Abstract 930: Treatment patterns and overall survival among men with metastatic castration-resistant prostate cancer harboring DDR mutations

Name: Work Video:
Duration: 3 min 30 s
David B. Solit; Niharika B. Mettu; Shannon J. McCall; Mallika Dhawan; Priyanka Bobbili; Maral DerSarkissian; Jasmina Ivanova; Bhakti Arondekar; Jane Chang; Alexander Niyazov; Jocelyn Lee; Risha Huq; Michelle Green; Michelle L. Turski; Aruna Muthukumar; Tracy Guo; Mei Sheng Duh; William Oh
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'therapy.': [104, 426], 'Data': [105], 'all': [107], 'lines': [109, 424], 'post-index': [112], 'were': [113, 131, 167, 260, 271, 317], 'collected.': [114], 'Outcomes': [115], 'reported': [116], 'include': [117], 'time': [118, 172], 'to': [119, 278], 'treatment': [120, 233, 395], 'discontinuation': [121], 'any': [123], 'reason': [124], '(TTTD)': [125], 'overall': [127, 474], 'survival': [128, 475], '(OS),': [129], 'which': [130], 'assessed': [132], 'using': [133], 'Kaplan-Meier': [134], 'analyses.': [135], 'Results': [136], 'response-related': [139], 'endpoints': [140], 'are': [141], 'forthcoming.': [142], 'Results:': [143], 'A': [144], 'total': [145], '138': [147], 'met': [151], 'inclusion': [153], 'criteria.': [154], 'mean': [156], 'age': [157], '68': [161], 'years,': [162], '76%': [164], 'White.': [168], 'median': [170], 'follow-up': [171], '27.1,': [174], '15.9,': [175], '11.3,': [176], '9.4': [178], 'months': [179, 327, 335, 344, 355, 366, 378], '1L,': [181, 279, 333, 364], '2L,': [182, 341, 375], '3L,': [183, 311], '4L+': [185], 'therapy,': [186], 'respectively.': [187], 'Common': [188, 201], 'sites': [189], 'metastases': [191], 'bone': [193], '(74%),': [194], 'lymph': [195], 'nodes': [196], '(69%),': [197], 'lungs': [199], '(10%).': [200], 'mutations': [204, 218, 485], 'CDK12': [206], '(48%),': [207], 'BRCA2': [208, 229], '(23%),': [209], 'ATM': [210], '(21%),': [211], 'BRCA1': [213], '(8%).': [214, 230], 'Assessment': [215], 'germline': [217], 'conducted': [220], '114': [222], '(83%)': [223], 'patients;': [224], 'most': [226, 261, 273], 'common': [227, 262], 'First-line': [231], '(1L)': [232], '119': [238], '(86%)': [239], 'patients,': [240], '2L': [241, 289, 305], '101': [243], '(73%),': [244], '3L': [246, 292], '75': [248], '(54%)': [249], 'patients.': [250, 322], 'Novel': [251], 'hormonal': [252], '(NHT;': [254], '55%)': [255], 'taxane': [257], 'chemotherapy': [258], '(20%)': [259], '1L.': [264], 'Enzalutamide': [265], '(35%)': [266], 'abiraterone': [268], 'acetate': [269], '(14%)': [270], 'frequently': [274], 'used': [275, 318], 'NHTs.': [276], 'Compared': [277], 'proportion': [281, 296], 'NHTs': [285], 'lower': [287], '(33%)': [290], '(17%),': [293], 'taxanes': [300], 'higher': [302], '(36%': [303], '31%': [307], '3L).': [309], 'In': [310], 'poly': [312], 'ADP-ribose': [313], 'polymerase': [314], '(PARP)': [315], 'inhibitors': [316], '21%': [320], 'Median': [323, 351], 'TTTD': [324], '5.6': [326], '(95%': [328, 336, 345, 356, 367, 379], 'CI:': [329, 337, 346, 357, 368, 380], '4.2,': [330], '7.2)': [331], '3.9': [334], '3.0,': [338], '4.6)': [339], '4.0': [343], '3.3,': [347], '4.7)': [348], '3L.': [350, 387], 'OS': [352], '36.3': [354], '30.7,': [358], '47.8)': [359], 'from': [360, 371, 383], 'start': [362, 373, 385], '21.1': [365], '15.6,': [369], '29.3)': [370], '14.1': [377], '9.5,': [381], '20.5)': [382], 'Conclusions:': [388], 'These': [389], 'findings': [390], 'provide': [391, 410], 'real-world': [392], 'insights': [393], 'patterns': [396, 472], 'harboring': [404, 483], 'Such': [407], 'insight': [408], 'may': [409], 'helpful': [412], 'benchmark': [413], 'research': [415], 'aimed': [416], 'improving': [418], 'outcomes,': [420], 'particularly': [421], 'later': [423], 'Citation': [427], 'Format:': [428], 'David': [429], 'B.': [430, 433], 'Solit,': [431], 'Niharika': [432], 'Mettu,': [434], 'Shannon': [435], 'J.': [436, 441], 'McCall,': [437], 'Mallika': [438], 'Dhawan,': [439], 'Priyanka': [440], 'Bobbili,': [442], 'Maral': [443], 'DerSarkissian,': [444], 'Jasmina': [445], 'Ivanova,': [446], 'Bhakti': [447], 'Arondekar,': [448], 'Jane': [449], 'Chang,': [450], 'Alexander': [451], 'Niyazov,': [452], 'Jocelyn': [453], 'Lee,': [454], 'Risha': [455], 'Huq,': [456], 'Michelle': [457, 459], 'Green,': [458], 'Turski,': [460], 'Aruna': [461], 'Muthukumar,': [462], 'Tracy': [463], 'Guo,': [464], 'Mei': [465], 'Sheng': [466], 'Duh,': [467], 'William': [468], 'K.': [469], 'Oh.': [470], 'Treatment': [471], '[abstract].': [486], 'In:': [487], 'Proceedings': [488], 'Annual': [496], 'Meeting': [497], '2023;': [498], 'Part': [499], '1': [500], '(Regular': [501], 'Invited': [503], 'Abstracts);': [504], '2023': [505], 'Apr': [506], '14-19;': [507], 'Orlando,': [508], 'FL.': [509], 'Philadelphia': [510], '(PA):': [511], 'AACR;': [512], 'Res': [514], '2023;83(7_Suppl):Abstract': [515], 'nr': [516], '930.': [517]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4362595147', 'counts_by_year': [], 'updated_date': '2024-12-15T09:38:22.074253', 'created_date': '2023-04-06'}
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