Title: Calcitonin gene-related peptide and adrenomedullin
Abstract: Alpha-calcitonin gene-related peptide (α-CGRP) and adrenomedullin (AM) are vasoactive peptides that belong to the calcitonin/CGRP peptide superfamily. Numerous studies have established a protective role of α-CGRP and AM in normal cardiovascular function and the pathophysiology of several cardiovascular diseases. Administration of AM or α-CGRP reduces blood pressure in both the hypertensive and normotensive state. Exogenous delivery of AM or α-CGRP significantly protects the heart secondary to hypertension and heart failure. The short half-life of the peptides in the serum, however, has hindered its ability to be an effective treatment option. Additionally, α-CGRP has been shown to play a significant role in precipitating migraine headaches. Hence, α-CGRP antagonists reduce migraine pain and the number of episodes. Currently, four α-CGRP antagonists are approved for the treatment of migraine. Thus, AM/α-CGRP-agonist(s) and α-CGRP-antagonist(s) are clinically relevant agents in the treatment of cardiovascular diseases and migraine, respectively.
Publication Year: 2023
Publication Date: 2023-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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