Publication Information

{'id': 'https://openalex.org/W4327847213', 'doi': 'https://doi.org/10.1016/s0022-5347(05)63998-5', 'title': 'Elevated Akt Activation and Its Impact on Clinicopathological Features of Renal Cell Carcinoma', 'display_name': 'Elevated Akt Activation and Its Impact on Clinicopathological Features of Renal Cell Carcinoma', 'publication_year': 2003, 'publication_date': '2003-02-01', 'ids': {'openalex': 'https://openalex.org/W4327847213', 'doi': 'https://doi.org/10.1016/s0022-5347(05)63998-5'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-5347(05)63998-5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039473258', 'display_name': 'Akio Horiguchi', 'orcid': 'https://orcid.org/0000-0002-7678-6375'}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}, {'id': 'https://openalex.org/I4402554133', 'display_name': 'National Hospital Organization Saitama Hospital', 'ror': 'https://ror.org/05jyayj71', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137409', 'https://openalex.org/I4402554133']}, {'id': 'https://openalex.org/I4210121151', 'display_name': 'Saitama Medical University Hospital', 'ror': 'https://ror.org/02tyjnv32', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210121151']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'AKIO HORIGUCHI', 'raw_affiliation_strings': ['From the Department of Clinical Research and Urology, National Saitama Hospital, Saitama and Department of Urology, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Clinical Research and Urology, National Saitama Hospital, Saitama and Department of Urology, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103', 'https://openalex.org/I4402554133', 'https://openalex.org/I4210121151']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086644570', 'display_name': 'Mototsugu Oya', 'orcid': 'https://orcid.org/0000-0002-2048-4263'}, 'institutions': [{'id': 'https://openalex.org/I4402554133', 'display_name': 'National Hospital Organization Saitama Hospital', 'ror': 'https://ror.org/05jyayj71', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137409', 'https://openalex.org/I4402554133']}, {'id': 'https://openalex.org/I4210121151', 'display_name': 'Saitama Medical University Hospital', 'ror': 'https://ror.org/02tyjnv32', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210121151']}, {'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'MOTOTSUGU OYA', 'raw_affiliation_strings': ['From the Department of Clinical Research and Urology, National Saitama Hospital, Saitama and Department of Urology, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Clinical Research and Urology, National Saitama Hospital, Saitama and Department of Urology, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4402554133', 'https://openalex.org/I4210121151', 'https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004119695', 'display_name': 'Atsushi Uchida', 'orcid': 'https://orcid.org/0000-0002-4654-8616'}, 'institutions': [{'id': 'https://openalex.org/I4402554133', 'display_name': 'National Hospital Organization Saitama Hospital', 'ror': 'https://ror.org/05jyayj71', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137409', 'https://openalex.org/I4402554133']}, {'id': 'https://openalex.org/I4210121151', 'display_name': 'Saitama Medical University Hospital', 'ror': 'https://ror.org/02tyjnv32', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210121151']}, {'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'ATSUSHI UCHIDA', 'raw_affiliation_strings': ['From the Department of Clinical Research and Urology, National Saitama Hospital, Saitama and Department of Urology, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Clinical Research and Urology, National Saitama Hospital, Saitama and Department of Urology, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4402554133', 'https://openalex.org/I4210121151', 'https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009251932', 'display_name': 'Ken Marumo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121151', 'display_name': 'Saitama Medical University Hospital', 'ror': 'https://ror.org/02tyjnv32', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210121151']}, {'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}, {'id': 'https://openalex.org/I4402554133', 'display_name': 'National Hospital Organization Saitama Hospital', 'ror': 'https://ror.org/05jyayj71', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137409', 'https://openalex.org/I4402554133']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'KEN MARUMO', 'raw_affiliation_strings': ['From the Department of Clinical Research and Urology, National Saitama Hospital, Saitama and Department of Urology, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Clinical Research and Urology, National Saitama Hospital, Saitama and Department of Urology, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210121151', 'https://openalex.org/I203951103', 'https://openalex.org/I4402554133']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111648816', 'display_name': 'Masaru Murai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121151', 'display_name': 'Saitama Medical University Hospital', 'ror': 'https://ror.org/02tyjnv32', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210121151']}, {'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}, {'id': 'https://openalex.org/I4402554133', 'display_name': 'National Hospital Organization Saitama Hospital', 'ror': 'https://ror.org/05jyayj71', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137409', 'https://openalex.org/I4402554133']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'MASARU MURAI', 'raw_affiliation_strings': ['From the Department of Clinical Research and Urology, National Saitama Hospital, Saitama and Department of Urology, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Clinical Research and Urology, National Saitama Hospital, Saitama and Department of Urology, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210121151', 'https://openalex.org/I203951103', 'https://openalex.org/I4402554133']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.248, 'has_fulltext': False, 'cited_by_count': 79, 'citation_normalized_percentile': {'value': 0.815216, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '169', 'issue': '2', 'first_page': '710', 'last_page': '713'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12835', 'display_name': 'FOXO transcription factor regulation', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12835', 'display_name': 'FOXO transcription factor regulation', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12829', 'display_name': 'Advanced Breast Cancer Therapies', 'score': 0.9894, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.95303386}, {'id': 'https://openalex.org/C2777472916', 'wikidata': 'https://www.wikidata.org/wiki/Q1164529', 'display_name': 'Renal cell carcinoma', 'level': 2, 'score': 0.7171293}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.49930906}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.43197143}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.42530966}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3987608}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.120125175}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.07016912}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-5347(05)63998-5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1564408770', 'https://openalex.org/W1726025741', 'https://openalex.org/W1927527067', 'https://openalex.org/W1977416006', 'https://openalex.org/W1984418041', 'https://openalex.org/W1986434780', 'https://openalex.org/W2004078164', 'https://openalex.org/W2017292900', 'https://openalex.org/W2024306318', 'https://openalex.org/W2026559965', 'https://openalex.org/W2027811142', 'https://openalex.org/W2031469256', 'https://openalex.org/W2033801757', 'https://openalex.org/W2044868069', 'https://openalex.org/W2058554371', 'https://openalex.org/W2069373667', 'https://openalex.org/W2073575984', 'https://openalex.org/W2111109989', 'https://openalex.org/W2135906488', 'https://openalex.org/W2137035181', 'https://openalex.org/W2137895670', 'https://openalex.org/W2152988906', 'https://openalex.org/W2395026578', 'https://openalex.org/W2442785944'], 'related_works': ['https://openalex.org/W3110433138', 'https://openalex.org/W2751784270', 'https://openalex.org/W2159000141', 'https://openalex.org/W2132898409', 'https://openalex.org/W2037631372', 'https://openalex.org/W2030889776', 'https://openalex.org/W1979139803', 'https://openalex.org/W1978297557', 'https://openalex.org/W1966504330', 'https://openalex.org/W1548146698'], 'abstract_inverted_index': {'No': [0], 'AccessJournal': [1], 'of': [2, 15, 73, 90, 103, 186, 302, 320, 361, 363, 419, 436, 451, 455, 459, 477, 497, 533, 645, 667, 690, 709, 715, 729, 842, 853, 858, 889, 904, 936, 946, 981, 1024, 1029], 'UrologyINVESTIGATIVE': [3], 'UROLOGY1': [4], 'Feb': [5], '2003Elevated': [6], 'Akt': [7, 64, 79, 95, 112, 131, 139, 187, 205, 251, 276, 315, 379, 481, 505, 534], 'Activation': [8], 'and': [9, 27, 46, 71, 92, 118, 125, 129, 170, 230, 288, 300, 369, 385, 453, 480, 512, 531, 571, 753, 758, 795, 803, 812, 845, 851, 880, 886, 924, 939, 966], 'Its': [10], 'Impact': [11], 'on': [12, 263, 271], 'Clinicopathological': [13], 'Features': [14], 'Renal': [16, 943], 'Cell': [17, 944], 'Carcinoma': [18], 'AKIO': [19, 30, 1011], 'HORIGUCHI,': [20], 'MOTOTSUGU': [21, 34, 1018], 'OYA,': [22], 'ATSUSHI': [23, 38, 1042], 'UCHIDA,': [24], 'KEN': [25, 42, 1049], 'MARUMO,': [26], 'MASARU': [28, 47, 1056], 'MURAI': [29, 49, 1057], 'HORIGUCHIAKIO': [31], 'HORIGUCHI': [32, 1012], ',': [33, 37, 41, 45], 'OYAMOTOTSUGU': [35], 'OYA': [36, 1019], 'UCHIDAATSUSHI': [39], 'UCHIDA': [40, 1043], 'MARUMOKEN': [43], 'MARUMO': [44, 1050], 'MURAIMASARU': [48], 'View': [50], 'All': [51, 1064], 'Author': [52], 'Informationhttps://doi.org/10.1016/S0022-5347(05)63998-5AboutFull': [53], 'TextPDF': [54], 'ToolsAdd': [55], 'to': [56, 502], 'favoritesDownload': [57], 'CitationsTrack': [58], 'CitationsPermissionsReprints': [59], 'ShareFacebookLinked': [60], 'InTwitterEmail': [61], 'Abstract': [62], 'Purpose:': [63], 'has': [65, 97], 'been': [66, 98], 'implicated': [67], 'in': [68, 86, 100, 114, 146, 284, 297, 348, 463, 483, 516, 535, 551, 568, 580, 672, 731, 774, 779, 801, 828, 942], 'the': [69, 88, 107, 298, 314, 321, 437, 603, 619, 732, 840], 'pathogenesis': [70, 299], 'progression': [72, 301], 'numerous': [74], 'human': [75, 464, 569, 623, 673, 710], 'malignant': [76, 104], 'tumors': [77, 155, 159, 173, 177], 'because': [78], 'regulates': [80], 'many': [81], 'key': [82], 'effector': [83], 'molecules': [84], 'involved': [85], 'controlling': [87], 'balance': [89], 'survival': [91, 261, 382], 'apoptosis.': [93, 336], 'Elevated': [94, 219, 275], 'activation': [96, 113, 132, 188, 277, 362, 450, 574, 666], 'demonstrated': [99, 202, 216], 'various': [101], 'types': [102], 'tumors.': [105], 'In': [106, 247], 'current': [108], 'study': [109], 'we': [110], 'evaluated': [111, 134], 'renal': [115, 150, 303, 674, 711, 754, 780, 805, 829, 1008], 'cell': [116, 151, 304, 381, 420, 675, 755, 781, 806, 830], 'carcinoma': [117, 712], 'investigated': [119], 'its': [120, 572, 650], 'association': [121, 185], 'with': [122, 149, 160, 165, 178, 190, 208, 224, 241, 256, 510, 737, 809], 'pathological': [123], 'features': [124, 192], 'clinical': [126], 'outcome.': [127], 'Materials': [128], 'Methods:': [130], 'was': [133, 193, 221, 238, 253], 'by': [135, 313, 367, 383, 424, 440, 457, 601, 863, 1002, 1015, 1039, 1046, 1053, 1060], 'immunohistochemistry': [136], 'using': [137], 'antiphospho-specific': [138, 204, 250], 'antibody,': [140], 'which': [141], 'recognizes': [142], 'only': [143], 'activated': [144, 550], 'Akt,': [145], '48': [147, 197], 'patients': [148, 198], 'carcinoma.': [152, 305, 485, 537, 676, 739, 831], 'High': [153], 'immunostaining': [154, 172, 206, 220, 252], 'were': [156, 174], 'defined': [157, 175], 'as': [158, 176, 772], 'increased': [161], 'staining': [162, 182], 'intensity': [163], 'compared': [164, 207], 'adjacent': [166, 209], 'nonneoplastic': [167, 210], 'kidney': [168, 211], 'tissue': [169], 'low': [171, 217], 'equivalent': [179], 'or': [180, 244], 'decreased': [181], 'intensity.': [183], 'The': [184, 309, 546, 641], 'status': [189], 'clinicopathological': [191], 'analyzed.': [194], 'Results:': [195], 'Of': [196], 'examined': [199], '18': [200, 663], '(37.5%)': [201], 'high': [203, 249, 285], 'tissue,': [212], 'while': [213, 236], '30': [214], '(62.5%)': [215], 'immunostaining.': [218], 'significantly': [222, 254], 'associated': [223, 240, 255, 509, 736], 'tumor': [225, 242, 287, 554, 595, 599, 620, 651], 'grade': [226, 286], '(p': [227, 233, 266], '=': [228, 234, 267], '0.0354)': [229], 'metastatic': [231, 289, 810], 'disease': [232], '0.0044),': [235], 'it': [237], 'not': [239, 270, 508], 'stage': [243], 'histological': [245], 'subtype.': [246], 'addition,': [248], 'a': [257, 280, 318, 387, 627], 'poor': [258], 'cancer': [259], 'specific': [260], 'rate': [262], 'univariate': [264], 'analysis': [265], '0.0109)': [268], 'but': [269, 507], 'multivariate': [272], 'analysis.': [273], 'Conclusions:': [274], 'could': [278, 292], 'be': [279], 'common': [281], 'finding,': [282], 'especially': [283], 'disease.': [290], 'It': [291], 'have': [293], 'an': [294, 773, 934], 'important': [295], 'role': [296, 714], 'References': [306], '1': [307], ':': [308, 331, 343, 359, 378, 397, 417, 432, 448, 473, 494, 529, 545, 562, 591, 617, 640, 664, 684, 706, 727, 748, 768, 790, 822], 'protein': [310, 364, 404, 669], 'kinase': [311, 345, 350, 365, 405, 548, 564], 'encoded': [312], 'proto-oncogene': [316], 'is': [317, 500, 549, 565, 575, 626, 647, 933], 'target': [319], 'PDGF-activated': [322], 'phosphatidylinositol': [323], '3-kinase.': [324], 'Cell1995;': [325], '81:': [326], '727.': [327], 'Google': [328, 340, 356, 375, 394, 414, 429, 445, 470, 491, 526, 542, 559, 588, 614, 637, 661, 681, 703, 724, 745, 765, 787, 819, 837], 'Scholar': [329, 341, 357, 376, 395, 415, 430, 446, 471, 492, 527, 543, 560, 589, 615, 638, 662, 682, 704, 725, 746, 766, 788, 820, 838], '2': [330], 'PI3K:': [332], 'downstream': [333], 'AKTion': [334], 'blocks': [335], 'Cell1997;': [337], '88:': [338], '435.': [339], '3': [342], 'Protein': [344], 'B': [346, 366, 406], '(c-Akt)': [347], 'phosphatidylinositol-3-OH': [349], 'signal': [351], 'transduction.': [352], 'Nature1995;': [353], '376:': [354], '599.': [355], '4': [358], 'Mechanism': [360], 'insulin': [368], 'IGF-1.': [370], 'EMBO': [371], 'J1996;': [372], '15:': [373], '6541.': [374], '5': [377], 'promotes': [380], 'phosphorylating': [384], 'inhibiting': [386], 'Forkhead': [388, 398], 'transcription': [389, 399], 'factor.': [390], 'Cell1999;': [391], '96:': [392, 612], '857.': [393], '6': [396], 'factors:': [400], 'new': [401], 'insights': [402, 593], 'into': [403, 594], '(c-akt)': [407], 'signaling.': [408], 'J': [409, 522, 584, 741, 832], 'Mol': [410], 'Med1999;': [411], '77:': [412], '656.': [413], '7': [416], 'Regulation': [418], 'death': [421], 'protease': [422], 'caspase-9': [423], 'phosphorylation.': [425], 'Science1998;': [426], '282:': [427], '1318.': [428], '8': [431], 'Differentiation': [433], 'stage-specific': [434], 'inhibition': [435, 458], 'Raf-MEK-ERK': [438], 'pathway': [439, 462], 'Akt.': [441], 'Science1999;': [442], '286:': [443], '1738.': [444], '9': [447], 'Frequent': [449, 495], 'AKT2': [452], 'induction': [454], 'apoptosis': [456], 'phosphoinositide-3-OH': [460], 'kinase/Akt': [461], 'ovarian': [465, 519], 'cancer.': [466], 'Oncogene2000;': [467], '19:': [468], '2324.': [469], '10': [472], 'Correlation': [474], 'between': [475], 'loss': [476, 496], 'PTEN': [478, 498, 597, 646], 'expression': [479, 499, 757, 800], 'phosphorylation': [482], 'endometrial': [484], 'Clin': [486, 814], 'Cancer': [487, 538, 677, 720, 815], 'Res2001;': [488, 539], '7:': [489], '892.': [490], '11': [493], 'linked': [501], 'elevated': [503, 567], 'phosphorylated': [504], 'levels,': [506], 'p27': [511], 'cyclin': [513], 'D1': [514], 'expression,': [515], 'primary': [517], 'epithelial': [518], 'carcinomas.': [520, 782], 'Am': [521, 583], 'Pathol2001;': [523, 585], '158:': [524], '2097.': [525], '12': [528], 'Overexpression': [530], 'overactivation': [532], 'thyroid': [536], '61:': [540], '6105.': [541], '13': [544], 'AKT': [547, 885], 'multiple': [552], 'myeloma': [553], 'cells.': [555, 582], 'Blood2001;': [556], '98:': [557], '2853.': [558], '14': [561], 'AKT1/PKBalpha': [563], 'frequently': [566], 'cancers': [570], 'constitutive': [573], 'required': [576], 'for': [577, 649, 1021], 'oncogenic': [578], 'transformation': [579], 'NIH3T3': [581], '159:': [586], '431.': [587], '15': [590], 'New': [592, 695], 'suppression:': [596], 'suppresses': [598], 'formation': [600], 'restraining': [602], 'phosphoinositide': [604], '3-kinase/AKT': [605], 'pathway.': [606], 'Proc': [607, 630, 654], 'Natl': [608, 631, 655], 'Acad': [609, 632, 656], 'Sci': [610, 633, 657], 'USA1999;': [611], '4240.': [613], '16': [616], 'P-TEN,': [618], 'suppressor': [621], 'from': [622], 'chromosome': [624], '10q23,': [625], 'dual-specificity': [628], 'phosphatase.': [629], 'USA1997;': [634], '94:': [635], '9052.': [636], '17': [639], 'lipid': [642], 'phosphatase': [643], 'activity': [644], 'critical': [648], 'supressor': [652], 'function.': [653], 'USA1998;': [658], '95:': [659], '13513.': [660], 'Constitutive': [665], 'mitogen-activated': [668], '(MAP)': [670], 'kinases': [671], 'Res1995;': [678, 816], '55:': [679], '4182.': [680], '19': [683], 'Urological': [685, 865, 1004], 'tumours.': [686], 'In:': [687], 'TNM': [688], 'Classification': [689], 'Malignant': [691], 'Tumours,': [692], '5th': [693], 'ed..': [694], 'York:': [696], 'John': [697], 'Wiley': [698], '&': [699, 999], 'Sons,': [700], 'Inc.1997:': [701], '180.': [702], '20': [705], 'Growth': [707], 'regulation': [708], 'cells:': [713], 'transforming': [716, 796], 'growth': [717, 750, 777, 792, 797], 'factor': [718, 751, 778, 793, 798], 'alpha.': [719], 'Res1992;': [721], '52:': [722], '3335.': [723], '21': [726], 'Role': [728], 'interleukin-6': [730], 'paraneoplastic': [733], 'inflammatory': [734], 'syndrome': [735], 'renal-cell': [738], 'Int': [740], 'Cancer1997;': [742], '72:': [743], '424.': [744], '22': [747], 'Epidermal': [749, 791], 'family': [752], 'carcinoma:': [756, 807], 'prognostic': [759], 'impact.': [760], 'Eur': [761], 'Urol1997;': [762], '31:': [763], '478.': [764], '23': [767], 'Interleukin-6': [769], '(IL-6)': [770], 'functions': [771], 'vitro': [775], 'autocrine': [776], 'FEBS': [783], 'Lett1989;': [784], '250:': [785], '607.': [786], '24': [789], 'receptor': [794], 'alpha': [799], 'papillary': [802], 'nonpapillary': [804], 'correlation': [808], 'behavior': [811], 'prognosis.': [813], '1:': [817], '913.': [818], '25': [821], 'Infrequent': [823], 'ras': [824], 'oncogene': [825], 'point': [826], 'mutations': [827], 'Urol1990;': [833], '143:': [834], '175.': [835], 'Link,': [836], 'From': [839], 'Department': [841, 852, 1023], 'Clinical': [843], 'Research': [844], 'Urology,': [846, 854, 890, 905, 947, 982, 1025], 'National': [847], 'Saitama': [848, 850], 'Hospital,': [849], 'Keio': [855, 1026], 'University': [856, 1027], 'School': [857, 1028], 'Medicine,': [859, 1030], 'Tokyo,': [860], 'Japan©': [861], '2003': [862, 1001], 'American': [864, 1003], 'Association,': [866, 1005], 'Inc.FiguresReferencesRelatedDetailsCited': [867], 'ByAtala': [868], 'A': [869], '(2018)': [870, 901, 927, 969], 'Re:': [871], 'Infiltrating': [872], 'Macrophages': [873], 'Increase': [874], 'RCC': [875], 'Epithelial': [876], 'Mesenchymal': [877], 'Transition': [878], '(EMT)': [879], 'Stem': [881], 'Cell-Like': [882], 'Populations': [883], 'via': [884], 'mTOR': [887], 'SignalingJournal': [888], 'VOL.': [891, 906, 948, 983], '197,': [892], 'NO.': [893, 908, 950, 985], '1,': [894], '(51-52),': [895], 'Online': [896, 911, 953, 988], 'publication': [897, 912, 954, 989], 'date:': [898, 913, 955, 990], '1-Jan-2017.Oya': [899], 'M': [900, 923, 926, 965, 968], 'Editorial': [902], 'CommentJournal': [903], '182,': [907], '6,': [909], '(2577-2577),': [910], '1-Dec-2009.Horiguchi': [914], 'A,': [915, 957], 'Asano': [916, 918], 'T,': [917, 919, 959, 963], 'Ito': [920], 'K,': [921], 'Sumitomo': [922], 'Hayakawa': [925], 'Fatty': [928], 'Acid': [929], 'Synthase': [930], 'Over': [931], 'Expression': [932], 'Indicator': [935], 'Tumor': [937], 'Aggressiveness': [938], 'Poor': [940], 'Prognosis': [941], 'CarcinomaJournal': [945], '180,': [949], '3,': [951], '(1137-1140),': [952], '1-Sep-2008.HORIGUCHI': [956], 'ASANO': [958, 962], 'ASAKUMA': [960], 'J,': [961], 'SUMITOMO': [964], 'HAYAKAWA': [967], 'IMPACT': [970], 'OF': [971], 'CAVEOLIN-1': [972], 'EXPRESSION': [973], 'ON': [974], 'CLINICOPATHOLOGICAL': [975], 'PARAMETERS': [976], 'IN': [977], 'RENAL': [978], 'CELL': [979], 'CARCINOMAJournal': [980], '172,': [984], '2,': [986], '(718-722),': [987], '1-Aug-2004.': [991], 'Volume': [992], '169Issue': [993], '2February': [994], '2003Page:': [995], '710-713': [996], 'Advertisement': [997, 1065], 'Copyright': [998], 'Permissions©': [1000], 'Inc.Keywordskidneyprotein': [1006], 'kinasescarcinoma,': [1007], 'cellMetricsAuthor': [1009], 'Information': [1010], 'More': [1013, 1037, 1044, 1051, 1058], 'articles': [1014, 1038, 1045, 1052, 1059], 'this': [1016, 1040, 1047, 1054, 1061], 'author': [1017, 1041, 1048, 1055, 1062], 'Requests': [1020], 'reprints:': [1022], '35': [1031], 'Shinanomachi,': [1032], 'Shinjuku-ku,': [1033], 'Tokyo': [1034], '160-8582,': [1035], 'Japan.': [1036], 'Expand': [1063], 'PDF': [1066], 'DownloadLoading': [1067], '...': [1068]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4327847213', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-15T07:13:38.634433', 'created_date': '2023-03-20'}