Publication Information

{'id': 'https://openalex.org/W4320732452', 'doi': 'https://doi.org/10.3390/molecules28041777', 'title': 'Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (CyreneTM)', 'display_name': 'Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (CyreneTM)', 'publication_year': 2023, 'publication_date': '2023-02-13', 'ids': {'openalex': 'https://openalex.org/W4320732452', 'doi': 'https://doi.org/10.3390/molecules28041777', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36838763'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/molecules28041777', 'pdf_url': 'https://www.mdpi.com/1420-3049/28/4/1777/pdf?version=1676887125', 'source': {'id': 'https://openalex.org/S108911230', 'display_name': 'Molecules', 'issn_l': '1420-3049', 'issn': ['1420-3049', '1433-1373'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1420-3049/28/4/1777/pdf?version=1676887125', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030706654', 'display_name': 'Tom Dekker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Tom Dekker', 'raw_affiliation_strings': ['Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063963273', 'display_name': 'Jaap W. Harteveld', 'orcid': 'https://orcid.org/0000-0002-0294-2320'}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jaap W. Harteveld', 'raw_affiliation_strings': ['Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010439999', 'display_name': 'Gábor Wágner', 'orcid': 'https://orcid.org/0000-0001-5111-6749'}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Gábor Wágner', 'raw_affiliation_strings': ['Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060991667', 'display_name': 'Max C. M. de Vries', 'orcid': 'https://orcid.org/0000-0003-2948-3870'}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Max C. M. de Vries', 'raw_affiliation_strings': ['Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058127662', 'display_name': 'Hans Custers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Hans Custers', 'raw_affiliation_strings': ['Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036965031', 'display_name': 'Andrea C. van de Stolpe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Andrea C. van de Stolpe', 'raw_affiliation_strings': ['Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044455499', 'display_name': 'Iwan J. P. de Esch', 'orcid': 'https://orcid.org/0000-0002-1969-0238'}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Iwan J. P. de Esch', 'raw_affiliation_strings': ['Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074907950', 'display_name': 'Maikel Wijtmans', 'orcid': 'https://orcid.org/0000-0001-8955-8016'}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Maikel Wijtmans', 'raw_affiliation_strings': ['Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5074907950'], 'corresponding_institution_ids': ['https://openalex.org/I865915315'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 0.341, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.653343, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 68, 'max': 79}, 'biblio': {'volume': '28', 'issue': '4', 'first_page': '1777', 'last_page': '1777'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13180', 'display_name': 'Chemistry and Chemical Engineering', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/2304', 'display_name': 'Environmental Chemistry'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13180', 'display_name': 'Chemistry and Chemical Engineering', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/2304', 'display_name': 'Environmental Chemistry'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9629, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.9586, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chemical-space', 'display_name': 'Chemical space', 'score': 0.8563889}, {'id': 'https://openalex.org/keywords/toolbox', 'display_name': 'Toolbox', 'score': 0.4761291}, {'id': 'https://openalex.org/keywords/fragment', 'display_name': 'Fragment (logic)', 'score': 0.42918685}], 'concepts': [{'id': 'https://openalex.org/C99726746', 'wikidata': 'https://www.wikidata.org/wiki/Q906396', 'display_name': 'Chemical space', 'level': 3, 'score': 0.8563889}, {'id': 'https://openalex.org/C74187038', 'wikidata': 'https://www.wikidata.org/wiki/Q1418791', 'display_name': 'Drug discovery', 'level': 2, 'score': 0.8347266}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.61622113}, {'id': 'https://openalex.org/C2777655017', 'wikidata': 'https://www.wikidata.org/wiki/Q1501161', 'display_name': 'Toolbox', 'level': 2, 'score': 0.4761291}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.4492572}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.4418788}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.43246734}, {'id': 'https://openalex.org/C2776235265', 'wikidata': 'https://www.wikidata.org/wiki/Q18392052', 'display_name': 'Fragment (logic)', 'level': 2, 'score': 0.42918685}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42129627}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.40304637}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.3411427}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19198337}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.1733836}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.15308109}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11243078}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.11101091}, {'id': 'https://openalex.org/C11413529', 'wikidata': 'https://www.wikidata.org/wiki/Q8366', 'display_name': 'Algorithm', 'level': 1, 'score': 0.10180622}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D055808', 'descriptor_name': 'Drug Discovery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D057166', 'descriptor_name': 'High-Throughput Screening Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018533', 'descriptor_name': 'Biomass', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002482', 'descriptor_name': 'Cellulose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055808', 'descriptor_name': 'Drug Discovery', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D015723', 'descriptor_name': 'Gene Library', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/molecules28041777', 'pdf_url': 'https://www.mdpi.com/1420-3049/28/4/1777/pdf?version=1676887125', 'source': {'id': 'https://openalex.org/S108911230', 'display_name': 'Molecules', 'issn_l': '1420-3049', 'issn': ['1420-3049', '1433-1373'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967789', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36838763', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/molecules28041777', 'pdf_url': 'https://www.mdpi.com/1420-3049/28/4/1777/pdf?version=1676887125', 'source': {'id': 'https://openalex.org/S108911230', 'display_name': 'Molecules', 'issn_l': '1420-3049', 'issn': ['1420-3049', '1433-1373'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.51, 'id': 'https://metadata.un.org/sdg/12', 'display_name': 'Responsible consumption and production'}], 'grants': [{'funder': 'https://openalex.org/F4320321800', 'funder_display_name': 'Nederlandse Organisatie voor Wetenschappelijk Onderzoek', 'award_id': '18019'}], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1980862340', 'https://openalex.org/W1982439835', 'https://openalex.org/W1993965618', 'https://openalex.org/W1996100382', 'https://openalex.org/W2013582193', 'https://openalex.org/W2017552574', 'https://openalex.org/W2023577722', 'https://openalex.org/W2035837653', 'https://openalex.org/W2043919191', 'https://openalex.org/W2047710091', 'https://openalex.org/W2048400438', 'https://openalex.org/W2083372859', 'https://openalex.org/W2091313400', 'https://openalex.org/W2095543189', 'https://openalex.org/W2109421815', 'https://openalex.org/W2168608396', 'https://openalex.org/W2171955717', 'https://openalex.org/W2393800793', 'https://openalex.org/W2467779447', 'https://openalex.org/W2514446858', 'https://openalex.org/W2525099755', 'https://openalex.org/W2552568957', 'https://openalex.org/W2560525274', 'https://openalex.org/W2605332436', 'https://openalex.org/W2606527804', 'https://openalex.org/W2754130911', 'https://openalex.org/W2762268256', 'https://openalex.org/W2765456915', 'https://openalex.org/W2767626397', 'https://openalex.org/W2790092116', 'https://openalex.org/W2803254750', 'https://openalex.org/W2803747351', 'https://openalex.org/W2883470877', 'https://openalex.org/W2916780599', 'https://openalex.org/W2922290491', 'https://openalex.org/W2923817065', 'https://openalex.org/W2947437176', 'https://openalex.org/W2952362976', 'https://openalex.org/W2953081166', 'https://openalex.org/W2973074952', 'https://openalex.org/W3016852037', 'https://openalex.org/W3023133198', 'https://openalex.org/W3037104128', 'https://openalex.org/W3041389065', 'https://openalex.org/W3082339478', 'https://openalex.org/W3088832597', 'https://openalex.org/W3092065368', 'https://openalex.org/W3104884246', 'https://openalex.org/W3112506902', 'https://openalex.org/W3131354537', 'https://openalex.org/W3173723866', 'https://openalex.org/W3175876940', 'https://openalex.org/W3196768207', 'https://openalex.org/W3199016389', 'https://openalex.org/W4200193829', 'https://openalex.org/W4200271695', 'https://openalex.org/W4281671172', 'https://openalex.org/W4283395020', 'https://openalex.org/W4285193097', 'https://openalex.org/W4306292953', 'https://openalex.org/W4308480454', 'https://openalex.org/W4312155134'], 'related_works': ['https://openalex.org/W4283395020', 'https://openalex.org/W3183930479', 'https://openalex.org/W2973074952', 'https://openalex.org/W2963031998', 'https://openalex.org/W2594328795', 'https://openalex.org/W2090936831', 'https://openalex.org/W2043850786', 'https://openalex.org/W2023630889', 'https://openalex.org/W1980425862', 'https://openalex.org/W131203294'], 'abstract_inverted_index': {'Biomass-derived': [0], 'molecules': [1], 'can': [2, 113], 'provide': [3], 'a': [4, 35, 53, 59, 68, 73, 102], 'basis': [5], 'for': [6, 119], 'sustainable': [7], 'drug': [8, 37, 48, 108, 122], 'discovery.': [9], 'However,': [10], 'their': [11], 'full': [12], 'exploration': [13], 'is': [14], 'hampered': [15], 'by': [16], 'the': [17, 107, 117], 'dominance': [18], 'of': [19, 21, 62, 86], 'millions': [20], 'old-fashioned': [22], 'screening': [23, 28], 'compounds': [24], 'in': [25, 75, 84, 115], 'classical': [26], 'high-throughput': [27], '(HTS)': [29], 'libraries': [30], 'frequently': [31], 'utilized.': [32], 'We': [33], 'propose': [34], 'fragment-based': [36], 'discovery': [38, 109], '(FBDD)': [39], 'approach': [40], 'as': [41], 'an': [42], 'efficient': [43], 'method': [44], 'to': [45, 106], 'navigate': [46], 'biomass-derived': [47], 'space.': [49], 'Here,': [50], 'we': [51], 'perform': [52], 'proof-of-concept': [54], 'study': [55, 96], 'with': [56, 72], 'dihydrolevoglucosenone': [57], '(CyreneTM),': [58], 'pyrolysis': [60], 'product': [61], 'cellulose.': [63], 'Diverse': [64], 'synthetic': [65], 'routes': [66], 'afforded': [67], '100-membered': [69], 'fragment': [70], 'library': [71, 80], 'diversity': [74], 'functional': [76], 'groups': [77], 'appended.': [78], 'The': [79], 'overall': [81], 'performs': [82], 'well': [83], 'terms': [85], 'novelty,': [87], 'physicochemical': [88], 'properties,': [89], 'aqueous': [90], 'solubility,': [91], 'stability,': [92], 'and': [93], 'three-dimensionality.': [94], 'Our': [95, 111], 'suggests': [97], 'that': [98, 124], 'Cyrene-based': [99], 'fragments': [100], 'are': [101, 125], 'valuable': [103], 'green': [104], 'addition': [105], 'toolbox.': [110], 'findings': [112], 'help': [114], 'paving': [116], 'way': [118], 'new': [120], 'hit': [121], 'candidates': [123], 'based': [126], 'on': [127], 'renewable': [128], 'resources.': [129]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4320732452', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-12-24T03:59:00.933764', 'created_date': '2023-02-15'}