Publication Information

{'id': 'https://openalex.org/W4360608164', 'doi': 'https://doi.org/10.1097/ju.0000000000003226.13', 'title': 'MP11-13 CLINICAL FRACTURE INCIDENCE IN METASTATIC HORMONE-SENSITIVE PROSTATE CANCER (mHSPC) AND RISK-REDUCTION FOLLOWING ADDITION OF ZOLEDRONIC ACID TO ANDROGEN DEPRIVATION THERAPY (ADT) WITH OR WITHOUT DOCETAXEL (DOC): LONG-TERM RESULTS FROM 2 PHASE 3 TRIALS FROM THE STAMPEDE PLATFORM PROTOCOL', 'display_name': 'MP11-13 CLINICAL FRACTURE INCIDENCE IN METASTATIC HORMONE-SENSITIVE PROSTATE CANCER (mHSPC) AND RISK-REDUCTION FOLLOWING ADDITION OF ZOLEDRONIC ACID TO ANDROGEN DEPRIVATION THERAPY (ADT) WITH OR WITHOUT DOCETAXEL (DOC): LONG-TERM RESULTS FROM 2 PHASE 3 TRIALS FROM THE STAMPEDE PLATFORM PROTOCOL', 'publication_year': 2023, 'publication_date': '2023-03-23', 'ids': {'openalex': 'https://openalex.org/W4360608164', 'doi': 'https://doi.org/10.1097/ju.0000000000003226.13'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/ju.0000000000003226.13', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102823075', 'display_name': 'Craig Jones', 'orcid': 'https://orcid.org/0000-0002-8767-2875'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Craig Jones', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005044154', 'display_name': 'Ashwin Sachdeva', 'orcid': 'https://orcid.org/0000-0002-7359-7114'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ashwin Sachdeva', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053664712', 'display_name': 'Laura Murphy', 'orcid': 'https://orcid.org/0000-0002-4787-8879'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Laura Murphy', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063549953', 'display_name': 'Macey L Murray', 'orcid': 'https://orcid.org/0000-0001-6418-0854'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Macey Murray', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082693401', 'display_name': 'Louise Brown', 'orcid': 'https://orcid.org/0000-0003-2827-6634'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Louise Brown', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037004738', 'display_name': 'Eugène McCloskey', 'orcid': 'https://orcid.org/0000-0003-0177-8140'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Eugene McCloskey', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056951639', 'display_name': 'Janet E. Brown', 'orcid': 'https://orcid.org/0000-0003-4960-3032'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Janet Brown', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000156180', 'display_name': 'Gerhardt Attard', 'orcid': 'https://orcid.org/0000-0002-4811-7983'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gerhardt Attard', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014097745', 'display_name': 'Mahesh Parmar', 'orcid': 'https://orcid.org/0000-0003-0166-1700'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mahesh Parmar', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022378006', 'display_name': 'Nicholas D. James', 'orcid': 'https://orcid.org/0000-0002-7314-8204'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Nicholas James', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059261043', 'display_name': 'Matthew R. Sydes', 'orcid': 'https://orcid.org/0000-0002-9323-1371'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Matthew Sydes', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065195021', 'display_name': 'Noel W. Clarke', 'orcid': 'https://orcid.org/0000-0001-7776-8059'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Noel Clarke', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.545, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.676465, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 68, 'max': 79}, 'biblio': {'volume': '209', 'issue': 'Supplement 4', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9416, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9416, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/zoledronic-acid', 'display_name': 'Zoledronic Acid', 'score': 0.7741327}], 'concepts': [{'id': 'https://openalex.org/C2776326535', 'wikidata': 'https://www.wikidata.org/wiki/Q218507', 'display_name': 'Zoledronic acid', 'level': 2, 'score': 0.7741327}, {'id': 'https://openalex.org/C2781190966', 'wikidata': 'https://www.wikidata.org/wiki/Q420436', 'display_name': 'Docetaxel', 'level': 3, 'score': 0.7534144}, {'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.74599046}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7427584}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.5843573}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.40911198}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3937524}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.34680158}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/ju.0000000000003226.13', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4200552296', 'https://openalex.org/W2960491491', 'https://openalex.org/W2896276799', 'https://openalex.org/W2753537866', 'https://openalex.org/W2728894889', 'https://openalex.org/W2665384252', 'https://openalex.org/W2522846761', 'https://openalex.org/W2035098213', 'https://openalex.org/W2033949587', 'https://openalex.org/W1963763301'], 'abstract_inverted_index': {'You': [0], 'have': [1], 'accessJournal': [2], 'of': [3, 169, 181, 193, 208, 283, 286, 293, 324, 342, 449], 'UrologyCME1': [4], 'Apr': [5], '2023MP11-13': [6], 'CLINICAL': [7], 'FRACTURE': [8], 'INCIDENCE': [9], 'IN': [10], 'METASTATIC': [11], 'HORMONE-SENSITIVE': [12], 'PROSTATE': [13], 'CANCER': [14], '(mHSPC)': [15], 'AND': [16, 131], 'RISK-REDUCTION': [17], 'FOLLOWING': [18], 'ADDITION': [19], 'OF': [20], 'ZOLEDRONIC': [21], 'ACID': [22], 'TO': [23], 'ANDROGEN': [24], 'DEPRIVATION': [25], 'THERAPY': [26], '(ADT)': [27], 'WITH': [28], 'OR': [29], 'WITHOUT': [30], 'DOCETAXEL': [31], '(DOC):': [32], 'LONG-TERM': [33], 'RESULTS': [34], 'FROM': [35, 40], '2': [36, 270], 'PHASE': [37], '3': [38], 'TRIALS': [39], 'THE': [41], 'STAMPEDE': [42, 151], 'PLATFORM': [43], 'PROTOCOL': [44], 'Craig': [45, 70, 482], 'Jones,': [46], 'Ashwin': [47, 74, 489], 'Sachdeva,': [48], 'Laura': [49, 78, 496], 'Murphy,': [50], 'Macey': [51, 82, 503], 'Murray,': [52], 'Louise': [53, 86, 510], 'Brown,': [54, 58], 'Eugene': [55, 90, 517], 'McCloskey,': [56], 'Janet': [57, 94, 524], 'Gerhardt': [59, 98, 531], 'Attard,': [60], 'Mahesh': [61, 102, 538], 'Parmar,': [62], 'Nicholas': [63, 106, 545], 'James,': [64], 'Matthew': [65, 110, 552], 'Sydes,': [66], 'and': [67, 114, 143, 205, 229, 248, 291, 295, 318, 363, 425, 459, 478], 'Noel': [68, 115, 559], 'Clarke': [69, 117, 560], 'JonesCraig': [71], 'Jones': [72, 483], ',': [73, 77, 81, 85, 89, 93, 97, 101, 105, 109, 113], 'SachdevaAshwin': [75], 'Sachdeva': [76, 490], 'MurphyLaura': [79], 'Murphy': [80, 497], 'MurrayMacey': [83], 'Murray': [84, 504], 'BrownLouise': [87], 'Brown': [88, 96, 511, 525], 'McCloskeyEugene': [91], 'McCloskey': [92, 518], 'BrownJanet': [95], 'AttardGerhardt': [99], 'Attard': [100, 532], 'ParmarMahesh': [103], 'Parmar': [104, 539], 'JamesNicholas': [107], 'James': [108, 546], 'SydesMatthew': [111], 'Sydes': [112, 553], 'ClarkeNoel': [116], 'View': [118], 'All': [119, 567], 'Author': [120], 'Informationhttps://doi.org/10.1097/JU.0000000000003226.13AboutPDF': [121], 'ToolsAdd': [122], 'to': [123, 200, 235, 307, 321, 441], 'favoritesDownload': [124], 'CitationsTrack': [125], 'CitationsPermissionsReprints': [126], 'ShareFacebookLinked': [127], 'InTwitterEmail': [128], 'Abstract': [129], 'INTRODUCTION': [130], 'OBJECTIVE:': [132], 'Long-term': [133], 'ADT': [134, 245], 'is': [135], 'recommended': [136], 'for': [137, 225, 239, 269, 309, 334], 'men': [138], 'with': [139, 371, 432], 'mHSPC:': [140], 'bone': [141, 212, 438], 'loss': [142], 'increased': [144], 'fracture': [145, 273, 327, 347, 383, 412], 'risk': [146, 384], 'are': [147], 'known': [148], 'complications.': [149], 'The': [150, 217], 'trial': [152, 198], 'compared': [153], 'ADT±docetaxel': [154], '(Doc)±zoledronic': [155], 'acid': [156], '(ZA):': [157], 'adding': [158], 'ZA': [159, 209, 260, 325, 369, 372, 380, 431], 'did': [160], 'not': [161, 176, 395], 'improve': [162], 'overall': [163], 'survival': [164], '(OS)': [165], 'but': [166, 394], 'long-term': [167, 202, 411], 'effects': [168], 'bisphosphonate': [170], 'treatment': [171, 203], 'on': [172, 326], 'skeletal': [173], 'health': [174], 'was': [175, 263, 349], 'formally': [177], 'collected': [178], 'as': [179, 210], 'part': [180], 'the': [182], 'trial.': [183], 'Accessible,': [184], 'high': [185], 'quality,': [186], 'routinely-collected': [187], 'healthcare': [188], 'data': [189, 195, 233, 435], '(RCHD)': [190], 'enables': [191], 'analysis': [192], 'outcome': [194], 'beyond': [196], 'standard': [197], 'follow-up': [199], 'evaluate': [201], 'toxicity': [204], 'clinical': [206], 'efficacy': [207], 'a': [211, 278], 'protective': [213, 439], 'agent': [214], 'in': [215, 227, 352, 356, 360, 385, 396, 416, 423, 428, 446], 'mHSPC.': [216, 447], 'Hospital': [218], 'Episode': [219], 'Statistics': [220], '(HES)': [221], 'database': [222], 'provides': [223], 'RCHD': [224], 'patients': [226, 240, 415], 'England': [228], 'Wales.': [230], 'METHODS:': [231], 'HES': [232], 'up': [234], '2018': [236], 'were': [237, 275, 305, 332, 420], 'obtained': [238], '(pts)': [241], 'randomised': [242], '2:1': [243], 'between': [244], '(Arm': [246, 250, 254, 258], 'A)': [247], 'ADT+ZA': [249], 'B),': [251], 'or': [252, 256], 'ADT+Doc': [253], 'C)': [255], 'ADT+Doc+ZA': [257], 'E).': [259], '(4': [261], 'mg)': [262], 'six': [264], '3-weekly': [265], 'cycles,': [266], 'then': [267], '4-weekly': [268], 'years.': [271], 'Clinical': [272], 'events': [274, 413], 'identified': [276], 'using': [277, 437], 'bespoke': [279], 'pre-specified': [280], 'coding': [281], 'framework': [282], 'International': [284], 'Classification': [285, 292], 'Diseases': [287], '(ICD': [288], '10)': [289], 'diagnosis': [290], 'Interventions': [294], 'Procedures': [296], '(OPCS': [297], '4)': [298], 'procedure': [299], 'codes.': [300], 'Multivariate': [301], 'Cox': [302], 'regression': [303], 'models': [304], 'developed': [306], 'adjust': [308], 'age,': [310], 'N': [311], 'stage,': [312], 'WHO': [313], 'performance': [314], 'status,': [315], 'Gleason': [316], 'score': [317], 'NSAID': [319], 'use': [320], 'determine': [322], 'impact': [323], 'risk.': [328], 'RESULTS:': [329], 'Connected': [330], 'datasets': [331], 'available': [333], '2,145': [335], 'eligible': [336], 'pts': [337, 354, 367, 387, 398, 429], '(796': [338], 'M0,': [339, 361], '1,349': [340], 'M1)': [341], '2,962': [343], '(72%).': [344], 'Overall,': [345], '5-year': [346], 'incidence': [348], '6.4%;': [350], 'higher': [351], 'M1': [353, 357, 366, 386, 424], '(9.6%': [355], 'vs': [358, 373], '2.1%': [359], 'p<0.0001),': [362], 'lower': [364], 'amongst': [365, 414], 'allocated': [368, 430], '(4.55%': [370], '12.9%': [374], 'without': [375], 'ZA,': [376], 'p<0.0001)': [377], '(Figure': [378], '1).': [379], 'significantly': [381, 427], 'reduced': [382, 426], '(HR': [388, 399], '0.36,': [389], '95%': [390, 401], 'CI': [391, 402], '0.22-0.57,': [392], 'p<0.0005)': [393], 'M0': [397], '0.67,': [400], '0.32-1.39,': [403], 'p=0.28).': [404], 'CONCLUSIONS:': [405], 'By': [406], 'accessing': [407], 'RCHD,': [408], 'we': [409], 'evaluated': [410], 'STAMPEDE.': [417], 'Fracture': [418], 'rates': [419], 'clinically': [421, 443], 'notable': [422], 'ADT±Doc.': [433], 'These': [434], 'support': [436], 'agents': [440], 'reduce': [442], 'significant': [444], 'fractures': [445], 'Source': [448], 'Funding:': [450], 'None': [451], '©': [452], '2023': [453, 472], 'by': [454, 473, 486, 493, 500, 507, 514, 521, 528, 535, 542, 549, 556, 563], 'American': [455, 474], 'Urological': [456, 475], 'Association': [457, 476], 'Education': [458, 477], 'Research,': [460, 479], 'Inc.FiguresReferencesRelatedDetails': [461], 'Volume': [462], '209Issue': [463], 'Supplement': [464], '4April': [465], '2023Page:': [466], 'e129': [467], 'Advertisement': [468, 568], 'Copyright': [469], '&': [470], 'Permissions©': [471], 'Inc.MetricsAuthor': [480], 'Information': [481], 'More': [484, 491, 498, 505, 512, 519, 526, 533, 540, 547, 554, 561], 'articles': [485, 492, 499, 506, 513, 520, 527, 534, 541, 548, 555, 562], 'this': [487, 494, 501, 508, 515, 522, 529, 536, 543, 550, 557, 564], 'author': [488, 495, 502, 509, 516, 523, 530, 537, 544, 551, 558, 565], 'Expand': [566], 'PDF': [569], 'downloadLoading': [570], '...': [571]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4360608164', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-12-08T03:00:06.116220', 'created_date': '2023-03-24'}