Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4366422903', 'doi': 'https://doi.org/10.1016/j.bcp.2023.115548', 'title': 'Selected cannabis terpenes synergize with THC to produce increased CB1 receptor activation', 'display_name': 'Selected cannabis terpenes synergize with THC to produce increased CB1 receptor activation', 'publication_year': 2023, 'publication_date': '2023-04-19', 'ids': {'openalex': 'https://openalex.org/W4366422903', 'doi': 'https://doi.org/10.1016/j.bcp.2023.115548', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37084981'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.bcp.2023.115548', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S185534594', 'display_name': 'Biochemical Pharmacology', 'issn_l': '0006-2952', 'issn': ['0006-2952', '1873-2968'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.bcp.2023.115548', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007083990', 'display_name': 'Noa Raz', 'orcid': 'https://orcid.org/0000-0001-6860-3826'}, 'institutions': [], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Noa Raz', 'raw_affiliation_strings': ['Bazelet Medical Cannabis Group, Or Akiva, Israel'], 'affiliations': [{'raw_affiliation_string': 'Bazelet Medical Cannabis Group, Or Akiva, Israel', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034775488', 'display_name': 'Aharon M. Eyal', 'orcid': None}, 'institutions': [], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Aharon M. Eyal', 'raw_affiliation_strings': ['Bazelet Medical Cannabis Group, Or Akiva, Israel'], 'affiliations': [{'raw_affiliation_string': 'Bazelet Medical Cannabis Group, Or Akiva, Israel', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058787495', 'display_name': 'Dana Berneman Zeitouni', 'orcid': None}, 'institutions': [], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Dana Berneman Zeitouni', 'raw_affiliation_strings': ['Bazelet Medical Cannabis Group, Or Akiva, Israel'], 'affiliations': [{'raw_affiliation_string': 'Bazelet Medical Cannabis Group, Or Akiva, Israel', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042868890', 'display_name': 'Danielle Hen-Shoval', 'orcid': 'https://orcid.org/0000-0002-6552-2227'}, 'institutions': [], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Danielle Hen-Shoval', 'raw_affiliation_strings': ['Bazelet Medical Cannabis Group, Or Akiva, Israel'], 'affiliations': [{'raw_affiliation_string': 'Bazelet Medical Cannabis Group, Or Akiva, Israel', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111913024', 'display_name': 'Elyad Davidson', 'orcid': None}, 'institutions': [], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Elyad M. Davidson', 'raw_affiliation_strings': ['Department of Anesthesiology, CCM and Pain Relief, Hadassah Hebrew University Hospital Jerusalem, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, CCM and Pain Relief, Hadassah Hebrew University Hospital Jerusalem, Israel', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027689715', 'display_name': 'Aviel Danieli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I164950643', 'display_name': 'Open University of Israel', 'ror': 'https://ror.org/027z64205', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I164950643']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Aviel Danieli', 'raw_affiliation_strings': ["Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel"], 'affiliations': [{'raw_affiliation_string': "Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel", 'institution_ids': ['https://openalex.org/I164950643']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068954530', 'display_name': 'Merav Tauber', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I164950643', 'display_name': 'Open University of Israel', 'ror': 'https://ror.org/027z64205', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I164950643']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Merav Tauber', 'raw_affiliation_strings': ["Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel"], 'affiliations': [{'raw_affiliation_string': "Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel", 'institution_ids': ['https://openalex.org/I164950643']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051205172', 'display_name': 'Yair Ben-Chaim', 'orcid': 'https://orcid.org/0000-0002-5639-6556'}, 'institutions': [{'id': 'https://openalex.org/I164950643', 'display_name': 'Open University of Israel', 'ror': 'https://ror.org/027z64205', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I164950643']}], 'countries': ['IL'], 'is_corresponding': True, 'raw_author_name': 'Yair Ben-Chaim', 'raw_affiliation_strings': ["Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel"], 'affiliations': [{'raw_affiliation_string': "Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel", 'institution_ids': ['https://openalex.org/I164950643']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5051205172'], 'corresponding_institution_ids': ['https://openalex.org/I164950643'], 'apc_list': {'value': 3700, 'currency': 'USD', 'value_usd': 3700, 'provenance': 'doaj'}, 'apc_paid': {'value': 3700, 'currency': 'USD', 'value_usd': 3700, 'provenance': 'doaj'}, 'fwci': 4.58, 'has_fulltext': False, 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.999896, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '212', 'issue': None, 'first_page': '115548', 'last_page': '115548'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10414', 'display_name': 'Cannabis and Cannabinoid Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10414', 'display_name': 'Cannabis and Cannabinoid Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9775, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13142', 'display_name': 'GABA and Rice Research', 'score': 0.9658, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/terpene', 'display_name': 'Terpene', 'score': 0.65129006}, {'id': 'https://openalex.org/keywords/tetrahydrocannabinol', 'display_name': 'Tetrahydrocannabinol', 'score': 0.5641646}], 'concepts': [{'id': 'https://openalex.org/C2777056318', 'wikidata': 'https://www.wikidata.org/wiki/Q79817', 'display_name': 'Cannabis', 'level': 2, 'score': 0.72189045}, {'id': 'https://openalex.org/C148001335', 'wikidata': 'https://www.wikidata.org/wiki/Q421237', 'display_name': 'Cannabinoid receptor', 'level': 4, 'score': 0.65427005}, {'id': 'https://openalex.org/C44937612', 'wikidata': 'https://www.wikidata.org/wiki/Q212364', 'display_name': 'Terpene', 'level': 2, 'score': 0.65129006}, {'id': 'https://openalex.org/C2780871563', 'wikidata': 'https://www.wikidata.org/wiki/Q422936', 'display_name': 'Cannabinoid', 'level': 3, 'score': 0.5972955}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5719135}, {'id': 'https://openalex.org/C2778563155', 'wikidata': 'https://www.wikidata.org/wiki/Q190067', 'display_name': 'Tetrahydrocannabinol', 'level': 4, 'score': 0.5641646}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49440312}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.455306}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3185949}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.18203908}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1814715}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.17018506}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002186', 'descriptor_name': 'Cannabinoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002188', 'descriptor_name': 'Cannabis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006213', 'descriptor_name': 'Hallucinogens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D063386', 'descriptor_name': 'Cannabinoid Receptor Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002186', 'descriptor_name': 'Cannabinoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002186', 'descriptor_name': 'Cannabinoids', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002188', 'descriptor_name': 'Cannabis', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013759', 'descriptor_name': 'Dronabinol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013759', 'descriptor_name': 'Dronabinol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043884', 'descriptor_name': 'Receptor, Cannabinoid, CB1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043885', 'descriptor_name': 'Receptor, Cannabinoid, CB2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013729', 'descriptor_name': 'Terpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013729', 'descriptor_name': 'Terpenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.bcp.2023.115548', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S185534594', 'display_name': 'Biochemical Pharmacology', 'issn_l': '0006-2952', 'issn': ['0006-2952', '1873-2968'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37084981', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.bcp.2023.115548', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S185534594', 'display_name': 'Biochemical Pharmacology', 'issn_l': '0006-2952', 'issn': ['0006-2952', '1873-2968'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.61, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320317241', 'funder_display_name': 'Open University of Israel', 'award_id': 'MT'}], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1484809697', 'https://openalex.org/W1627321564', 'https://openalex.org/W1886084954', 'https://openalex.org/W1929055273', 'https://openalex.org/W1973534594', 'https://openalex.org/W1983622758', 'https://openalex.org/W1995435438', 'https://openalex.org/W1997076138', 'https://openalex.org/W2019282049', 'https://openalex.org/W2027706303', 'https://openalex.org/W2035759650', 'https://openalex.org/W2050362005', 'https://openalex.org/W2057327972', 'https://openalex.org/W2059050046', 'https://openalex.org/W2062934002', 'https://openalex.org/W2119826244', 'https://openalex.org/W2148841660', 'https://openalex.org/W2157965341', 'https://openalex.org/W2166997091', 'https://openalex.org/W2199386566', 'https://openalex.org/W2590013388', 'https://openalex.org/W2622030582', 'https://openalex.org/W2655539838', 'https://openalex.org/W2769524427', 'https://openalex.org/W2789315705', 'https://openalex.org/W2807494230', 'https://openalex.org/W2886322003', 'https://openalex.org/W2889428989', 'https://openalex.org/W2890407376', 'https://openalex.org/W2897650757', 'https://openalex.org/W2904575308', 'https://openalex.org/W2960691480', 'https://openalex.org/W2964555159', 'https://openalex.org/W2971755357', 'https://openalex.org/W2985918245', 'https://openalex.org/W3003788473', 'https://openalex.org/W3010257381', 'https://openalex.org/W3010891685', 'https://openalex.org/W3013811158', 'https://openalex.org/W3014260934', 'https://openalex.org/W3015847218', 'https://openalex.org/W3025105292', 'https://openalex.org/W3034724295', 'https://openalex.org/W3040154603', 'https://openalex.org/W3048510910', 'https://openalex.org/W3092463427', 'https://openalex.org/W3152710445', 'https://openalex.org/W3189058011', 'https://openalex.org/W3206435422', 'https://openalex.org/W3211084842', 'https://openalex.org/W3217246882', 'https://openalex.org/W4200329633', 'https://openalex.org/W4224222991', 'https://openalex.org/W4224232139', 'https://openalex.org/W4304172347', 'https://openalex.org/W4306398990'], 'related_works': ['https://openalex.org/W4392167355', 'https://openalex.org/W4391565717', 'https://openalex.org/W4387331402', 'https://openalex.org/W2245953918', 'https://openalex.org/W2124754186', 'https://openalex.org/W2043406429', 'https://openalex.org/W2025759782', 'https://openalex.org/W2012942066', 'https://openalex.org/W2009732294', 'https://openalex.org/W1991461690'], 'abstract_inverted_index': {'The': [0, 22, 75, 96], 'cannabis': [1, 25, 64, 137, 207], 'plant': [2], 'exerts': [3], 'its': [4], 'pharmaceutical': [5], 'activity': [6, 108], 'primarily': [7], 'by': [8, 62, 67, 72, 93, 151, 164, 229], 'the': [9, 44, 57, 91, 107, 110, 136, 148, 159, 162, 165, 182, 185, 190, 194, 201, 206, 238], 'binding': [10], 'of': [11, 59, 90, 98, 100, 109, 161, 179, 181], 'cannabinoids': [12], 'to': [13, 55, 114, 129, 133], 'two': [14], 'G': [15], 'protein-coupled': [16], 'cannabinoid': [17], 'receptors,': [18, 86], 'CB1': [19, 60, 85, 111, 191], 'and': [20, 34, 71, 189, 244], 'CB2.': [21], 'role': [23], 'that': [24, 78], 'terpenes': [26, 65, 102, 183, 197], 'play': [27], 'in': [28, 135, 205], 'this': [29, 123], 'activation': [30, 58, 92, 149], 'has': [31], 'been': [32], 'considered': [33], 'debated': [35], 'repeatedly,': [36], 'based': [37], 'on': [38, 184], 'only': [39], 'limited': [40], 'experimental': [41], 'results.': [42], 'In': [43, 117], 'current': [45], 'study': [46], 'we': [47], 'used': [48], 'a': [49, 169, 176], 'controlled': [50], 'in-vitro': [51], 'heterologous': [52], 'expression': [53], 'system': [54], 'quantify': [56], 'receptors': [61], 'sixteen': [63], 'individually,': [66, 83], 'tetrahydrocannabinol': [68], '(THC)': [69], 'alone': [70], 'THC-terpenes': [73], 'mixtures.': [74], 'results': [76, 173], 'demonstrate': [77], 'all': [79], 'terpenes,': [80, 147], 'when': [81], 'tested': [82], 'activate': [84], 'at': [87, 127], 'about': [88], '10–50%': [89], 'THC': [94, 104, 115, 130, 188], 'alone.': [95, 116], 'combination': [97], 'some': [99, 118, 146, 180], 'these': [101], 'with': [103, 232], 'significantly': [105], 'increases': [106], 'receptor,': [112], 'compared': [113], 'cases,': [119], 'several': [120], 'fold.': [121], 'Importantly,': [122], 'amplification': [124], 'is': [125, 155, 216], 'evident': [126], 'terpene': [128, 143, 153], 'ratios': [131], 'similar': [132], 'those': [134], 'plant,': [138, 208], 'which': [139], 'reflect': [140], 'very': [141], 'low': [142], 'concentrations.': [144], 'For': [145, 221], 'obtained': [150], 'THC-': [152], 'mixtures': [154], 'notably': [156], 'greater': [157], 'than': [158], 'sum': [160], 'activations': [163], 'individual': [166], 'components,': [167], 'suggesting': [168], 'synergistic': [170], 'effect.': [171], 'Our': [172], 'strongly': [174], 'support': [175], 'modulatory': [177], 'effect': [178], 'interaction': [186], 'between': [187], 'receptor.': [192], 'As': [193], 'most': [195, 202], 'effective': [196], 'are': [198, 227], 'not': [199, 217], 'necessarily': [200, 218], 'abundant': [203], 'ones': [204], 'reaching': [209], '"whole': [210], 'plant"': [211], 'or': [212], '"full': [213], 'spectrum"': [214], 'composition': [215], 'an': [219], 'advantage.': [220], 'enhanced': [222], 'therapeutic': [223], 'effects,': [224], 'desired': [225, 242], 'compositions': [226, 236], 'attainable': [228], 'enriching': [230], 'extracts': [231], 'selected': [233], 'terpenes.': [234], 'These': [235], 'adjust': [237], 'treatment': [239], 'for': [240], 'various': [241], 'medicinal': [243], 'personal': [245], 'needs.': [246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4366422903', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 6}], 'updated_date': '2024-12-11T09:37:45.325012', 'created_date': '2023-04-21'}