, 2027, 2451, 2730, 3202, 3444, 3983], 'important': [884, 922, 1034, 1673, 2030, 2454, 2733, 3205, 3447, 3986], 'mosquitoes.Front.': [889, 1039, 1678, 2035, 2459, 2529, 2738, 2773, 3210, 3452, 3588, 3991], 'Cell.': [890, 1040, 1416, 1679, 2036, 2460, 2530, 2739, 2774, 3211, 3453, 3589, 3992, 4029], 'Infect.': [891, 1041, 1680, 2037, 2461, 2531, 2740, 2775, 3212, 3454, 3590, 3993], 'Microbiol.': [892, 1042, 1681, 2038, 2462, 2532, 2741, 2776, 3213, 3455, 3591, 3994, 4140], '11654216Google': [894, 1044, 1683, 2040, 2464, 2743, 3215, 3457, 3996], '10Cui': [896], 'Niu': [898, 2482, 2510, 2754, 3569, 3667, 3883, 3928], 'V.L.': [901, 4076], 'Analysis': [906], 'blood-induced': [908], 'reveals': [919, 3742], 'genes': [921, 3841], 'transmission.Sci.': [925], '1014316Google': [928], 'Scholar)': [929, 1437, 1829, 1859, 1916, 2504, 3657], 'inducing': [931], 'evasions': [933], 'such': [934, 1388, 1539, 3521], 'recent': [937], 'Pfs47': [938, 946, 984, 3554], 'Pfs47Rec': [940], '(11Molina-Cruz': [942], 'Barillas-Mury': [944, 1455, 1494, 3603], 'vaccine': [951, 3506, 3747], 'target.Am.': [952], 'Trop.': [954], 'Hyg.': [956], '2022;': [957, 1826], 'https://doi.org/10.4269/ajtmh.21-1325Google': [958], '12Molina-Cruz': [960], 'Canepa': [962, 1492, 3532, 3599], 'G.E.': [963, 1493, 3533, 3600], 'Alves': [964, 3534], 'E.S.T.L.': [965, 3535], 'Williams': [966, 1554, 3536, 3597], 'A.E.': [967, 3537, 3598], 'Nagyal': [968, 3538], 'S.': [969, 991, 1243, 1285, 1315, 1513, 1621, 2515, 2759, 3539, 3561, 3574, 3786, 3849, 3880, 3882, 3927, 4016, 4109, 4116], 'Yenkoidiok-Douti': [970, 3540], 'al.Plasmodium': [973, 3543], 'evades': [975, 1498, 3545], 'interacting': [981, 3551], 'receptor.Proc.': [986, 3556], 'Natl.': [987, 1311, 1509, 3557, 3782, 3845, 4105], 'Acad.': [988, 1312, 1510, 3558, 3783, 3846, 4106], 'Sci.': [989, 1313, 1511, 1912, 3559, 3784, 3847, 4107], 'U.': [990, 1314, 1512, 3560, 3785, 3848, 4108], '117:': [994, 3564], '2597-2605Google': [995, 3565], 'One': [997], 'emerging': [1001], 'molecules': [1002, 3344, 3463, 3860], 'PF3D7_0406200,': [1005], 'commonly': [1006], 'referred': [1007], 'expression': [1047, 1082, 2152], 'induced': [1051], 'immediately': [1052], 'following': [1053], 'sexually': [1062], 'committed': [1063], 'ring-stage': [1064], 'continues': [1067], 'throughout': [1068], 'gametocytogenesis': [1069, 1169, 1211], '(13Dechering': [1070], 'K.J.': [1071], 'Thompson': [1072], 'Dodemont': [1074], 'H.J.': [1075], 'Eling': [1076], 'W.': [1077], 'Konings': [1078], 'R.N.': [1079], 'Developmentally': [1080], 'regulated': [1081], 'pfs16,': [1084], 'marker': [1086], 'human': [1092], 'falciparum.Mol.': [1096], 'Biochem.': [1097, 1176, 1218], '1997;': [1099], '89:': [1100], '235-244Google': [1101], 'Notably,': [1103], 'it': [1104, 3167, 4157], 'located': [1106], 'primarily': [1107], 'gametocytes': [1114, 1150, 2065, 2327], '(14Baker': [1115, 4047], 'Daramola': [1117, 4049], 'O.': [1118, 3765, 4050], 'McCrossan': [1119, 4051], 'M.V.': [1120, 4052], 'Harmer': [1121, 4053], 'Targett': [1123, 4055], 'G.A.': [1124, 4056], 'Subcellular': [1125, 4057], 'localization': [1126, 4058], 'Pfs16,': [1128, 3037, 4060], 'antigen.Parasitology.': [1133, 4065], '1994;': [1134, 4066], '108:': [1135, 4067], '129-137Google': [1136, 4068], 'gene': [1140, 1174, 1216], 'knockout': [1141], '4-': [1145], '5-fold': [1147], 'reduction': [1148], 'generated': [1151, 2004, 2168], '(15Kongkasuriyachai': [1152, 1194], 'D.': [1153, 1195, 1555, 1591, 2513, 2757, 3572, 3734], 'Fujioka': [1154, 1196], 'H.': [1155, 1197, 1402, 1549, 1553, 3794], 'Kumar': [1156, 1198], 'N.': [1157, 1199, 1404, 1581, 3736], 'Functional': [1158, 1200], 'gametogenesis': [1171, 1213], 'targeted': [1173, 1215], 'disruption.Mol.': [1175, 1217], '2004;': [1178, 1220, 1576], '133:': [1179, 1221], '275-285Google': [1180, 1222], 'KO': [1183], 'failed': [1185], 'when': [1189, 2360, 3390], 'WT': [1192], 'deploy': [1227], 'effective': [1229, 4155], 'antiplasmodial': [1230, 1467], 'responses': [1231, 1413], 'activating': [1233, 1396], 'signaling': [1236, 1298, 1408], 'cascades': [1237], '(16Frolet': [1238], 'Thoma': [1240], 'Blandin': [1242], 'Hoffmann': [1244], 'J.A.': [1245, 1623, 4087], 'Levashina': [1246], 'E.A.': [1247], 'Boosting': [1248], 'NF-kappaB-dependent': [1249], 'basal': [1250], 'aborts': [1255], 'berghei.Immunity.': [1259], '2006;': [1260], '25:': [1261, 3917], '677-685Google': [1262], '17Garver': [1264], 'L.S.': [1265, 1450, 1489, 1617], 'Dong': [1266, 1626, 2486, 3671], 'Dimopoulos': [1268], 'Caspar': [1270], 'controls': [1271], 'resistance': [1272, 3840], 'diverse': [1277, 3887], 'species.PLoS': [1279], 'Pathog.': [1280, 1469, 1640, 1964], '2009;': [1281, 4141], '5e1000335Google': [1282], '18Meister': [1284], 'Kanzok': [1286, 3760], 'S.M.': [1287, 3761], 'Zheng': [1288], 'X.L.': [1289], 'Luna': [1290], 'T.R.': [1293], 'Hoa': [1294], 'N.T.': [1295], 'al.Immune': [1297, 1593], 'pathways': [1299, 1409, 1485, 1527, 1534, 1612], 'regulating': [1300, 1750], 'bacterial': [1301], 'infection': [1305, 1445, 1636, 2284, 2378, 2392, 2402, 2612, 2657, 3913], 'gambiae.Proc.': [1310, 3844], '2005;': [1317, 1337], '102:': [1318], '11420-11425Google': [1319], '(JNK)': [1324], 'pathway': [1325, 1459, 1521, 1631], '(19Stronach': [1326], 'B.': [1327, 1349, 1835, 1898, 1900, 3626, 3693], 'Dissecting': [1328], 'JNK': [1329, 1374, 1458, 1484, 1520, 1598, 1752, 2824], 'signaling,': [1330], 'KKKinase': [1332], 'time.Dev.': [1335], 'Dyn.': [1336], '232:': [1338], '575-584Google': [1339], 'Scholar),': [1340, 1383, 2465, 3458, 4069], 'mediated': [1341], 'mitogen-activated': [1343, 1360], 'kinases': [1345], '(20Horton': [1346], 'A.A.': [1347, 3833], 'Camp': [1350], 'Price': [1352], 'M.S.': [1353], 'Arshi': [1354], 'Nagy': [1356], 'al.The': [1359, 3738], 'kinome': [1362], 'gambiae:': [1365], 'identification,': [1366], 'phylogeny': [1367], 'functional': [1369, 1996], 'characterization': [1370], 'ERK,': [1373], 'p38': [1376], 'MAP': [1377], 'kinases.BMC': [1378], 'Genomics.': [1379], '12:': [1381], '574Google': [1382], 'involves': [1384], 'various': [1385], 'biological': [1386], 'processes': [1387], 'apoptosis,': [1390], 'immunity,': [1391], 'proliferation': [1394], 'specific': [1397, 1687], 'caspases': [1398], '(21Boutros': [1399], 'Agaisse': [1401], 'Perrimon': [1403], 'Sequential': [1405], 'activation': [1406, 1482, 1594, 1758], 'Drosophila.Dev.': [1415], '2002;': [1417], '3:': [1418], '711-722Google': [1419], '22Dhanasekaran': [1421], 'D.N.': [1422], 'Reddy': [1423], 'E.P.': [1424], 'JNK-signaling:': [1425], 'multiplexing': [1427], 'hub': [1428], 'programmed': [1430], 'death.Genes': [1432], 'Cancer.': [1433], '682-694Google': [1436], 'generates': [1439], 'effectors': [1441, 1634], 'inhibit': [1443, 2800], '(23Garver': [1449], 'de': [1451], 'Almeida': [1452], 'Oliveira': [1453], 'mediator': [1463], 'immunity.PLoS': [1468], '2013;': [1470, 3851], '9e1003622Google': [1471], 'Indeed,': [1473], 'activities': [1476, 2817, 2895, 2930, 2939, 2970, 3007, 3066, 3085, 3124, 3163], 'used': [1478, 2344, 2846, 2851, 2877, 3259, 3285], 'monitor': [1480], '(24Ramphul': [1486], 'U.N.': [1487], 'Garver': [1488], 'Molina-Cruz': [1490, 3601], 'disrupting': [1502], 'JNK-mediated': [1503, 1570], 'apoptosis': [1504], 'invaded': [1506], 'cells.Proc.': [1508], '2015;': [1515, 2501, 3686, 3752], '112:': [1516], '1273-1280Google': [1517], 'also': [1522, 3115, 3477, 3503, 3862], 'interplays': [1523], 'other': [1525, 2382], 'deficiency': [1531, 1609], 'Toll': [1533, 1611], 'sharing': [1536], 'proteins,': [1538], 'transforming': [1541], 'growth': [1542], 'factor-β-activated': [1543], '1': [1545, 1870, 2308, 2322], '(25Park': [1546], 'Brady': [1548], 'Ruocco': [1550], 'M.G.': [1551], 'Sun': [1552], 'Lee': [1556], 'al.Targeting': [1559, 2521, 2765, 3580], 'TAK1': [1561], 'NF-kappa': [1564], 'B': [1565, 3910], 'Relish': [1567], 'regulates': [1568], 'response': [1572, 1753], 'Drosophila.Genes': [1574], 'Dev.': [1575], '18:': [1577], '584-594Google': [1578], '26Silverman': [1580], 'Zhou': [1582], 'Erlich': [1584], 'R.L.': [1585], 'Hunter': [1586], 'Bernstein': [1588], 'Schneider': [1590], 'NF-kappaB': [1596], 'requires': [1599], 'Drosophila': [1600], 'TAK1.J.': [1601], 'Biol.': [1602, 1855, 2499, 3684, 3751], 'Chem.': [1603, 2500, 3685], '2003;': [1604], '278:': [1605], '48928-48934Google': [1606], 'Immune': [1608], 'mediate': [1613], 'ookinete': [1614], 'lysis': [1615, 2195], '(27Garver': [1616], 'Bahia': [1618], 'A.C.': [1619], 'Das': [1620], 'Souza-Neto': [1622], 'Shiao': [1624], 'al.Anopheles': [1629, 2493, 3678], 'Imd': [1630], 'intensity-dependent': [1637], 'anti-Plasmodium': [1638], 'action.PLoS': [1639], '2012;': [1641], '8e1002737Google': [1642], 'Pfs16-inhibited': [1649], 'unknown.': [1690], 'mechanisms': [1693, 1770, 1957, 3950], 'exist': [1694, 3478], 'where': [1695], 'exhibit': [1698], 'effects': [1700, 2554, 2579, 2788, 2808], 'mosquitoes:': [1705], '(1)': [1706], 'direct': [1707, 1724], 'position': [1710], 'invasion,': [1714], '(2)': [1715], 'enzymatic': [1716], 'digestion': [1717], 'disrupt': [1719], 'physical': [1721], 'barriers,': [1722], '(3)': [1723], 'indirect': [1726, 3361], 'inhibition': [1727], 'promote': [1734], 'transmission,': [1735, 3511], 'among': [1736, 2971], 'others.': [1737], 'work,': [1740], 'facilitated': [1745], 'negatively': [1749], 'pathway,': [1759, 2825], 'increasing': [1760], 'findings': [1767], 'provide': [1768], 'insightful': [1769], 'newly': [1772], 'discovered': [1773, 3517], 'parasite-mosquito': [1774], 'interplay': [1775], 'present': [1780], 'prime': [1784], 'candidate': [1785], 'development.': [1788], '157': [1791], 'amino': [1792], 'acid': [1793], 'residues': [1794], 'length.': [1796], 'SignalP': [1797], '(28Teufel': [1798], 'Almagro': [1800], 'Armenteros': [1801], 'J.J.': [1802], 'Johansen': [1803], 'A.R.': [1804], 'Gislason': [1805], 'M.H.': [1806], 'Pihl': [1807], 'S.I.': [1808], 'Tsirigos': [1809], 'al.SignalP': [1812], '6.0': [1813], 'predicts': [1814], 'all': [1815, 3049, 3055], 'five': [1816], 'types': [1817], 'signal': [1819, 1866], 'peptides': [1820], 'using': [1821, 2053, 2149, 2262, 2903, 3360], 'language': [1823], 'models.Nat.': [1824], 'Biotechnol.': [1825], '40:': [1827], '1023-1025Google': [1828], 'TMHMM': [1831], '(29Krogh': [1832], 'Larsson': [1834], 'von': [1836], 'Heijne': [1837], 'Sonnhammer': [1839], 'E.L.': [1840], 'Predicting': [1841], 'topology': [1844], 'hidden': [1847], 'Markov': [1848], 'model:': [1849], 'application': [1850], 'complete': [1852], 'genomes.J.': [1853], 'Mol.': [1854, 1911, 3750], '305:': [1857], '567-580Google': [1858], 'predicted': [1860, 1917], 'consists': [1863], 'peptide': [1867], 'residue': [1869, 1881, 1930], '25': [1872], 'protein-membrane': [1874], 'trafficking': [1875], '105': [1882, 2310, 2324], '125': [1884], '(89–100': [1885], 'mature': [1888, 1922, 1971], 'form)': [1890], 'integration.': [1893], 'AlphaFold2': [1894], '(30Pakhrin': [1895], 'S.C.': [1896, 3726, 3804], 'Shrestha': [1897], 'Adhikari': [1899], 'Kc': [1901], 'D.B.': [1902], 'Deep': [1903], 'learning-based': [1904], 'advances': [1905], 'structure': [1908, 1919, 3741], 'prediction.Int.': [1909], '5553Google': [1915], 'contains': [1925, 2198], 'long': [1927], 'α-helix': [1928], '54': [1931], '100.': [1933], 'synthesized': [1938], 'help': [1948], 'translocon': [1950], 'machinery': [1951], '(31Beck': [1952], 'J.R.': [1953], 'Ho': [1954], 'C.M.': [1955, 2485, 3670], 'Transport': [1956], 'parasite-host': [1961], 'interface.PLoS': [1963], '17e1009394Google': [1966], 'Taking': [1968], 'together,': [1969], 'N-terminal': [1980], 'C-terminal': [1986], 'cytoplasm,': [1989], 'respectively': [1990, 2417], '(Fig.': [1991, 2134, 2165, 2237, 2273, 2383, 2616, 2959, 2999, 3050, 3310, 3396, 3414], '1A).': [1992], 'To': [1993, 2291], 'investigate': [1994, 2861], 'protein,': [2001, 2082, 2868], 'previously': [2003], 'rabbit': [2005, 2561, 2585, 2874, 3275], 'Escherichia': [2009], 'coli–expressed': [2010], 'Using': [2042], 'antibodies,': [2044], 'determined': [2046], 'endogenous': [2048, 2114, 2249, 3025, 3036], 'cellular': [2051], 'fraction': [2052, 2123, 2133], 'antibody': [2056, 2578, 2882, 2956, 3359], 'Western': [2058, 2108], 'blotting': [2059], 'assays.': [2060, 2558], 'brief,': [2062], 'lysed': [2067], 'Tris': [2069], 'buffer': [2070, 2196], 'obtain': [2072], 'soluble': [2074, 2081, 2097, 2132], 'fraction.': [2075], 'centrifugation,': [2077], 'supernatant': [2079], 'contained': [2080, 3024], 'insoluble': [2085], 'pellet': [2086], 'extracted': [2088, 2191], 'Tris–Triton': [2090], 'extract': [2092], 'proteins.': [2095], 'separated': [2102], 'SDS-PAGE': [2104, 2272], 'analyzed': [2106], 'blotting.': [2109], 'result': [2111, 3338, 3417, 3423], 'detected': [2118, 3273, 3356], 'only': [2119], 'lysate': [2127], 'not': [2129, 2240, 3092, 3328, 3644, 3711], '1B),': [2135], 'confirming': [2136], 'protein.': [2142], 'expressed': [2144, 2173, 2227], 'baculovirus': [2151, 2171], 'system': [2153], 'High': [2155], 'Five': [2156], '(Hi5)': [2157], 'cloned': [2162], 'pFastBac': [2164], '2A),': [2166], 'Hi5': [2176, 2229, 2312, 2338], 'cells': [2179, 2189, 2212, 2230, 2258, 2313, 2339, 3404], 'harvested': [2181], 'different': [2183, 3175], 'times': [2184], 'centrifugation.': [2186], 'Proteins': [2187], 'native': [2193, 2298], 'detergent': [2199], 'protease': [2201, 4129], 'inhibitors.': [2202], 'amount': [2204], 'culture': [2209, 2243], 'medium': [2210], 'quantified': [2214], 'anti-His': [2216], 'mAb': [2217], 'ELISA.': [2219, 3222], 'results': [2221, 2349, 2370, 2543, 2703], 'highly': [2226], '72': [2232], 'h': [2233, 2236, 2890, 2916, 3240], '96': [2235], '2B)': [2238], 'but': [2239, 3091, 3643, 3710], 'medium,': [2244], 'consistent': [2247, 2981, 3134, 3419, 4010], 'Pfs16.': [2250, 3026], 'isolated': [2255, 3245], 'via': [2259], 'FPLC': [2260], 'chromatography': [2261], 'HisTrap': [2263], 'affinity': [2264], 'column': [2265], 'single': [2268], 'major': [2269], 'band': [2270], '2C).': [2274], 'examined': [2276, 2388, 2806], 'effect': [2278, 4126], 'rPfs16.': [2290, 3268], 'keep': [2292, 2592], 'forms': [2300], 'mimic': [2302], 'whorls,': [2304], 'about': [2307, 2321], '×': [2309, 2323], 'rPfs16-expressing': [2311], '300': [2315], 'μl': [2316], 'falciparum–infected': [2318, 2570, 2834, 3119], 'containing': [2320, 2340], 'V': [2326], 'performed': [2329], 'standard': [2330], 'membrane-feeding': [2331], '(SMFAs).': [2333], 'same': [2335, 2369], 'empty': [2341], 'vectors': [2342], 'control.': [2347, 2849, 3288, 3372], 'per': [2356, 2626], 'group.': [2365], 'observed': [2367, 2619, 3002], 'replicates,': [2373], 'having': [2376], 'higher': [2377, 3306], 'prevalence': [2379, 2393, 2405, 2613, 2658, 2681], 'than': [2380, 2946, 3307, 3408], '3).': [2384], 'addition,': [2386], 'difference': [2390, 2965], 'low': [2399], 'experiments,': [2403], 'oocyst': [2404, 2624, 2650], '39%': [2409], '60%': [2411], '57%': [2414], '90%,': [2416], '(p': [2418, 2653, 3067], '<': [2419, 2654, 2689, 2692, 2695, 3068], '0.05).': [2420], 'Since': [2421, 2780, 3159, 3324, 4145], 'our': [2422, 2466, 3425], 'previous': [2423, 2706, 3178, 3426, 4013], 'inhibited': [2430], 'initial': [2467, 2538], 'hypothesis': [2468, 2539], 'similar': [2474], 'FREP1,': [2477], 'anchors': [2479], '(32Zhang': [2480, 3665], 'Franca': [2484, 3669], 'Butler': [2490, 3675], 'N.S.': [2491, 3676], 'FREP1': [2495, 3661, 3680], 'mediates': [2496, 3681], 'invasion.J.': [2498, 3683], '290:': [2502, 3687], '16490-16501Google': [2503, 3688], 'orientates': [2506], '(33Zhang': [2508, 2752], 'Hooker': [2512, 2756, 3571], 'Shabani': [2514, 2758, 3573], 'α-tubulin-1': [2523, 2767, 3526, 3582], '2023;': [2533, 2777, 3592], '131132647Google': [2534, 2778, 3593], 'If': [2536], 'true,': [2541], 'unexpected.': [2549], 'Thus,': [2550], 'reexamined': [2552, 3218], 'Pfs16-specific': [2556], 'antibody-blocking': [2557], 'purified': [2560, 2584], 'fed': [2573, 3224], 'analyze': [2577], 'nonspecific': [2586, 2873, 2955, 2978, 3014, 3078], 'added': [2590], 'total': [2594, 3650, 3717], 'concentration': [2596, 2631], '0.4': [2598, 2644, 2676], 'mg/ml.': [2599], 'anti-Pfs16': [2603, 2781, 2810, 2972, 3032, 3042, 3277, 3358], 'decreased': [2606, 2682], 'SMFAs': [2615], '4).': [2617], 'dose-dependent': [2621], 'decrease': [2622], 'load': [2625, 2651], 'analyzed.': [2628], 'highest': [2630, 2634, 3047], 'had': [2632], 'inhibition.': [2635], 'All': [2636], 'concentrations': [2637], '0.1': [2639, 2671], 'mg/ml,': [2640, 2642, 2672, 2674], '0.2': [2641, 2673], 'mg/ml': [2645, 2677, 3256], 'able': [2647], 'reduce': [2649], '0.001).': [2655], 'calculated': [2660, 2697], '88%,': [2663], '72%,': [2664], '58%,': [2665], '36%': [2667], 'control,': [2670, 2883], 'groups,': [2678], 'respectively.': [2679, 2884], '(∗p': [2688], '0.05,': [2690], '∗∗∗p': [2691], '0.001,': [2693], '∗∗∗∗p': [2694], '0.0001),': [2696], 'chi-square': [2700], 'test.': [2701], 'These': [2702], 'confirmed': [2704], 'blocked': [2712], 'must': [2747], 'beyond': [2749], 'simple': [2750], 'opposite': [2787], 'hypothesized': [2796], 'might': [2799], 'immunity.': [2803, 3144], 'enzymes': [2822], 'uninfected': [2831, 2853, 2924, 2991, 3094, 3103], 'blood-fed,': [2832, 2835], 'naïve': [2837, 2933, 3246, 3298], 'Bovine': [2839], 'serum': [2840], 'albumin': [2841], '(BSA)': [2842], 'PBS': [2844], 'blood-fed': [2854, 2925, 3089, 3095, 3100, 3104, 3248, 3300, 3314, 3334], 'baseline': [2859], '3/7': [2864, 2898, 2938, 2969], 'activity.': [2865], 'A': [2866, 3112], 'nonrelated': [2867], 'BSA': [2869, 2953, 3012, 3076, 3283, 3368, 3394], 'PBS,': [2871], 'IgG': [2875], 'Mosquito': [2885], 'collected': [2888], '18': [2889], 'after': [2891], 'treatments,': [2892], 'measured': [2902, 2910], 'Apo-ONE.': [2904], 'relative': [2906], 'fluorescence': [2907, 3400], 'units': [2908], 'every': [2911], '30': [2912], 'min': [2913], '5': [2915], 'optimize': [2918], 'incubation': [2920, 3266], 'time.': [2921], 'For': [2922], 'blood-feeding': [2927], 'rPfs16-fed': [2941], 'lower': [2945], 'those': [2947, 3010], 'controls,': [2950, 2980, 3073], 'example,': [2952, 3075, 3513], '(Ab)-fed': [2957], '5A).': [2960], 'There': [2961], 'no': [2963, 2988, 3321], 'Ab-fed': [2973, 3015, 3079], 'BSA,': [2976], 'Ab': [2979], 'fact': [2984, 3137], 'there': [2986, 3319], 'blood.': [2992], 'Plasmodium-infected': [2995], '5B),': [3000], 'controls.': [3016], 'Different': [3017], 'noninfected': [3019, 3130], 'show': [3028], 'upon': [3030], 'adding': [3031], 'Ab,': [3033], 'neutralized': [3035], 'Ab-treated': [3043], '5B).': [3051], 'Statistical': [3052], 'analyses': [3053], 'treated': [3057], '0.0001)': [3069], 'Anti-Pfs16': [3081], 'Analyzing': [3097], 'comparing': [3109, 3313], 'Figure': [3110], '5,': [3111], 'B,': [3114], 'stimulates': [3142], 'Collectively,': [3145], 'inhibits': [3149, 3161, 3911, 3937], 'caspases,': [3153], 'components': [3154], 'response.': [3158], 'cells,': [3166], 'should': [3168], 'interact': [3169, 3964], 'This': [3173, 3416], 'suggested': [3181], 'interacts': [3183], 'peritrophic': [3185, 3331, 3412, 3481], 'matrix': [3186, 3332, 3413], '3-': [3225], '5-day-old': [3227], 'removed': [3232], 'bolus': [3235], '24': [3239], 'post': [3241], 'meal.': [3243], 'homogenized,': [3252], 'supernatants': [3254], '(1': [3255], 'proteins)': [3257], 'coat': [3261], 'plates,': [3263], 'followed': [3264], 'retained': [3270], 'antibody.': [3278], 'wells': [3280, 3303], 'coated': [3281], 'both': [3297], 'lysate-coated': [3302], '6A).': [3311], 'versus': [3315], 'sugar-fed': [3316, 3325], 'lysates,': [3318], 'difference.': [3323], 'do': [3327], 'while': [3333], 'do,': [3336], 'suggests': [3339], 'binds': [3342], 'epithelial.': [3346], 'Blood-fed': [3347], 'sections': [3350], 'incubated': [3352], 'immunofluorescence': [3362], 'assay.': [3363], 'Substitution': [3364], 'negative': [3371], '(red': [3379], 'color)': [3380], 'broad': [3383], 'areas': [3384], '6B).': [3397], 'Specifically,': [3398], 'intensity': [3401], 'stronger': [3407], '6C).': [3415], 'actual': [3427], 'data': [3428], 'i.e.,': [3459], 'layer,': [3468], 'although': [3469], 'cannot': [3471], 'exclude': [3472], 'molecules,': [3474], 'may': [3476], 'matrix.': [3482], 'leading': [3486], 'Besides': [3488], 'regular': [3489], 'prevent': [3492], 'humans,': [3496], 'many': [3497], 'over': [3499], 'last': [3501], 'decade': [3502], 'focused': [3504], 'vaccines,': [3515], 'Pfs25,': [3523], 'Pfs47,': [3524], '(12Molina-Cruz': [3530], '33Zhang': [3567], '34Yenkoidiok-Douti': [3595], 'Engineering': [3605], 'virus-like': [3607], 'particle': [3608], 'antigenic': [3611], 'platform': [3612], 'Pfs47-targeted': [3615], 'vaccine.Sci.': [3618], '2019;': [3620], '916833Google': [3621], '35Huang': [3623, 3690], 'W.C.': [3624, 3691], 'Deng': [3625, 3692], 'Mabrouk': [3627, 3694], 'Seffouh': [3629, 3696], 'Ortega': [3631, 3698], 'Long': [3633, 3700, 3801], 'al.Particle-based,': [3636, 3703], 'Pfs230': [3637, 3704], 'Pfs25': [3639, 3706], 'immunization': [3640, 3707], 'effective,': [3642, 3709], 'improved': [3645, 3712], 'duplexing': [3647, 3714], 'fixed': [3649, 3716], 'antigen': [3651, 3718], 'dose.Malar.': [3652, 3719], '309Google': [3656, 3723], 'AnAPN1': [3659], '36Atkinson': [3725], 'Armistead': [3727], 'J.S.': [3728], 'Mathias': [3729], 'D.K.': [3730], 'Sandeu': [3731], 'M.M.': [3732], 'Tao': [3733], 'Borhani-Dizaji': [3735], 'Anopheles-midgut': [3739], 'APN1': [3740], 'new': [3744], 'epitope.Nat.': [3748], 'Struct.': [3749], '532-539Google': [3754], '37Dinglasan': [3756], 'R.R.': [3757], 'Kalume': [3758], 'Ghosh': [3762], 'A.K.': [3763], 'Muratova': [3764], 'Pandey': [3766], 'al.Disruption': [3769], 'conserved': [3778], 'antigen.Proc.': [3781], '2007;': [3788], '104:': [3789], '13461-13466Google': [3790], '38de': [3792], 'Graaf': [3793], 'Payne': [3795], 'R.O.': [3796], 'Taylor': [3797], 'I.': [3798], 'Miura': [3799], 'C.A.': [3802], 'Elias': [3803], 'al.Safety': [3806], 'immunogenicity': [3808], 'ChAd63/MVA': [3810], 'Pfs25-IMX313': [3811], 'phase': [3814], 'I': [3815], 'first-in-human': [3816], 'trial.Front.': [3817], 'Immunol.': [3818], '12694759Google': [3820], '39Li': [3822], 'Zhang': [3826], 'Githure': [3828], 'J.I.': [3829], 'Yan': [3830], 'James': [3832], 'Genome-block': [3834], 'expression-assisted': [3835], 'association': [3836], 'discover': [3838], '110:': [3852], '20675-20680Google': [3853], 'Blocking': [3855], 'small': [3859], 'under': [3863], 'investigation,': [3864], 'fungal': [3867, 3889, 3935], 'secondary': [3868], 'metabolites': [3869], '(40Niu': [3873], 'Annamalai': [3875], 'T.': [3876], 'Munga': [3881], 'library': [3890], 'drug': [3892], 'discovery.PeerJ.': [3893], '8e10392Google': [3895], '41Niu': [3897], 'Hao': [3899, 3924], 'Gao': [3903], 'Fungal': [3907], 'metabolite': [3908, 3936], 'asperaculane': [3909], 'transmission.Molecules.': [3915], '3018Google': [3918], '42Niu': [3920], 'Kandel': [3926], 'Raptis': [3930], 'R.G.': [3931], 'novel': [3934], 'infection.Parasit.': [3942], 'Vectors.': [3943], '14:': [3945], '177Google': [3946], 'remain': [3957], 'elusive.': [3958], 'Recently,': [3959], 'reported': [3962], 'PVM,': [4009], '(43Eksi': [4015], 'Williamson': [4017], 'K.C.': [4018], 'Protein': [4019], 'targeting': [4020], 'falciparum.Eukaryot.': [4028], '10:': [4031], '744-752Google': [4032], 'egress,': [4035], 'termed': [4044], 'multilaminated': [4045, 4168], 'whorls': [4046, 4169], 'ruptures': [4071], 'multilaminar': [4073], 'vesicles': [4074, 4175], '(44Hale': [4075], 'Watermeyer': [4077], 'Hackett': [4079], 'Vizcay-Barrena': [4081], 'van': [4083], 'Ooij': [4084], 'Thomas': [4086], 'al.Parasitophorous': [4089], 'poration': [4091], 'precedes': [4092], 'rapid': [4096], 'cytoskeleton': [4099], 'collapse': [4100], 'egress.Proc.': [4104], '114:': [4112], '3439-3444Google': [4113], '45Glushakova': [4115], 'Mazar': [4117], 'Hohmann-Marriott': [4119], 'M.F.': [4120], 'Hama': [4121], 'Irreversible': [4125], 'cysteine': [4128], 'inhibitors': [4130], 'release': [4133], 'erythrocytes.Cell.': [4139], '11:': [4142], '95-105Google': [4143], 'protozoan': [4146], 'known': [4149], 'resourceful': [4152], 'invaders/evaders,': [4156], 'plausible': [4159], 'use': [4165], 'remaining': [4167], 'type': [4172], 'extracellular': [4174], 'exosomes': [4177], 'communication,': [4179], 'pathogenesis,': [4180], 'and/or': [4181], 'regulation': [4183], '(46Co': [4184]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4377010973', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 1}], 'updated_date': '2025-01-05T17:25:05.813310', 'created_date': '2023-05-19'}
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