Hypoxia and Cardiac Function in Patients With Prior Myocardial Infarction

Name: Work Video:
Duration: 3 min 30 s
Jan‐Niklas Hönemann; Darius A. Gerlach; Fabian Hoffmann; Tilmann Kramer; Henning Weis; Christine E. Hellweg; Bikash Konda; Vlad G. Zaha; Hesham A. Sadek; Antonius Herwarden; André J. Olthaar; Hannes Reuter; Stephan Baldus; Benjamin D. Levine; Jens Jordan; Jens Tank; Ulrich Limper
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German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany (J.-N.H., D.G., F.H., T.K., H.W., C.E.H., B.K., J.J., J.T., U.L.).', 'German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany (J.-N.H., D.G., F.H., T.K., H.W., C.E.H., B.K., J.J., J.T., U.L.).'], 'affiliations': [{'raw_affiliation_string': 'Fabian Hoffmann https://orcid.org/0000-0002-3199-9924 Department of Internal Medicine III, Division of Cardiology, Pneumology, Angiology, and Intensive Care (J.-N.H., F.H., T.K., S.B.), University of Cologne, Germany. 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German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany (J.-N.H., D.G., F.H., T.K., H.W., C.E.H., B.K., J.J., J.T., U.L.).', 'institution_ids': ['https://openalex.org/I2898391981', 'https://openalex.org/I180923762']}, {'raw_affiliation_string': 'German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany (J.-N.H., D.G., F.H., T.K., H.W., C.E.H., B.K., J.J., J.T., U.L.).', 'institution_ids': ['https://openalex.org/I2898391981']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066771654', 'display_name': 'Henning Weis', 'orcid': 'https://orcid.org/0000-0001-8638-3281'}, 'institutions': [{'id': 'https://openalex.org/I4210153755', 'display_name': 'University Hospital Cologne', 'ror': 'https://ror.org/05mxhda18', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153755']}, {'id': 'https://openalex.org/I2898391981', 'display_name': 'Deutsches Zentrum für Luft- und Raumfahrt e. V. 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274, 300, 323, 525, 577, 601], 'J.J.,': [121, 145, 190, 235, 275, 301, 324, 526, 578, 602], 'J.T.,': [122, 146, 191, 236, 276, 302, 325, 527, 579, 603], 'U.L.).': [123, 147, 192, 237, 277, 303, 326, 528, 580, 604], ',': [124, 148, 193, 238, 278, 304, 327, 361, 397, 416, 433, 444, 470, 505, 538], 'GerlachDarius': [126], 'Gerlach': [127], 'https://orcid.org/0000-0001-7044-6065': [128], 'HoffmannFabian': [150], 'Hoffmann': [151, 1864, 2009, 2204], 'https://orcid.org/0000-0002-3199-9924': [152], 'KramerTilmann': [195], 'Kramer': [196, 2198], 'https://orcid.org/0000-0003-0265-7607': [197], 'WeisHenning': [240], 'Weis': [241, 2202], 'https://orcid.org/0000-0001-8638-3281': [242], 'Nuclear': [245], 'Faculty': [247, 1846], 'Hospital': [252], 'Cologne': [253], '(H.W.),': [254], 'HellwegChristine': [281], 'Hellweg': [283], 'https://orcid.org/0000-0002-2223-3580': [284], 'KondaBikash': [306], 'Konda': [307], 'ZahaVlad': [330], 'Zaha': [332, 2013], 'https://orcid.org/0000-0003-4878-891X': [333], '(V.G.Z.,': [341, 375, 484], 'H.A.S.,': [342, 376, 485], 'B.D.L.),': [343, 377, 486], 'UT': [344, 355, 378, 391, 487], 'Southwestern': [345, 356, 379, 392, 488], 'Medical': [346, 357, 380, 393, 409, 426, 489, 613], 'Dallas,': [348, 359, 382, 395, 491], 'TX.': [349, 360, 383, 396, 492], 'Advanced': [350], 'Imaging': [351], 'Research': [352], 'Center': [353, 384, 786, 1871], '(V.G.Z.),': [354], 'SadekHesham': [364], 'Sadek': [366], 'https://orcid.org/0000-0002-4745-366X': [367], 'for': [385, 494, 717, 808, 880, 897, 930, 1120, 1734, 1758, 1766, 1814, 1991, 2086, 2093], 'Regenerative': [386], 'Science': [387], '(H.A.S.),': [390], 'HerwardenAntonius': [401], 'Herwarden': [404], 'Laboratory': [405, 422], 'Radboud': [407, 424], 'Nijmegen,': [411, 428], 'the': [412, 429, 631, 640, 696, 736, 759, 781, 783, 792, 822, 833, 947, 1008, 1034, 1047, 1060, 1101, 1196, 1199, 1404, 1485, 1642, 1720, 1732, 1767, 1795, 1845, 1850, 1868, 1873, 1995, 2079, 2109, 2147, 2151, 2173, 2239], 'Netherlands': [413, 430], '(A.E.v.H.,': [414, 431], 'A.J.O.).': [415, 432], 'OlthaarAndré': [419], 'Olthaar': [421], 'ReuterHannes': [435], 'Reuter': [436, 2015], 'Cardiology': [437], 'Department,': [438], 'EVK': [439], 'Weyertal,': [440], '(H.R.).': [443], 'BaldusStephan': [446], 'Baldus': [447, 2023, 2208], 'https://orcid.org/0000-0001-8259-1737': [448], 'LevineBenjamin': [473], 'Levine': [475, 2025, 2212], 'https://orcid.org/0000-0001-9064-7251': [476], 'Exercise': [495], 'Environmental': [497], 'Texas': [499], 'Health': [500, 1848], 'Presbyterian': [501], 'Hospital,': [502], 'Dallas': [503], '(B.D.L.).': [504], 'JordanJens': [507], 'Jordan': [508, 1808, 2027, 2214], 'https://orcid.org/0000-0003-4518-0706': [509], 'Head': [529], '(J.J.).': [537], 'TankJens': [540], 'Correspondence': [542, 2180], 'to:': [543, 1909], 'Tank,': [545, 1895, 1911], 'MD,': [546, 1912], 'Linder': [551, 1917], 'Hoehe,': [552, 1918], '51147': [553, 1919], 'Email': [556, 1922], 'E-mail': [557], 'Address:': [558], '[email': [559], 'protected]': [560], 'https://orcid.org/0000-0002-5672-1187': [561], 'LimperUlrich': [583], 'https://orcid.org/0000-0001-9927-4180': [585], 'Anesthesiology': [607], 'Merheim': [612], 'Hospitals': [615], 'Witten/Herdecke,': [620], '(U.L.).': [622], 'Originally': [623, 2261], 'published3': [624], 'Apr': [625], '2023https://doi.org/10.1161/CIRCRESAHA.122.322334Circulation': [626], 'Research.': [627, 2242], '2023;132:1165–1167is': [628], 'related': [629], 'toMeet': [630], 'First': [632, 737, 2240], 'AuthorsOther': [633], 'version(s)': [634], 'this': [636, 645, 1021], 'articleYou': [637], 'are': [638, 1725, 1782, 2082, 2091, 2101, 2106, 2114, 2121, 2141], 'viewing': [639], 'most': [641, 1200, 1407], 'recent': [642], 'version': [643], 'article.': [646], 'Previous': [647, 2191], 'versions:': [648], 'April': [649, 2244], '3,': [650, 2263], '2023:': [651], 'Ahead': [652], 'Print': [654], 'In': [655, 1540, 2183], 'mice': [656], 'with': [657, 705, 744, 1026, 1067, 1084, 1092, 1198, 1269, 1406, 1430, 1489, 1497, 1511, 1545, 1571, 1791, 1973], 'experimental': [658], 'myocardial': [659, 670, 687, 707, 746, 1133, 1255, 1259, 1263, 1296, 1546, 1573, 1603, 1637, 1643, 1685, 2231], 'infarction,': [660, 747, 1260, 1547, 2232], 'sustained': [661, 1438, 1533, 1655, 1743, 2037, 2225], 'normobaric': [662, 710, 1577, 2226], 'hypoxia': [663, 711, 722, 788, 948, 997, 1088, 1383, 1518, 1534, 1548, 1578, 1619, 1650, 1671, 1712, 1744, 2227], 'corresponding': [664, 712, 957, 1431, 1535], '8000': [666], 'm': [667, 715, 774, 1538], 'altitude': [668, 716, 958], 'improves': [669], 'regeneration': [671, 1638, 1747, 1949], 'left': [673, 1282], 'ventricular': [674, 844, 1161, 1277], '(LV)': [675], 'function': [676, 726, 1608, 1612, 1635], 'likely': [677], 'by': [678, 799, 909, 1050, 1557, 1844], 'reducing': [679], 'oxidative': [680], 'DNA': [681, 728, 907, 931, 1040, 1068, 1086, 1491, 1504, 1513, 1663, 1700, 1970, 2053], 'damage.1': [682], 'Hypoxia-induced': [683, 1333], 'pulmonary': [684, 861, 1334, 1596, 2033], 'hypertension': [685, 1335, 2034], 'or': [686, 755, 1605, 1632, 1636, 1640], 'ischemia': [688, 1604], 'could': [689, 1623], 'limit': [690], 'translation': [691], 'patients.': [693], 'We': [694, 720, 817, 864, 892, 903, 1265], 'tested': [695], 'feasibility': [697], 'safety': [699], 'exposing': [701, 910], 'highly': [702, 1721], 'selected': [703, 1722], 'patients': [704, 743, 915, 1544, 1570, 1599, 1717, 2229], 'previous': [706, 745, 1214], 'infarction': [708, 1256, 1574], '≈4500': [714], '4.5': [718, 809], 'days.': [719], 'evaluated': [721], 'influences': [723, 1738], 'on': [724, 821, 1010, 1039, 1745, 2163], 'LV': [725, 852, 855, 1167, 1177, 1183, 1392, 1398, 1411, 1432, 1463, 1553, 1611, 1704], 'repair': [729, 908, 934, 1045, 1505], 'peripheral': [731], 'blood': [732, 895, 989, 1002, 1804], 'mononuclear': [733, 990, 1805], 'cells': [734, 929, 991, 1066, 1083], '(PBMCs).2Meet': [735], 'Author,': [738], 'see': [739, 1906], 'p': [740], '1103We': [741], 'recruited': [742], 'fully': [748, 1291, 1566], 'revascularized': [749, 1292], 'LAD': [750], 'lesions,': [751], 'no': [752, 1889, 2129], 'angina': [753], 'pectoris,': [754], 'cardiac': [756, 868, 1318, 1409, 1558, 1590, 1607, 1746, 1772], 'decompensation': [757, 1319], 'past': [760], '12': [761, 1427], 'months': [762, 1253], 'who': [763], 'were': [764, 993, 1005, 1074, 1110, 1118, 1126], 'otherwise': [765], 'healthy,': [766], 'physically': [767], 'fit,': [768], 'had': [770, 1280], 'previously': [771], 'tolerated': [772], '>2000': [773], 'altitude.': [775], 'The': [776, 1071, 1080, 1508, 1621, 1706, 1885], 'local': [777], 'ethics': [778], 'committee': [779], 'approved': [780], 'study.In': [782], '(DLR):envihab': [787], 'module,': [789], 'we': [790, 1233, 1522], 'decreased': [791, 1089, 1346], 'fraction': [793, 1163, 1377, 1413, 1555], 'inspired': [795, 953, 1801], 'oxygen': [796, 937, 954, 1038, 1072, 1343, 1580], '(FIO2)': [797, 955], 'stepwise': [798], 'adding': [800], 'nitrogen': [801], 'over': [802, 962, 1584], '14': [803], 'days,': [804], 'maintained': [805, 968, 1075], '0.118': [806, 829, 887, 964, 1306], 'FIO2': [807, 830, 840, 965, 976], 'days': [810, 837, 1011, 1587], '(hypoxia),': [811], 'returned': [813], 'normoxia': [814, 1093], '(Figure': [815, 1303, 1340, 1402, 1506], '[A]).': [816], 'obtained': [818, 893, 1111], 'transthoracic': [819], 'echocardiograms': [820], 'second': [823], 'acclimatization': [824], 'day': [825, 1017], 'daily': [827], 'at': [828, 838, 872, 885, 916, 1046, 1365, 1416, 1422], 'during': [832, 877, 918, 921, 969, 977, 995, 1087, 1369, 1374, 1380, 1419, 1517, 1609, 1649, 2035, 2224], 'first': [834], '2': [835, 1495, 1524], 'recovery': [836, 922, 1000, 1339], '0.209': [839], 'assess': [842], 'right': [843, 1276], 'anatomy,': [845], 'tricuspid': [846, 1225], 'annular': [847, 1226], 'plane': [848, 1227], 'systolic': [849, 860, 1169, 1228], 'excursion,': [850], 'biplane': [851], 'ejection': [853, 1162, 1376, 1412, 1554], 'fraction,': [854], 'global': [856, 1184, 1390, 1396], 'longitudinal': [857, 1391], 'strain,': [858], 'artery': [862, 1285, 1597], 'pressure.': [863], 'acquired': [865], 'short-axis': [866], 'real-time': [867, 1771, 1992], 'magnetic': [869, 1773], 'resonance': [870, 1106, 1774], 'imaging': [871, 1107], '33': [873], 'ms': [874], 'temporal': [875], 'resolution': [876], 'spontaneous': [878], 'breathing': [879], '9.9': [881], 's': [882], 'per': [883, 1248], 'slice3': [884], 'baseline,': [886, 917, 1191, 1326, 1366, 1417, 1446], 'FIO2,': [888, 1307], 'early': [890, 1423], 'recovery.': [891], 'venous': [894], 'samples': [896, 1003], 'cardiovascular': [898, 2057], 'biomarker': [899], 'catecholamine': [901], 'measurements.': [902], 'examined': [904], 'ex': [905, 939, 1024], 'vivo': [906, 1025, 1481], 'PBMCs': [911, 1488, 1667], 'isolated': [912, 994, 1281], 'from': [913, 1001, 1007, 1347, 1833, 1867, 2059], 'all': [914, 1308], 'hypoxia,': [919, 1328, 1370, 1420, 1449, 1469], '1G': [924], 'X-Ray': [925], 'irradiation': [926, 1031, 1482], 'assessed': [928], 'double-strand': [932, 1041, 1069, 1971], 'break': [933, 1042], 'while': [935, 1166, 1588], 'maintaining': [936], 'conditions': [938], 'vivo.Download': [940], 'figureDownload': [941], 'PowerPointFigure.': [942], 'Schedule': [943], 'results': [945], 'study.': [949], 'A,': [950, 1933], 'Fraction': [951], 'equivalents': [959], 'meters': [961], 'time.': [963], 'level': [966, 1049], 'was': [967, 972, 1356, 1362, 1378, 1414, 1515, 1789, 1842], 'daytime': [970], 'increased': [973, 1165, 1484, 1646], '0.148': [975], 'nighttime': [978], 'ameliorate': [980], 'sleep': [981], 'acute': [983, 1311], 'mountain': [984, 1312], 'sickness': [985, 1313], 'symptoms.': [986], 'B,': [987, 2213], 'Peripheral': [988], '(PBMCs)': [992], 'normoxia,': [996], '(11.8%),': [998], 'that': [1004, 1670], 'taken': [1006], 'subjects': [1009, 1125], '1,': [1012], '16,': [1013], '21': [1015], '(second': [1016], 'recovery)': [1019], 'study,': [1022], 'irradiated': [1023], 'radiographs': [1027], 'incubated': [1029], 'after': [1030, 1382, 1494, 2230], 'investigate': [1033], 'effects': [1035], 'atmospheric': [1037], 'induction': [1043], 'cellular': [1048], 'flow': [1051], 'cytometric': [1052], 'analysis': [1053, 1187, 1206], 'using': [1054, 1998], 'γ-H2AX': [1055], '(phosphorylated': [1056], 'Ser-139': [1057], 'residue': [1058], 'histone': [1061], 'variant': [1062], 'H2AX),': [1063], 'which': [1064, 1172], 'indicates': [1065, 1218], 'breaks.': [1070], 'concentrations': [1073], 'until': [1076], 'fixation': [1077], 'PBMCs.': [1079], 'percentage': [1081], 'unrepaired': [1085, 1490, 1512], 'significantly': [1090], 'compared': [1091], '(Friedman': [1094], 'test,': [1095, 1387], 'n=4).': [1096, 1104, 1388], 'C,': [1097], 'Central': [1098], 'findings': [1099, 1117, 1688], 'study': [1102, 1730, 1788], '(mean±SD,': [1103], 'Magnetic': [1105], '(MRI)': [1108], 'data': [1109], 'a': [1113, 1174, 1812, 1822, 2084, 2186], 'blinded': [1114], 'analysis;': [1115], 'echocardiographic-derived': [1116], 'nonblinded': [1119], 'reasons': [1121], 'safety.': [1123], 'All': [1124, 1298], 'under': [1127], 'standard': [1128], 'medical': [1129], 'therapy': [1130], 'following': [1131, 1254, 1520, 1618, 1658], 'their': [1132], 'infarctions': [1134], '(2/4': [1135], 'aspirin,': [1136], '1/4': [1137, 1139, 1153, 1155, 1158], 'marcumar,': [1138], 'anti-Xa-antagonist,': [1140], '4/4': [1141, 1143], 'statin,': [1142], 'ACE': [1144], '(angiotensin-converting': [1145], 'enzyme)': [1146], 'inhibitor/AT1': [1147], '(angiotensin': [1148], 'type': [1149], '1': [1150, 1267, 1530], 'receptor)': [1151], 'antagonist,': [1152], 'azetidinone,': [1154], 'β-blockers,': [1156], 'dihydropiyridine).': [1159], 'Left': [1160], '(LVEF)': [1164], 'end': [1168], 'volume': [1170, 1465], 'decreased,': [1171], 'emphasizes': [1173], 'reduction': [1175], 'dysfunction.': [1178], 'D,': [1179], "Bull's": [1180], 'eye': [1181], 'circumferential': [1185, 1397], 'strain': [1186, 1393, 1399, 1433], '(real-time': [1188], 'MRI)': [1189], 'recovery,': [1192, 1330, 1424, 1452, 1472, 1563], 'follow-up': [1194], 'subject': [1197], 'pronounced': [1201], 'increase': [1202, 1209], 'LVEF.': [1204], 'Sectoral': [1205], 'revealed': [1207], 'an': [1208, 2074, 2118], 'viable': [1211, 1630], 'but': [1212, 1679], 'also': [1213, 1436], 'hypokinetic': [1215], 'areas.': [1216], 'NT-proBNP': [1217, 1441, 1614], 'N-terminal': [1219], 'pro-B-type': [1220, 1443], 'natriuretic': [1221, 1444], 'peptide;': [1222, 1445], 'TAPSE,': [1224], 'excursion.Of': [1229], '11': [1230], 'screened': [1231], 'patients,': [1232], 'included': [1234], '4': [1235], 'men': [1236], '(age,': [1237], '54–63': [1238], 'years;body': [1239], 'mass': [1240], 'index,': [1241], '21–25': [1242], 'kg/m2;': [1243], 'VO2': [1244], 'max,': [1245], '32–43': [1246], 'mL/kg': [1247], 'minute)': [1249], '37': [1250], '104': [1252], '(3×': [1257], 'ST-segment–elevation': [1258], '1×': [1261], 'non–ST-segment–elevation': [1262], 'infarction).': [1264], 'excluded': [1266], 'woman': [1268, 1273], 'thrombocytosis': [1270], 'another': [1272], 'because': [1274], 'involvement.': [1278], 'Participants': [1279], 'anterior': [1283], 'descending': [1284], 'mid-segmental': [1286], 'ostial': [1288], 'culprit': [1289], 'lesions': [1290], 'through': [1293, 1626, 1633, 1784], 'interventions': [1294], 'scars.': [1297], 'received': [1299, 1831, 1865], 'heart': [1300, 1948, 1997], 'failure': [1301], 'medications': [1302], '[C]).': [1304, 1341], 'At': [1305], 'participants': [1309], 'experienced': [1310], 'symptoms': [1314], 'without': [1315], 'signs': [1316], '(Lake': [1320], 'Louise': [1321], 'Acute': [1322], 'Mountain': [1323], 'Sickness': [1324], 'Score:': [1325], '3.25±1.5;': [1327], '5.25±1.04;': [1329], '0.75±0.96': [1331], 'points).': [1332], 'rapidly': [1336], 'abated': [1337], 'Arterial': [1342], 'partial': [1344], 'pressure': [1345], '94±10': [1348], '51±3': [1350], 'mm': [1351], 'Hg.': [1352], 'High-sensitivity': [1353], 'troponin': [1354], 'I': [1355], 'never': [1357], 'elevated.': [1358], 'Supine': [1359], 'plasma': [1360], 'norepinephrine': [1361, 1647], '2.24±0.09': [1363], 'nmol/L': [1364, 1368, 1373], '5.33±1.55': [1367], '4.01±1.4': [1372], 'recovery.LV': [1375], 'improved': [1379, 1400, 1634, 1662], 'exposure': [1384, 1549], '(P=0.0046,': [1385], 'Friedman': [1386], 'Echocardiographic-derived': [1389], 'MRI-derived': [1395], 'modestly': [1401], '[C]).In': [1403], 'participant': [1405], 'impaired': [1408], 'function,': [1410], '36%': [1415], '44%': [1418], '48%': [1421], '47%': [1426], 'weeks': [1428], 'thereafter': [1429], 'improvement.': [1434], 'He': [1435], 'showed': [1437], 'improvement': [1439], '(N-terminal': [1442], '477': [1447], 'pg/mL;': [1448, 1451, 1454, 1458], '218': [1450], '174': [1453], '12-week': [1455, 1475], 'follow-up,': [1456, 1476], '229': [1457], 'Figure': [1459, 1479], '[D])': [1460], 'reduced': [1462, 1516], 'end-systolic': [1464], '(baseline,': [1466, 1561], '159': [1467], 'mL;': [1468, 1474, 1478], '137': [1470], 'mL:': [1471], '127': [1473, 1477], '[D]).Ex': [1480], 'massively': [1483], 'number': [1486, 1510], 'damage': [1492, 1514, 1664, 1701, 2054], 'peaking': [1493], 'hours': [1496], 'subsequent': [1498], 'return': [1499], 'baseline': [1501], 'due': [1502], '[B]).': [1507], 'PBMC': [1509], 'recovery.Previously,': [1521], 'exposed': [1523, 1565], 'healthy': [1525], 'people': [1526], '(1': [1527], 'man': [1528], 'woman)': [1531], '≈7000': [1537], 'altitude.4': [1539], 'contrast': [1541], 'our': [1543, 1729], 'did': [1550, 1600], 'not': [1551, 1601, 2083, 2102, 2115, 2122], 'augment': [1552], 'measured': [1556], 'cine': [1559], 'MRI': [1560, 1993], '68.7±2.8;': [1562], '64.1±0.38).We': [1564], 'revascularized,': [1567], 'physical': [1568], 'active': [1569], 'prior': [1572], 'substantial': [1576], '(peripheral': [1579], 'saturation': [1581], '[SpO2],': [1582], '<90%)': [1583], 'about': [1585], '10': [1586], 'monitoring': [1589], 'function.': [1591], 'Despite': [1592], 'reversible': [1593], 'increases': [1594], 'pressure,': [1598], 'experience': [1602], 'worsened': [1606], 'hypoxia.': [1610], 'tended': [1615], 'improve': [1617], 'exposure.': [1620], 'response': [1622, 1665, 1702, 2055], 'be': [1624, 1681, 2128, 2137, 2154, 2170], 'mediated': [1625], 'augmented': [1627], 'contractility': [1628, 1656], 'myocardium': [1631], 'around': [1641], 'scar.': [1644], 'Transiently': [1645], 'release': [1648], 'is': [1651, 1821], 'unlikely': [1652], 'explain': [1654], 'improvements': [1657], 'cessation': [1659], 'hypoxia.An': [1661], 'might': [1668], 'suggest': [1669], 'may': [1672], 'have': [1673], 'engaged': [1674], 'potentially': [1675], 'favorable': [1676], 'molecular': [1677], 'pathways': [1678], 'cannot': [1680], 'simply': [1682], 'extrapolated': [1683], 'cells.': [1686], 'Our': [1687], 'encourage': [1689], 'validation': [1690], 'human': [1692, 1749, 1996], 'cardiomyocytes': [1693], 'further': [1695], 'explore': [1696], 'cross': [1697], 'talk': [1698], 'between': [1699], 'remodeling.5': [1705], 'small': [1707], 'sample': [1708], 'size,': [1709], 'relatively': [1710], 'short': [1711], 'period,1': [1713], 'inclusion': [1714], 'male': [1716], 'only,': [1718], 'patient': [1723], 'population': [1724], 'important': [1726], 'limitations.': [1727], 'Nevertheless,': [1728], 'lays': [1731], 'foundation': [1733], 'future': [1735], 'studies': [1736], 'assessing': [1737], 'more': [1740], 'severe': [1741, 2036], 'beings.Article': [1750], 'InformationAcknowledgmentsWe': [1751], 'thank': [1752], 'Frahm': [1754, 1986], '(Max': [1755], 'Planck': [1756], 'Multidisciplinary': [1759], 'Sciences,': [1760], 'Goettingen,': [1761], 'Germany)': [1762], 'his': [1764], 'team': [1765], 'support': [1768, 1793], 'establishing': [1770], 'imaging.': [1775], 'REGISTRATION:': [1776], 'Unique': [1777], 'Identifier:': [1778], 'DRKS00013772': [1779], '(https://drks.de/search/en/trial/DRKS00013772).Data': [1780], 'AvailabilityData': [1781], 'available': [1783], 'https://doi.org/10.5281/zenodo.5910897.Sources': [1785], 'FundingThe': [1787], 'conducted': [1790], 'programmatic': [1792], 'Center.Non-Standard': [1798], 'AbbreviationsFIO2fraction': [1799], 'oxygenLVleft': [1802], 'ventricularPBMCperipheral': [1803], 'cellsDisclosures': [1806], 'has': [1809], 'served': [1810], 'as': [1811, 2158], 'consultant': [1813], 'Novartis,': [1815], 'Boehringer': [1816, 1836], 'Ingelheim,': [1817, 1837], 'Novo-Nordisk': [1819], 'cofounder': [1823], 'Eternygen': [1825], 'GmbH': [1826], '(modest': [1827], 'relationship).': [1828], 'funding': [1832, 1866], 'Boston': [1834], 'Scientific,': [1835], 'Novo-Nordisk.': [1839], 'U.': [1840, 1897], 'supported': [1843], 'Witten/Herdecke': [1853], 'internal': [1854], 'grant': [1855], 'program': [1856], '(project': [1857], 'IFF': [1858], '2020-26).': [1859], 'J.-N.': [1860], 'F.': [1863], 'Federal': [1875], 'Ministry': [1876], 'Industry': [1878], 'Technology': [1880], '(BMWK,': [1881], '50WB1517': [1882], '50WB1816).': [1884], 'other': [1886], 'authors': [1887], 'report': [1888], 'conflicts.Footnotes*J.-N.': [1890], 'contributed': [1899], 'equally.For': [1900], 'Sources': [1901], 'Funding': [1903], 'Disclosures,': [1905], 'page': [1907], '1167.Correspondence': [1908], '[email protected].': [1923], 'Nakada': [1924], 'Y,': [1925, 2049], 'Canseco': [1926], 'DC,': [1927], 'Thet': [1928], 'S,': [1929, 1931, 1985, 2024, 2207, 2209], 'Abdisalaam': [1930], 'Asaithamby': [1932], 'Santos': [1934], 'CX,': [1935], 'Shah': [1936], 'AM,': [1937], 'Zhang': [1938, 1984, 2048], 'H,': [1939, 2016, 2203], 'Faber': [1940], 'JE,': [1941], 'Kinter': [1942], 'MT,': [1943], 'et': [1944, 2029], 'al.': [1945, 2030], 'Hypoxia': [1946], 'induces': [1947], 'adult': [1951], 'mice.Nature.': [1952], '2017;': [1953], '541:222–227.': [1954], 'doi:': [1955, 1979, 2006, 2041, 2066], '10.1038/nature20173CrossrefMedlineGoogle': [1956], 'Scholar2.': [1957], 'Sedelnikova': [1958], 'OA,': [1959], 'Rogakou': [1960], 'EP,': [1961], 'Panyutin': [1962], 'IG,': [1963], 'Bonner': [1964], 'WM.': [1965], 'Quantitative': [1966], 'detection': [1967], '(125)IdU-induced': [1969], 'breaks': [1972], 'gamma-H2AX': [1974], 'antibody.Radiat': [1975], 'Res.': [1976, 2064], '2002;': [1977], '158:486–492.': [1978], '10.1667/0033-7587(2002)158[0486:qdoiid]2.0.co;2CrossrefMedlineGoogle': [1980], 'Scholar3.': [1981], 'Uecker': [1982], 'M,': [1983, 2022, 2211], 'Nonlinear': [1988], 'inverse': [1989], 'reconstruction': [1990], 'undersampled': [1999], 'radial': [2000], 'FLASH.Magn': [2001], 'Reson': [2002], 'Med.': [2003], '2010;': [2004], '63:1456–1462.': [2005], '10.1002/mrm.22453CrossrefMedlineGoogle': [2007], 'Scholar4.': [2008], 'F,': [2010, 2205], 'U,': [2012], 'VG,': [2014], 'Zange': [2017], 'L,': [2018, 2045], 'Schulz-Menger': [2019], 'J,': [2020, 2028, 2201, 2215], 'Hein': [2021], 'BD,': [2026], 'Evolution': [2031], 'hypoxia.Circulation.': [2038], '2020;': [2039], '141:1504–1506.': [2040], '10.1161/CIRCULATIONAHA.119.045192LinkGoogle': [2042], 'Scholar5.': [2043], 'Wu': [2044], 'Sowers': [2046], 'JR,': [2047], 'Ren': [2050], 'Targeting': [2052], 'diseases:': [2058], 'pathophysiology': [2060], 'therapeutic': [2062], 'implications.Cardiovasc': [2063], '2022:cvac080.': [2065], '10.1093/cvr/cvac080CrossrefMedlineGoogle': [2067], 'Scholar': [2068], 'eLetters(0)': [2069], 'eLetters': [2070], 'should': [2071, 2127, 2169], 'relate': [2072], 'article': [2075, 2148], 'recently': [2076], 'published': [2077, 2116], 'journal': [2080, 2110], 'forum': [2085], 'providing': [2087], 'unpublished': [2088], 'data.': [2089], 'Comments': [2090, 2100, 2113, 2126, 2160], 'reviewed': [2092], 'appropriate': [2094], 'use': [2095], 'tone': [2097], 'language.': [2099], 'peer-reviewed.': [2103], 'Acceptable': [2104], 'comments': [2105], 'posted': [2107, 2138], 'website': [2111], 'only.': [2112], 'issue': [2119], 'indexed': [2123], 'PubMed.': [2125], 'longer': [2130], 'than': [2131], '500': [2132], 'words': [2133], 'will': [2135, 2153], 'only': [2136], 'online.': [2139], 'References': [2140], 'limited': [2142], '10.': [2144], 'Authors': [2145], 'cited': [2149], 'comment': [2152], 'invited': [2155], 'reply,': [2157], 'appropriate.': [2159], 'feedback': [2162], 'AHA/ASA': [2164, 2174], 'Scientific': [2165, 2233], 'Statements': [2166], 'Guidelines': [2168], 'directed': [2171], 'Manuscript': [2175], 'Oversight': [2176], 'Committee': [2177], 'via': [2178], 'its': [2179], 'page.': [2181], 'Sign': [2182], 'Submit': [2185], 'Response': [2187], 'This': [2189], 'Article': [2190, 2251], 'Back': [2192], 'top': [2194], 'Next': [2195], 'FiguresReferencesRelatedDetailsCited': [2196], 'By': [2197], 'T,': [2199], 'Hoenemann': [2200], 'Rosenkranz': [2206], 'Hellmich': [2210], 'J': [2217], 'U': [2220], '(2023)': [2221], 'Electrocardiographic': [2222], 'changes': [2223], 'Reports,': [2234], '10.1038/s41598-023-43707-5,': [2235], '13:1': [2236], 'Related': [2237], 'articlesMeet': [2238], 'AuthorsCirculation': [2241], '2023;132:1102-1103': [2243], '28,': [2245], '2023Vol': [2246], 'Issue': [2248], '9': [2249], 'Advertisement': [2250, 2270], 'Information': [2252], 'Metrics': [2253], '©': [2254], '2023': [2255, 2264], 'American': [2256], 'Heart': [2257, 2274], 'Association,': [2258], 'Inc.https://doi.org/10.1161/CIRCRESAHA.122.322334PMID:': [2259], '37009742': [2260], 'publishedApril': [2262], 'Keywordsaltitudeheart': [2265], 'failurehypoxiamyocardial': [2266], 'infarctiontranslational': [2267], 'sciencebiomedicalPDF': [2268], 'download': [2269], 'Subjects': [2271], 'Chronic': [2272], 'Ischemic': [2273], 'Disease': [2275]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4362506733', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 4}], 'updated_date': '2024-12-24T03:51:35.341607', 'created_date': '2023-04-05'}
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