Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4362593105', 'doi': 'https://doi.org/10.1158/1538-7445.am2023-3275', 'title': 'Abstract 3275: Combination of talimogene laherparepvec (T-VEC) with pembrolizumab (pembro) in advanced melanoma patients following progression on a prior PD-1 inhibitor: SWOG S1607', 'display_name': 'Abstract 3275: Combination of talimogene laherparepvec (T-VEC) with pembrolizumab (pembro) in advanced melanoma patients following progression on a prior PD-1 inhibitor: SWOG S1607', 'publication_year': 2023, 'publication_date': '2023-04-04', 'ids': {'openalex': 'https://openalex.org/W4362593105', 'doi': 'https://doi.org/10.1158/1538-7445.am2023-3275'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2023-3275', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062344802', 'display_name': 'Siwen Hu‐Lieskovan', 'orcid': 'https://orcid.org/0000-0001-5836-4710'}, 'institutions': [{'id': 'https://openalex.org/I2801159745', 'display_name': 'Huntsman Cancer Institute', 'ror': 'https://ror.org/03v7tx966', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801159745', 'https://openalex.org/I4210148268']}, {'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Siwen Hu-Lieskovan', 'raw_affiliation_strings': ['1University of Utah Huntsman Cancer Institute, Salt Lake City, UT;'], 'affiliations': [{'raw_affiliation_string': '1University of Utah Huntsman Cancer Institute, Salt Lake City, UT;', 'institution_ids': ['https://openalex.org/I2801159745', 'https://openalex.org/I223532165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055015137', 'display_name': 'James J. Moon', 'orcid': 'https://orcid.org/0000-0001-8246-931X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'James Moon', 'raw_affiliation_strings': ['2SWOG Statistics and Data Management Center, Seattle, WA;'], 'affiliations': [{'raw_affiliation_string': '2SWOG Statistics and Data Management Center, Seattle, WA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002699089', 'display_name': 'John Hyngstrom', 'orcid': 'https://orcid.org/0000-0002-4833-3838'}, 'institutions': [{'id': 'https://openalex.org/I2801159745', 'display_name': 'Huntsman Cancer Institute', 'ror': 'https://ror.org/03v7tx966', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801159745', 'https://openalex.org/I4210148268']}, {'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John Hyngstrom', 'raw_affiliation_strings': ['1University of Utah Huntsman Cancer Institute, Salt Lake City, UT;'], 'affiliations': [{'raw_affiliation_string': '1University of Utah Huntsman Cancer Institute, Salt Lake City, UT;', 'institution_ids': ['https://openalex.org/I2801159745', 'https://openalex.org/I223532165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052134884', 'display_name': 'Katie M. Campbell', 'orcid': 'https://orcid.org/0000-0001-6491-4432'}, 'institutions': [{'id': 'https://openalex.org/I4390039293', 'display_name': 'UCLA Jonsson Comprehensive Cancer Center', 'ror': 'https://ror.org/0599cs764', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799798094', 'https://openalex.org/I4390039293']}], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Katie M. Campbell', 'raw_affiliation_strings': ['3UCLA Johnson Comprehensive Cancer Center, Los Angeles, CA;'], 'affiliations': [{'raw_affiliation_string': '3UCLA Johnson Comprehensive Cancer Center, Los Angeles, CA;', 'institution_ids': ['https://openalex.org/I4390039293']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001155783', 'display_name': 'Gino K. In', 'orcid': 'https://orcid.org/0000-0002-7060-5123'}, 'institutions': [{'id': 'https://openalex.org/I1174212', 'display_name': 'University of Southern California', 'ror': 'https://ror.org/03taz7m60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1174212']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gino K. In', 'raw_affiliation_strings': ['4University of Southern California (USC) Norris Comprehensive Cancer Center, Los Angeles, CA;'], 'affiliations': [{'raw_affiliation_string': '4University of Southern California (USC) Norris Comprehensive Cancer Center, Los Angeles, CA;', 'institution_ids': ['https://openalex.org/I1174212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103165801', 'display_name': 'Theodore F. Logan', 'orcid': 'https://orcid.org/0000-0002-9245-0820'}, 'institutions': [{'id': 'https://openalex.org/I1283055418', 'display_name': 'Indiana University Health', 'ror': 'https://ror.org/01aaptx40', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283055418', 'https://openalex.org/I4388446366', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I4390039234', 'display_name': 'Indiana University Melvin and Bren Simon Comprehensive Cancer Center', 'ror': 'https://ror.org/00g1d7b60', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4390039234', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Theodore F. Logan', 'raw_affiliation_strings': ['5Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN;'], 'affiliations': [{'raw_affiliation_string': '5Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN;', 'institution_ids': ['https://openalex.org/I1283055418', 'https://openalex.org/I55769427', 'https://openalex.org/I4390039234']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045110376', 'display_name': 'Kari Kendra', 'orcid': 'https://orcid.org/0000-0001-5936-6689'}, 'institutions': [{'id': 'https://openalex.org/I4210106879', 'display_name': 'Ohio University', 'ror': 'https://ror.org/01jr3y717', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210106879']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kari L. Kendra', 'raw_affiliation_strings': ['6Ohio State University, Columbus, OH;'], 'affiliations': [{'raw_affiliation_string': '6Ohio State University, Columbus, OH;', 'institution_ids': ['https://openalex.org/I4210106879']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084576835', 'display_name': 'Ding M. Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210090317', 'display_name': 'The Barbara Ann Karmanos Cancer Institute', 'ror': 'https://ror.org/00ee40h97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2800590384', 'https://openalex.org/I4210090317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ding M. Wang', 'raw_affiliation_strings': ['7Henry Ford Cancer Institute, Detroit, MI;'], 'affiliations': [{'raw_affiliation_string': '7Henry Ford Cancer Institute, Detroit, MI;', 'institution_ids': ['https://openalex.org/I4210090317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025067315', 'display_name': 'Douglas B. Johnson', 'orcid': 'https://orcid.org/0000-0002-6390-773X'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Douglas B. Johnson', 'raw_affiliation_strings': ['8Vanderbilt University, Nashville, TN;'], 'affiliations': [{'raw_affiliation_string': '8Vanderbilt University, Nashville, TN;', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085936753', 'display_name': 'Gary C. Doolittle', 'orcid': 'https://orcid.org/0000-0002-9141-449X'}, 'institutions': [{'id': 'https://openalex.org/I4210097601', 'display_name': 'The University of Kansas Cancer Center', 'ror': 'https://ror.org/00cj35179', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097601']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gary C. Doolittle', 'raw_affiliation_strings': ['9The Kansas University Cancer Center, Kansas City, KS;'], 'affiliations': [{'raw_affiliation_string': '9The Kansas University Cancer Center, Kansas City, KS;', 'institution_ids': ['https://openalex.org/I4210097601']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076269626', 'display_name': 'Alan Tan', 'orcid': 'https://orcid.org/0000-0001-5925-8565'}, 'institutions': [{'id': 'https://openalex.org/I179638627', 'display_name': 'Cancer Treatment Centers of America', 'ror': 'https://ror.org/045ns1x37', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I179638627']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alan Tan', 'raw_affiliation_strings': ['10Cancer Treatment Centers of America, Phoenix, AZ;'], 'affiliations': [{'raw_affiliation_string': '10Cancer Treatment Centers of America, Phoenix, AZ;', 'institution_ids': ['https://openalex.org/I179638627']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041474007', 'display_name': 'Ann W. Silk', 'orcid': 'https://orcid.org/0000-0003-3877-3984'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ann W. Silk', 'raw_affiliation_strings': ['11Dana-Farber Cancer Institute, Boston, MA;'], 'affiliations': [{'raw_affiliation_string': '11Dana-Farber Cancer Institute, Boston, MA;', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073549408', 'display_name': 'Kenneth F. Grossmann', 'orcid': 'https://orcid.org/0000-0002-8523-7407'}, 'institutions': [{'id': 'https://openalex.org/I2801159745', 'display_name': 'Huntsman Cancer Institute', 'ror': 'https://ror.org/03v7tx966', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801159745', 'https://openalex.org/I4210148268']}, {'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenneth F. Grossmann', 'raw_affiliation_strings': ['1University of Utah Huntsman Cancer Institute, Salt Lake City, UT;'], 'affiliations': [{'raw_affiliation_string': '1University of Utah Huntsman Cancer Institute, Salt Lake City, UT;', 'institution_ids': ['https://openalex.org/I2801159745', 'https://openalex.org/I223532165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042631007', 'display_name': 'Christopher W. Ryan', 'orcid': 'https://orcid.org/0000-0002-4259-1123'}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher W. Ryan', 'raw_affiliation_strings': ['12Oregon Health & Science University, Portland, OR;'], 'affiliations': [{'raw_affiliation_string': '12Oregon Health & Science University, Portland, OR;', 'institution_ids': ['https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035218748', 'display_name': 'Sapna P. Patel', 'orcid': 'https://orcid.org/0000-0003-1339-1517'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sapna P. Patel', 'raw_affiliation_strings': ['13MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '13MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034942361', 'display_name': 'Shay Bellasea', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shay Bellasea', 'raw_affiliation_strings': ['2SWOG Statistics and Data Management Center, Seattle, WA;'], 'affiliations': [{'raw_affiliation_string': '2SWOG Statistics and Data Management Center, Seattle, WA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000129649', 'display_name': 'Michael C. Wu', 'orcid': 'https://orcid.org/0000-0002-3357-6570'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Michael C. Wu', 'raw_affiliation_strings': ['2SWOG Statistics and Data Management Center, Seattle, WA;'], 'affiliations': [{'raw_affiliation_string': '2SWOG Statistics and Data Management Center, Seattle, WA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007239425', 'display_name': 'John M. Kirkwood', 'orcid': 'https://orcid.org/0000-0002-3570-4476'}, 'institutions': [{'id': 'https://openalex.org/I4210134769', 'display_name': 'University of Pittsburgh Medical Center', 'ror': 'https://ror.org/04ehecz88', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098814', 'https://openalex.org/I4210134769']}, {'id': 'https://openalex.org/I4210128526', 'display_name': 'UPMC Hillman Cancer Center', 'ror': 'https://ror.org/03bw34a45', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I170201317', 'https://openalex.org/I4210128526']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John M. Kirkwood', 'raw_affiliation_strings': ['14University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA;'], 'affiliations': [{'raw_affiliation_string': '14University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA;', 'institution_ids': ['https://openalex.org/I4210134769', 'https://openalex.org/I4210128526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110476583', 'display_name': 'Helen X. Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Helen X. Chen', 'raw_affiliation_strings': ['15National Cancer Institute Cancer Therapy Evaluation Program, Bethesda, MD.'], 'affiliations': [{'raw_affiliation_string': '15National Cancer Institute Cancer Therapy Evaluation Program, Bethesda, MD.', 'institution_ids': ['https://openalex.org/I4210140884']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083745558', 'display_name': 'Antoni Ribas', 'orcid': 'https://orcid.org/0000-0003-3669-8458'}, 'institutions': [{'id': 'https://openalex.org/I4390039293', 'display_name': 'UCLA Jonsson Comprehensive Cancer Center', 'ror': 'https://ror.org/0599cs764', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799798094', 'https://openalex.org/I4390039293']}], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Antoni Ribas', 'raw_affiliation_strings': ['3UCLA Johnson Comprehensive Cancer Center, Los Angeles, CA;'], 'affiliations': [{'raw_affiliation_string': '3UCLA Johnson Comprehensive Cancer Center, Los Angeles, CA;', 'institution_ids': ['https://openalex.org/I4390039293']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 18, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.168, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.99996, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 84, 'max': 88}, 'biblio': {'volume': '83', 'issue': '7_Supplement', 'first_page': '3275', 'last_page': '3275'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.50735134}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.82466596}, {'id': 'https://openalex.org/C72563966', 'wikidata': 'https://www.wikidata.org/wiki/Q1303415', 'display_name': 'Cohort', 'level': 2, 'score': 0.69492835}, {'id': 'https://openalex.org/C2780057760', 'wikidata': 'https://www.wikidata.org/wiki/Q13896859', 'display_name': 'Pembrolizumab', 'level': 4, 'score': 0.6586028}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.52155614}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.50735134}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5026531}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43300462}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.41127092}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.32433742}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.2655582}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.21535268}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.11770743}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2023-3275', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4221123017', 'https://openalex.org/W4200023723', 'https://openalex.org/W3041652591', 'https://openalex.org/W3037068108', 'https://openalex.org/W2945780494', 'https://openalex.org/W2891524425', 'https://openalex.org/W2585407512', 'https://openalex.org/W2517747645', 'https://openalex.org/W2062691140', 'https://openalex.org/W2059423835'], 'abstract_inverted_index': {'Abstract': [0], 'We': [1], 'hypothesize': [2], 'that': [3], 'a': [4, 40, 130, 562], 'significant': [5], 'number': [6], 'of': [7, 46, 180, 296, 548, 571], 'patients': [8, 51, 103, 115, 176, 259, 283, 298, 558], 'do': [9], 'not': [10, 117, 264], 'respond': [11], 'to': [12, 75, 171], 'PD-1/L1': [13, 56], 'blockade': [14], 'because': [15], 'there': [16, 229], 'are': [17, 149, 164, 248], 'no': [18, 222], 'pre-existing': [19], 'tumor': [20, 254], 'antigen-specific': [21], 'T-cells,': [22], 'and': [23, 93, 98, 137, 146, 153, 159, 211, 584], 'this': [24, 239], 'can': [25], 'be': [26, 76], 'addressed': [27], 'by': [28, 64], 'combination': [29], 'therapy': [30, 290], 'with': [31, 52, 129, 195, 221, 552], 'an': [32, 125], 'oncolytic': [33], 'virus': [34], 'such': [35], 'as': [36], 'T-VEC.': [37], 'S1607': [38, 567], 'is': [39, 62, 273], 'single': [41], 'arm': [42], 'Phase': [43], '2': [44, 172, 235, 426, 434, 446], 'study': [45, 272], 'T-VEC': [47, 136, 278], 'plus': [48, 279], 'pembro': [49, 138, 280], 'in': [50, 89, 112, 250, 260, 281, 293, 345, 451, 485, 555], 'advanced': [53, 556], 'melanoma': [54, 282, 297, 557], 'after': [55, 217], 'inhibitor': [57], 'progression.': [58], 'The': [59], 'primary': [60], 'endpoint': [61], 'ORR': [63, 88, 242], 'modified': [65], 'RECIST': [66], '(progression': [67], 'at': [68, 106, 151], 'the': [69, 184, 294, 572], 'first': [70], 'follow-up': [71], 'disease': [72], 'assessment': [73], 'had': [74, 124], 'confirmed).': [77], 'Secondary': [78], 'endpoints': [79], 'include': [80], 'durable': [81], 'response': [82, 336], 'rate': [83], '(response': [84], '≥': [85], '6': [86, 362], 'months),': [87], 'injected,': [90], 'non-visceral': [91, 301], 'non-injected,': [92], 'visceral': [94, 110, 120], 'lesions,': [95], 'PFS,': [96], 'OS': [97], 'toxicity.': [99], 'In': [100, 225], 'Cohort': [101, 113, 213, 226, 261, 305, 308], 'A': [102, 214, 306], 'must': [104, 116], 'have': [105, 118, 285, 300], 'least': [107], 'one': [108], 'measurable': [109], 'lesion;': [111], 'B': [114, 227, 262], 'any': [119], 'lesions.': [121], 'Each': [122], 'cohort': [123], 'independent': [126], 'accrual': [127], 'goal': [128], '2-stage': [131], 'design.': [132], 'All': [133], 'received': [134], 'intratumoral': [135], '200mg': [139], 'IV': [140], 'every': [141, 166], '21': [142], 'days.': [143], 'Tumor': [144, 162], 'biopsy': [145], 'research': [147], 'blood': [148], 'taken': [150], 'baseline': [152], 'on': [154, 287, 561], 'Day': [155], '28': [156, 189], '(both': [157], 'injected': [158], 'non-injected': [160], 'lesions).': [161], 'assessments': [163], 'performed': [165], '12': [167], 'weeks': [168], 'for': [169, 275, 575], 'up': [170, 187], 'years.': [173], '38': [174], 'evaluable': [175], 'were': [177, 230, 263], 'enrolled.': [178], 'As': [179], 'July': [181], '26,': [182], '2022,': [183], 'median': [185], 'follow': [186], 'was': [188, 192, 215], 'months.': [190], 'Treatment': [191], 'well': [193], 'tolerated,': [194], '5/38': [196], '(13%)': [197], 'grade': [198, 202], '3': [199, 389, 425], 'AE': [200], '(no': [201], '4/5)': [203], 'including': [204], 'injection': [205], 'site': [206], 'reactions,': [207], 'lymphocyte': [208], 'count': [209], 'decrease,': [210], 'hypoxia.': [212], 'closed': [216], 'stage': [218], 'I': [219], '(n=11)': [220], 'confirmed': [223, 232], 'responses.': [224], '(n=27),': [228], '7': [231, 323, 480], 'responses': [233], '(26%;': [234, 324, 402], 'CR,': [236], '5': [237, 401, 468], 'PR;': [238], 'rejected': [240], 'H0:': [241], '=': [243], '10%,': [244], 'p=0.01).': [245], 'Clinical': [246], 'outcomes': [247], 'summarized': [249], 'Table': [251, 303], '1.': [252], 'Baseline': [253], 'mutational': [255], 'burden': [256], 'from': [257], '17': [258], 'different': [265], 'between': [266], 'responder': [267], 'vs': [268], 'non-responders': [269], '(p=0.96).': [270], 'Translational': [271], 'ongoing': [274], 'pharmacodynamic': [276], 'confirmation.': [277], 'who': [284, 299], 'progressed': [286], 'prior': [288, 563], 'anti-PD1/L1': [289], 'has': [291], 'efficacy': [292], 'subset': [295], 'metastases.': [302], '1': [304, 329, 371, 420, 477, 582], '(Visceral)': [307], 'B(Non-Visceral)': [309], 'N': [310], '(%;': [311], '95%': [312], 'CI)': [313], '11': [314, 353, 406], '27': [315, 354], 'Confirmed': [316, 326, 355, 365, 382, 392, 407, 414, 427, 437, 461, 471], 'PR': [317, 356, 368, 383, 395, 408, 417, 428, 440, 462, 474], '+': [318, 327, 357, 366, 369, 384, 393, 396, 409, 415, 418, 429, 438, 441, 463, 472, 475], 'CR': [319, 358, 370, 385, 397, 410, 419, 430, 442, 464, 476], '0': [320, 337, 359, 386, 398, 411, 431, 443, 465], '(0%;': [321, 338, 360, 387, 399, 412, 432, 444, 466], '0%-28%)': [322, 339, 361, 413], '11%-46%)': [325], 'Unconfirmed': [328], '(9%;': [330, 372, 421], '0%-41%)': [331, 373, 422], '9': [332], '(33%;': [333], '17%-54%)': [334], 'Durable': [335], '4': [340], '(15%;': [341], '4%-34%)': [342], 'Median': [343, 449, 483], 'PFS': [344, 450, 484], 'months': [346, 452, 486], '2.1': [347, 453, 489], '(0.7-5.5)': [348], '2.3': [349], '(1.9-6.2)': [350], 'INJECTED': [351], 'LESIONS': [352, 379, 405], '(22%;': [363], '9%-42%)': [364], 'Unconfirmed,': [367, 394, 416, 439, 473], '8': [374, 380, 459], '(30%;': [375], '14%-50%)': [376], 'NON-INJECTED,': [377], 'NON-VISCERAL': [378], '19': [381], '0%-37%)': [388, 400, 467], '(16%;': [390], '3%-40%)': [391], '9%-51%)': [403], 'VISCERAL': [404], 'ACQUIRED': [423], 'RESISTANCE': [424, 458], '0%-71%)': [433, 445], '(100%;': [435, 447], '16%-100%)': [436, 448], '(2.0-4.1)': [454], 'NR': [455], '(8.0-∞)': [456], 'PRIMARY': [457], '25': [460], '(20%;': [469], '7%-41%)': [470], '(13%;': [478], '0%-53%)': [479], '(28%;': [481], '12%-49%)': [482], '1.8': [487], '(0.3-6.2)': [488], '(1.9-3.3)': [490], 'Citation': [491], 'Format:': [492], 'Siwen': [493], 'Hu-Lieskovan,': [494], 'James': [495], 'Moon,': [496], 'John': [497, 539], 'Hyngstrom,': [498], 'Katie': [499], 'M.': [500, 512, 540], 'Campbell,': [501], 'Gino': [502], 'K.': [503], 'In,': [504], 'Theodore': [505], 'F.': [506, 526], 'Logan,': [507], 'Kari': [508], 'L.': [509], 'Kendra,': [510], 'Ding': [511], 'Wang,': [513], 'Douglas': [514], 'B.': [515], 'Johnson,': [516], 'Gary': [517], 'C.': [518, 537], 'Doolittle,': [519], 'Alan': [520], 'Tan,': [521], 'Ann': [522], 'W.': [523, 529], 'Silk,': [524], 'Kenneth': [525], 'Grossmann,': [527], 'Christopher': [528], 'Ryan,': [530], 'Sapna': [531], 'P.': [532], 'Patel,': [533], 'Shay': [534], 'Bellasea,': [535], 'Michael': [536], 'Wu,': [538], 'Kirkwood,': [541], 'Helen': [542], 'X.': [543], 'Chen,': [544], 'Antoni': [545], 'Ribas.': [546], 'Combination': [547], 'talimogene': [549], 'laherparepvec': [550], '(T-VEC)': [551], 'pembrolizumab': [553], '(pembro)': [554], 'following': [559], 'progression': [560], 'PD-1': [564], 'inhibitor:': [565], 'SWOG': [566], '[abstract].': [568], 'In:': [569], 'Proceedings': [570], 'American': [573], 'Association': [574], 'Cancer': [576, 595], 'Research': [577], 'Annual': [578], 'Meeting': [579], '2023;': [580], 'Part': [581], '(Regular': [583], 'Invited': [585], 'Abstracts);': [586], '2023': [587], 'Apr': [588], '14-19;': [589], 'Orlando,': [590], 'FL.': [591], 'Philadelphia': [592], '(PA):': [593], 'AACR;': [594], 'Res': [596], '2023;83(7_Suppl):Abstract': [597], 'nr': [598], '3275.': [599]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4362593105', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-12-24T21:02:30.053726', 'created_date': '2023-04-06'}