Title: Synthetic strategy of 2-thioxo-4-thiazolidinone with core chemistry and biological importance
Abstract: Due to the vast range of biological actions that rhodanine and its derivatives exhibit, they are recognized as privileged structures in pharmacological research. However, the rhodanine skeleton synthesis process has certain limitations. However, the rhodanine ring’s reactivity enabled the creation of various arylidenes at position 5 and carboxylic acids at position 3, respectively. The principal pathways of heterocycle alteration are determined by the most reactive sites in 4-thiazolidinone, which are 3 and 5. In a review paper, the chemistry of 4-thiazolidinones was discussed, in particular the rhodanine ring and several methods for its reactions, including ring modification. The study deals with thioureas and thioglycolic acid react in a single step, catalyzed by protic acid, resulting in the direct preparation of N-aryl rhodanines as well as the rhodanine skeleton, offering a novel method for the synthesis of rhodanine and its derivatives. The presented approach is simple, effective, atom-efficient, and practical in high yields.