Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy

Name: Work Video:
Duration: 3 min 30 s
Yunhua Peng; Jing Liu; Hiroyuki Inuzuka; Wenyi Wei
{'id': 'https://openalex.org/W4322772375', 'doi': 'https://doi.org/10.1016/j.jbc.2023.104572', 'title': 'Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy', 'display_name': 'Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy', 'publication_year': 2023, 'publication_date': '2023-03-02', 'ids': {'openalex': 'https://openalex.org/W4322772375', 'doi': 'https://doi.org/10.1016/j.jbc.2023.104572', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36870680'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jbc.2023.104572', 'pdf_url': 'http://www.jbc.org/article/S0021925823002144/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.jbc.org/article/S0021925823002144/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067049667', 'display_name': 'Yunhua Peng', 'orcid': 'https://orcid.org/0000-0001-8814-2801'}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I87445476', 'display_name': "Xi'an Jiaotong University", 'ror': 'https://ror.org/017zhmm22', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87445476']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Yunhua Peng', 'raw_affiliation_strings': ['Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA', "The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Center for Mitochondrial Biology and Medicine, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China"], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I136199984']}, {'raw_affiliation_string': "The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Center for Mitochondrial Biology and Medicine, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China", 'institution_ids': ['https://openalex.org/I87445476']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100374990', 'display_name': 'Jing Liu', 'orcid': 'https://orcid.org/0000-0002-3113-4015'}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jing Liu', 'raw_affiliation_strings': ['Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086354882', 'display_name': 'Hiroyuki Inuzuka', 'orcid': 'https://orcid.org/0000-0002-4892-0047'}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hiroyuki Inuzuka', 'raw_affiliation_strings': ['Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005394879', 'display_name': 'Wenyi Wei', 'orcid': 'https://orcid.org/0000-0003-0512-3811'}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Wenyi Wei', 'raw_affiliation_strings': ['Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5005394879'], 'corresponding_institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I136199984'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.326, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.999739, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '299', 'issue': '4', 'first_page': '104572', 'last_page': '104572'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/posttranslational-modification', 'display_name': 'Posttranslational modification', 'score': 0.57110006}, {'id': 'https://openalex.org/keywords/cancer-therapy', 'display_name': 'Cancer Therapy', 'score': 0.5097105}], 'concepts': [{'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.59657335}, {'id': 'https://openalex.org/C100631289', 'wikidata': 'https://www.wikidata.org/wiki/Q898362', 'display_name': 'Posttranslational modification', 'level': 3, 'score': 0.57110006}, {'id': 'https://openalex.org/C2983331546', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer therapy', 'level': 3, 'score': 0.5097105}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.47819045}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.42031097}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40472525}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.39404222}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32667553}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31507662}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.16539174}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.1435734}], 'mesh': [{'descriptor_ui': 'D000107', 'descriptor_name': 'Acetylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006031', 'descriptor_name': 'Glycosylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jbc.2023.104572', 'pdf_url': 'http://www.jbc.org/article/S0021925823002144/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050664', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36870680', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jbc.2023.104572', 'pdf_url': 'http://www.jbc.org/article/S0021925823002144/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.82}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': None}, {'funder': 'https://openalex.org/F4320337338', 'funder_display_name': 'National Heart, Lung, and Blood Institute', 'award_id': 'HL148667'}, {'funder': 'https://openalex.org/F4320337351', 'funder_display_name': 'National Cancer Institute', 'award_id': 'R35CA253027'}], 'datasets': [], 'versions': [], 'referenced_works_count': 114, 'referenced_works': ['https://openalex.org/W1481480776', 'https://openalex.org/W1512690422', 'https://openalex.org/W1527383154', 'https://openalex.org/W1556690865', 'https://openalex.org/W1565539350', 'https://openalex.org/W1589654967', 'https://openalex.org/W1625510017', 'https://openalex.org/W1652316604', 'https://openalex.org/W1848212160', 'https://openalex.org/W1986231077', 'https://openalex.org/W1988376074', 'https://openalex.org/W1995827055', 'https://openalex.org/W1997835441', 'https://openalex.org/W1997952190', 'https://openalex.org/W2006731482', 'https://openalex.org/W2008207297', 'https://openalex.org/W2009826707', 'https://openalex.org/W2013853442', 'https://openalex.org/W2015345028', 'https://openalex.org/W2025722611', 'https://openalex.org/W2026507072', 'https://openalex.org/W2026576443', 'https://openalex.org/W2029852810', 'https://openalex.org/W2030205108', 'https://openalex.org/W2036170302', 'https://openalex.org/W2041967294', 'https://openalex.org/W2043794217', 'https://openalex.org/W2044694582', 'https://openalex.org/W2046725709', 'https://openalex.org/W2049324939', 'https://openalex.org/W2055397908', 'https://openalex.org/W2061325032', 'https://openalex.org/W2062491810', 'https://openalex.org/W2068412287', 'https://openalex.org/W2069157717', 'https://openalex.org/W2080791122', 'https://openalex.org/W2083469632', 'https://openalex.org/W2093931104', 'https://openalex.org/W2101876702', 'https://openalex.org/W2113267766', 'https://openalex.org/W2117672117', 'https://openalex.org/W2123647733', 'https://openalex.org/W2134945705', 'https://openalex.org/W2143714027', 'https://openalex.org/W2147917253', 'https://openalex.org/W2151683271', 'https://openalex.org/W2165915223', 'https://openalex.org/W2166987747', 'https://openalex.org/W2168448928', 'https://openalex.org/W2258401599', 'https://openalex.org/W2301131921', 'https://openalex.org/W2318245760', 'https://openalex.org/W2337925307', 'https://openalex.org/W2470671857', 'https://openalex.org/W2580091136', 'https://openalex.org/W2583517964', 'https://openalex.org/W2596064219', 'https://openalex.org/W2597078857', 'https://openalex.org/W2607132510', 'https://openalex.org/W2613065881', 'https://openalex.org/W2635415917', 'https://openalex.org/W2789732912', 'https://openalex.org/W2802147764', 'https://openalex.org/W2886283685', 'https://openalex.org/W2891710607', 'https://openalex.org/W2899910765', 'https://openalex.org/W2978105110', 'https://openalex.org/W2980052892', 'https://openalex.org/W2982548291', 'https://openalex.org/W2985405196', 'https://openalex.org/W2996958440', 'https://openalex.org/W2997947903', 'https://openalex.org/W3000673710', 'https://openalex.org/W3005962215', 'https://openalex.org/W3028901078', 'https://openalex.org/W3045619116', 'https://openalex.org/W3046236678', 'https://openalex.org/W3046939357', 'https://openalex.org/W3055246865', 'https://openalex.org/W3087201669', 'https://openalex.org/W3097843874', 'https://openalex.org/W3135254146', 'https://openalex.org/W3136546688', 'https://openalex.org/W3159594352', 'https://openalex.org/W3166285126', 'https://openalex.org/W3176618876', 'https://openalex.org/W3181605807', 'https://openalex.org/W3204435125', 'https://openalex.org/W3212657068', 'https://openalex.org/W3212685950', 'https://openalex.org/W3213568827', 'https://openalex.org/W4200315554', 'https://openalex.org/W4200579298', 'https://openalex.org/W4205305242', 'https://openalex.org/W4205379795', 'https://openalex.org/W4210536779', 'https://openalex.org/W4213015661', 'https://openalex.org/W4221133910', 'https://openalex.org/W4224452846', 'https://openalex.org/W4225364558', 'https://openalex.org/W4281666442', 'https://openalex.org/W4281806416', 'https://openalex.org/W4282935215', 'https://openalex.org/W4283802541', 'https://openalex.org/W4283836349', 'https://openalex.org/W4296691508', 'https://openalex.org/W4296700653', 'https://openalex.org/W4310380205', 'https://openalex.org/W4313379823', 'https://openalex.org/W4313478312', 'https://openalex.org/W4313893730', 'https://openalex.org/W4315642941', 'https://openalex.org/W4319458885', 'https://openalex.org/W4401391081'], 'related_works': ['https://openalex.org/W4302381976', 'https://openalex.org/W4285386966', 'https://openalex.org/W4283798085', 'https://openalex.org/W4256487025', 'https://openalex.org/W4246546673', 'https://openalex.org/W2531913951', 'https://openalex.org/W2366940514', 'https://openalex.org/W2186113122', 'https://openalex.org/W2127236662', 'https://openalex.org/W1523310174'], 'abstract_inverted_index': {'Post-translational': [0, 218, 491, 514, 538], 'modifications': [1, 219, 441, 492, 515, 539, 589], '(PTMs)': [2, 220, 442], 'regulate': [3, 95, 145, 203, 221, 313, 363, 421, 444, 1014, 1262], 'all': [4, 186, 222, 404, 561, 867, 897], 'aspects': [5, 223, 868], 'of': [6, 12, 35, 59, 83, 99, 136, 188, 200, 224, 230, 253, 277, 301, 317, 354, 406, 418, 470, 496, 599, 630, 662, 695, 712, 721, 737, 780, 792, 822, 848, 869, 879, 899, 915, 956, 993, 1018, 1033, 1055, 1063, 1085, 1138, 1208, 1408, 1427, 1433, 1481, 1500, 1511, 1626, 1680, 1780, 1782, 1812, 1847, 2061, 2119, 2141, 2177, 2196, 2229, 2268, 2304, 2316, 2333, 2463, 2481, 2496, 2533, 2561, 2660, 2694, 2728, 2749, 2753, 2771, 2801, 2829, 2864, 2993, 3203, 3276, 3310, 3384, 3390, 3413, 3471, 3502, 3519, 3580, 3607, 3644, 3682, 3800, 3819, 3834, 3857, 3876, 3895, 3920, 3953, 3998, 4003, 4027, 4079, 4146, 4153, 4185], 'protein': [7, 102, 146, 204, 225, 320, 364, 422, 445, 471, 740, 870, 894, 1021, 1068, 1079, 1156, 1182, 1209, 1271, 1282, 1474, 1518, 1545, 1636, 1657, 1739, 1749, 1781, 1912, 1973, 1999, 2048, 2063, 2147, 2298, 2311, 2396, 2444, 2484, 2727, 3354, 3520, 3552, 3685, 3737, 3754, 3936, 3941, 4067, 4171], 'function.': [8, 226], 'Therefore,': [9, 90, 227, 308, 990, 1008, 4161], 'upstream': [10, 38, 52, 228, 256, 270, 873, 933, 978], 'regulators': [11, 39, 53, 229, 257, 271, 934, 955, 996], 'PTMs,': [13, 189, 231, 407, 900, 957, 1263], 'such': [14, 167, 190, 232, 385, 408, 565, 588, 604, 619, 901, 958, 1038, 1907, 2509, 3116, 3949, 4192], 'as': [15, 127, 168, 191, 233, 345, 386, 409, 566, 605, 620, 799, 902, 939, 959, 1039, 1045, 1134, 1175, 1275, 1277, 1553, 1908, 2041, 2341, 2374, 2510, 2628, 3027, 3117, 3244, 3506, 3749, 3767, 3950, 4193], 'kinases,': [16, 234], 'acetyltransferases,': [17, 235], 'or': [18, 236, 706, 716, 1097, 1306, 1727, 1733, 1785, 1793, 2279, 3662, 4082], 'methyltransferases,': [19, 237], 'are': [20, 40, 46, 172, 238, 258, 264, 390, 558, 842, 882, 1022, 1088, 1300, 1497, 1721, 1742, 2187, 2460, 2963, 3759], 'potential': [21, 157, 239, 375, 1048, 2293], 'therapeutic': [22, 240, 497, 941, 988, 2376, 4181], 'targets': [23, 241, 942, 3498, 3942], 'for': [24, 214, 242, 432, 886, 943, 968, 1049, 1074, 1140, 1178, 1281, 1468, 1557, 1729, 1795, 1831, 1885, 1904, 1936, 2044, 2145, 2193, 2299, 2308, 2327, 2345, 2446, 2488, 2767, 3528, 3550, 3578, 3611, 3641, 3755, 3797, 3854, 3892, 3924, 4074, 4088, 4128, 4155, 4180], 'human': [25, 243, 669, 944, 1056, 1673, 4090], 'diseases,': [26, 244, 945], 'including': [27, 245, 851, 1752, 1851, 2716, 2778, 3530], 'cancer.': [28, 246, 947], 'To': [29, 118, 247, 336], 'date,': [30, 248, 2508], 'multiple': [31, 249, 982, 2566, 2834, 2932], 'inhibitors': [32, 250, 3172, 3224, 3448, 4078, 4097], 'and/or': [33, 251, 1094], 'agonists': [34, 252], 'these': [36, 51, 84, 254, 269, 302, 880, 932, 954, 2772], 'PTM': [37, 98, 205, 255, 316, 423, 995, 1017, 1036], 'in': [41, 48, 86, 110, 174, 206, 211, 259, 266, 304, 328, 392, 424, 429, 493, 516, 544, 560, 668, 739, 784, 801, 865, 974, 984, 1005, 1023, 1052, 1081, 1109, 1141, 1179, 1214, 1258, 1444, 1659, 1708, 1971, 2045, 2172, 2237, 2276, 2478, 2565, 2833, 2866, 2931, 2999, 3063, 3184, 3331, 3438, 4018, 4098], 'clinical': [42, 88, 162, 175, 212, 260, 306, 380, 393, 430, 1050, 2191], 'use,': [43, 261], 'while': [44, 262, 4172], 'others': [45, 263, 909], 'still': [47, 265], 'development.': [49, 267, 975, 1172, 2038, 2318, 3512], 'However,': [50, 268, 592, 976, 4142], 'control': [54, 272, 1447], 'not': [55, 273, 3987], 'only': [56, 274, 1682, 2502, 4168], 'the': [57, 81, 100, 275, 299, 318, 494, 596, 684, 691, 708, 718, 777, 788, 793, 872, 892, 987, 994, 1006, 1015, 1027, 1053, 1061, 1215, 1297, 1304, 1380, 1405, 1411, 1415, 1420, 1425, 1430, 1470, 1509, 1516, 1524, 1598, 1624, 1627, 1631, 1634, 1660, 1724, 1790, 1801, 1807, 1865, 1932, 2108, 2111, 2117, 2120, 2124, 2174, 2178, 2194, 2292, 2302, 2309, 2313, 2331, 2398, 2469, 2474, 2479, 2482, 2494, 2530, 2729, 2798, 2899, 3124, 3335, 3340, 3361, 3378, 3500, 3547, 3741, 3746, 3816, 3821, 3893, 3944, 4000, 4004, 4012, 4024, 4030, 4150, 4169, 4206], 'PTMs': [58, 276, 557, 618, 774, 841, 860, 881], 'disease-related': [60, 278], 'target': [61, 103, 143, 279, 321, 361, 953, 1181, 1929, 2047, 2295, 2310, 2475, 2483, 2593, 2752, 3151, 3362, 3753, 3835, 4170, 4176], 'proteins': [62, 280, 632, 1293, 1299, 1435, 1720, 1735, 1930, 2962, 3389, 3495, 3505, 3527, 3836, 3898, 4177, 4187], 'but': [63, 281, 783], 'also': [64, 210, 282, 428, 616, 796, 3348], 'other': [65, 283, 2324, 3517, 4174], 'disease-irrelevant': [66, 284], 'substrate': [67, 285, 1434, 1635, 1639, 2930, 3061], 'proteins.': [68, 286, 889], 'Thus,': [69, 287], 'nontargeted': [70, 288], 'perturbing': [71, 289], 'activities': [72, 290], 'may': [73, 104, 291, 322, 997, 3347], 'introduce': [74, 292, 998, 1777], 'unwanted': [75, 293, 999, 1734], 'off-target': [76, 294], 'toxicity': [77, 295], 'issues': [78, 296], 'that': [79, 93, 297, 311, 952, 1010, 1092, 1261, 1269, 1746, 1863, 1928, 2466, 2633, 3173, 3249, 3345, 3355, 3488, 3545, 3659, 3734, 3762, 3938, 4022], 'limit': [80, 298], 'use': [82, 300, 3763], 'drugs': [85, 92, 163, 303, 310, 381, 951, 1009], 'successful': [87, 305], 'applications.': [89, 307], 'alternative': [91, 309], 'solely': [94, 312], 'a': [96, 106, 128, 155, 197, 314, 324, 346, 373, 415, 846, 862, 1019, 1135, 1176, 1265, 1554, 1683, 1828, 1852, 1860, 1882, 2003, 2042, 2104, 2270, 2305, 2375, 2461, 2486, 2503, 2629, 2661, 2750, 2927, 2995, 3028, 3059, 3245, 3277, 3352, 3357, 3365, 3382, 3428, 3439, 3764, 3768, 3772, 3777, 3886, 3903, 3989, 3994, 4019, 4143, 4156, 4162, 4200], 'specific': [97, 315, 634, 1016, 2306, 3990, 4164], 'disease-relevant': [101, 319], 'provide': [105, 323], 'more': [107, 178, 325, 396, 973, 1012, 2170, 3444, 4163], 'precise': [108, 326], 'effect': [109, 327], 'treating': [111, 329], 'disease': [112, 330], 'with': [113, 331, 971, 1240, 1264, 1464, 1503, 2107, 2501, 3180, 3360], 'relatively': [114, 332], 'low': [115, 333], 'side': [116, 334, 778, 1000], 'effects.': [117, 335], 'this': [119, 337, 1252, 4147], 'end,': [120, 338], 'chemically': [121, 339, 1066], 'induced': [122, 340, 1067, 1107, 2001, 3100], 'proximity': [123, 137, 341, 355, 1059, 1069, 1086, 1108, 1139, 3092], 'has': [124, 342, 981, 2291, 3369], 'recently': [125, 343], 'emerged': [126, 344, 1044], 'powerful': [129, 347], 'research': [130, 208, 348, 426], 'tool,': [131, 349], 'and': [132, 144, 150, 164, 170, 193, 209, 350, 362, 368, 382, 388, 411, 427, 450, 571, 583, 612, 645, 664, 702, 726, 763, 814, 855, 876, 908, 935, 962, 1065, 1077, 1111, 1226, 1273, 1285, 1296, 1377, 1419, 1424, 1448, 1484, 1539, 1595, 1653, 1736, 1769, 1810, 1859, 1938, 2058, 2110, 2185, 2199, 2207, 2266, 2343, 2420, 2473, 2490, 2563, 2677, 2719, 2764, 2831, 2862, 2959, 3076, 3103, 3120, 3178, 3293, 3436, 3449, 3508, 3515, 3622, 3647, 3665, 3698, 3745, 3776, 3803, 3831, 3860, 3882, 3899, 4077], 'several': [133, 165, 351, 383, 1031, 1278, 1743, 4190], 'chemical': [134, 352, 1034, 1136, 1861, 2009, 2700, 3316, 3951, 3996], 'inducers': [135, 353, 1084, 3952, 3997], '(CIPs)': [138, 356, 1087], 'have': [139, 154, 357, 372, 965, 1043, 1685, 1901, 2775, 3522, 3946, 4084], 'been': [140, 358, 966, 1902, 2776, 3370, 3523, 3947, 4085], 'used': [141, 359], 'to': [142, 158, 181, 184, 202, 360, 376, 399, 402, 420, 443, 986, 1308, 1385, 1508, 1559, 1603, 1637, 1723, 1789, 1805, 1931, 2008, 2123, 2160, 2294, 2323, 2507, 2601, 2667, 2723, 2898, 3095, 3129, 3159, 3283, 3372, 3381, 3492, 3525, 3752, 3902, 4011, 4166, 4189], 'ubiquitination,': [147, 365, 570, 906], 'phosphorylation,': [148, 366, 567, 903, 1283], 'acetylation,': [149, 367, 568, 904, 1284], 'glycosylation.': [151, 369], 'These': [152, 370, 1775], 'CIPs': [153, 179, 371, 397, 1268, 1280], 'high': [156, 374, 1047], 'be': [159, 182, 377, 400, 797, 3349], 'translated': [160, 378], 'into': [161, 379, 2485, 3496, 3943], 'examples': [166, 384, 2505], 'PROTACs': [169, 387, 2373, 3102], 'MGDs': [171, 389, 2459], 'now': [173, 391], 'trials.': [176, 394], 'Hence,': [177, 395], 'need': [180, 398], 'developed': [183, 401, 3371, 3524], 'cover': [185, 403], 'types': [187, 405, 898, 1032, 1499, 3518], 'methylation': [192, 410], 'palmitoylation,': [194, 412], 'thus': [195, 413, 2115], 'providing': [196, 414], 'full': [198, 416], 'spectrum': [199, 417], 'tools': [201, 419, 2344], 'basic': [207, 425], 'application': [213, 431, 1004], 'effective': [215, 433], 'cancer': [216, 434, 969, 1832, 1886, 2198, 2241, 2447, 3185, 4099, 4129], 'treatment.': [217, 435], 'Eukaryotic': [436], 'cells': [437, 3332], 'rely': [438], 'on': [439, 540, 690, 707, 717, 761, 1267, 1655, 2330], 'posttranslational': [440, 472], 'activity,': [446], 'stability,': [447], 'subcellular': [448, 1192], 'localization,': [449], 'protein–protein': [451], 'interactions': [452, 3099], '(PPIs)': [453], '(1Beltrao': [454], 'P.': [455, 1644, 1648, 2551, 2649, 2819, 3265], 'Albanèse': [456], 'V.': [457, 1125, 1127], 'Kenner': [458], 'L.R.': [459], 'Swaney': [460], 'D.L.': [461, 1161, 2027], 'Burlingame': [462], 'A.': [463, 625, 627, 1167, 1203, 1313, 1315, 1364, 1374, 1582, 1592, 1918, 1945, 1960, 2033, 2129, 2549, 2817, 3712], 'Villén': [464], 'J.': [465, 535, 537, 1163, 1689, 1815, 1817, 1821, 1869, 1871, 1875, 2029, 2218, 2258, 2362, 2441, 2545, 2587, 2813, 2847, 2913, 2951, 2980, 3020, 3051, 3145, 3601, 3676, 3704, 3914, 4113, 4117, 4119, 4121], 'et': [466, 659, 1132, 1170, 1206, 1375, 1593, 1700, 1826, 1880, 1969, 2036, 2077, 2138, 2225, 2263, 2524, 2556, 2590, 2622, 2658, 2691, 2747, 2792, 2824, 2858, 2891, 2924, 2989, 3023, 3056, 3090, 3148, 3200, 3238, 3274, 3307, 3405, 3463, 3604, 3636, 3679, 3713, 3792, 3849, 3917, 3967, 4048], 'al.Systematic': [467], 'functional': [468, 1849], 'prioritization': [469], 'modifications.Cell.': [473], '2012;': [474, 1338], '150:': [475], '413-425Abstract': [476], 'Full': [477, 479, 830, 832, 921, 923, 1392, 1394, 1530, 1610, 1612, 2090, 2092, 2351, 2353, 3212, 3214, 3724, 3726], 'Text': [478, 480, 831, 833, 922, 924, 1393, 1395, 1531, 1611, 1613, 2091, 2093, 2352, 2354, 3213, 3215, 3725, 3727], 'PDF': [481, 834, 925, 1396, 1532, 1614, 2094, 2355, 3216, 3728], 'PubMed': [482, 503, 525, 552, 640, 675, 749, 769, 835, 926, 1115, 1149, 1187, 1221, 1246, 1324, 1341, 1358, 1397, 1455, 1491, 1533, 1576, 1615, 1667, 1714, 1839, 1893, 1949, 1983, 2017, 2053, 2095, 2154, 2356, 2383, 2408, 2427, 2454, 2539, 2572, 2640, 2674, 2707, 2759, 2807, 2840, 2873, 2906, 2940, 2971, 3006, 3037, 3071, 3110, 3217, 3256, 3290, 3323, 3422, 3480, 3559, 3586, 3617, 3654, 3693, 3729, 3810, 3867, 3930, 3980, 4061, 4107, 4137], 'Scopus': [483, 504, 526, 553, 641, 676, 750, 770, 836, 927, 1116, 1150, 1188, 1222, 1325, 1342, 1359, 1398, 1456, 1492, 1577, 1616, 1668, 1715, 1840, 1894, 1950, 1984, 2018, 2054, 2096, 2155, 2357, 2384, 2409, 2455, 2540, 2573, 2605, 2641, 2708, 2760, 2808, 2841, 2874, 2907, 2941, 2972, 3007, 3038, 3072, 3111, 3163, 3218, 3257, 3324, 3423, 3481, 3560, 3587, 3618, 3655, 3694, 3730, 3811, 3868, 3931, 3981, 4062, 4108, 4138], '(306)': [484], 'Google': [485, 506, 528, 555, 643, 678, 752, 772, 838, 929, 1118, 1152, 1190, 1224, 1247, 1327, 1344, 1361, 1400, 1458, 1494, 1534, 1579, 1618, 1670, 1717, 1842, 1896, 1952, 1986, 2020, 2056, 2098, 2157, 2249, 2287, 2359, 2386, 2411, 2428, 2457, 2542, 2575, 2607, 2643, 2675, 2710, 2762, 2810, 2843, 2876, 2909, 2943, 2974, 3009, 3040, 3074, 3113, 3165, 3220, 3259, 3291, 3326, 3425, 3483, 3562, 3589, 3620, 3657, 3696, 3732, 3813, 3870, 3933, 3983, 4064, 4110, 4140], 'Scholar,': [486, 507, 529, 753, 1119, 1328, 1345, 1362, 1580, 2250, 2360, 2387, 2412, 2429, 2543, 2811, 3010, 3563, 4111], '2Walsh': [487], 'G.': [488, 1347, 1565, 2513, 2615, 2781, 2882, 3018, 3231, 3533, 3571], 'Jefferis': [489], 'R.': [490, 2070, 2220, 2260], 'context': [495], 'proteins.Nat.': [498, 3649, 3805, 3862], 'Biotechnol.': [499, 3650, 3806, 3863], '2006;': [500], '24:': [501], '1241-1252Crossref': [502], '(742)': [505], '3Deribe': [508], 'Y.L.': [509], 'Pawson': [510], 'T.': [511, 1205, 2579, 2736, 2740, 2742, 2884, 2915, 2923, 2949, 2957, 3044, 3053, 3137, 3678, 3706], 'Dikic': [512, 1521], 'I.': [513, 1522], 'signal': [517, 1227, 1238, 1561], 'integration.Nat.': [518], 'Struct.': [519], 'Mol.': [520, 743], 'Biol.': [521, 547, 745, 825, 1145, 1835, 1889, 1979, 2085, 2150, 2379, 2703, 2936, 2967, 3033, 3067, 3319, 3555, 3976, 4057, 4133], '2010;': [522, 637, 2756], '17:': [523, 3557], '666-672Crossref': [524], '(541)': [527], '4Peng': [530], 'Y.': [531, 1819, 1823, 1873, 1877, 2364, 2439, 2653, 2657, 2746, 2917, 2953, 3081, 3269, 3273, 3394, 3396, 3452, 3454, 4115], 'Liu': [532, 534, 1698, 1818, 1872, 4120], 'H.': [533, 2366, 2517, 2690, 2738, 2785, 2921, 2955, 3046, 3306, 3398, 3456, 3593, 3906], 'Long': [536, 4118], 'mitochondrial': [541], 'metabolic': [542], 'enzymes': [543], 'cancer.Free': [545], 'Radic.': [546], 'Med.': [548, 2011, 4132], '2022;': [549, 1146, 2246, 2284, 2380, 2405, 2424, 3107, 3419, 3477, 3614, 3651, 3807, 3864, 3927], '179:': [550], '11-23Crossref': [551], '(0)': [554, 1151, 2908, 2973, 3112, 3424, 3482, 3982, 4063], 'Scholar).': [556, 773, 839, 930, 1401, 1459, 1495, 1535, 1619, 1671, 1718, 1843, 1897, 2099, 2158, 2288, 2458, 2711, 3114, 3221, 3426, 3484, 3814, 3871, 3934, 4065, 4141], 'present': [559, 594, 2419], 'polar': [562], 'amino': [563, 575, 602, 710, 781, 790], 'acids,': [564, 603], 'methylation,': [569, 905], 'glycosylation,': [572], 'whereas': [573, 1547], 'nonpolar': [574, 601], 'acids': [576, 782], 'like': [577], '(Leu,': [578], 'L),': [579], 'isoleucine': [580], '(Ile,': [581], 'I),': [582], 'phenylalanine': [584, 4202], '(Phe,': [585], 'F)': [586], 'lack': [587], '(Fig.': [590, 680, 857, 1249, 1288, 1773], '1).': [591, 681], 'when': [593], 'at': [595, 803], 'N': [597], 'terminus': [598], 'proteins,': [600, 3664], 'alanine': [606], '(Ala,': [607], 'A),': [608], 'valine': [609], '(Val,': [610], 'V),': [611], 'methionine': [613], '(Met,': [614], 'M)': [615], 'undergo': [617, 1294], 'N-acetylation': [621, 802], '(5Hwang': [622], 'C.-S.': [623], 'Shemorry': [624], 'Varshavsky': [626], 'N-terminal': [628, 789], 'acetylation': [629, 821], 'cellular': [631, 1353, 1571, 2059, 2175], 'creates': [633], 'degradation': [635, 1157, 1658, 1750, 1811, 2000, 2445, 2560, 2598, 2828, 2863, 2992, 3156, 3412, 3470, 3579, 3643, 3799, 3833, 3856, 3894, 3954, 3969, 4026, 4050, 4184], 'signals.Science.': [636], '327:': [638, 2757], '973-977Crossref': [639], '(467)': [642], 'Scholar)': [644, 679, 1248, 3327, 3658, 3697, 3733], 'N-myristylation': [646], '(6Thinon': [647], 'E.': [648, 1964, 2252, 2585, 3143, 3191, 3195, 3708, 3710], 'Serwa': [649], 'R.A.': [650], 'Broncel': [651], 'M.': [652, 1332, 1372, 1590, 1642, 1646, 1992, 2072, 2074, 2389, 2433, 2519, 2555, 2581, 2611, 2619, 2684, 2688, 2787, 2823, 3049, 3089, 3139, 3199, 3227, 3235, 3300, 3304], 'Brannigan': [653], 'J.A.': [654, 732, 3627, 3783, 3840], 'Brassat': [655], 'U.': [656, 1943], 'Wright': [657], 'M.H.': [658], 'al.Global': [660], 'profiling': [661], 'co-': [663], 'post-translationally': [665], 'N-myristoylated': [666], 'proteomes': [667], 'cells.Nat.': [670, 2934], 'Commun.': [671, 1663, 1710, 3106], '2014;': [672, 2536, 2569, 2804, 2837], '5:': [673], '4919Crossref': [674], '(161)': [677], 'Phosphorylation': [682], 'is': [683, 1060, 1070, 1462, 2400, 2498, 2926, 3058, 3490, 3873, 4009, 4069, 4149, 4178, 4197], 'most': [685], 'widely': [686], 'studied': [687, 885], 'PTM,': [688], 'occurring': [689], 'side-chain': [692, 709], 'hydroxyl': [693], 'group': [694, 711, 720, 791], 'tyrosine': [696], '(Tyr,': [697], 'Y),': [698], 'serine': [699], '(Ser,': [700], 'S),': [701], 'threonine': [703], '(Thr,': [704], 'T),': [705], 'histidine': [713], '(His,': [714], 'H),': [715], 'carboxyl': [719], 'aspartic': [722], 'acid': [723, 728], '(Asp,': [724], 'D)': [725], 'glutamic': [727], '(Glu,': [729], 'E)': [730], '(7Ubersax': [731], 'Ferrell': [733], 'Jr.,': [734], 'J.E.': [735], 'Mechanisms': [736, 1480], 'specificity': [738, 1483, 1625, 1640, 1654], 'phosphorylation.Nat.': [741], 'Rev.': [742, 1319, 1336, 1486, 2402, 2423, 2449, 4101], 'Cell': [744], '2007;': [746], '8:': [747], '530-541Crossref': [748], '(1009)': [751], '8Attwood': [754], 'P.V.': [755], 'Besant': [756], 'P.G.': [757], 'Piggott': [758], 'M.J.': [759, 1121], 'Focus': [760], 'phosphoaspartate': [762], 'phosphoglutamate.Amino': [764], 'Acids.': [765], '2011;': [766], '40:': [767, 2247], '1035-1051Crossref': [768], '(34)': [771], 'primarily': [775], 'affect': [776], 'chain': [779, 1472, 1550, 2122], 'some': [785], 'rare': [786], 'cases': [787], 'peptide': [794], 'can': [795, 1011, 2321], 'modified,': [798], 'seen': [800], 'Ala,': [804], 'cysteine': [805], '(Cys,': [806], 'C),': [807], 'glycine': [808], '(Gly,': [809], 'G),': [810], 'Met,': [811], 'Ser,': [812], 'Thr,': [813], 'Val': [815], '(9Polevoda': [816], 'B.': [817, 2431, 2886, 3197], 'Sherman': [818], 'F.': [819, 1437, 1920, 2076, 3631, 3787, 3844], 'Nα-terminal': [820], 'eukaryotic': [823, 1291], 'proteins.J.': [824], 'Chem.': [826, 1144, 1978, 2012, 2086, 2149, 2702, 2935, 3032, 3066, 3318, 3417, 3475, 3554, 3975, 4056], '2000;': [827, 1218], '275:': [828], '36479-36482Abstract': [829], '(285)': [837], 'Protein': [840, 1058], 'tightly': [843], 'regulated': [844, 1656], 'by': [845, 1303, 1410, 1975, 2002, 2082, 2372, 2595, 3101, 3153, 3333, 3351, 3376, 3686, 4029, 4199], 'network': [847], 'enzymatic': [849], 'regulators,': [850], 'respective': [852], 'writers,': [853], 'erasers,': [854], 'readers': [856, 2320], '2).': [858, 1250], 'As': [859, 3427], 'play': [861], 'critical': [863], 'role': [864], 'almost': [866], 'function,': [871], 'regulatory': [874], 'mechanism(s)': [875], 'downstream': [877, 936, 4175], 'effect(s)': [878], 'being': [883], 'intensively': [884], 'many': [887, 972], 'key': [888], 'For': [890, 1536], 'instance,': [891], 'p53': [893, 916], 'undergoes': [895], 'nearly': [896], 'PARylation,': [907], '(10Kruse': [910], 'J.-P.': [911], 'Gu': [912], 'W.': [913, 1441, 1695, 2135, 2368, 4123], 'Modes': [914], 'regulation.Cell.': [917], '2009;': [918], '137:': [919], '609-622Abstract': [920], '(1299)': [928], 'Consequently,': [931], 'effectors': [937], 'serve': [938], 'ideal': [940, 4179], 'particularly': [946], 'Several': [948, 2769], 'hundred': [949], 'small-molecule': [950, 1976, 2162], 'kinase,': [960], 'deacetylase,': [961], 'methyltransferase': [963], 'inhibitors,': [964, 2163], 'approved': [967], 'treatment,': [970], 'each': [977], 'regulator': [979, 4211], 'typically': [980], 'substrates': [983, 1475, 4154], 'addition': [985, 2118], 'target.': [989], 'indiscriminate': [991], 'inhibition': [992], 'effects,': [1001], 'limiting': [1002], 'their': [1003], 'clinic.': [1007], 'precisely': [1013], 'single': [1020, 4201], 'realistic': [1024], 'need.': [1025], 'In': [1026, 1251, 1290, 3815, 3993], 'past': [1028, 2399], '2': [1029], 'decades,': [1030], 'proximity-induced': [1035], 'methods,': [1037], 'proteolysis-targeting': [1040, 1770], 'chimera': [1041, 1759, 1767, 3409, 3467, 3700], '(PROTAC),': [1042], 'having': [1046], 'translation': [1051], 'treatment': [1054, 2195], 'diseases.': [1057], 'foundation': [1062], 'PPIs,': [1064], 'an': [1071, 1855, 2231, 2725, 3132, 4070], 'emerging': [1072], 'tool': [1073], 'manipulating': [1075], 'PPI': [1076, 1099, 1558], 'regulating': [1078, 1155], 'function': [1080, 2176], 'cells.': [1082], 'Chemical': [1083], 'drug-like': [1089], 'small': [1090, 2004], 'molecules': [1091, 1927, 2079], 'induce': [1093, 1270, 3175], 'remove': [1095], 'native': [1096], 'new': [1098], '(11Stanton': [1100], 'B.Z.': [1101], 'Chory': [1102], 'E.J.': [1103], 'Crabtree': [1104, 1235], 'G.R.': [1105, 1236], 'Chemically': [1106], 'biology': [1110], 'medicine.Science.': [1112], '2018;': [1113, 3004, 3034], '359eaao5902Crossref': [1114], '(169)': [1117], '12Ziegler': [1120], 'Yserentant': [1122], 'K.': [1123, 1131, 1520, 2066, 2068, 2414, 2744, 2890, 3022, 3085, 3087, 3567, 3599, 3625, 3781, 3838, 3912], 'Dunsing': [1124], 'Middel': [1126], 'Gralak': [1128], 'A.J.': [1129], 'Pakari': [1130], 'al.Mandipropamid': [1133], 'inducer': [1137], 'vivo': [1142, 1180, 1972, 2046], 'applications.Nat.': [1143], '18:': [1147, 2015], '64-69Crossref': [1148], 'Scholar),': [1153, 1191, 1225, 1953, 1987, 2021, 2057, 2576, 2608, 2644, 2676, 2763, 2844, 2877, 2910, 2944, 2975, 3041, 3075, 3166, 3260, 3292, 3590, 3621, 3984], 'thereby': [1154, 2167], '(13Winter': [1158, 2024], 'G.E.': [1159, 2025], 'Buckley': [1160, 2026], 'Paulk': [1162, 2028], 'Roberts': [1164, 2030], 'J.M.': [1165, 2031], 'Souza': [1166, 2032], 'Dhe-Paganon': [1168, 2034], 'S.': [1169, 1199, 1944, 1966, 2035, 2682, 2919, 3014, 3079, 3083, 3298, 3569, 3958, 4039], 'al.Drug': [1171, 2037], 'Phthalimide': [1173, 2039], 'conjugation': [1174, 2040], 'strategy': [1177, 1830, 1884, 2043, 4165], 'degradation.Science.': [1183, 2049], '2015;': [1184, 1980, 2050, 2870], '348:': [1185, 2051], '1376-1381Crossref': [1186, 2052], '(996)': [1189, 2055], 'translocation': [1193], '(14Rivera': [1194], 'V.M.': [1195], 'Wang': [1196, 1824, 1878, 3669, 3671], 'X.': [1197, 2131, 2213, 3016, 3400, 3458], 'Wardwell': [1198], 'Courage': [1200], 'N.L.': [1201], 'Volchuk': [1202], 'Keenan': [1204], 'al.Regulation': [1207], 'secretion': [1210], 'through': [1211, 1383, 1601, 1705, 2202, 3499], 'controlled': [1212], 'aggregation': [1213], 'endoplasmic': [1216], 'reticulum.Science.': [1217], '287:': [1219], '826-830Crossref': [1220], '(276)': [1223], 'transduction': [1228, 1239, 1562], '(15Spencer': [1229], 'D.M.': [1230], 'Wandless': [1231], 'T.J.': [1232], 'Schreiber': [1233], 'S.L.': [1234], 'Controlling': [1237], 'synthetic': [1241], 'ligands.Science.': [1242], '1993;': [1243], '262:': [1244], '1019-1024Crossref': [1245], 'review,': [1253], 'we': [1254], 'summarize': [1255], 'recent': [1256], 'advances': [1257], 'CIP': [1259, 1744], 'technologies': [1260], 'focus': [1266], 'ubiquitination': [1272, 1628, 1809, 1937, 2489, 2861, 4035], 'degradation,': [1274, 1546, 1730, 2301, 3529, 3999], 'well': [1276], 'novel': [1279, 1829, 1883, 2271, 2893], 'O-linked-N-acetylglucosaminylation': [1286], '(O-GlcNAcylation)': [1287], '3).': [1289], 'cells,': [1292], 'polyubiquitination': [1295], 'ubiquitinated': [1298], 'subsequently': [1301], 'degraded': [1302], 'proteasome': [1305, 1726, 1792, 3945, 3973, 4032, 4054, 4083], 'lysosome': [1307, 1728, 1794], 'transduce': [1309], 'cell': [1310, 1445, 3645, 3801, 3858], 'signals': [1311], '(16Hershko': [1312], 'Ciechanover': [1314], 'The': [1316, 1333, 1672, 1797, 2100, 2712, 3485], 'ubiquitin': [1317, 1334, 1409, 1421, 1428, 1517, 1525, 1621, 2471, 2732, 2901, 3126, 3609, 3890, 3922, 4159], 'system.Annu.': [1318], 'Biochem.': [1320, 1337, 1487], '1998;': [1321], '67:': [1322, 1837, 1891], '425-479Crossref': [1323], '(6931)': [1326], '17Komander': [1329], 'D.': [1330, 1479, 3702], 'Rape': [1331], 'code.Annu.': [1335], '81:': [1339], '203-229Crossref': [1340], '(2285)': [1343], '18Vogel': [1346], 'Nobel': [1348, 1566], 'prizes.': [1349, 1567], 'Gold': [1350, 1568], 'medal': [1351, 1569], 'from': [1352, 1473, 1570], 'trash.Science.': [1354, 1572], '2004;': [1355, 1389, 1573, 1607], '306:': [1356, 1574], '400-401Crossref': [1357, 1575], '(9)': [1360, 1578], '19Kanayama': [1363, 1581], 'Seth': [1365, 1583], 'R.B.': [1366, 1584], 'Sun': [1367, 1585, 2516, 2784], 'L.': [1368, 1439, 1586, 2254, 2647, 2651, 3263, 3267, 3404, 3462], 'Ea': [1369, 1587], 'C.K.': [1370, 1588], 'Hong': [1371, 1589], 'Shaito': [1373, 1591], 'al.TAB2': [1376, 1594], 'TAB3': [1378, 1596], 'activate': [1379, 1597], 'NF-kappaB': [1381, 1599], 'pathway': [1382, 1600], 'binding': [1384, 1602, 3387, 3504], 'polyubiquitin': [1386, 1471, 1501, 1541, 1549, 1604, 1778, 2121], 'chains.Mol.': [1387, 1605], 'Cell.': [1388, 1606, 3720], '15:': [1390, 1608, 3069], '535-548Abstract': [1391, 1609], '(701)': [1399, 1617], 'This': [1402, 1460], 'process': [1403, 1461], 'involves': [1404], 'sequential': [1406], 'catalysis': [1407], 'ubiquitin-activating': [1412], 'enzyme': [1413, 1417], 'E1,': [1414], 'ubiquitin-conjugating': [1416], 'E2,': [1418], 'ligase': [1422, 1857, 2472, 2733, 3098, 3127], 'E3,': [1423], 'transfer': [1426], 'onto': [1429, 3339], 'lysine': [1431, 1513], 'residues': [1432, 1514], '(20Dang': [1436], 'Nie': [1438], 'Wei': [1440, 2367, 4122], 'Ubiquitin': [1442], 'signaling': [1443], 'cycle': [1446], 'tumorigenesis.Cell': [1449], 'Death': [1450], 'Differ.': [1451], '2021;': [1452, 1711, 2451, 2968, 3209, 3556], '28:': [1453], '427-438Crossref': [1454], '(29)': [1457], 'reversible,': [1463], 'deubiquitinases': [1465], '(DUBs)': [1466], 'responsible': [1467], 'removing': [1469], '(21Mevissen': [1476], 'T.E.': [1477], 'Komander': [1478], 'deubiquitinase': [1482], 'regulation.Annu.': [1485], '2017;': [1488, 2151, 2603, 3161, 4104], '86:': [1489, 2381], '159-192Crossref': [1490], '(540)': [1493], 'There': [1496, 1741], 'different': [1498], 'chains': [1502, 1542], 'distinct': [1504], 'biological': [1505, 2346], 'functions': [1506, 3900], 'due': [1507], 'presence': [1510], 'seven': [1512], 'within': [1515, 1633, 4205], '(22Rajalingam': [1519], 'Expanding': [1523], 'code.Cell.': [1526], '2016;': [1527, 1664, 2903], '164:': [1528], '1074-1074.e1Abstract': [1529], 'example,': [1537], 'K11': [1538], 'K48': [1540], 'mainly': [1543], 'promote': [1544], 'K63': [1548], 'usually': [1551, 2499], 'serves': [1552], 'docking': [1555, 3750, 3769], 'site': [1556], 'facilitate': [1560, 1747], 'events': [1563], '(18Vogel': [1564], 'E3': [1620, 1678, 1856, 1899, 2113, 2470, 2731, 3125, 3342, 3608, 3889, 3921, 3991, 4080, 4126, 4158], 'ligases': [1622, 1900, 3610, 3923, 4081, 4127], 'dictate': [1623], 'substrate,': [1629], 'recognizing': [1630], 'degron': [1632, 1706], 'confer': [1638, 1651], '(23Guharoy': [1641], 'Bhowmick': [1643], 'Sallam': [1645], 'Tompa': [1647], 'Tripartite': [1649], 'degrons': [1650, 1687], 'diversity': [1652], 'ubiquitin-proteasome': [1661, 1803], 'system.Nat.': [1662], '7:': [1665], '10239Crossref': [1666], '(84)': [1669], 'genome': [1674], 'contains': [1675], 'over': [1676], '600': [1677], 'ligases,': [1679], 'which': [1681, 3167, 3828, 3879, 3985, 4196], 'few': [1684, 2504], 'well-defined': [1686], '(24Liu': [1688], 'Tokheim': [1690], 'C.': [1691, 2680, 3296, 3603, 3670, 3674, 3916, 3956, 4037], 'Lee': [1692], 'J.D.': [1693, 3193], 'Gan': [1694], 'North': [1696], 'B.J.': [1697], 'X.S.': [1699], 'al.Genetic': [1701], 'fusions': [1702], 'favor': [1703], 'tumorigenesis': [1704], 'loss': [1707], 'oncogenes.Nat.': [1709], '12:': [1712], '6704Crossref': [1713], '(1)': [1716, 3656, 3812, 3869], 'Ubiquitinated': [1719], 'recruited': [1722], '26S': [1725, 1791, 3972, 4005, 4031, 4053], 'eliminating': [1731], 'misfolded': [1732], 'governing': [1737], 'intracellular': [1738, 1998, 2297], 'homeostasis.': [1740], 'approaches': [1745], 'targeted': [1748, 1808, 2395, 2443, 3551, 3642, 3798, 3855], '(TPD),': [1751], 'PROTAC,': [1753, 2493], 'molecular': [1754, 2630, 2662, 2695, 3104, 3246, 3278, 3311], 'glue': [1755, 2631, 2663, 2696, 3247, 3279, 3312], 'degraders': [1756, 2697, 3313, 3450, 3521, 3716, 3937], '(MGDs),': [1757], 'lysosome-targeting': [1758], '(LYTAC),': [1760], 'autophagy-targeting': [1761, 3699], 'chimera,': [1762], 'autophagosome-tethering': [1763], 'compound,': [1764], 'cytokine': [1765, 3638, 3765, 3773, 3794, 3822, 3851], 'receptor-targeting': [1766, 3639, 3795, 3852], '(KineTAC),': [1768], 'antibody': [1771], '(PROTAB)': [1772], '4).': [1774], 'methods': [1776], 'modification': [1779], 'interest': [1783], '(POI)': [1784], 'directly': [1786, 3939], 'recruit': [1787, 2765, 3123, 3940], 'POI': [1788, 1813, 1853, 2109, 2125, 3503], 'degradation.': [1796, 2491, 2768, 3738, 3757], 'PROTAC': [1798, 1844, 1905, 2101, 2142, 2164, 2182, 2235, 2272, 2290, 2317, 2334, 2394, 3367, 3511, 3514, 3872, 3904], 'approach': [1799, 3094, 4148], 'hijacks': [1800], 'endogenous': [1802], 'system': [1804], 'enable': [1806], '(25Liu': [1814, 1868], 'Ma': [1816, 1870], 'Xia': [1820, 1874], 'Li': [1822, 1876, 2616, 2652, 3232, 3268, 3675], 'Z.P.': [1825, 1879], 'al.PROTACs:': [1827, 1881], 'therapy.Semin.': [1833, 1887], 'Cancer': [1834, 1888, 2378], '2020;': [1836, 1890, 2348, 2637, 2672, 2704, 2937, 3253, 3288, 3320, 3583, 4134], '171-179Crossref': [1838, 1892], '(73)': [1841, 1895], 'molecule': [1845, 2102], 'consists': [1846], 'three': [1848], 'modalities,': [1850], 'ligand,': [1854, 1858], 'linker': [1862, 3688], 'bridges': [1864], 'two': [1866, 2181], 'ligands': [1867], 'Various': [1898], 'employed': [1903], 'development,': [1906, 4076], 'β-transducin': [1909], 'repeat': [1910], 'containing': [1911, 3771], '(26Sakamoto': [1913], 'K.M.': [1914], 'Kim': [1915, 2586, 3144], 'K.B.': [1916], 'Kumagai': [1917], 'Mercurio': [1919], 'Crews': [1921, 1995, 2337, 2392, 2415], 'C.M.': [1922, 1996, 2338, 2393, 2416], 'Deshaies': [1923], 'R.J.': [1924, 3962, 4043], 'Protacs:': [1925], 'chimeric': [1926], 'Skp1-Cullin-F': [1933], 'box': [1934], 'complex': [1935, 2106, 2734, 3338, 3359, 4021], 'degradation.Proc.': [1939], 'Natl.': [1940], 'Acad.': [1941], 'Sci.': [1942], '2001;': [1946], '98:': [1947], '8554-8559Crossref': [1948], '(1062)': [1951], 'von': [1954], 'Hippel-Lindau': [1955], '(VHL)': [1956], '(27Bondeson': [1957], 'D.P.': [1958], 'Mares': [1959], 'Smith': [1961], 'I.E.': [1962], 'Ko': [1963], 'Campos': [1965], 'Miah': [1967], 'A.H.': [1968], 'al.Catalytic': [1970], 'knockdown': [1974], 'PROTACs.Nat.': [1977], '11:': [1981], '611-617Crossref': [1982], '(705)': [1985], 'MDM2': [1988], '(28Schneekloth': [1989], 'A.R.': [1990], 'Pucheault': [1991], 'Tae': [1993], 'H.S.': [1994, 2256], 'Targeted': [1997, 4066], 'molecule:': [2005], 'en': [2006], 'route': [2007], 'proteomics.Bioorg.': [2010], 'Lett.': [2013], '2008;': [2014, 2087], '5904-5908Crossref': [2016], '(347)': [2019], 'Cereblon': [2022], '(CRBN)': [2023], 'inhibitor': [2060, 2625, 3241], 'apoptosis': [2062], '1': [2064], '(29Sekine': [2065], 'Takubo': [2067], 'Kikuchi': [2069], 'Nishimoto': [2071], 'Kitagawa': [2073], 'Abe': [2075], 'al.Small': [2078], 'destabilize': [2080], 'cIAP1': [2081], 'activating': [2083], 'auto-ubiquitylation.J.': [2084], '283:': [2088], '8961-8968Abstract': [2089], '(129)': [2097], 'forms': [2103, 3356], 'ternary': [2105, 4020], 'corresponding': [2112], 'ligase,': [2114, 3343, 3891], 'facilitating': [2116], '(30Gadd': [2126], 'M.S.': [2127], 'Testa': [2128], 'Lucas': [2130], 'Chan': [2132], 'K.-H.': [2133], 'Chen': [2134, 2648, 3264], 'Lamont': [2136], 'D.J.': [2137], 'al.Structural': [2139], 'basis': [2140], 'cooperative': [2143], 'recognition': [2144], 'selective': [2146, 2559, 2827, 3718], 'degradation.Nat.': [2148, 3553], '13:': [2152, 3108], '514-521Crossref': [2153], '(556)': [2156], 'Compared': [2159], 'conventional': [2161], 'acts': [2165, 2627, 3243], 'catalytically,': [2166], 'making': [2168, 3442], 'it': [2169, 3443, 3489], 'potent': [2171, 3445], 'suppressing': [2173], 'POI.': [2179], 'Currently,': [2180], 'compounds,': [2183, 2715], 'ARV-110': [2184], 'ARV-447,': [2186], 'undergoing': [2188], 'Phase': [2189], 'II': [2190], 'trials': [2192], 'prostate': [2197, 2240], 'breast': [2200, 2281], 'cancer,': [2201], 'degrading': [2203], 'androgen': [2204, 2232], 'receptor': [2205, 2209, 2233, 2274, 3549, 3612, 3744, 3748, 3766, 3925], '(AR)': [2206, 2234], 'estrogen': [2208, 2273], '(ER),': [2210], 'respectively': [2211], '(31Gao': [2212], 'Burris': [2214], 'III,': [2215], 'H.A.': [2216], 'Vuky': [2217], 'Dreicer': [2219], 'Sartor': [2221], 'A.O.': [2222], 'Sternberg': [2223], 'C.N.': [2224], 'al.Phase': [2226], '1/2': [2227], 'study': [2228], 'ARV-110,': [2230], 'degrader,': [2236, 2275], 'metastatic': [2238, 2280], 'castration-resistant': [2239], '(mCRPC).Am.': [2242], 'Soc.': [2243, 2422, 3418, 3476], 'Clin.': [2244, 4102], 'Oncol.': [2245, 4103], '17Crossref': [2248], '32Hamilton': [2251], 'Vahdat': [2253], 'Han': [2255], 'Ranciato': [2257], 'Gedrich': [2259], 'Keung': [2261], 'C.F.': [2262], 'al.First-in-human': [2264], 'safety': [2265], 'activity': [2267], 'ARV-471,': [2269], 'ER+/HER2-locally': [2277], 'advanced': [2278], 'cancer.Cancer': [2282], 'Res.': [2283], '82:': [2285], 'PD13-PD18Crossref': [2286], 'Although': [2289], 'any': [2296], 'proteasomal': [2300], 'identification': [2303], 'ligand': [2307, 3380, 3383, 4002, 4015], 'remains': [2312], 'primary': [2314, 2751], 'challenge': [2315], 'Interested': [2319], 'refer': [2322], 'comprehensive': [2325], 'reviews': [2326], 'further': [2328], 'information': [2329], 'progress': [2332], '(33Burslem': [2335], 'G.M.': [2336], 'Proteolysis-targeting': [2339], 'chimeras': [2340, 3640, 3796, 3853], 'therapeutics': [2342], 'discovery.Cell.': [2347], '181:': [2349], '102-114Abstract': [2350], '(383)': [2358], '34Liu': [2361], 'Peng': [2363, 4114], 'Inuzuka': [2365], 'Targeting': [2369, 4124], 'micro-environmental': [2370], 'pathways': [2371], 'strategy.Semin.': [2377], '269-279Crossref': [2382], '(2)': [2385], '35Békés': [2388], 'Langley': [2390], 'D.R.': [2391], 'degraders:': [2397], 'prologue.Nat.': [2401], 'Drug': [2403], 'Discov.': [2404], '21:': [2406, 2452], '181-200Crossref': [2407], '(299)': [2410], '36Li': [2413], 'PROTACs:': [2417], 'past,': [2418], 'future.Chem.': [2421], '51:': [2425], '5214-5236Crossref': [2426], '37Dale': [2430], 'Cheng': [2432], 'Park': [2434, 3401, 3459], 'K.-S.': [2435], 'Kaniskan': [2436], 'H.Ü.': [2437], 'Xiong': [2438], 'Jin': [2440], 'Advancing': [2442], 'therapy.Nat.': [2448, 4100], 'Cancer.': [2450], '638-654Crossref': [2453], '(136)': [2456], 'class': [2462], 'monovalent': [2464], 'compounds': [2465, 2774], 'bind': [2467, 2722], 'both': [2468, 3433], 'protein,': [2476], 'resulting': [2477, 4017], 'conversion': [2480], 'neo-substrate': [2487], 'Unlike': [2492], 'discovery': [2495, 2693, 3309], 'MGD': [2497], 'serendipitous,': [2500], 'reported': [2506], 'phthalidomides': [2511], '(38Lu': [2512, 2780], 'Middleton': [2514, 2782], 'R.E.': [2515, 2783], 'Naniong': [2518, 2786], 'Ott': [2520, 2788], 'C.J.': [2521, 2789], 'Mitsiades': [2522, 2790], 'C.S.': [2523, 2791], 'al.The': [2525, 2623, 2793, 3239], 'myeloma': [2526, 2567, 2794, 2835, 2933], 'drug': [2527, 2795, 4075], 'lenalidomide': [2528, 2796], 'promotes': [2529, 2797, 2991], 'cereblon-dependent': [2531, 2799], 'destruction': [2532, 2800], 'Ikaros': [2534, 2802], 'proteins.Science.': [2535, 2803], '343:': [2537, 2570, 2805, 2838], '305-309Crossref': [2538, 2806], '(975)': [2541, 2809], '39Krönke': [2544, 2812], 'Udeshi': [2546, 2814, 2856], 'N.D.': [2547, 2815, 2857], 'Narla': [2548, 2816], 'Grauman': [2550, 2818], 'Hurst': [2552, 2820, 2854], 'S.N.': [2553, 2821, 2855], 'McConkey': [2554, 2822], 'al.Lenalidomide': [2557, 2825, 2859], 'causes': [2558, 2826], 'IKZF1': [2562, 2830], 'IKZF3': [2564, 2832], 'cells.Science.': [2568, 2836], '301-305Crossref': [2571, 2839], '(1104)': [2574, 2842], 'sulfonamides': [2577, 2592, 3150], '(40Han': [2578, 3136], 'Goralski': [2580, 3138], 'Gaskill': [2582, 3140], 'N.': [2583, 2947, 3055, 3141], 'Capota': [2584, 3142], 'Ting': [2588, 3146], 'T.C.': [2589, 3147], 'al.Anticancer': [2591, 3149], 'splicing': [2594, 3134, 3152, 3171, 3205], 'inducing': [2596, 3154], 'RBM39': [2597, 3155], 'via': [2599, 2698, 3157, 3314, 3970, 4051], 'recruitment': [2600, 3158], 'DCAF15.Science.': [2602, 3160], '356eaal3755Crossref': [2604, 3162], '(319)': [2606, 3164], 'CR8': [2609, 2626, 3225, 3242], '(41Słabicki': [2610, 3226], 'Kozicka': [2612, 2685, 3228, 3301], 'Z.': [2613, 2655, 2686, 3229, 3271, 3302, 3668, 3672], 'Petzold': [2614, 3230], 'Y.D.': [2617, 3233], 'Manojkumar': [2618, 3234], 'Bunker': [2620, 3236], 'R.D.': [2621, 3237], 'CDK': [2624, 3223, 3240], 'degrader': [2632, 3248], 'depletes': [2634, 3250], 'cyclin': [2635, 2669, 3251, 3285, 3434], 'K.Nature.': [2636, 3252], '585:': [2638, 3254], '293-297Crossref': [2639, 3255], '(144)': [2642, 3258], 'HQ461': [2645, 3261], '(42Lv': [2646, 3262], 'Cao': [2650, 3266], 'Zeng': [2654, 3270], 'Cui': [2656, 3272], 'al.Discovery': [2659, 3275], 'promoting': [2664, 3280], 'CDK12-DDB1': [2665, 3281], 'interaction': [2666, 3282], 'trigger': [2668, 3284], 'K': [2670, 3286, 3330, 3337], 'degradation.Elife.': [2671, 3287], '9e59994Crossref': [2673, 3289], 'dCeMM': [2678, 3294], '(43Mayor-Ruiz': [2679, 3295], 'Bauer': [2681, 3297], 'Brand': [2683, 3299], 'Siklos': [2687, 3303], 'Imrichova': [2689, 3305], 'al.Rational': [2692, 3308], 'scalable': [2699, 3315], 'profiling.Nat.': [2701, 3317], '16:': [2705, 2938, 3321], '1199-1207Crossref': [2706, 3322], '(121)': [2709, 3325], 'well-studied': [2713], 'phthalidomide': [2714, 2773], 'thalidomide,': [2717], 'pomalidomide,': [2718], 'lenalidomide,': [2720], 'specifically': [2721, 3825], 'CRBN,': [2724], 'adaptor': [2726], 'CUL4': [2730], '(44Ito': [2735], 'Ando': [2737, 3045], 'Suzuki': [2739], 'Ogura': [2741], 'Hotta': [2743], 'Imamura': [2745], 'al.Identification': [2748], 'thalidomide': [2754, 3064], 'teratogenicity.Science.': [2755], '1345-1350Crossref': [2758], '(1323)': [2761], 'neo-substrates': [2766, 2770], 'identified,': [2777], 'IKZF': [2779], 'CK1α': [2845, 2865], '(45Krönke': [2846], 'Fink': [2848, 2985], 'E.C.': [2849, 2986], 'Hollenbach': [2850], 'P.W.': [2851], 'MacBeth': [2852], 'K.J.': [2853], 'induces': [2860], 'del': [2867], '(5q)': [2868], 'MDS.Nature.': [2869], '523:': [2871], '183-188Crossref': [2872], '(536)': [2875], 'GSPT1': [2878, 2897], '(46Matyskiela': [2879], 'M.E.': [2880, 3012], 'Lu': [2881, 2887, 3017], 'Ito': [2883, 2956], 'Pagarigan': [2885], 'C.-C.': [2888], 'Miller': [2889, 3536], 'al.A': [2892, 3091], 'cereblon': [2894, 3030, 3060], 'modulator': [2895], 'recruits': [2896], 'CRL4CRBN': [2900], 'ligase.Nature.': [2902], '535:': [2904], '252-257Crossref': [2905], 'ARID2': [2911], '(47Yamamoto': [2912], 'Suwa': [2914], 'Murase': [2916], 'Tateno': [2918], 'Mizutome': [2920], 'Asatsuma-Okumura': [2922, 2948], 'al.ARID2': [2925], 'pomalidomide-dependent': [2928, 2964], 'CRL4(CRBN)': [2929], '1208-1217Crossref': [2939], '(36)': [2942], 'PLZF': [2945, 2958], '(48Shimizu': [2946], 'Yamamoto': [2950, 3050], 'Yamaguchi': [2952], 'Handa': [2954], 'its': [2960], 'fusion': [2961], 'CRBN': [2965], 'neosubstrates.Commun.': [2966], '4:': [2969], '1277Crossref': [2970], 'SALL4': [2976], '(49Donovan': [2977], 'K.A.': [2978], 'An': [2979], 'Nowak': [2981], 'R.P.': [2982], 'Yuan': [2983], 'J.C.': [2984], 'Berry': [2987], 'B.C.': [2988], 'al.Thalidomide': [2990], 'SALL4,': [2994], 'transcription': [2996], 'factor': [2997, 3135], 'implicated': [2998], 'duane': [3000], 'radial': [3001], 'ray': [3002], 'syndrome.Elife.': [3003], '7e38430Crossref': [3005], '(218)': [3008], '50Matyskiela': [3011], 'Couto': [3013], 'Zheng': [3015], 'Hui': [3019], 'Stamp': [3021], 'al.SALL4': [3024], 'mediates': [3025], 'teratogenicity': [3026], 'thalidomide-dependent': [3029], 'substrate.Nat.': [3031], '14:': [3035, 4105], '981-987Crossref': [3036], '(148)': [3039], 'p63': [3042], '(51Asatsuma-Okumura': [3043], 'De': [3047, 3189], 'Simone': [3048], 'Sato': [3052, 3711], 'Shimizu': [3054], 'al.p63': [3057], 'involved': [3062], 'teratogenicity.Nat.': [3065], '2019;': [3068, 3690, 3721], '1077-1084Crossref': [3070], '(69)': [3073], 'ZMYM2': [3077], '(52Yamanaka': [3078], 'Horiuchi': [3080], 'Matsuoka': [3082], 'Kido': [3084], 'Nishino': [3086], 'Maeno': [3088], 'biotinylation-based': [3093], 'identify': [3096], 'protein-E3': [3097], 'glues.Nat.': [3105], '183Crossref': [3109], 'Sulfonamides,': [3115], 'indisulam,': [3118], 'tasisulam,': [3119], 'chloroquinoxaline': [3121], 'sulfonamide,': [3122], 'CUL4-DCAF15': [3128], 'degrade': [3130, 3328, 3373, 3660, 3735], 'RBM39,': [3131], 'mRNA': [3133], 'makes': [3168], 'them': [3169], 'promising': [3170, 4072], 'could': [3174], 'antitumor': [3176], 'immunity': [3177], 'synergize': [3179], 'immune': [3181], 'checkpoint': [3182], 'blockades': [3183], 'immunotherapy': [3186], '(53Lu': [3187], 'S.X.': [3188], 'Neef': [3190], 'Thomas': [3192], 'Sabio': [3194], 'Rousseau': [3196], 'Gigoux': [3198], 'al.Pharmacologic': [3201], 'modulation': [3202], 'RNA': [3204], 'enhances': [3206], 'anti-tumor': [3207], 'immunity.Cell.': [3208], '184:': [3210], '4032-4047.e1Abstract': [3211], '(60)': [3219], 'Additionally,': [3222], 'Cyclin': [3329, 3374, 3391], 'recruiting': [3334], 'CDK12/Cyclin': [3336], 'DDB1-CUL4-RBX1': [3341], 'suggesting': [3344], 'TPD': [3346], 'initiated': [3350], 'bridging': [3353], 'stable': [3358, 3386], 'protein.': [3363], 'Moreover,': [3364, 3935], 'bridge': [3366, 3509], 'MS28': [3368, 3430], 'D1': [3375, 3392, 3435], 'conjugating': [3377], 'VHL': [3379], 'CDK4/6,': [3385], 'partner': [3388], '(54Xiong': [3393, 3451], 'Zhong': [3395, 3453], 'Yim': [3397, 3455], 'Yang': [3399, 3457], 'K.S.': [3402, 3460], 'Xie': [3403, 3461], 'al.Bridged': [3406, 3464], 'proteolysis': [3407, 3465], 'targeting': [3408, 3466, 3606, 3919], '(PROTAC)': [3410, 3468], 'enables': [3411, 3469], 'undruggable': [3414, 3472, 3494], 'targets.J.': [3415, 3473], 'Am.': [3416, 3474], '144:': [3420, 3478], '22622-22632Crossref': [3421, 3479], 'result,': [3429], 'effectively': [3431], 'degrades': [3432], 'CDK4/6': [3437, 3447], 'VHL-dependent': [3440], 'manner,': [3441], 'than': [3446], 'studies': [3486], 'suggest': [3487], 'possible': [3491], 'transform': [3493], 'druggable': [3497], 'utilization': [3501], 'bait': [3507], 'during': [3510], 'Besides': [3513], 'MGD,': [3516], 'target-specific': [3526], 'LYTAC': [3531], '(55Ahn': [3532], 'Banik': [3534], 'S.M.': [3535, 3565], 'C.L.': [3537], 'Riley': [3538, 3572], 'N.M.': [3539, 3573], 'Cochran': [3540], 'J.R.': [3541, 3629, 3785, 3842], 'Bertozzi': [3542, 3574], 'C.R.': [3543, 3575], 'LYTACs': [3544, 3739], 'engage': [3546], 'asialoglycoprotein': [3548, 3747], '937-946Crossref': [3558], '(103)': [3561], '56Banik': [3564], 'Pedram': [3566], 'Wisnovsky': [3568], 'Ahn': [3570], 'Lysosome-targeting': [3576], 'chimaeras': [3577], 'extracellular': [3581, 3648, 3663, 3804, 3861], 'proteins.Nature.': [3582], '584:': [3584], '291-297Crossref': [3585], '(277)': [3588], 'PROTAB': [3591], '(57Marei': [3592, 3905], 'Tsai': [3594, 3907], 'W.K.': [3595, 3908], 'Kee': [3596, 3909], 'Y.S.': [3597, 3910], 'Ruiz': [3598, 3911], 'He': [3600, 3913], 'Cox': [3602, 3915], 'al.Antibody': [3605, 3918], 'degradation.Nature.': [3613, 3926], '610:': [3615, 3928], '182-189Crossref': [3616, 3929], '(4)': [3619, 3932], 'KineTACs': [3623, 3758], '(58Pance': [3624, 3780, 3837], 'Gramespacher': [3626, 3782, 3839], 'Byrnes': [3628, 3784, 3841], 'Salangsang': [3630, 3786, 3843], 'Serrano': [3632, 3788, 3845], 'J.-A.C.': [3633, 3789, 3846], 'Cotton': [3634, 3790, 3847], 'A.D.': [3635, 3791, 3848], 'al.Modular': [3637, 3793, 3850], 'surface': [3646, 3802, 3859], '41:': [3652, 3808, 3865], '273-281Crossref': [3653, 3809, 3866], 'transmembrane': [3661, 3897, 4209], 'ATTEC': [3666], '(59Li': [3667], 'Zhu': [3673], 'Sha': [3677], 'al.Allele-selective': [3680], 'lowering': [3681], 'mutant': [3683], 'HTT': [3684], 'HTT-LC3': [3687], 'compounds.Nature.': [3689], '575:': [3691], '203-209Crossref': [3692], '(196)': [3695], '(60Takahashi': [3701], 'Moriyama': [3703], 'Nakamura': [3705], 'Miki': [3707], 'Takahashi': [3709], 'al.AUTACs:': [3714], 'cargo-specific': [3715], 'using': [3717], 'autophagy.Mol.': [3719], '76:': [3722], '797-810.e10Abstract': [3723], '(199)': [3731], 'lysosome-mediated': [3736], 'utilize': [3740], 'cation-independent': [3742], 'mannose-6-phosphate': [3743], 'sites': [3751], 'lysosomal': [3756, 3832], 'bispecific': [3760, 3877], 'antibodies': [3761], 'site,': [3770], 'receptor-binding': [3774], 'arm': [3775, 3779, 3824], 'target-binding': [3778], 'first': [3817], 'example': [3818], 'KineTAC,': [3820], 'CXCL12': [3823], 'binds': [3826], 'CXCR7,': [3827], 'triggers': [3829], 'endocytosis': [3830], 'another': [3874], 'type': [3875], 'antibody,': [3878], 'utilizes': [3880], 'Zinc': [3881], 'Ring': [3883], 'Finger': [3884], '3,': [3885], 'plasma': [3887], 'membrane': [3888], 'various': [3896, 4089], 'similarly': [3901], 'developed,': [3948], '(61Bashore': [3955, 4036], 'Prakash': [3957, 4038], 'Johnson': [3959, 4040], 'M.C.': [3960, 4041], 'Conrad': [3961, 4042], 'Kekessie': [3963, 4044], 'I.A.': [3964, 4045], 'Scales': [3965, 4046], 'S.J.': [3966, 4047], 'al.Targeted': [3968, 4049], 'direct': [3971, 4025, 4052], 'recruitment.Nat.': [3974, 4055], '2023;': [3977, 4058], '19:': [3978, 4059], '55-63Crossref': [3979, 4060], 'do': [3986], 'require': [3988], 'ligase.': [3992, 4160], 'proof-of-concept': [3995], 'macrocyclic': [4001], 'subunit': [4006], 'PSMD2,': [4007], 'MC1,': [4008], 'conjugated': [4010], 'bromodomain': [4013], '(BRD)-4': [4014], 'BETi,': [4016], 'facilitates': [4023], 'BRD4': [4028], 'without': [4033], 'prior': [4034], 'stabilization': [4068], 'increasing': [4071], 'avenue': [4073], 'extensively': [4086], 'tested': [4087], 'diseases': [4091], '(62Manasanch': [4092], 'E.E.': [4093], 'Orlowski': [4094], 'R.Z.': [4095], 'Proteasome': [4096], '417-433Crossref': [4106], '(538)': [4109], '63Liu': [4112], 'Zhang': [4116], 'SCF': [4125], 'therapies.Adv.': [4130], 'Exp.': [4131], '1217:': [4135], '123-146Crossref': [4136], '(26)': [4139], 'major': [4144], 'limitation': [4145], 'broad': [4151], 'range': [4152], 'given': [4157], 'stabilize': [4167], 'sparing': [4173], 'purposes.': [4182], 'Abnormal': [4183], 'certain': [4186], 'contributes': [4188], 'pathologies,': [4191], 'cystic': [4194, 4207], 'fibrosis,': [4195], 'caused': [4198], '(F508)': [4203], 'deletion': [4204], 'fibrosis': [4208], 'conductance': [4210]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4322772375', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 10}], 'updated_date': '2025-01-08T06:55:30.804187', 'created_date': '2023-03-03'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
