Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4322772284', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs22-p1-13-20', 'title': 'Abstract P1-13-20: Reprogramming of oncogenic signal pathways and metabolism during trastuzumab resistance formation of HER2 positive breast cancer', 'display_name': 'Abstract P1-13-20: Reprogramming of oncogenic signal pathways and metabolism during trastuzumab resistance formation of HER2 positive breast cancer', 'publication_year': 2023, 'publication_date': '2023-03-01', 'ids': {'openalex': 'https://openalex.org/W4322772284', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs22-p1-13-20'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs22-p1-13-20', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020301186', 'display_name': 'Ningjun Duan', 'orcid': 'https://orcid.org/0000-0001-6316-3796'}, 'institutions': [{'id': 'https://openalex.org/I4210152119', 'display_name': 'Jiangsu Province Hospital', 'ror': 'https://ror.org/04py1g812', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152119']}, {'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ningjun Duan', 'raw_affiliation_strings': ['1The First Affiliated Hospital of Nanjing Medical University'], 'affiliations': [{'raw_affiliation_string': '1The First Affiliated Hospital of Nanjing Medical University', 'institution_ids': ['https://openalex.org/I4210152119', 'https://openalex.org/I83519826']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5114068671', 'display_name': 'Yijia Hua', 'orcid': 'https://orcid.org/0009-0006-4323-8715'}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}, {'id': 'https://openalex.org/I4210152119', 'display_name': 'Jiangsu Province Hospital', 'ror': 'https://ror.org/04py1g812', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152119']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yijia Hua', 'raw_affiliation_strings': ['2The First Affiliated Hospital of Nanjing Medical University'], 'affiliations': [{'raw_affiliation_string': '2The First Affiliated Hospital of Nanjing Medical University', 'institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210152119']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100681729', 'display_name': 'Shuang Hu', 'orcid': 'https://orcid.org/0000-0001-5287-6002'}, 'institutions': [{'id': 'https://openalex.org/I4210143313', 'display_name': 'Jilin Maternity and Child Health Care Hospital', 'ror': 'https://ror.org/0516vxk09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210143313']}, {'id': 'https://openalex.org/I4210100029', 'display_name': 'Nanjing Maternity and Child Health Care Hospital', 'ror': 'https://ror.org/01a2gef28', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100029']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shuang Hu', 'raw_affiliation_strings': ['3Nanjing Maternity and Child Health Care Hospital'], 'affiliations': [{'raw_affiliation_string': '3Nanjing Maternity and Child Health Care Hospital', 'institution_ids': ['https://openalex.org/I4210143313', 'https://openalex.org/I4210100029']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080028212', 'display_name': 'Yongmei Yin', 'orcid': 'https://orcid.org/0000-0003-3335-369X'}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}, {'id': 'https://openalex.org/I4210152119', 'display_name': 'Jiangsu Province Hospital', 'ror': 'https://ror.org/04py1g812', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152119']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yongmei Yin', 'raw_affiliation_strings': ['4The First Affiliated Hospital of Nanjing Medical University.'], 'affiliations': [{'raw_affiliation_string': '4The First Affiliated Hospital of Nanjing Medical University.', 'institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210152119']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 68}, 'biblio': {'volume': '83', 'issue': '5_Supplement', 'first_page': 'P1', 'last_page': '20'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9692, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9692, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11297', 'display_name': 'Ferroptosis and cancer prognosis', 'score': 0.9178, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9114, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/skbr3', 'display_name': 'SKBR3', 'score': 0.9763899}], 'concepts': [{'id': 'https://openalex.org/C191560914', 'wikidata': 'https://www.wikidata.org/wiki/Q7390592', 'display_name': 'SKBR3', 'level': 5, 'score': 0.9763899}, {'id': 'https://openalex.org/C2779786085', 'wikidata': 'https://www.wikidata.org/wiki/Q412616', 'display_name': 'Trastuzumab', 'level': 4, 'score': 0.912346}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.57599264}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.47575825}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.46345067}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.45834586}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.4208843}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4053168}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37864757}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.29885554}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26966995}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12222004}, {'id': 'https://openalex.org/C2994423619', 'wikidata': 'https://www.wikidata.org/wiki/Q9103', 'display_name': 'Human breast', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs22-p1-13-20', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.83, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W34965712', 'https://openalex.org/W3025149516', 'https://openalex.org/W3006441332', 'https://openalex.org/W2914195240', 'https://openalex.org/W2808686791', 'https://openalex.org/W2355063016', 'https://openalex.org/W2270690696', 'https://openalex.org/W2032610835', 'https://openalex.org/W2012480315', 'https://openalex.org/W1601510090'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'The': [2, 105, 162, 191], 'formation': [3, 48, 409, 552], 'of': [4, 12, 32, 49, 82, 91, 122, 131, 193, 207, 211, 223, 269, 312, 325, 339, 345, 375, 394, 410, 450, 461, 483, 496, 523, 543, 553, 561], 'resistance': [5, 50, 551], 'against': [6], 'trastuzumab': [7, 27, 83, 98, 106, 132, 144, 411, 484, 516, 550], 'deeply': [8], 'affects': [9], 'the': [10, 26, 29, 38, 47, 80, 89, 119, 129, 237, 271, 310, 320, 323, 337, 343, 373, 392, 408, 417, 448, 454, 478, 494, 511, 519, 562], 'treatment': [11, 268, 530], 'HER2': [13, 100, 123, 326, 554], 'positive': [14, 101, 124, 555], 'breast': [15, 102, 556], 'cancer.': [16, 103], 'Although': [17], 'studies': [18], 'have': [19], 'demonstrated': [20], 'several': [21, 59, 313], 'possible': [22], 'reasons': [23], 'that': [24, 88, 178, 292, 421, 493], 'cause': [25], 'resistance,': [28, 412], 'precise': [30], 'changes': [31, 61, 177, 351, 495], 'cell': [33, 108, 114, 138, 157, 164, 185, 195, 201, 251, 273, 284, 314, 332, 346, 488], 'process': [34, 121], 'as': [35, 37, 66, 68, 172, 227, 229, 236, 307, 309, 356, 397], 'well': [36, 67, 173, 228, 308], 'interaction': [39], 'between': [40], 'cancer': [41, 557], 'cells': [42, 216, 525], 'and': [43, 74, 154, 214, 234, 295, 329, 360, 381, 402, 431, 442, 452, 480, 486, 507, 547], 'tumor': [44, 125], 'microenvironment': [45], 'during': [46, 79, 407, 549], 'are': [51, 318, 509], 'still': [52], 'poorly': [53], 'understood.': [54], 'Here': [55], 'we': [56, 490], 'figured': [57], 'out': [58, 492], 'crucial': [60], 'including': [62, 372], 'oncogenic': [63, 224, 497, 544], 'signal': [64, 225, 288, 327, 335, 498, 545], 'pathways': [65, 226, 297, 546], 'metabolism': [69, 230, 340, 393, 433, 502, 548], 'processes': [70, 231], 'especially': [71], 'amino': [72, 369, 505], 'acids': [73, 77, 506], 'polyunsaturated': [75], 'fatty': [76], '(PUFAs)': [78], 'establishment': [81], 'resistance.': [84], 'We': [85], 'further': [86], 'suggested': [87], 'inducers': [90], 'ferroptosis': [92, 463, 521], 'may': [93], 'be': [94, 470, 527], 'promising': [95], 'reagents': [96], 'for': [97, 169, 219, 257], 'resistant': [99, 107], 'Methods': [104], 'was': [109, 133, 148, 160, 167, 255, 383, 405, 414], 'generated': [110], 'from': [111, 150], 'a': [112, 155, 277, 300, 528], 'sensitive': [113, 283, 485], 'line': [115, 158, 165, 186, 274, 285], 'SKBR3.': [116, 286], 'To': [117], 'simulate': [118], 'adaptation': [120, 347], 'to': [126, 136, 152, 174, 322, 348, 446, 514], 'anti-tumor': [127], 'drug,': [128], 'concentration': [130, 145, 206], 'changed': [134], 'gently': [135], 'prevent': [137], 'death.': [139], 'After': [140, 265], '8': [141, 170, 266], 'weeks': [142, 171, 267], 'treatment,': [143], 'in': [146, 246, 249, 304, 352, 365, 386, 426, 472], 'medium': [147], 'raised': [149], '1μg/ml': [151], '6μg/ml,': [153], '“persister”': [156], 'SKBR3_HP': [159, 215, 275, 305, 366, 387, 427, 473], 'obtained.': [161], 'original': [163, 282], 'SKBR3': [166, 213], 'cultured': [168], 'exclude': [175], 'any': [176], 'caused': [179], 'by': [180, 199, 416], 'culture': [181], 'condition.': [182], 'And': [183, 518], 'each': [184], 'includes': [187], '3': [188], 'biological': [189], 'repeats.': [190], 'viability': [192, 280], 'two': [194], 'lines': [196], 'is': [197, 341], 'measured': [198], 'CCK8': [200], 'proliferation': [202], 'test': [203], 'with': [204, 262, 437, 501], 'different': [205], 'trastuzumab.': [208, 349], 'Total': [209], 'RNA': [210], 'both': [212], 'were': [217, 232, 363, 444], 'prepared': [218], 'sequencing.': [220], 'Activity': [221], 'scores': [222], 'defined': [233], 'calculated': [235], 'relative': [238], 'gene': [239], 'expression': [240], 'value': [241], 'averaged': [242], 'over': [243], 'all': [244, 319, 510], 'genes': [245], 'this': [247], 'pathway': [248, 289], 'certain': [250], 'type.': [252], 'Flow': [253], 'cytometry': [254], 'applied': [256, 445], 'reactive': [258], 'oxygen': [259], 'species': [260], 'measurement': [261], 'BODIPY-C11.': [263], 'Results': [264], 'trastuzumab,': [270], 'persister': [272, 487, 524], 'showed': [276], 'significant': [278], 'higher': [279, 462, 520], 'than': [281], 'Oncogenic': [287], 'analysis': [290], 'revealed': [291], 'RTK-Ras,': [293], 'MYC': [294], 'HIPPO': [296], 'turn': [298], 'into': [299], 'more': [301], 'active': [302], 'state': [303], 'cells,': [306], 'upregulation': [311], 'cycle': [315, 359], 'genes,': [316], 'which': [317, 413], 'response': [321], 'blockage': [324], 'cascade': [328], 'together': [330, 500], 'maintains': [331], 'proliferation.': [333], 'Beside': [334], 'pathway,': [336, 499], 'reprogramming': [338], 'also': [342], 'consequence': [344], 'Minor': [350], 'energy': [353], 'metabolism,': [354, 371], 'such': [355, 396], 'glycolysis,': [357], 'citrate': [358], 'oxidative': [361], 'phosphorylation': [362], 'observed': [364], 'cells.': [367, 388, 428, 474], 'However,': [368], 'acid': [370, 401], 'synthesis': [374], 'phenylalanine,': [376], 'histidine,': [377], 'arginine,': [378], 'proline,': [379], 'cysteine': [380, 430, 451], 'methionine,': [382], 'largely': [384], 'enhanced': [385], 'Fatty': [389], 'acid,': [390, 399, 404], 'specifically': [391], 'PUFAs,': [395, 508], 'linoleic': [398], 'alpha-linolenic': [400], 'arachidonic': [403], 'activated': [406], 'confirmed': [415], 'lipid': [418, 455], 'metabolomics': [419, 481], 'data': [420, 482], 'most': [422], 'n-3/n-6': [423], 'PUFAs': [424, 432], 'decreased': [425], 'As': [429], 'might': [434], 'closely': [435], 'associate': [436], 'cellular': [438, 512], 'redox': [439], 'balances,': [440], 'erastin': [441], 'RSL3': [443], 'interrupt': [447], 'intake': [449], 'potentiate': [453], 'peroxidation': [456], 'process,': [457], 'respectively.': [458], 'A': [459], 'situation': [460], 'sensitivity': [464, 522], 'accompanies': [465], 'raising': [466], 'peroxidated': [467], 'lipids': [468], 'could': [469, 526], 'detected': [471], 'Conclusion': [475], 'By': [476], 'analyzing': [477], 'transcriptome': [479], 'lines,': [489], 'pointed': [491], 'variation,': [503], 'particularly': [504], 'adaptations': [513], 'high': [515], 'environment.': [517], 'valuable': [529], 'target.': [531], 'Citation': [532], 'Format:': [533], 'Ningjun': [534], 'Duan,': [535], 'Yijia': [536], 'Hua,': [537], 'Shuang': [538], 'Hu,': [539], 'Yongmei': [540], 'Yin.': [541], 'Reprogramming': [542], '[abstract].': [558], 'In:': [559], 'Proceedings': [560], '2022': [563, 569], 'San': [564, 572], 'Antonio': [565], 'Breast': [566], 'Cancer': [567, 578], 'Symposium;': [568], 'Dec': [570], '6-10;': [571], 'Antonio,': [573], 'TX.': [574], 'Philadelphia': [575], '(PA):': [576], 'AACR;': [577], 'Res': [579], '2023;83(5': [580], 'Suppl):Abstract': [581], 'nr': [582], 'P1-13-20.': [583]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4322772284', 'counts_by_year': [], 'updated_date': '2024-12-09T22:26:29.808428', 'created_date': '2023-03-03'}