Inebilizumab Reduces Attack Risk Independent of Low Affinity IgG Fc Region Receptor III-A Gene Polymorphisms in Neuromyelitis Optica Spectrum Disorder (P13-5.015)

Name: Work Video:
Duration: 3 min 30 s
Brian G. Weinshenker; Jeffrey L. Bennett; Bruce Cree; Friedemann Paul; Jung Bin Kim; Hans‐Peter Hartung; Kristina Patterson; Michael Smith; William A. Rees; Dewei She; Orhan Aktaş
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'placebo,': [157], 'n=38)': [158], 'consented': [159], 'genotyping': [161], 'via': [162], 'TaqMan': [163], 'qPCR': [164], 'assay.': [165], '<h3>Results:</h3>': [166], 'V-allele': [167], 'carriers': [168], '(V-allele': [169], 'genotype': [170], '[V/V': [171], 'V/F],': [173], 'n=74)': [174], 'F/F–allele': [176], 'homozygotes': [177], '(n=68)': [178], 'did': [179, 227, 289], 'not': [180, 228, 290], 'demonstrate': [181, 291], 'significant': [183], 'difference': [184, 231], 'baseline': [186], 'demographics': [187], 'duration.': [190], 'Depletion': [191], 'CD20<sup>+</sup>': [193], 'B-cells': [194], 'similar': [196], 'V': [198, 251, 301], 'vs': [200, 206, 252], 'F/F': [201, 253, 278], '(0.6': [204], '(0.1–3.2)': [205], '1.3': [207], '(0.5–4.2)': [208], 'cells/μL': [209], 'end': [211], 'RCP)': [213], 'sustained': [216], 'both': [218], 'groups': [219], 'throughout': [220], 'duration': [222], 'study.': [225], 'We': [226], 'find': [229], 'any': [230], 'risk': [233], 'relapse': [235], '(OR': [236], '0.94': [237], '(0.39,': [238], '2.24))': [239], 'Expanded': [241], 'Disability': [242], 'Status': [243], 'Scale': [244], 'worsening': [245], '(OR:': [246], '1.55': [247], '(0.54,': [248], '4.70))': [249], 'Annualized': [256], 'attack': [257], 'rates': [258], '(Standard': [259], 'Error': [260], 'Mean': [263], '[SEM])': [264], 'patients': [266], 'V/V': [271], '0.00': [272], '(0.00),': [273], 'V/F': [274], '0.10': [275], '(0.04),': [276], '0.06': [279], '(0.03).': [280], '<h3>Conclusions:</h3>': [281], 'Inebilizumab': [282], 'treated': [283], 'differences': [292], 'clinical': [294], 'outcomes': [295], 'those': [297], 'genotypes.': [303], '<b>Disclosure:</b>': [304], 'Dr.': [305, 324, 343, 367, 392, 420, 448, 459, 475, 496, 519, 538, 556, 574, 593, 612, 630, 648, 666, 685, 704, 722, 740, 765, 789, 808, 827, 849, 860, 868, 884, 900, 921, 942, 964, 985, 1006, 1028, 1049, 1070, 1088, 1107, 1125, 1143, 1162, 1180, 1198, 1216, 1244, 1252, 1268, 1292, 1311, 1335, 1359, 1384, 1409, 1433, 1452, 1471, 1490, 1510, 1529, 1548, 1567, 1590, 1615, 1637, 1665, 1696, 1715, 1733, 1757, 1781, 1805, 1829, 1854, 1878, 1904, 1922, 2033, 2051, 2069, 2088, 2107, 2126, 2145, 2167, 2180, 2194], 'Weinshenker': [306, 325, 344, 368, 393, 421, 449, 460, 476, 497], 'has': [307, 326, 345, 369, 394, 422, 450, 461, 477, 498, 521, 540, 558, 576, 595, 614, 632, 650, 668, 687, 706, 724, 742, 767, 791, 810, 829, 851, 862, 870, 886, 902, 923, 944, 966, 987, 1008, 1030, 1051, 1072, 1090, 1109, 1127, 1145, 1164, 1182, 1200, 1218, 1246, 1254, 1270, 1294, 1313, 1337, 1361, 1386, 1411, 1435, 1454, 1473, 1492, 1512, 1531, 1550, 1569, 1592, 1617, 1639, 1667, 1698, 1717, 1735, 1759, 1783, 1807, 1831, 1856, 1880, 1906, 1924, 1931, 1937, 1951, 1965, 1977, 1989, 2005, 2021, 2035, 2053, 2071, 2090, 2109, 2128, 2147, 2169, 2182, 2196], 'received': [308, 327, 346, 370, 395, 423, 451, 462, 478, 499, 522, 541, 559, 577, 596, 615, 633, 651, 669, 688, 707, 725, 743, 768, 792, 811, 830, 852, 863, 871, 887, 903, 924, 945, 967, 988, 1009, 1031, 1052, 1073, 1091, 1110, 1128, 1146, 1165, 1183, 1201, 1219, 1247, 1255, 1271, 1295, 1314, 1338, 1362, 1387, 1412, 1436, 1455, 1474, 1493, 1513, 1532, 1551, 1570, 1593, 1618, 1640, 1668, 1699, 1718, 1736, 1760, 1784, 1808, 1832, 1857, 1881, 1907, 1938, 1952, 1966, 1978, 1990, 2006, 2022, 2036, 2054, 2072, 2091, 2110, 2129, 2148, 2170, 2183, 2197], 'personal': [309, 328, 347, 371, 396, 424, 479, 500, 523, 542, 560, 578, 597, 616, 634, 652, 670, 689, 708, 726, 744, 769, 793, 812, 831, 904, 925, 946, 968, 989, 1010, 1032, 1053, 1074, 1092, 1111, 1129, 1147, 1166, 1184, 1202, 1220, 1272, 1296, 1315, 1339, 1363, 1388, 1413, 1437, 1456, 1475, 1494, 1514, 1533, 1552, 1571, 1594, 1619, 1641, 1669, 1700, 1719, 1737, 1761, 1785, 1809, 1833, 1858, 1882, 1908, 1939, 1953, 2023, 2037, 2055, 2073, 2092, 2111, 2130, 2149], 'compensation': [310, 329, 348, 372, 397, 425, 480, 501, 524, 543, 561, 579, 598, 617, 635, 653, 671, 690, 709, 727, 745, 770, 794, 813, 832, 905, 926, 947, 969, 990, 1011, 1033, 1054, 1075, 1093, 1112, 1130, 1148, 1167, 1185, 1203, 1221, 1273, 1297, 1316, 1340, 1364, 1389, 1414, 1438, 1457, 1476, 1495, 1515, 1534, 1553, 1572, 1595, 1620, 1642, 1670, 1701, 1720, 1738, 1762, 1786, 1810, 1834, 1859, 1883, 1909, 1940, 1954, 2024, 2038, 2056, 2074, 2093, 2112, 2131, 2150], 'range': [313, 332, 351, 375, 400, 428, 483, 504, 527, 546, 564, 582, 601, 620, 638, 656, 674, 693, 712, 730, 748, 773, 797, 816, 835, 908, 929, 950, 972, 993, 1014, 1036, 1057, 1078, 1096, 1115, 1133, 1151, 1170, 1188, 1206, 1224, 1276, 1300, 1319, 1343, 1367, 1392, 1417, 1441, 1460, 1479, 1498, 1518, 1537, 1556, 1575, 1598, 1623, 1645, 1673, 1704, 1723, 1741, 1765, 1789, 1813, 1837, 1862, 1886, 2041, 2059, 2077, 2096, 2115, 2134, 2153], '$500-$4,999': [315, 334, 430, 485, 584, 603, 658, 676, 732, 750, 995, 1038, 1059, 1080, 1098, 1135, 1153, 1172, 1190, 1208, 1226, 1278, 1302, 1321, 1345, 1394, 1419, 1443, 1462, 1481, 1500, 1520, 1539, 1558, 1577, 1600, 1625, 1647, 1706, 1767, 1791, 1839, 1864, 1888, 2043, 2061, 2098, 2136, 2155], 'serving': [317, 336, 355, 379, 404, 432, 487, 508, 531, 550, 568, 586, 605, 624, 642, 660, 678, 697, 716, 734, 752, 777, 801, 820, 839, 912, 933, 954, 976, 997, 1018, 1040, 1061, 1082, 1100, 1119, 1137, 1155, 1174, 1192, 1210, 1228, 1280, 1304, 1323, 1347, 1371, 1396, 1421, 1445, 1464, 1483, 1502, 1522, 1541, 1560, 1579, 1602, 1627, 1649, 1677, 1708, 1727, 1745, 1769, 1793, 1817, 1841, 1866, 1890, 1911, 1942, 1956, 2026, 2045, 2063, 2081, 2100, 2119, 2138, 2157], 'as': [318, 337, 488, 509, 532, 551, 569, 587, 606, 625, 643, 661, 679, 698, 717, 735, 821, 840, 913, 934, 955, 977, 998, 1019, 1041, 1062, 1083, 1101, 1120, 1138, 1156, 1175, 1193, 1211, 1281, 1305, 1603, 1628, 1678, 1709, 1728, 1891, 1912, 1943, 1957, 2027, 2046, 2064], 'Consultant': [320, 339, 534, 553, 571, 589, 608, 627, 645, 663, 681, 700, 719, 737, 915, 936, 957, 979, 1000, 1021, 1043, 1064, 1085, 1103, 1122, 1140, 1158, 1177, 1195, 1213, 1283, 1307, 1630, 1711, 1730, 2048, 2066], 'Mitsubishi': [322, 683, 1285], 'Tanabe.': [323, 684], 'CANbridge': [341], 'Pharmaceuticals.': [342, 444], '$10,000-$49,999': [353, 377, 402, 529, 548, 622, 640, 775, 952, 974, 1725], 'Scientific': [358, 382, 407, 435, 755, 780, 1231, 1326, 1350, 1374, 1399, 1424, 1748, 1772, 1796, 1820, 1844, 1869], 'Advisory': [359, 383, 408, 436, 756, 781, 1232, 1327, 1351, 1375, 1400, 1425, 1610, 1685, 1749, 1773, 1797, 1821, 1845, 1870, 1898], 'Safety': [362, 386, 411, 439, 759, 784, 1235, 1330, 1354, 1378, 1403, 1428, 1752, 1776, 1800, 1824, 1848, 1873], 'Monitoring': [363, 387, 412, 440, 760, 785, 1236, 1331, 1355, 1379, 1404, 1429, 1753, 1777, 1801, 1825, 1849, 1874], 'board': [364, 388, 413, 441, 761, 786, 1237, 1332, 1356, 1380, 1405, 1430, 1754, 1778, 1802, 1826, 1850, 1875], 'Alexion.': [366, 555, 807, 867, 1087, 1334, 1528, 2050, 2087], 'Viela': [390, 1508, 1635, 1961, 1985], 'Bio.': [391, 611, 1106, 1509, 1636, 1962, 1986], 'Roche': [415], 'Group': [416, 2204], '(Chugai,': [417], 'Genentech,': [418], 'Roche).': [419], 'UCB': [443, 1407], 'institution': [446, 847, 858, 898, 919, 940, 962, 983, 1004, 1026, 1047, 1068, 1242, 1266, 1290, 1588, 2165, 2178, 2192], 'research': [452, 853, 864, 1248, 2171, 2184, 2198], 'support': [453, 854, 865, 1249, 2172, 2185, 2199], 'Guthy': [455], 'Jackson': [456], 'Charitable': [457], 'Foundation.': [458, 2176], 'intellectual': [463, 872, 1991, 2007], 'property': [464, 873, 1992, 2008], 'interests': [465, 874, 1993, 2009], 'discovery': [468, 877, 1996, 2012], 'technology': [470, 879, 1998, 2014], 'relating': [471, 880, 893, 1261, 1999, 2015], 'health': [473, 882, 895, 1263, 2001, 2017], 'care.': [474, 883, 896, 1264, 2002, 2018], 'speaker': [490, 511], 'internal': [492, 513], 'meeting': [493, 514], 'Genentech.': [495, 573, 1251], '$5,000-$9,999': [506, 566, 695, 714, 799, 818, 837, 910, 931, 1016, 1117, 1675, 1743, 1815, 2079, 2117], 'symposium': [516], 'Horizon.': [518, 1124, 2068, 2125], 'Bennett': [520, 539, 557, 575, 594, 613, 631, 649, 667, 686, 705, 723, 741, 766, 790, 809, 828, 850, 861, 869, 885], 'Horizon': [536, 1927, 1947, 1973, 2031], 'Therapeutics.': [537, 592, 1024, 1853, 1928, 1948, 1974, 2032], 'TG': [591, 1023, 1852], 'Reistone': [610], 'Roche.': [629, 788, 1358, 1547, 1877, 2106], 'Antigenomycs.': [647], 'Chugai.': [665], 'EMD': [702, 959], 'Serono.': [703, 960, 1586], 'MedEdicus.': [721], 'ImCyse.': [739], 'Clene': [763], 'Nanomedicine.': [764], 'Speakers': [804, 1448, 1467, 1486, 1505, 1525, 1544, 1563, 1582, 1652, 2084, 2103, 2122, 2141, 2160], 'Bureau': [805, 1449, 1468, 1487, 1506, 1526, 1545, 1564, 1583, 1653, 2085, 2104, 2123, 2142, 2161], 'Expert': [823, 842], 'Witness': [824, 843], 'Podoll.': [826], 'Patterson.': [845], 'Novartis.': [856, 981, 1470, 1756, 1780, 2144], 'publishing': [888, 1256], 'royalties': [889, 1257], 'publication': [892, 1260], 'Cree': [901, 922, 943, 965, 986, 1007, 1029, 1050, 1071, 1089, 1108, 1126, 1144, 1163, 1181, 1199, 1217, 1245, 1253], 'Atara.': [917], 'Biogen.': [938], 'Sanofi.': [1002, 2163], 'Autobahn.': [1045], 'Avotres.': [1066], 'Gossamer': [1105], 'Neuron23.': [1142], 'Boston': [1160], 'Pharma.': [1161, 1408], 'Hexal/Sandoz.': [1179], 'Siemens.': [1197], 'Therini.': [1215], 'Immunic': [1239], 'AG.': [1240], 'Paul': [1269, 1293, 1312, 1336, 1360, 1385, 1410, 1434, 1453, 1472, 1491, 1511, 1530, 1549, 1568, 1591], 'Tanabe': [1286], 'PC': [1287], '(MTPC).': [1288], 'Aarhus': [1309], 'University.': [1310], '$0-$499': [1369], 'Sanofi': [1382, 1662], 'Genzyme.': [1383], 'CELGENE.': [1432], 'Bayer.': [1451, 1828], 'ACRELION.': [1489], 'Pfizter.': [1566], 'Merck': [1585, 1659], 'Editor,': [1605, 1607, 1680, 1682, 1893, 1895], 'Associate': [1606, 1681, 1894], 'Editorial': [1609, 1684, 1897], 'Board': [1611, 1686, 1899], 'Member': [1612, 1687, 1900], 'Springer.': [1614], 'Kim': [1616, 1638, 1666], 'Aprilbio,': [1632], 'HanAll': [1633], 'BioPharma,': [1634], 'Alexion,': [1655], 'Biogen,': [1656], 'Celltrion,': [1657], 'Eisai,': [1658], 'Serono,': [1660], 'Novartis,': [1661], 'Genzyme,': [1663], 'Teva-Handok.': [1664], 'Multiple': [1689], 'Sclerosis': [1690], 'Journal,': [1691], 'Journal': [1692], 'Clinical': [1694], 'Neurology.': [1695, 1903], 'Hartung': [1697, 1716, 1734, 1758, 1782, 1806, 1830, 1855, 1879], 'BMS': [1713], 'Celgene.': [1714], 'Geneuro.': [1732], 'Merck.': [1804], 'Frontiers': [1902], 'Patterson': [1905, 1923], 'employee': [1914, 1945, 1959, 2029], 'Hospital': [1916], 'University': [1919], 'Pennsylvania.': [1921], 'stock': [1925, 1967, 1979], 'Michael': [1929], 'Smith': [1930], 'nothing': [1932], 'disclose.': [1934], 'William': [1935, 1949, 1963, 1975, 1987, 2003], 'Rees': [1936, 1950, 1964, 1976, 1988, 2004], 'ownership': [1970, 1982], 'interest': [1971, 1983], 'Dewei': [2019], 'She': [2020], 'Aktas': [2034, 2052, 2070, 2089, 2108, 2127, 2146, 2168, 2181, 2195], 'German': [2174, 2187], 'Research': [2175], 'Ministry': [2188], 'Science.': [2190], 'Neuromyelitis': [2201], 'Study': [2203], '(NEMOS).': [2205]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4367304064', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2025-01-09T23:31:49.266799', 'created_date': '2023-04-29'}
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