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{'id': 'https://openalex.org/W4361816328', 'doi': 'https://doi.org/10.1158/1078-0432.c.6524436', 'title': 'Data from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors', 'display_name': 'Data from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors', 'publication_year': 2023, 'publication_date': '2023-03-31', 'ids': {'openalex': 'https://openalex.org/W4361816328', 'doi': 'https://doi.org/10.1158/1078-0432.c.6524436'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.c.6524436', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081904850', 'display_name': 'Vasilis Bikos', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Vasilis Bikos', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081855147', 'display_name': 'Maria Karypidou', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Maria Karypidou', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023652883', 'display_name': 'Evangelia Stalika', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Evangelia Stalika', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037707569', 'display_name': 'Panagiotis Baliakas', 'orcid': 'https://orcid.org/0000-0002-5634-7156'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Panagiotis Baliakas', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019232305', 'display_name': 'Aliki Xochelli', 'orcid': 'https://orcid.org/0009-0001-3143-0375'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Aliki Xochelli', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087781912', 'display_name': 'Lesley‐Ann Sutton', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lesley-Ann Sutton', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033815092', 'display_name': 'George Α. 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'landing_page_url': 'https://doi.org/10.1158/1078-0432.c.6524436', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4390589932', 'https://openalex.org/W4315796090', 'https://openalex.org/W4313240779', 'https://openalex.org/W4311367181', 'https://openalex.org/W3163440335', 'https://openalex.org/W2565469387', 'https://openalex.org/W2273167526', 'https://openalex.org/W2194452929', 'https://openalex.org/W2062581231', 'https://openalex.org/W1979734953'], 'abstract_inverted_index': {'<div>Abstract<p><b>Purpose:</b>': [0], 'Prompted': [1], 'by': [2, 116], 'the': [3, 7, 42, 71, 122, 151, 180], 'extensive': [4], 'biases': [5], 'in': [6, 20, 64, 94, 161], 'immunoglobulin': [8, 72], '(IG)': [9], 'gene': [10, 76, 100], 'repertoire': [11], 'of': [12, 41, 45, 66, 79, 137, 143, 148, 165, 179], 'splenic': [13], 'marginal-zone': [14], 'lymphoma': [15], '(SMZL),': [16], 'supporting': [17], 'antigen': [18, 28, 159], 'selection': [19], 'SMZL': [21, 47, 166, 172], 'ontogeny,': [22], 'we': [23], 'sought': [24], 'to': [25, 56], 'investigate': [26], 'whether': [27], 'involvement': [29, 160], 'is': [30], 'also': [31, 92], 'relevant': [32], 'post-transformation.</p><p><b>Experimental': [33], 'Design:</b>': [34], 'We': [35], 'conducted': [36], 'a': [37, 134, 141, 162, 175], 'large-scale': [38], 'subcloning': [39], 'study': [40], 'IG': [43, 97, 108], 'rearrangements': [44, 69, 82], '40': [46], 'cases': [48, 131, 149], 'aimed': [49], 'at': [50], 'assessing': [51], 'intraclonal': [52], 'diversification': [53], '(ID)': [54], 'due': [55], 'ongoing': [57, 127, 138, 158], 'somatic': [58], 'hypermutation': [59], '(SHM).</p><p><b>Results:</b>': [60], 'ID': [61, 90], 'was': [62, 91, 103], 'identified': [63], '17': [65], '21': [67], '(81%)': [68], 'using': [70], 'heavy': [73, 109], 'variable': [74], '(IGHV)1-2*04': [75], 'versus': [77], '8': [78], '19': [80], '(40%)': [81], 'utilizing': [83, 121, 150], 'other': [84], 'IGHV': [85, 153], 'genes': [86], '(<i>P</i>': [87], '=': [88], '0.001).': [89], 'evident': [93], 'most': [95], 'analyzed': [96], 'light': [98], 'chain': [99], 'rearrangements,': [101], 'albeit': [102], 'more': [104], 'limited': [105], 'compared': [106], 'with': [107], 'chains.': [110], 'Identical': [111], 'sequence': [112], 'changes': [113], 'were': [114], 'shared': [115, 144], 'subclones': [117], 'from': [118], 'different': [119], 'patients': [120], 'IGHV1-2*04': [123, 171], 'gene,': [124], 'confirming': [125], 'restricted': [126], 'SHM': [128], 'profiles.': [129], 'Non-IGHV1-2*04': [130], 'displayed': [132], 'both': [133], 'lower': [135], 'number': [136], 'SHMs': [139], 'and': [140, 167], 'lack': [142], 'mutations': [145], '(per': [146], 'group': [147], 'same': [152], 'gene).</p><p><b>Conclusions:</b>': [154], 'These': [155], 'findings': [156], 'support': [157], 'sizable': [163], 'portion': [164], 'further': [168], 'argue': [169], 'that': [170], 'may': [173], 'represent': [174], 'distinct': [176], 'molecular': [177], 'subtype': [178], 'disease.': [181], '<i>Clin': [182], 'Cancer': [183], 'Res;': [184], '22(8);': [185], '2032–40.': [186], '©2015': [187], 'AACR</i>.</p></div>': [188]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4361816328', 'counts_by_year': [], 'updated_date': '2024-09-10T01:30:45.884326', 'created_date': '2023-04-05'}