Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4361949892', 'doi': 'https://doi.org/10.1158/1078-0432.c.6520121.v1', 'title': 'Data from Development and Characterization of a Novel CD19CherryLuciferase (CD19CL) Transgenic Mouse for the Preclinical Study of B-Cell Lymphomas', 'display_name': 'Data from Development and Characterization of a Novel CD19CherryLuciferase (CD19CL) Transgenic Mouse for the Preclinical Study of B-Cell Lymphomas', 'publication_year': 2023, 'publication_date': '2023-03-31', 'ids': {'openalex': 'https://openalex.org/W4361949892', 'doi': 'https://doi.org/10.1158/1078-0432.c.6520121.v1'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.c.6520121.v1', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016848239', 'display_name': 'Luigi Scotto', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Luigi Scotto', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032290331', 'display_name': 'Marianna Kruithof‐de Julio', 'orcid': 'https://orcid.org/0000-0002-6085-7706'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Marianna Kruithof-de Julio', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062618199', 'display_name': 'Luca Paoluzzi', 'orcid': 'https://orcid.org/0000-0002-2656-5224'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Luca Paoluzzi', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053153501', 'display_name': 'Matko Kalac', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Matko Kalac', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102738050', 'display_name': 'Enrica Marchi', 'orcid': 'https://orcid.org/0000-0002-6661-9119'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Enrica Marchi', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086916698', 'display_name': 'Jairo Baquero Buitrago', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jairo Baquero Buitrago', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075692970', 'display_name': 'Jennifer E. Amengual', 'orcid': 'https://orcid.org/0000-0003-4117-2469'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jennifer Amengual', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025125161', 'display_name': 'Michael M. Shen', 'orcid': 'https://orcid.org/0000-0002-4042-1657'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Michael M. Shen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002126535', 'display_name': 'Owen A. O’Connor', 'orcid': 'https://orcid.org/0000-0002-5631-0011'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': "Owen A. O'Connor", 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 68}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/b-cell-lymphoma', 'display_name': 'B-cell lymphoma', 'score': 0.60006136}, {'id': 'https://openalex.org/keywords/ex-vivo', 'display_name': 'Ex vivo', 'score': 0.41736796}], 'concepts': [{'id': 'https://openalex.org/C141035611', 'wikidata': 'https://www.wikidata.org/wiki/Q5532934', 'display_name': 'Genetically modified mouse', 'level': 4, 'score': 0.7774441}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.6954344}, {'id': 'https://openalex.org/C2778453870', 'wikidata': 'https://www.wikidata.org/wiki/Q188930', 'display_name': 'B cell', 'level': 3, 'score': 0.67877}, {'id': 'https://openalex.org/C2779338263', 'wikidata': 'https://www.wikidata.org/wiki/Q208414', 'display_name': 'Lymphoma', 'level': 2, 'score': 0.6502337}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.6456101}, {'id': 'https://openalex.org/C2777257650', 'wikidata': 'https://www.wikidata.org/wiki/Q4833719', 'display_name': 'B-cell lymphoma', 'level': 3, 'score': 0.60006136}, {'id': 'https://openalex.org/C2778957590', 'wikidata': 'https://www.wikidata.org/wiki/Q798033', 'display_name': 'CD19', 'level': 3, 'score': 0.5285971}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.47361752}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45122826}, {'id': 'https://openalex.org/C26291073', 'wikidata': 'https://www.wikidata.org/wiki/Q310484', 'display_name': 'Ex vivo', 'level': 3, 'score': 0.41736796}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.39813882}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.25638956}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.25085866}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.21848989}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.21221578}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09931886}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.08812404}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.c.6520121.v1', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/10', 'score': 0.68, 'display_name': 'Reduced inequalities'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4361949892', 'https://openalex.org/W4361944300', 'https://openalex.org/W4313382585', 'https://openalex.org/W4307510822', 'https://openalex.org/W2477464193', 'https://openalex.org/W2432572033', 'https://openalex.org/W2160295522', 'https://openalex.org/W2098045335', 'https://openalex.org/W2039046783', 'https://openalex.org/W1984985329'], 'abstract_inverted_index': {'<div>Abstract<p><b>Purpose:</b>': [0], 'To': [1], 'generate': [2], 'a': [3, 38, 47, 54, 79, 119, 128, 140], 'transgenic': [4, 51, 70, 130, 137, 156, 174], 'mouse': [5, 11, 52, 71, 138, 141, 157, 175], 'that': [6, 200], 'when': [7], 'crossed': [8], 'with': [9, 197], 'spontaneous': [10], 'models': [12, 72], 'of': [13, 22, 29, 73, 78, 106, 113, 143, 153, 161, 170, 181, 192], 'lymphoma': [14, 41, 108, 117], 'will': [15, 208], 'allow': [16], 'for': [17], 'quantitative': [18], '<i>in': [19, 88], 'vivo</i>': [20, 89, 98], 'measurement': [21], 'tumor': [23], 'burden': [24], 'over': [25], 'the': [26, 30, 60, 87, 111, 135, 151, 154, 159, 168, 179, 198, 202], 'entire': [27], 'spectrum': [28], 'disease': [31], 'and': [32, 110], 'or': [33, 40], 'response': [34, 112], 'to': [35, 59, 63, 85, 94, 118, 122, 139, 185, 188], 'therapy': [36], 'in': [37, 69, 127, 158, 167, 195, 212], '“disease”': [39], 'subtype-specific': [42], 'manner.</p><p><b>Experimental': [43], 'Design:</b>': [44], 'We': [45], 'developed': [46], 'novel': [48, 193], 'genetically': [49], 'engineered': [50], 'using': [53], 'CherryLuciferase': [55], 'fusion': [56], 'gene': [57], 'targeted': [58], 'CD19': [61], 'locus': [62], 'achieve': [64], 'B-cell–restricted': [65], 'fluorescent': [66], 'bioluminescent': [67], 'emission': [68], 'living': [74], 'mice.': [75], 'The': [76, 103, 148, 173], 'use': [77, 152], 'dual': [80], 'function': [81], 'protein': [82], 'enables': [83], 'one': [84], 'link': [86], 'analysis': [90], 'via': [91, 100], 'bioluminescence': [92], 'imaging': [93], 'cell': [95], 'discriminating': [96], '<i>ex': [97], 'analyses': [99], 'fluorescence': [101], 'emission.</p><p><b>Results:</b>': [102], 'spatiotemporal': [104], 'tracking': [105], 'B-cell': [107, 116, 146], 'growth': [109], 'an': [114, 144, 162], 'established': [115], 'drug': [120, 164], 'known': [121], 'induce': [123], 'remission': [124], 'was': [125], 'evaluated': [126], 'double': [129], 'animal': [131], 'obtained': [132], 'by': [133], 'crossing': [134], 'CD19CherryLuciferase': [136, 155], 'model': [142], 'aggressive': [145], 'lymphoma.': [147], 'observations': [149], 'validated': [150], 'assessment': [160], 'active': [163], 'routinely': [165], 'used': [166, 187], 'treatment': [169], 'lymphoproliferative': [171], 'malignancies.</p><p><b>Conclusions:</b>': [172], 'described': [176], 'here': [177], 'is': [178], 'first': [180], 'its': [182], 'kind,': [183], 'intended': [184], 'be': [186], 'hasten': [189], 'translational': [190], 'studies': [191], 'agents': [194], 'lymphoma,': [196], 'intent': [199], 'understanding': [201], 'relevant': [203], 'pharmacology': [204], 'before': [205], 'clinical': [206, 213], 'study': [207], 'accelerate': [209], 'successful': [210], 'development': [211], 'studies.': [214], '<i>Clin': [215], 'Cancer': [216], 'Res;': [217], '18(14);': [218], '3803–11.': [219], '©2012': [220], 'AACR</i>.</p></div>': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4361949892', 'counts_by_year': [], 'updated_date': '2024-12-06T02:56:09.395433', 'created_date': '2023-04-05'}