Supplementary Figure 2 from DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas

Name: Work Video:
Duration: 3 min 30 s
Description: &lt;p&gt;PDF file - 1.5MB, (A) Effects of siRNA-mediated NPM1 knockdown on DDX31 localization in the RCC cell line, Caki-1. NPM1 knockdown did not affect DDX31 nucleolar localization. (B) Effects of DDX31 knockdown on Nucleolin localization. Nucleolin localization was not affected by the presence or the absence of DDX31. Scale bar shows 50 mum&lt;/p&gt;
Tomoya Fukawa; Masaya Ono; Taisuke Matsuo; Hisanori Uehara; Tsuneharu Miki; Yusuke Nakamura; Hiro‐omi Kanayama; Toyomasa Katagiri
{'id': 'https://openalex.org/W4361895328', 'doi': 'https://doi.org/10.1158/0008-5472.22395845.v1', 'title': 'Supplementary Figure 2 from DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas', 'display_name': 'Supplementary Figure 2 from DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas', 'publication_year': 2023, 'publication_date': '2023-03-30', 'ids': {'openalex': 'https://openalex.org/W4361895328', 'doi': 'https://doi.org/10.1158/0008-5472.22395845.v1'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22395845.v1', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395845/1/files/39841475.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395845/1/files/39841475.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048767460', 'display_name': 'Tomoya Fukawa', 'orcid': 'https://orcid.org/0000-0001-7806-3667'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Tomoya Fukawa', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104110274', 'display_name': 'Masaya Ono', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Masaya Ono', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017964973', 'display_name': 'Taisuke Matsuo', 'orcid': 'https://orcid.org/0000-0002-1777-8586'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Taisuke Matsuo', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045972519', 'display_name': 'Hisanori Uehara', 'orcid': 'https://orcid.org/0000-0003-1709-1386'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hisanori Uehara', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113821547', 'display_name': 'Tsuneharu Miki', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Tsuneharu Miki', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101940699', 'display_name': 'Yusuke Nakamura', 'orcid': 'https://orcid.org/0000-0001-5288-5750'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yusuke Nakamura', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029699256', 'display_name': 'Hiro‐omi Kanayama', 'orcid': 'https://orcid.org/0000-0001-6355-5060'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hiro-omi Kanayama', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5075105059', 'display_name': 'Toyomasa Katagiri', 'orcid': 'https://orcid.org/0000-0001-5086-7444'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Toyomasa Katagiri', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 68}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12140', 'display_name': 'Renal and related cancers', 'score': 0.9222, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12140', 'display_name': 'Renal and related cancers', 'score': 0.9222, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nucleolin', 'display_name': 'Nucleolin', 'score': 0.96169996}, {'id': 'https://openalex.org/keywords/npm1', 'display_name': 'NPM1', 'score': 0.50074935}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.45223707}], 'concepts': [{'id': 'https://openalex.org/C2776525860', 'wikidata': 'https://www.wikidata.org/wiki/Q18029887', 'display_name': 'Nucleolin', 'level': 4, 'score': 0.96169996}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.94690144}, {'id': 'https://openalex.org/C2483381', 'wikidata': 'https://www.wikidata.org/wiki/Q18030194', 'display_name': 'NPM1', 'level': 5, 'score': 0.50074935}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.47322357}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.45223707}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4462336}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3977938}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.374167}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37375173}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.36425245}, {'id': 'https://openalex.org/C183873130', 'wikidata': 'https://www.wikidata.org/wiki/Q30869', 'display_name': 'Nucleolus', 'level': 3, 'score': 0.19376534}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.17752996}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.10895598}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C53226629', 'wikidata': 'https://www.wikidata.org/wiki/Q189967', 'display_name': 'Karyotype', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C30481170', 'wikidata': 'https://www.wikidata.org/wiki/Q37748', 'display_name': 'Chromosome', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22395845.v1', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395845/1/files/39841475.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-12-1645', 'pdf_url': 'https://cancerres.aacrjournals.org/content/canres/72/22/5867.full.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395845', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395845/1/files/39841475.pdf', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395848', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395848/1/files/39841478.pdf', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395842', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395842/1/files/39841472.pdf', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395839', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395839/1/files/39841469.pdf', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395836', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395836/1/files/39841466.pdf', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22395845.v1', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_DDX31_Regulates_the_p53-HDM2_Pathway_and_rRNA_Gene_Transcription_through_Its_Interaction_with_NPM1_in_Renal_Cell_Carcinomas/22395845/1/files/39841475.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.74, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4361895328', 'https://openalex.org/W4361841236', 'https://openalex.org/W3048341121', 'https://openalex.org/W2415081316', 'https://openalex.org/W2171277769', 'https://openalex.org/W2069415082', 'https://openalex.org/W2065464189', 'https://openalex.org/W2011743605', 'https://openalex.org/W2001677368', 'https://openalex.org/W1907977597'], 'abstract_inverted_index': {'&lt;p&gt;PDF': [0], 'file': [1], '-': [2], '1.5MB,': [3], '(A)': [4], 'Effects': [5, 28], 'of': [6, 29, 46], 'siRNA-mediated': [7], 'NPM1': [8, 19], 'knockdown': [9, 20, 31], 'on': [10, 32], 'DDX31': [11, 24, 30], 'localization': [12, 36], 'in': [13], 'the': [14, 41, 44], 'RCC': [15], 'cell': [16], 'line,': [17], 'Caki-1.': [18], 'did': [21], 'not': [22, 38], 'affect': [23], 'nucleolar': [25], 'localization.': [26, 34], '(B)': [27], 'Nucleolin': [33, 35], 'was': [37], 'affected': [39], 'by': [40], 'presence': [42], 'or': [43], 'absence': [45], 'DDX31.': [47], 'Scale': [48], 'bar': [49], 'shows': [50], '50': [51], 'mum&lt;/p&gt;': [52]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4361895328', 'counts_by_year': [], 'updated_date': '2024-12-06T02:15:53.204815', 'created_date': '2023-04-05'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
