Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4367596576', 'doi': 'https://doi.org/10.3390/biology12050671', 'title': 'Chromosomal Instability in Genome Evolution: From Cancer to Macroevolution', 'display_name': 'Chromosomal Instability in Genome Evolution: From Cancer to Macroevolution', 'publication_year': 2023, 'publication_date': '2023-04-28', 'ids': {'openalex': 'https://openalex.org/W4367596576', 'doi': 'https://doi.org/10.3390/biology12050671', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37237485'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biology12050671', 'pdf_url': 'https://www.mdpi.com/2079-7737/12/5/671/pdf?version=1683188722', 'source': {'id': 'https://openalex.org/S153489431', 'display_name': 'Biology', 'issn_l': '2079-7737', 'issn': ['2079-7737'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2079-7737/12/5/671/pdf?version=1683188722', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086919061', 'display_name': 'Valentine Comaills', 'orcid': 'https://orcid.org/0000-0001-8857-6976'}, 'institutions': [{'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I918821925', 'display_name': 'Junta de Andalucía', 'ror': 'https://ror.org/01jem9c82', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I918821925']}, {'id': 'https://openalex.org/I79238269', 'display_name': 'Universidad de Sevilla', 'ror': 'https://ror.org/03yxnpp24', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I79238269']}, {'id': 'https://openalex.org/I4210150311', 'display_name': 'Centro Andaluz de Biología Molecular y Medicina Regenerativa', 'ror': 'https://ror.org/03nb7bx92', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210150311', 'https://openalex.org/I79238269']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Valentine Comaills', 'raw_affiliation_strings': ['Andalusian Center for Molecular Biology and Regenerative Medicine—CABIMER, University of Pablo de Olavide—University of Seville—CSIC, Junta de Andalucía, 41092 Seville, Spain'], 'affiliations': [{'raw_affiliation_string': 'Andalusian Center for Molecular Biology and Regenerative Medicine—CABIMER, University of Pablo de Olavide—University of Seville—CSIC, Junta de Andalucía, 41092 Seville, Spain', 'institution_ids': ['https://openalex.org/I95013407', 'https://openalex.org/I918821925', 'https://openalex.org/I79238269', 'https://openalex.org/I4210150311']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005940091', 'display_name': 'Maikel Castellano‐Pozo', 'orcid': 'https://orcid.org/0000-0003-4134-9025'}, 'institutions': [{'id': 'https://openalex.org/I4210150311', 'display_name': 'Centro Andaluz de Biología Molecular y Medicina Regenerativa', 'ror': 'https://ror.org/03nb7bx92', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210150311', 'https://openalex.org/I79238269']}, {'id': 'https://openalex.org/I918821925', 'display_name': 'Junta de Andalucía', 'ror': 'https://ror.org/01jem9c82', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I918821925']}, {'id': 'https://openalex.org/I79238269', 'display_name': 'Universidad de Sevilla', 'ror': 'https://ror.org/03yxnpp24', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I79238269']}, {'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Maikel Castellano-Pozo', 'raw_affiliation_strings': ['Andalusian Center for Molecular Biology and Regenerative Medicine—CABIMER, University of Pablo de Olavide—University of Seville—CSIC, Junta de Andalucía, 41092 Seville, Spain', 'Genetic Department, Faculty of Biology, University of Seville, 41080 Seville, Spain'], 'affiliations': [{'raw_affiliation_string': 'Andalusian Center for Molecular Biology and Regenerative Medicine—CABIMER, University of Pablo de Olavide—University of Seville—CSIC, Junta de Andalucía, 41092 Seville, Spain', 'institution_ids': ['https://openalex.org/I4210150311', 'https://openalex.org/I918821925', 'https://openalex.org/I79238269', 'https://openalex.org/I95013407']}, {'raw_affiliation_string': 'Genetic Department, Faculty of Biology, University of Seville, 41080 Seville, Spain', 'institution_ids': ['https://openalex.org/I79238269']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5086919061', 'https://openalex.org/A5005940091'], 'corresponding_institution_ids': ['https://openalex.org/I95013407', 'https://openalex.org/I918821925', 'https://openalex.org/I79238269', 'https://openalex.org/I4210150311', 'https://openalex.org/I4210150311', 'https://openalex.org/I918821925', 'https://openalex.org/I79238269', 'https://openalex.org/I95013407'], 'apc_list': {'value': 2000, 'currency': 'CHF', 'value_usd': 2165, 'provenance': 'doaj'}, 'apc_paid': {'value': 2000, 'currency': 'CHF', 'value_usd': 2165, 'provenance': 'doaj'}, 'fwci': 1.512, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.999136, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '12', 'issue': '5', 'first_page': '671', 'last_page': '671'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10434', 'display_name': 'Genome Evolution and Polyploidy in Plants', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10434', 'display_name': 'Genome Evolution and Polyploidy in Plants', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11213', 'display_name': 'Genomic Rearrangements and Copy Number Variations', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Regulation and Function of Microtubules in Cell Division', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chromothripsis', 'display_name': 'Chromothripsis', 'score': 0.8660765}, {'id': 'https://openalex.org/keywords/chromosome-instability', 'display_name': 'Chromosome instability', 'score': 0.82500166}, {'id': 'https://openalex.org/keywords/chromosomal-instability', 'display_name': 'Chromosomal Instability', 'score': 0.583944}, {'id': 'https://openalex.org/keywords/chromosome-duplication', 'display_name': 'Chromosome Duplication', 'score': 0.509573}, {'id': 'https://openalex.org/keywords/tumor-progression', 'display_name': 'Tumor progression', 'score': 0.46439746}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.92346275}, {'id': 'https://openalex.org/C178169997', 'wikidata': 'https://www.wikidata.org/wiki/Q2892636', 'display_name': 'Genome instability', 'level': 4, 'score': 0.8947571}, {'id': 'https://openalex.org/C99983632', 'wikidata': 'https://www.wikidata.org/wiki/Q1087765', 'display_name': 'Chromothripsis', 'level': 5, 'score': 0.8660765}, {'id': 'https://openalex.org/C140752955', 'wikidata': 'https://www.wikidata.org/wiki/Q1087752', 'display_name': 'Chromosome instability', 'level': 4, 'score': 0.82500166}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.6315293}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.63013184}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.6259054}, {'id': 'https://openalex.org/C174600577', 'wikidata': 'https://www.wikidata.org/wiki/Q5533491', 'display_name': 'Genome evolution', 'level': 4, 'score': 0.5092267}, {'id': 'https://openalex.org/C113968399', 'wikidata': 'https://www.wikidata.org/wiki/Q7559241', 'display_name': 'Somatic evolution in cancer', 'level': 3, 'score': 0.47870898}, {'id': 'https://openalex.org/C2779256057', 'wikidata': 'https://www.wikidata.org/wiki/Q16909647', 'display_name': 'Tumor progression', 'level': 3, 'score': 0.46439746}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43020627}, {'id': 'https://openalex.org/C78458016', 'wikidata': 'https://www.wikidata.org/wiki/Q840400', 'display_name': 'Evolutionary biology', 'level': 1, 'score': 0.38490042}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.26353943}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.23890704}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.20739853}, {'id': 'https://openalex.org/C30481170', 'wikidata': 'https://www.wikidata.org/wiki/Q37748', 'display_name': 'Chromosome', 'level': 3, 'score': 0.14513817}], 'mesh': [], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biology12050671', 'pdf_url': 'https://www.mdpi.com/2079-7737/12/5/671/pdf?version=1683188722', 'source': {'id': 'https://openalex.org/S153489431', 'display_name': 'Biology', 'issn_l': '2079-7737', 'issn': ['2079-7737'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://dx.doi.org/10.3390/biology12050671', 'pdf_url': 'https://www.mdpi.com/2079-7737/12/5/671/pdf?version=1682697860', 'source': {'id': 'https://openalex.org/S4306400947', 'display_name': 'MDPI (MDPI AG)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210097602', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute (Switzerland)', 'host_organization_lineage': ['https://openalex.org/I4210097602'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute (Switzerland)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10261/335918', 'pdf_url': 'https://digital.csic.es/bitstream/10261/335918/1/biology-12-00671-v2.pdf', 'source': {'id': 'https://openalex.org/S4306400616', 'display_name': 'DIGITAL.CSIC (Spanish National Research Council (CSIC))', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I134820265', 'host_organization_name': 'Consejo Superior de Investigaciones Científicas', 'host_organization_lineage': ['https://openalex.org/I134820265'], 'host_organization_lineage_names': ['Consejo Superior de Investigaciones Científicas'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://idus.us.es/handle//11441/145271', 'pdf_url': 'https://idus.us.es/bitstream/11441/145271/1/biology-12-00671.pdf', 'source': {'id': 'https://openalex.org/S4306401665', 'display_name': 'Deposito de Investigacion Universidad de Sevilla (University of Seville)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I79238269', 'host_organization_name': 'Universidad de Sevilla', 'host_organization_lineage': ['https://openalex.org/I79238269'], 'host_organization_lineage_names': ['Universidad de Sevilla'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215859', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37237485', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biology12050671', 'pdf_url': 'https://www.mdpi.com/2079-7737/12/5/671/pdf?version=1683188722', 'source': {'id': 'https://openalex.org/S153489431', 'display_name': 'Biology', 'issn_l': '2079-7737', 'issn': ['2079-7737'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15', 'score': 0.55}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 266, 'referenced_works': ['https://openalex.org/W1193031612', 'https://openalex.org/W1504371864', 'https://openalex.org/W1514318255', 'https://openalex.org/W1529934215', 'https://openalex.org/W1558701786', 'https://openalex.org/W1601755300', 'https://openalex.org/W1641544182', 'https://openalex.org/W1744046902', 'https://openalex.org/W1895753987', 'https://openalex.org/W1900287502', 'https://openalex.org/W1950949528', 'https://openalex.org/W1963581046', 'https://openalex.org/W1963651352', 'https://openalex.org/W1963756058', 'https://openalex.org/W1963998725', 'https://openalex.org/W1964640891', 'https://openalex.org/W1967304777', 'https://openalex.org/W1967454295', 'https://openalex.org/W1969016839', 'https://openalex.org/W1969665013', 'https://openalex.org/W1970283686', 'https://openalex.org/W1972809713', 'https://openalex.org/W1972984145', 'https://openalex.org/W1973062929', 'https://openalex.org/W1973426090', 'https://openalex.org/W1975250427', 'https://openalex.org/W1977252364', 'https://openalex.org/W1979327836', 'https://openalex.org/W1981975859', 'https://openalex.org/W1983107959', 'https://openalex.org/W1987681742', 'https://openalex.org/W1988980934', 'https://openalex.org/W1989293552', 'https://openalex.org/W1990699200', 'https://openalex.org/W1991867417', 'https://openalex.org/W1993344012', 'https://openalex.org/W1996536755', 'https://openalex.org/W2000916610', 'https://openalex.org/W2002454928', 'https://openalex.org/W2003515720', 'https://openalex.org/W2006124071', 'https://openalex.org/W2006301813', 'https://openalex.org/W2009088119', 'https://openalex.org/W2010396758', 'https://openalex.org/W2010407417', 'https://openalex.org/W2010552409', 'https://openalex.org/W2011798292', 'https://openalex.org/W2011957420', 'https://openalex.org/W2013550946', 'https://openalex.org/W2014342923', 'https://openalex.org/W2016492976', 'https://openalex.org/W2016661249', 'https://openalex.org/W2023411715', 'https://openalex.org/W2024459631', 'https://openalex.org/W2024552334', 'https://openalex.org/W2026960083', 'https://openalex.org/W2029878366', 'https://openalex.org/W2032518018', 'https://openalex.org/W2034499270', 'https://openalex.org/W2035252444', 'https://openalex.org/W2037169282', 'https://openalex.org/W2037291218', 'https://openalex.org/W2037404897', 'https://openalex.org/W2038489248', 'https://openalex.org/W2041156660', 'https://openalex.org/W2041993682', 'https://openalex.org/W2043178637', 'https://openalex.org/W2047657819', 'https://openalex.org/W2049951752', 'https://openalex.org/W2053779322', 'https://openalex.org/W2057652201', 'https://openalex.org/W2059325101', 'https://openalex.org/W2060955969', 'https://openalex.org/W2061284385', 'https://openalex.org/W2063382533', 'https://openalex.org/W2065636600', 'https://openalex.org/W2070744469', 'https://openalex.org/W2072401812', 'https://openalex.org/W2077145482', 'https://openalex.org/W2081116295', 'https://openalex.org/W2081933515', 'https://openalex.org/W2082884397', 'https://openalex.org/W2084139224', 'https://openalex.org/W2084833108', 'https://openalex.org/W2085048059', 'https://openalex.org/W2085275533', 'https://openalex.org/W2087601715', 'https://openalex.org/W2090037139', 'https://openalex.org/W2094746916', 'https://openalex.org/W2094892383', 'https://openalex.org/W2095617425', 'https://openalex.org/W2097710447', 'https://openalex.org/W2098152017', 'https://openalex.org/W2099448734', 'https://openalex.org/W2100238259', 'https://openalex.org/W2100302477', 'https://openalex.org/W2102502996', 'https://openalex.org/W2104154956', 'https://openalex.org/W2104549677', 'https://openalex.org/W2104945387', 'https://openalex.org/W2109948920', 'https://openalex.org/W2110818168', 'https://openalex.org/W2112273746', 'https://openalex.org/W2116811037', 'https://openalex.org/W2117692326', 'https://openalex.org/W2121152082', 'https://openalex.org/W2123227225', 'https://openalex.org/W2123303153', 'https://openalex.org/W2123618943', 'https://openalex.org/W2126187754', 'https://openalex.org/W2133381977', 'https://openalex.org/W2136355941', 'https://openalex.org/W2136856258', 'https://openalex.org/W2139266962', 'https://openalex.org/W2139790154', 'https://openalex.org/W2141459352', 'https://openalex.org/W2143719385', 'https://openalex.org/W2146848384', 'https://openalex.org/W2148821835', 'https://openalex.org/W2150734014', 'https://openalex.org/W2159359702', 'https://openalex.org/W2159862605', 'https://openalex.org/W2160248428', 'https://openalex.org/W2163211502', 'https://openalex.org/W2164086255', 'https://openalex.org/W2165860917', 'https://openalex.org/W2166223300', 'https://openalex.org/W2170008898', 'https://openalex.org/W2197269124', 'https://openalex.org/W2224253930', 'https://openalex.org/W2236303786', 'https://openalex.org/W2255537226', 'https://openalex.org/W2256525674', 'https://openalex.org/W2256812860', 'https://openalex.org/W2285387404', 'https://openalex.org/W2295696738', 'https://openalex.org/W2303653884', 'https://openalex.org/W2311649981', 'https://openalex.org/W2315338617', 'https://openalex.org/W2337283254', 'https://openalex.org/W2348784353', 'https://openalex.org/W2414771725', 'https://openalex.org/W2419083620', 'https://openalex.org/W2507144075', 'https://openalex.org/W2515472395', 'https://openalex.org/W2519954332', 'https://openalex.org/W2531301510', 'https://openalex.org/W2531887049', 'https://openalex.org/W2551102722', 'https://openalex.org/W2554698035', 'https://openalex.org/W2560367415', 'https://openalex.org/W2560524936', 'https://openalex.org/W2560567639', 'https://openalex.org/W2563646853', 'https://openalex.org/W2574604975', 'https://openalex.org/W2577796153', 'https://openalex.org/W2587213787', 'https://openalex.org/W2587990010', 'https://openalex.org/W2588691895', 'https://openalex.org/W2612079819', 'https://openalex.org/W2691929059', 'https://openalex.org/W2746672093', 'https://openalex.org/W2748025878', 'https://openalex.org/W2775567101', 'https://openalex.org/W2781608882', 'https://openalex.org/W2782634000', 'https://openalex.org/W2783667606', 'https://openalex.org/W2786089085', 'https://openalex.org/W2787979900', 'https://openalex.org/W2790208381', 'https://openalex.org/W2791872112', 'https://openalex.org/W2796208126', 'https://openalex.org/W2797725119', 'https://openalex.org/W2799343775', 'https://openalex.org/W2799448805', 'https://openalex.org/W2804603137', 'https://openalex.org/W2807733000', 'https://openalex.org/W2881537705', 'https://openalex.org/W2884903585', 'https://openalex.org/W2885295334', 'https://openalex.org/W2891405227', 'https://openalex.org/W2896600424', 'https://openalex.org/W2903005412', 'https://openalex.org/W2913116862', 'https://openalex.org/W2920347438', 'https://openalex.org/W2920841323', 'https://openalex.org/W2922323966', 'https://openalex.org/W2946749527', 'https://openalex.org/W2949203785', 'https://openalex.org/W2950214184', 'https://openalex.org/W2950657649', 'https://openalex.org/W2952421220', 'https://openalex.org/W2952687085', 'https://openalex.org/W2953339074', 'https://openalex.org/W2953467956', 'https://openalex.org/W2960109591', 'https://openalex.org/W2964649258', 'https://openalex.org/W2969709096', 'https://openalex.org/W2987249603', 'https://openalex.org/W3000539421', 'https://openalex.org/W3001381700', 'https://openalex.org/W3003152033', 'https://openalex.org/W3003839555', 'https://openalex.org/W3004480399', 'https://openalex.org/W3005053607', 'https://openalex.org/W3006050666', 'https://openalex.org/W3006500278', 'https://openalex.org/W3013355236', 'https://openalex.org/W3016718031', 'https://openalex.org/W3022927847', 'https://openalex.org/W3030556878', 'https://openalex.org/W3032034316', 'https://openalex.org/W3036733852', 'https://openalex.org/W3037469178', 'https://openalex.org/W3044175205', 'https://openalex.org/W3044343904', 'https://openalex.org/W307888633', 'https://openalex.org/W3080928337', 'https://openalex.org/W3082714866', 'https://openalex.org/W3090251225', 'https://openalex.org/W3116548071', 'https://openalex.org/W3123988232', 'https://openalex.org/W3131824848', 'https://openalex.org/W3138417159', 'https://openalex.org/W3155280715', 'https://openalex.org/W3159677655', 'https://openalex.org/W3160240361', 'https://openalex.org/W3163653137', 'https://openalex.org/W3180694999', 'https://openalex.org/W3181687372', 'https://openalex.org/W3186985508', 'https://openalex.org/W3191628783', 'https://openalex.org/W3198677380', 'https://openalex.org/W3200172023', 'https://openalex.org/W3210280275', 'https://openalex.org/W3213253836', 'https://openalex.org/W3217652874', 'https://openalex.org/W4200146564', 'https://openalex.org/W4206395681', 'https://openalex.org/W4206662285', 'https://openalex.org/W4207044299', 'https://openalex.org/W4210272319', 'https://openalex.org/W4213311213', 'https://openalex.org/W4225103222', 'https://openalex.org/W4225529913', 'https://openalex.org/W4226052652', 'https://openalex.org/W4229013360', 'https://openalex.org/W4282965548', 'https://openalex.org/W4282980285', 'https://openalex.org/W4284991750', 'https://openalex.org/W4285084726', 'https://openalex.org/W4292122046', 'https://openalex.org/W4292756221', 'https://openalex.org/W4293458020', 'https://openalex.org/W4306809829', 'https://openalex.org/W4306810879', 'https://openalex.org/W4306844784', 'https://openalex.org/W4306861370', 'https://openalex.org/W4307362411', 'https://openalex.org/W4309845476', 'https://openalex.org/W4310155569', 'https://openalex.org/W4310439030', 'https://openalex.org/W4313587320', 'https://openalex.org/W4322008861', 'https://openalex.org/W4324009880', 'https://openalex.org/W873873667'], 'related_works': ['https://openalex.org/W4387330087', 'https://openalex.org/W4367596576', 'https://openalex.org/W4319602003', 'https://openalex.org/W4255206274', 'https://openalex.org/W3190756576', 'https://openalex.org/W3040856802', 'https://openalex.org/W2352719856', 'https://openalex.org/W2152859477', 'https://openalex.org/W2084475506', 'https://openalex.org/W2025216788'], 'abstract_inverted_index': {'The': [0, 142], 'integrity': [1], 'of': [2, 10, 37, 45, 52, 90, 145, 153, 160, 174, 223], 'the': [3, 8, 38, 43, 50, 64, 84, 107, 116, 131, 151, 158, 166, 169, 221], 'genome': [4, 86, 109], 'is': [5, 35, 218], 'crucial': [6], 'for': [7, 24, 220], 'survival': [9], 'all': [11], 'living': [12], 'organisms.': [13], 'However,': [14], 'genomes': [15], 'need': [16], 'to': [17, 19, 30, 42, 111, 130, 140, 180, 185, 226], 'adapt': [18], 'survive': [20], 'certain': [21], 'pressures,': [22], 'and': [23, 54, 68, 138, 172, 209], 'this': [25, 59], 'purpose': [26], 'use': [27], 'several': [28, 196], 'mechanisms': [29, 40, 167, 224], 'diversify.': [31], 'Chromosomal': [32], 'instability': [33, 214], '(CIN)': [34], 'one': [36], 'main': [39], 'leading': [41, 225], 'creation': [44], 'genomic': [46, 132], 'heterogeneity': [47], 'by': [48], 'altering': [49], 'number': [51], 'chromosomes': [53, 176], 'changing': [55], 'their': [56], 'structures.': [57], 'In': [58], 'review,': [60], 'we': [61, 192], 'will': [62, 147, 163, 193], 'discuss': [63], 'different': [65, 143], 'chromosomal': [66, 118, 213], 'patterns': [67, 187], 'changes': [69, 104, 114, 123], 'observed': [70, 124, 134, 177, 188], 'in': [71, 73, 102, 202], 'speciation,': [72], 'evolutional': [74], 'biology': [75], 'as': [76, 78, 95, 106, 115, 150, 215], 'well': [77, 96], 'during': [79, 92, 97, 125, 135, 178, 189], 'tumor': [80, 136, 227], 'progression.': [81, 228], 'By': [82], 'nature,': [83], 'human': [85], 'shows': [87], 'an': [88], 'induction': [89], 'diversity': [91], 'gametogenesis': [93], 'but': [94], 'tumorigenesis': [98], 'that': [99], 'can': [100], 'conclude': [101], 'drastic': [103], 'such': [105], 'whole': [108, 217], 'doubling': [110], 'more': [112], 'discrete': [113], 'complex': [117], 'rearrangement': [119], 'chromothripsis.': [120], 'More': [121], 'importantly,': [122], 'speciation': [126], 'are': [127], 'strikingly': [128], 'similar': [129, 186], 'evolution': [133], 'progression': [137], 'resistance': [139], 'therapy.': [141], 'origins': [144], 'CIN': [146], 'be': [148], 'treated': [149], 'importance': [152], 'double-strand': [154], 'breaks': [155], '(DSBs)': [156], 'or': [157], 'consequences': [159], 'micronuclei.': [161], 'We': [162], 'also': [164, 194], 'explain': [165, 181], 'behind': [168], 'controlled': [170], 'DSBs,': [171], 'recombination': [173], 'homologous': [175], 'meiosis,': [179], 'how': [182], 'errors': [183], 'lead': [184], 'tumorigenesis.': [190], 'Then,': [191], 'list': [195], 'diseases': [197], 'associated': [198], 'with': [199], 'CIN,': [200], 'resulting': [201], 'fertility': [203], 'issues,': [204], 'miscarriage,': [205], 'rare': [206], 'genetic': [207], 'diseases,': [208], 'cancer.': [210], 'Understanding': [211], 'better': [212], 'a': [216], 'primordial': [219], 'understanding': [222]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4367596576', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-09-12T11:08:45.865291', 'created_date': '2023-05-02'}