Abstract PD13-11: PD13-11 Final Overall Survival Analysis of Monarch 2 : A Phase 3 trial of Abemaciclib Plus Fulvestrant in Patients with Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Name: Work Video:
Duration: 3 min 30 s
Antonio Llombart‐Cussac; George W. Sledge; Masakazu Toi; Patrick Neven; Joohyuk Sohn; Kenichi Inoue; Xavier Pivot; Meena Okera; Norikazu Masuda; Peter A. Kaufman; Han Koh; Eva‐Maria Grischke; Pierfranco Conté; Valérie André; Yuanyuan Bian; Ashwin Shahir; Gertjan van Hal
{'id': 'https://openalex.org/W4322775049', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs22-pd13-11', 'title': 'Abstract PD13-11: PD13-11 Final Overall Survival Analysis of Monarch 2 : A Phase 3 trial of Abemaciclib Plus Fulvestrant in Patients with Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer', 'display_name': 'Abstract PD13-11: PD13-11 Final Overall Survival Analysis of Monarch 2 : A Phase 3 trial of Abemaciclib Plus Fulvestrant in Patients with Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer', 'publication_year': 2023, 'publication_date': '2023-03-01', 'ids': {'openalex': 'https://openalex.org/W4322775049', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs22-pd13-11'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs22-pd13-11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030451537', 'display_name': 'Antonio Llombart‐Cussac', 'orcid': 'https://orcid.org/0000-0003-4515-8293'}, 'institutions': [{'id': 'https://openalex.org/I4210119293', 'display_name': 'Hospital Arnau de Vilanova', 'ror': 'https://ror.org/02s7fkk92', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210119293']}, {'id': 'https://openalex.org/I4210097149', 'display_name': 'Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana', 'ror': 'https://ror.org/0116vew40', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210097149']}, {'id': 'https://openalex.org/I4210102398', 'display_name': 'MedSIR (Spain)', 'ror': 'https://ror.org/00t6sz979', 'country_code': 'ES', 'type': 'company', 'lineage': ['https://openalex.org/I4210102398']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Antonio Llombart-Cussac', 'raw_affiliation_strings': ['1Hospital Arnau de Vilanova; FISABIO, Valencia, Spain. Catholic University, Valencia, Spain. Medica Scientia Innovation Research (MEDSIR), Barcelona, Spain and Ridgewood, New Jersey, US., Spain', 'Hospital Arnau de Vilanova'], 'affiliations': [{'raw_affiliation_string': '1Hospital Arnau de Vilanova; FISABIO, Valencia, Spain. Catholic University, Valencia, Spain. Medica Scientia Innovation Research (MEDSIR), Barcelona, Spain and Ridgewood, New Jersey, US., Spain', 'institution_ids': ['https://openalex.org/I4210119293', 'https://openalex.org/I4210097149', 'https://openalex.org/I4210102398']}, {'raw_affiliation_string': 'Hospital Arnau de Vilanova', 'institution_ids': ['https://openalex.org/I4210119293']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066769011', 'display_name': 'George W. Sledge', 'orcid': 'https://orcid.org/0000-0003-0297-0775'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George Sledge', 'raw_affiliation_strings': ['2Stanford University, Stanford, CA'], 'affiliations': [{'raw_affiliation_string': '2Stanford University, Stanford, CA', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091245889', 'display_name': 'Masakazu Toi', 'orcid': 'https://orcid.org/0000-0003-1488-9958'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masakazu Toi', 'raw_affiliation_strings': ['3Graduate School of Medicine, Kyoto University, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': '3Graduate School of Medicine, Kyoto University, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007579054', 'display_name': 'Patrick Neven', 'orcid': 'https://orcid.org/0000-0002-1434-9460'}, 'institutions': [{'id': 'https://openalex.org/I2800231306', 'display_name': 'Universitair Ziekenhuis Leuven', 'ror': 'https://ror.org/0424bsv16', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800231306']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Patrick Neven', 'raw_affiliation_strings': ['4Universitair Ziekenhuis Leuven, Leuven, Belgium, Leuven, Vlaams-Brabant, Belgium'], 'affiliations': [{'raw_affiliation_string': '4Universitair Ziekenhuis Leuven, Leuven, Belgium, Leuven, Vlaams-Brabant, Belgium', 'institution_ids': ['https://openalex.org/I2800231306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030577122', 'display_name': 'Joohyuk Sohn', 'orcid': 'https://orcid.org/0000-0002-2303-2764'}, 'institutions': [], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Joo Hyuk Sohn', 'raw_affiliation_strings': ['5Yonsei Cancer Center, Seoul, Republic of Korea, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': '5Yonsei Cancer Center, Seoul, Republic of Korea, Republic of Korea', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100785002', 'display_name': 'Kenichi Inoue', 'orcid': 'https://orcid.org/0000-0003-2686-8732'}, 'institutions': [{'id': 'https://openalex.org/I4210123465', 'display_name': 'Saitama Cancer Center', 'ror': 'https://ror.org/03a4d7t12', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123465']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenichi Inoue', 'raw_affiliation_strings': ['6Saitama Cancer Center, Saitama, Japan'], 'affiliations': [{'raw_affiliation_string': '6Saitama Cancer Center, Saitama, Japan', 'institution_ids': ['https://openalex.org/I4210123465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044903892', 'display_name': 'Xavier Pivot', 'orcid': 'https://orcid.org/0000-0003-3689-5013'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Xavier Pivot', 'raw_affiliation_strings': ['7Centre Paul Strauss, INSERM 110, Strasbourg, France'], 'affiliations': [{'raw_affiliation_string': '7Centre Paul Strauss, INSERM 110, Strasbourg, France', 'institution_ids': ['https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069176422', 'display_name': 'Meena Okera', 'orcid': 'https://orcid.org/0000-0002-0027-5798'}, 'institutions': [{'id': 'https://openalex.org/I4210140852', 'display_name': 'Centre for Cancer Biology', 'ror': 'https://ror.org/03yg7hz06', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I107656453', 'https://openalex.org/I170239107', 'https://openalex.org/I4210140852']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Meena Okera', 'raw_affiliation_strings': ['8Adelaide Cancer Centre, Adelaide, Australia'], 'affiliations': [{'raw_affiliation_string': '8Adelaide Cancer Centre, Adelaide, Australia', 'institution_ids': ['https://openalex.org/I4210140852']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067189124', 'display_name': 'Norikazu Masuda', 'orcid': 'https://orcid.org/0000-0002-7302-0278'}, 'institutions': [{'id': 'https://openalex.org/I4210090372', 'display_name': 'Osaka National Hospital', 'ror': 'https://ror.org/00b6s9f18', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210090372', 'https://openalex.org/I4210137409']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Norikazu Masuda', 'raw_affiliation_strings': ['9Nagoya University Graduate School of Medicine, Department of Surgery, Breast Oncology NHO Osaka National Hospital'], 'affiliations': [{'raw_affiliation_string': '9Nagoya University Graduate School of Medicine, Department of Surgery, Breast Oncology NHO Osaka National Hospital', 'institution_ids': ['https://openalex.org/I4210090372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014192243', 'display_name': 'Peter A. Kaufman', 'orcid': 'https://orcid.org/0000-0003-3677-6807'}, 'institutions': [{'id': 'https://openalex.org/I111236770', 'display_name': 'University of Vermont', 'ror': 'https://ror.org/0155zta11', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111236770']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter A. Kaufman', 'raw_affiliation_strings': ['10University of Vermont Cancer Center, Burlington, VT'], 'affiliations': [{'raw_affiliation_string': '10University of Vermont Cancer Center, Burlington, VT', 'institution_ids': ['https://openalex.org/I111236770']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112293584', 'display_name': 'Han Koh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I26347476', 'display_name': 'Loma Linda University', 'ror': 'https://ror.org/04bj28v14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I26347476']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Han Koh', 'raw_affiliation_strings': ['11School of Medicine, Loma Linda University, Loma Linda, California 92350'], 'affiliations': [{'raw_affiliation_string': '11School of Medicine, Loma Linda University, Loma Linda, California 92350', 'institution_ids': ['https://openalex.org/I26347476']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013148496', 'display_name': 'Eva‐Maria Grischke', 'orcid': 'https://orcid.org/0000-0001-7413-5053'}, 'institutions': [{'id': 'https://openalex.org/I4210122374', 'display_name': 'Universitäts Frauenklinik', 'ror': 'https://ror.org/02veq1j93', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094118', 'https://openalex.org/I4210122374']}, {'id': 'https://openalex.org/I8087733', 'display_name': 'University of Tübingen', 'ror': 'https://ror.org/03a1kwz48', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8087733']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Eva-Maria Grischke', 'raw_affiliation_strings': ['12Universitäts-Frauenklinik Tubingen, Eberhard Karls University, Tubingen, Germany'], 'affiliations': [{'raw_affiliation_string': '12Universitäts-Frauenklinik Tubingen, Eberhard Karls University, Tubingen, Germany', 'institution_ids': ['https://openalex.org/I4210122374', 'https://openalex.org/I8087733']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034987953', 'display_name': 'Pierfranco Conté', 'orcid': 'https://orcid.org/0000-0002-5210-5344'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'PierFranco Conte', 'raw_affiliation_strings': ['13DiSCOG, University of Padova and Medical Oncology'], 'affiliations': [{'raw_affiliation_string': '13DiSCOG, University of Padova and Medical Oncology', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088961889', 'display_name': 'Valérie André', 'orcid': 'https://orcid.org/0000-0003-4968-1479'}, 'institutions': [{'id': 'https://openalex.org/I168537998', 'display_name': 'Eli Lilly (United States)', 'ror': 'https://ror.org/01qat3289', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I168537998']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Valerie Andre', 'raw_affiliation_strings': ['14Eli Lilly and Company'], 'affiliations': [{'raw_affiliation_string': '14Eli Lilly and Company', 'institution_ids': ['https://openalex.org/I168537998']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103147019', 'display_name': 'Yuanyuan Bian', 'orcid': 'https://orcid.org/0000-0003-4736-2597'}, 'institutions': [{'id': 'https://openalex.org/I168537998', 'display_name': 'Eli Lilly (United States)', 'ror': 'https://ror.org/01qat3289', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I168537998']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yuanyuan Bian', 'raw_affiliation_strings': ['15Eli Lilly and Company'], 'affiliations': [{'raw_affiliation_string': '15Eli Lilly and Company', 'institution_ids': ['https://openalex.org/I168537998']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048281465', 'display_name': 'Ashwin Shahir', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I168537998', 'display_name': 'Eli Lilly (United States)', 'ror': 'https://ror.org/01qat3289', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I168537998']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ashwin Shahir', 'raw_affiliation_strings': ['16Eli Lilly and Company'], 'affiliations': [{'raw_affiliation_string': '16Eli Lilly and Company', 'institution_ids': ['https://openalex.org/I168537998']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5044825175', 'display_name': 'Gertjan van Hal', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I168537998', 'display_name': 'Eli Lilly (United States)', 'ror': 'https://ror.org/01qat3289', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I168537998']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gertjan van Hal', 'raw_affiliation_strings': ['17Eli Lilly and Company.'], 'affiliations': [{'raw_affiliation_string': '17Eli Lilly and Company.', 'institution_ids': ['https://openalex.org/I168537998']}]}], 'institution_assertions': [], 'countries_distinct_count': 9, 'institutions_distinct_count': 16, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.812, 'has_fulltext': False, 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.999972, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '83', 'issue': '5_Supplement', 'first_page': 'PD13', 'last_page': '11'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12829', 'display_name': 'Advanced Breast Cancer Therapies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12829', 'display_name': 'Advanced Breast Cancer Therapies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fulvestrant', 'display_name': 'Fulvestrant', 'score': 0.9224245}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.5885855}], 'concepts': [{'id': 'https://openalex.org/C2780482068', 'wikidata': 'https://www.wikidata.org/wiki/Q5508491', 'display_name': 'Fulvestrant', 'level': 5, 'score': 0.9224245}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7815403}, {'id': 'https://openalex.org/C207103383', 'wikidata': 'https://www.wikidata.org/wiki/Q3930246', 'display_name': 'Hazard ratio', 'level': 3, 'score': 0.72748625}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6664383}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.5885855}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.5687377}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.55663496}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.55543804}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.53701437}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4942584}, {'id': 'https://openalex.org/C204243189', 'wikidata': 'https://www.wikidata.org/wiki/Q1363085', 'display_name': 'Randomization', 'level': 3, 'score': 0.4480607}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.37262693}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.16453442}, {'id': 'https://openalex.org/C44249647', 'wikidata': 'https://www.wikidata.org/wiki/Q208498', 'display_name': 'Confidence interval', 'level': 2, 'score': 0.14560217}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.060124665}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs22-pd13-11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.87}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4283528480', 'https://openalex.org/W4221067269', 'https://openalex.org/W4206711305', 'https://openalex.org/W3161515104', 'https://openalex.org/W3012234284', 'https://openalex.org/W3010858585', 'https://openalex.org/W2970181139', 'https://openalex.org/W2944020043', 'https://openalex.org/W2508852616', 'https://openalex.org/W2318928440'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'Abemaciclib': [2, 620], 'is': [3, 352, 391, 546], 'approved': [4], 'for': [5, 64, 106, 550], 'patients': [6, 527], '(pts)': [7], 'with': [8, 18, 69, 114, 396, 445, 469, 496, 520, 528, 536, 552, 564, 625], 'hormone': [9], 'receptor-positive': [10], '(HR+),': [11], 'HER2-negative': [12], '(HER2-)': [13], 'advanced': [14], 'breast': [15], 'cancer': [16], '(ABC)': [17], 'progression': [19], 'on': [20, 147, 227], 'prior': [21, 159], 'endocrine': [22], 'therapy': [23], '(ET).': [24], 'The': [25, 218, 269, 320, 342, 554], 'MONARCH': [26, 84, 89, 493], '2': [27, 85, 90, 494, 613], 'trial': [28, 86, 99, 618], 'showed': [29], 'a': [30, 60, 92, 387, 397, 497, 537], 'statistically': [31, 504], 'significantly': [32], 'benefit': [33, 381, 390, 506, 514, 534], 'in': [34, 293, 299, 308, 326, 333, 357, 393, 448, 623], 'progression-free': [35], 'survival': [36, 49, 79, 173, 451, 533, 543], '(PFS)': [37], '(hazard': [38], 'ratio': [39, 216], '[HR]:': [40], '0.553;': [41], '95%': [42, 53, 339, 406, 415, 425, 442], 'CI:': [43, 54, 340, 407, 416, 426, 443], '0.449-0.681;': [44], 'p': [45, 56], '&amp;lt;': [46], '0.001),': [47], 'overall': [48, 78], '(OS)': [50, 80], '(HR:': [51, 337, 404, 413, 423, 440], '0.757;': [52], '0.606-0.945;': [55], '=': [57, 248, 253], '0.01)': [58], 'and': [59, 156, 165, 171, 277, 330, 361, 511], 'manageable': [61], 'safety': [62, 166, 477, 561], 'profile': [63], 'abemaciclib': [65, 101, 134, 246, 295, 328, 375, 432, 563], 'plus': [66, 104, 141, 255], 'fulvestrant': [67, 70, 105, 434], 'compared': [68], 'alone.': [71], 'Here': [72], 'we': [73], 'report': [74], 'the': [75, 83, 180, 192, 279, 282, 294, 300, 309, 327, 334, 346, 350, 355, 358, 429, 436, 486, 492, 503, 532, 541, 560, 636], 'pre-specified': [76], 'final': [77, 220, 488], 'analysis': [81, 221, 490], 'from': [82, 182], '(NCT02107703).': [87], 'Methods': [88], 'was': [91, 144, 174, 197, 209, 222, 234, 273, 323, 382, 509, 515], 'global,': [93], 'randomized,': [94], 'placebo-controlled,': [95], 'double-blind': [96], 'phase': [97], '3': [98, 617], 'of': [100, 108, 149, 186, 281, 286, 345, 431, 438, 491, 500, 540, 559, 562, 611, 619, 635], 'or': [102, 111, 135, 154, 188, 250, 418, 479], 'placebo,': [103, 136], 'treatment': [107, 213], 'pre-,': [109], 'peri-': [110], 'postmenopausal': [112], 'women': [113, 240], 'CDK': [115], '4': [116, 458], '&amp;': [117], '6': [118], 'inhibitor': [119], 'naïve': [120], 'HR+,': [121], 'HER2-': [122], 'ABC': [123], 'that': [124], 'progressed': [125], 'during': [126], 'ET.': [127], 'Pts': [128], 'were': [129, 167, 241, 288, 306, 482], 'randomized': [130, 242], '2:1': [131, 243], 'to': [132, 158, 184, 199, 211, 224, 244, 411, 433, 472], 'receive': [133, 245], '150': [137], 'mg': [138], 'twice': [139], 'daily,': [140], 'fulvestrant.': [142, 256], 'Randomization': [143], 'stratified': [145, 204], 'based': [146, 226], 'site': [148], 'metastasis': [150], '(visceral,': [151], 'bone': [152], 'only,': [153], 'other)': [155], 'resistance': [157, 410], 'ET': [160, 412], '(primary': [161], 'versus': [162, 297, 369, 373, 376], 'secondary).': [163], 'OS': [164, 230, 304, 322, 363, 380, 489, 513], 'key': [168], 'secondary': [169], 'endpoints,': [170], 'chemotherapy-free': [172, 450, 542], 'an': [175, 547], 'exploratory': [176], 'endpoint': [177], 'defined': [178], 'as': [179, 401], 'time': [181, 272, 280], 'randomization': [183], 'initiation': [185, 437], 'chemotherapy': [187, 439], 'death,': [189], 'whichever': [190], 'occurs': [191], 'earliest.': [193], 'Kaplan-Meier': [194], '(KM)': [195], 'method': [196], 'used': [198, 210], 'analyze': [200], 'time-to-event': [201], 'variables.': [202], 'A': [203, 615], 'Cox': [205], 'proportional': [206], 'hazards': [207], 'model': [208], 'estimate': [212], 'effect': [214, 523], 'hazard': [215], '(HR).': [217], 'prespecified': [219, 487], 'planned': [223], 'occur': [225], 'approximately': [228, 274], '441': [229], 'events.': [231], 'Data': [232], 'cutoff': [233], 'March': [235], '18,': [236], '2022.': [237], 'Results': [238], '669': [239], '(n': [247, 252], '446)': [249], 'placebo': [251, 301, 316, 335, 377], '223),': [254], 'Baseline': [257], 'characteristics': [258], 'have': [259], 'been': [260], 'previously': [261, 507], 'reported': [262], '(Sledge': [263], 'et.': [264], 'al.,': [265], 'Jama': [266], 'Oncol': [267], '2020).': [268], 'median': [270, 321, 498], 'follow-up': [271, 499], '80': [275], 'months': [276, 325, 332], 'at': [278], 'data': [283], 'cutoff,': [284], '11%': [285], 'pts': [287, 551], 'still': [289], 'receiving': [290], 'study': [291], 'drug': [292], 'arm': [296, 329, 336], '2%': [298], 'arm.': [302], '440': [303], 'events': [305], 'observed': [307, 525], 'ITT': [310], 'population': [311], '(abemaciclib': [312], 'arm:': [313, 317], '283': [314], 'events;': [315], '157': [318], 'events).': [319], '45.8': [324], '37.2': [331], '0.784;': [338], '0.644-0.955).': [341], 'maintained': [343], 'separation': [344], 'KM': [347], 'curves': [348], 'beyond': [349], 'medians': [351], 'illustrated': [353], 'by': [354], 'differences': [356], 'estimated': [359], '5-': [360], '6-year': [362], 'rates': [364, 452], 'between': [365], 'arms': [366], '(5-year:': [367], '41.2%': [368], '29.2%;': [370], '6-year:': [371], '34.7%': [372], '23.7%;': [374], 'respectively).': [378], 'While': [379], 'generally': [383, 516], 'consistent': [384, 517], 'across': [385, 518], 'subgroups,': [386, 519], 'more': [388], 'pronounced': [389], 'noted': [392], 'subgroups': [394], 'associated': [395], 'poorer': [398, 529], 'prognosis': [399], 'such': [400], 'visceral': [402], 'disease': [403], '0.643;': [405], '0.499-0.829),': [408], 'primary': [409], '0.634;': [414], '0.436-0.922)': [417], 'negative': [419], 'progesterone': [420], 'receptor': [421], 'status': [422], '0.623;': [424], '0.405-0.959).': [427], 'Moreover,': [428], 'addition': [430], 'deferred': [435], '0.674;': [441], '0.562-0.809),': [444], 'substantial': [446, 538], 'difference': [447], 'yearly': [449], '(3': [453], 'year:': [454, 459, 464], '42%': [455], 'vs': [456, 461, 466], '29.3%;': [457], '37%': [460], '18.6%;': [462], '5': [463], '32.4%': [465], '14.7%).': [467], 'Notably': [468], 'longer': [470], 'exposure': [471], 'abemaciclib,': [473], 'no': [474], 'new': [475], 'additional': [476], 'risks': [478], 'cumulative': [480], 'toxicities': [481], 'identified.': [483], 'Conclusions': [484], 'At': [485], 'trial,': [495], '6.5': [501], 'years,': [502], 'significant': [505], 'demonstrated': [508], 'confirmed': [510], 'maintained.': [512], 'numerically': [521], 'greater': [522], 'size': [524], 'among': [526], 'prognosis.': [530], 'Importantly,': [531], 'came': [535], 'extension': [539], 'time,': [544], 'which': [545], 'important': [548], 'consideration': [549], 'ABC.': [553], 'results': [555], 'also': [556], 'provide': [557], 'assurance': [558], 'longer-term': [565], 'use.': [566], 'Citation': [567], 'Format:': [568], 'Antonio': [569, 639], 'Llombart-Cussac,': [570], 'George': [571], 'Sledge,': [572], 'Masakazu': [573], 'Toi,': [574], 'Patrick': [575], 'Neven,': [576], 'Joo': [577], 'Hyuk': [578], 'Sohn,': [579], 'Kenichi': [580], 'Inoue,': [581], 'Xavier': [582], 'Pivot,': [583], 'Meena': [584], 'Okera,': [585], 'Norikazu': [586], 'Masuda,': [587], 'Peter': [588], 'A.': [589], 'Kaufman,': [590], 'Han': [591], 'Koh,': [592], 'Eva-Maria': [593], 'Grischke,': [594], 'PierFranco': [595], 'Conte,': [596], 'Valerie': [597], 'Andre,': [598], 'Yuanyuan': [599], 'Bian,': [600], 'Ashwin': [601], 'Shahir,': [602], 'Gertjan': [603], 'van': [604], 'Hal.': [605], 'PD13-11': [606], 'Final': [607], 'Overall': [608], 'Survival': [609], 'Analysis': [610], 'Monarch': [612], ':': [614], 'Phase': [616], 'Plus': [621], 'Fulvestrant': [622], 'Patients': [624], 'Hormone': [626], 'Receptor-Positive,': [627], 'HER2-Negative': [628], 'Advanced': [629], 'Breast': [630, 640], 'Cancer': [631, 641, 652], '[abstract].': [632], 'In:': [633], 'Proceedings': [634], '2022': [637, 643], 'San': [638, 646], 'Symposium;': [642], 'Dec': [644], '6-10;': [645], 'Antonio,': [647], 'TX.': [648], 'Philadelphia': [649], '(PA):': [650], 'AACR;': [651], 'Res': [653], '2023;83(5': [654], 'Suppl):Abstract': [655], 'nr': [656], 'PD13-11.': [657]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4322775049', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 2}], 'updated_date': '2025-01-08T21:38:59.316240', 'created_date': '2023-03-03'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
