Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4367596256', 'doi': 'https://doi.org/10.1021/acs.joc.3c00553', 'title': 'Chemical Synthesis of a Keto Sugar Nucleotide', 'display_name': 'Chemical Synthesis of a Keto Sugar Nucleotide', 'publication_year': 2023, 'publication_date': '2023-05-01', 'ids': {'openalex': 'https://openalex.org/W4367596256', 'doi': 'https://doi.org/10.1021/acs.joc.3c00553', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37126664'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.joc.3c00553', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205050996', 'display_name': 'The Journal of Organic Chemistry', 'issn_l': '0022-3263', 'issn': ['0022-3263', '1520-6904'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045381396', 'display_name': 'Zhongrui Li', 'orcid': 'https://orcid.org/0000-0001-5371-7628'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhong-Rui Li', 'raw_affiliation_strings': ['Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078161370', 'display_name': 'Ruofan Li', 'orcid': 'https://orcid.org/0000-0001-8060-897X'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ruofan Li', 'raw_affiliation_strings': ['Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082333462', 'display_name': 'Laura B. Pasternack', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laura Pasternack', 'raw_affiliation_strings': ['Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006126517', 'display_name': 'Pengxi Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pengxi Chen', 'raw_affiliation_strings': ['Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056753239', 'display_name': 'Chi‐Huey Wong', 'orcid': 'https://orcid.org/0000-0002-9961-7865'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Chi-Huey Wong', 'raw_affiliation_strings': ['Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States', 'institution_ids': ['https://openalex.org/I123431417']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5056753239'], 'corresponding_institution_ids': ['https://openalex.org/I123431417'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.376, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.552095, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 71, 'max': 82}, 'biblio': {'volume': '88', 'issue': '11', 'first_page': '7580', 'last_page': '7585'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10835', 'display_name': 'Chemical Glycobiology and Therapeutic Applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10835', 'display_name': 'Chemical Glycobiology and Therapeutic Applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation in Health and Disease', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10252', 'display_name': 'Natural Products as Sources of New Drugs', 'score': 0.9775, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nucleotide-sugar', 'display_name': 'Nucleotide sugar', 'score': 0.7925303}, {'id': 'https://openalex.org/keywords/glycoprotein-synthesis', 'display_name': 'Glycoprotein Synthesis', 'score': 0.507517}], 'concepts': [{'id': 'https://openalex.org/C161019410', 'wikidata': 'https://www.wikidata.org/wiki/Q67201373', 'display_name': 'Glycosyltransferase', 'level': 3, 'score': 0.8533628}, {'id': 'https://openalex.org/C512185932', 'wikidata': 'https://www.wikidata.org/wiki/Q28745', 'display_name': 'Nucleotide', 'level': 3, 'score': 0.8442886}, {'id': 'https://openalex.org/C26664279', 'wikidata': 'https://www.wikidata.org/wiki/Q117973', 'display_name': 'Nucleotide sugar', 'level': 4, 'score': 0.7925303}, {'id': 'https://openalex.org/C2777108408', 'wikidata': 'https://www.wikidata.org/wiki/Q11002', 'display_name': 'Sugar', 'level': 2, 'score': 0.7664205}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.60456264}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.5956646}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5732914}, {'id': 'https://openalex.org/C22222904', 'wikidata': 'https://www.wikidata.org/wiki/Q422882', 'display_name': 'Glycolipid', 'level': 2, 'score': 0.49759534}, {'id': 'https://openalex.org/C114373084', 'wikidata': 'https://www.wikidata.org/wiki/Q273499', 'display_name': 'Chemical synthesis', 'level': 3, 'score': 0.46306294}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.37474823}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.17827058}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07991269}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009711', 'descriptor_name': 'Nucleotides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016695', 'descriptor_name': 'Glycosyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.joc.3c00553', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205050996', 'display_name': 'The Journal of Organic Chemistry', 'issn_l': '0022-3263', 'issn': ['0022-3263', '1520-6904'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37126664', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320306076', 'funder_display_name': 'National Science Foundation', 'award_id': 'CHE-1954031'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'AI130227'}], 'datasets': [], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W118675692', 'https://openalex.org/W124605747', 'https://openalex.org/W1565936311', 'https://openalex.org/W1604805669', 'https://openalex.org/W1946114797', 'https://openalex.org/W1966998190', 'https://openalex.org/W1973640312', 'https://openalex.org/W1980675650', 'https://openalex.org/W1984732368', 'https://openalex.org/W1988195709', 'https://openalex.org/W1989689041', 'https://openalex.org/W1989959413', 'https://openalex.org/W1995177332', 'https://openalex.org/W2004929894', 'https://openalex.org/W2017107299', 'https://openalex.org/W2018109009', 'https://openalex.org/W2021702367', 'https://openalex.org/W2024101375', 'https://openalex.org/W2026703806', 'https://openalex.org/W2028485920', 'https://openalex.org/W2036448942', 'https://openalex.org/W2043289237', 'https://openalex.org/W2046428639', 'https://openalex.org/W2051263360', 'https://openalex.org/W2053677915', 'https://openalex.org/W2073815736', 'https://openalex.org/W2089653154', 'https://openalex.org/W2090808342', 'https://openalex.org/W2091743294', 'https://openalex.org/W2094202195', 'https://openalex.org/W2104433134', 'https://openalex.org/W2109670638', 'https://openalex.org/W2110657809', 'https://openalex.org/W2117672117', 'https://openalex.org/W2129001639', 'https://openalex.org/W2135960109', 'https://openalex.org/W2141287219', 'https://openalex.org/W2165062809', 'https://openalex.org/W2177906561', 'https://openalex.org/W2323827058', 'https://openalex.org/W2326415945', 'https://openalex.org/W2463920377', 'https://openalex.org/W2579901592', 'https://openalex.org/W2619498391', 'https://openalex.org/W2626586627', 'https://openalex.org/W2753828504', 'https://openalex.org/W2789739192', 'https://openalex.org/W2799610005', 'https://openalex.org/W2951911872', 'https://openalex.org/W2953378878', 'https://openalex.org/W2972508509', 'https://openalex.org/W2995491240', 'https://openalex.org/W3031007558', 'https://openalex.org/W3082443484', 'https://openalex.org/W3087612995', 'https://openalex.org/W3095020181', 'https://openalex.org/W3110695681', 'https://openalex.org/W3129326069', 'https://openalex.org/W4205755645', 'https://openalex.org/W4254394441', 'https://openalex.org/W4280562165', 'https://openalex.org/W4321996892', 'https://openalex.org/W4360609432'], 'related_works': ['https://openalex.org/W4367596256', 'https://openalex.org/W4243084055', 'https://openalex.org/W3151525282', 'https://openalex.org/W2342084522', 'https://openalex.org/W2087942040', 'https://openalex.org/W2031798358', 'https://openalex.org/W2010230508', 'https://openalex.org/W1995301350', 'https://openalex.org/W1988473330', 'https://openalex.org/W198820092'], 'abstract_inverted_index': {'Keto': [0], 'sugar': [1, 12], 'nucleotides': [2], '(KSNs)': [3], 'are': [4, 15], 'common': [5], 'and': [6, 28, 60, 69], 'versatile': [7], 'precursors': [8], 'to': [9, 40, 66], 'various': [10], 'deoxy': [11], 'nucleotides,': [13], 'which': [14], 'substrates': [16], 'for': [17, 76], 'the': [18, 23, 41, 45, 50], 'corresponding': [19], 'glycosyltransferases': [20], 'involved': [21], 'in': [22], 'biosynthesis': [24], 'of': [25, 49], 'glycoproteins,': [26], 'glycolipids,': [27], 'natural': [29], 'products.': [30], 'However,': [31], 'there': [32], 'has': [33], 'been': [34], 'no': [35], 'KSN': [36, 52], 'synthesized': [37], 'chemically': [38], 'due': [39], 'inherent': [42], 'instability.': [43], 'Herein,': [44], 'first': [46], 'chemical': [47], 'synthesis': [48], 'archetypal': [51], 'TDP-4-keto-6-deoxy-d-glucose': [53], '(1)': [54], 'is': [55], 'achieved': [56], 'by': [57], 'an': [58], 'efficient': [59], 'optimized': [61], 'route,': [62], 'providing': [63], 'feasible': [64], 'access': [65], 'other': [67], 'KSNs': [68], 'analogues,': [70], 'thereby': [71], 'opening': [72], 'a': [73], 'new': [74, 77], 'avenue': [75], 'applications.': [78]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4367596256', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-09-15T03:36:04.030097', 'created_date': '2023-05-02'}