Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4362543665', 'doi': 'https://doi.org/10.1158/1538-7445.am2023-1256', 'title': 'Abstract 1256: Transglutaminase-2 is elevated in the invasive cell state and modulates the tumor immune microenvironment in cutaneous melanoma', 'display_name': 'Abstract 1256: Transglutaminase-2 is elevated in the invasive cell state and modulates the tumor immune microenvironment in cutaneous melanoma', 'publication_year': 2023, 'publication_date': '2023-04-04', 'ids': {'openalex': 'https://openalex.org/W4362543665', 'doi': 'https://doi.org/10.1158/1538-7445.am2023-1256'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2023-1256', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067328803', 'display_name': 'Signe Caksa', 'orcid': 'https://orcid.org/0000-0002-0133-0015'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Signe Caksa', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051077512', 'display_name': 'Nicole A. Wilski', 'orcid': 'https://orcid.org/0000-0003-0285-0853'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicole A. Wilski', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075178927', 'display_name': 'Erica Kitterman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Erica L. Kitterman', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005614588', 'display_name': 'McKenna Q. Glasheen', 'orcid': 'https://orcid.org/0000-0001-5651-2345'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'McKenna Q. Glasheen', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054672145', 'display_name': 'Jacob S. Heilizer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jacob S. Heilizer', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085398803', 'display_name': 'Timothy J. Purwin', 'orcid': 'https://orcid.org/0000-0002-7053-8039'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Timothy J. Purwin', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008451208', 'display_name': 'Claudia Capparelli', 'orcid': 'https://orcid.org/0000-0001-9834-8539'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Claudia Capparelli', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062746446', 'display_name': 'Andrew E. Aplin', 'orcid': 'https://orcid.org/0000-0002-2734-3244'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew E. Aplin', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA.'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA.', 'institution_ids': ['https://openalex.org/I149251103']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 68}, 'biblio': {'volume': '83', 'issue': '7_Supplement', 'first_page': '1256', 'last_page': '1256'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11721', 'display_name': 'Blood properties and coagulation', 'score': 0.985, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11721', 'display_name': 'Blood properties and coagulation', 'score': 0.985, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/microphthalmia-associated-transcription-factor', 'display_name': 'Microphthalmia-associated transcription factor', 'score': 0.4340679}], 'concepts': [{'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.76941454}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.7088353}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.66959083}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6077348}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.5764241}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.5513357}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.5461456}, {'id': 'https://openalex.org/C177504595', 'wikidata': 'https://www.wikidata.org/wiki/Q336500', 'display_name': 'Microphthalmia-associated transcription factor', 'level': 4, 'score': 0.4340679}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.42456692}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.34578454}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.29668096}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2023-1256', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.7, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4247833810', 'https://openalex.org/W4242240318', 'https://openalex.org/W3127487613', 'https://openalex.org/W3048105303', 'https://openalex.org/W2908056899', 'https://openalex.org/W2904239912', 'https://openalex.org/W2110517464', 'https://openalex.org/W2062767635', 'https://openalex.org/W1968932537', 'https://openalex.org/W1595732636'], 'abstract_inverted_index': {'Abstract': [0], 'Cutaneous': [1], 'melanoma': [2, 55, 77, 112, 117, 126, 186, 205, 280, 305, 364], 'is': [3, 51, 103, 159, 299, 308, 349], 'the': [4, 39, 82, 107, 149, 170, 191, 196, 228, 243, 249, 277, 303, 311, 322, 352, 358, 369], 'most': [5], 'fatal': [6], 'skin': [7], 'cancer;': [8], 'resistance': [9, 20], 'to': [10, 14, 36, 53, 61, 81, 211, 219, 224, 276, 288], 'targeted': [11, 289], 'therapies': [12], 'contributes': [13], 'poor': [15], 'prognosis.': [16], 'In': [17], 'some': [18], 'cases,': [19], 'arises': [21], 'from': [22, 58], 'pre-existing': [23], 'tumor': [24, 171, 250, 359], 'heterogeneity,': [25], 'which': [26, 261], 'allows': [27], 'subpopulations': [28], 'of': [29, 41, 45, 84, 92, 122, 143, 151, 193, 232, 245, 263, 368], 'drug-tolerant': [30, 64], 'cells': [31, 163, 235, 266, 269, 320], 'with': [32, 181], 'distinct': [33], 'transcriptional': [34], 'states': [35], 'survive': [37], 'in': [38, 73, 106, 111, 124, 185, 202, 213, 227, 242, 248, 291, 302, 321, 351, 362], 'presence': [40], 'drug.': [42], 'The': [43], 'loss': [44], 'SOX10,': [46], 'a': [47, 59, 87, 240], 'lineage-specific': [48], 'transcription': [49, 313], 'factor,': [50, 314], 'known': [52], 'drive': [54], 'phenotype': [56], 'switching': [57], 'proliferative': [60], 'an': [62, 225], 'invasive': [63, 108, 304, 353], 'state.': [65], 'Here,': [66], 'we': [67, 155, 198], 'found': [68, 156], 'that': [69, 101, 141, 157, 166, 176, 297], 'knocking': [70], 'out': [71], 'SOX10': [72, 123, 312], 'human': [74], 'and': [75, 96, 115, 135, 164, 208, 230, 236, 239, 267, 282, 315, 356, 381], 'mouse': [76, 204], 'cell': [78, 109, 113, 206, 306, 354], 'lines': [79, 114, 207], 'leads': [80], 'upregulation': [83], 'transglutaminase-2': [85], '(TGM2),': [86], 'calcium-dependent': [88], 'cross-linking': [89], 'enzyme.': [90], 'Analysis': [91], 'publicly': [93], 'available': [94], 'bulk': [95], 'single-cell': [97], 'RNA-sequencing': [98], 'data': [99, 295], 'showed': [100, 140], 'TGM2': [102, 129, 144, 158, 177, 194, 284, 298], 'highly': [104, 300], 'expressed': [105, 301], 'state': [110, 355], 'patient-derived': [116, 125], 'cultures,': [118], 'respectively.': [119], 'Furthermore,': [120], 'knockdown': [121, 142], 'cultures': [127], 'increases': [128], 'mRNA': [130], 'expression.': [131], '3D': [132], 'spheroid': [133], 'assays': [134, 139], 'extracellular': [136], 'matrix': [137], 'production/remodeling': [138], 'has': [145, 178], 'no': [146], 'effect': [147, 192], 'on': [148, 195], 'invasiveness': [150], 'SOX10-deficient': [152, 162], 'cells.': [153], 'However,': [154], 'secreted': [160], 'by': [161, 253, 310], 'hypothesized': [165], 'it': [167], 'could': [168], 'modulate': [169, 317], 'immune': [172, 183, 251, 319, 360], 'microenvironment': [173, 361], '(TIME)': [174], 'given': [175], 'been': [179], 'associated': [180], 'increased': [182], 'infiltration': [184], 'patient': [187], 'samples.': [188], 'To': [189], 'investigate': [190], 'TIME,': [197], 'stably': [199], 'overexpressed': [200], 'TGM2/Tgm2': [201], 'syngeneic': [203], 'allowed': [209], 'tumors': [210], 'grow': [212], 'immune-competent': [214], 'C57BL/6': [215], 'mice.': [216], 'As': [217], 'compared': [218], 'empty': [220], 'vector,': [221], 'TGM2/Tgm2-overexpression': [222], 'led': [223], 'increase': [226], 'percentage': [229], 'number': [231, 244], 'CD4+': [233, 264], 'T': [234, 265], 'B': [237, 268], 'cells,': [238, 247], 'decrease': [241], 'myeloid': [246], 'compartment': [252], 'flow': [254], 'cytometry': [255], 'analysis.': [256], 'Future': [257], 'studies': [258], 'will': [259], 'assess': [260], 'subsets': [262], 'infiltrate': [270], 'TGM2/Tgm2-overexpressing': [271], 'tumors,': [272], 'how': [273], 'these': [274], 'changes': [275], 'TIME': [278], 'affect': [279], 'invasiveness,': [281], 'if': [283], 'expression': [285], 'affects': [286], 'response': [287], 'therapy': [290], 'vivo.': [292], 'Overall,': [293], 'our': [294], 'suggest': [296], 'state,': [307], 'regulated': [309], 'can': [316], 'adaptive': [318], 'TIME.': [323], 'Citation': [324], 'Format:': [325], 'Signe': [326], 'Caksa,': [327], 'Nicole': [328], 'A.': [329], 'Wilski,': [330], 'Erica': [331], 'L.': [332], 'Kitterman,': [333], 'McKenna': [334], 'Q.': [335], 'Glasheen,': [336], 'Jacob': [337], 'S.': [338], 'Heilizer,': [339], 'Timothy': [340], 'J.': [341], 'Purwin,': [342], 'Claudia': [343], 'Capparelli,': [344], 'Andrew': [345], 'E.': [346], 'Aplin.': [347], 'Transglutaminase-2': [348], 'elevated': [350], 'modulates': [357], 'cutaneous': [363], '[abstract].': [365], 'In:': [366], 'Proceedings': [367], 'American': [370], 'Association': [371], 'for': [372], 'Cancer': [373, 392], 'Research': [374], 'Annual': [375], 'Meeting': [376], '2023;': [377], 'Part': [378], '1': [379], '(Regular': [380], 'Invited': [382], 'Abstracts);': [383], '2023': [384], 'Apr': [385], '14-19;': [386], 'Orlando,': [387], 'FL.': [388], 'Philadelphia': [389], '(PA):': [390], 'AACR;': [391], 'Res': [393], '2023;83(7_Suppl):Abstract': [394], 'nr': [395], '1256.': [396]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4362543665', 'counts_by_year': [], 'updated_date': '2024-12-11T07:50:03.647381', 'created_date': '2023-04-06'}