Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4318763294', 'doi': 'https://doi.org/10.21608/eajbsc.2023.282963', 'title': 'Regulation of Breast Cancer Stem Cells Associated-miRNAs by Ginger and Persimmon Extracts', 'display_name': 'Regulation of Breast Cancer Stem Cells Associated-miRNAs by Ginger and Persimmon Extracts', 'publication_year': 2023, 'publication_date': '2023-02-01', 'ids': {'openalex': 'https://openalex.org/W4318763294', 'doi': 'https://doi.org/10.21608/eajbsc.2023.282963'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21608/eajbsc.2023.282963', 'pdf_url': 'https://eajbsc.journals.ekb.eg/article_282963_a4ea587db13532e77427403ef0a8f062.pdf', 'source': {'id': 'https://openalex.org/S4210232938', 'display_name': 'Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology', 'issn_l': '2090-0767', 'issn': ['2090-0767', '2090-083X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://eajbsc.journals.ekb.eg/article_282963_a4ea587db13532e77427403ef0a8f062.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025224316', 'display_name': 'Abd El-Rahman Khazbak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I184834183', 'display_name': 'Al-Azhar University', 'ror': 'https://ror.org/05fnp1145', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I184834183']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Abd El-Rahman Khazbak', 'raw_affiliation_strings': ['Zoology Department, Faculty of Science, Al Azhar University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Zoology Department, Faculty of Science, Al Azhar University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I184834183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059598471', 'display_name': 'Sohair Salem', 'orcid': 'https://orcid.org/0000-0001-6811-431X'}, 'institutions': [{'id': 'https://openalex.org/I4210131959', 'display_name': 'National Research Centre', 'ror': 'https://ror.org/02n85j827', 'country_code': 'EG', 'type': 'facility', 'lineage': ['https://openalex.org/I4210131959']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Sohair Salem', 'raw_affiliation_strings': ['Molecular Genetics & Enzymology Department, National Research Centre, Giza, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Genetics & Enzymology Department, National Research Centre, Giza, Egypt.', 'institution_ids': ['https://openalex.org/I4210131959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109597523', 'display_name': 'Hanaa Rady', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131959', 'display_name': 'National Research Centre', 'ror': 'https://ror.org/02n85j827', 'country_code': 'EG', 'type': 'facility', 'lineage': ['https://openalex.org/I4210131959']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Hanaa Rady', 'raw_affiliation_strings': ['Chemistry of Natural Compounds Department, National Research Centre, Giza, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Chemistry of Natural Compounds Department, National Research Centre, Giza, Egypt.', 'institution_ids': ['https://openalex.org/I4210131959']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041497042', 'display_name': 'Mohamed Bashandy', 'orcid': 'https://orcid.org/0000-0002-6266-3550'}, 'institutions': [{'id': 'https://openalex.org/I184834183', 'display_name': 'Al-Azhar University', 'ror': 'https://ror.org/05fnp1145', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I184834183']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Mohamed Bashandy', 'raw_affiliation_strings': ['Zoology Department, Faculty of Science, Al Azhar University, Cairo, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Zoology Department, Faculty of Science, Al Azhar University, Cairo, Egypt.', 'institution_ids': ['https://openalex.org/I184834183']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 100, 'currency': 'USD', 'value_usd': 100, 'provenance': 'doaj'}, 'apc_paid': {'value': 100, 'currency': 'USD', 'value_usd': 100, 'provenance': 'doaj'}, 'fwci': 1.547, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.999747, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 84, 'max': 88}, 'biblio': {'volume': '15', 'issue': '1', 'first_page': '109', 'last_page': '119'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12347', 'display_name': 'Ginger and Zingiberaceae research', 'score': 0.9391, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12347', 'display_name': 'Ginger and Zingiberaceae research', 'score': 0.9391, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9116, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.70199126}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.52362704}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.52169794}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.5180028}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.47851765}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4296481}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.42849123}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.32496217}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.27501774}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.17991075}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12835711}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.109954804}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.21608/eajbsc.2023.282963', 'pdf_url': 'https://eajbsc.journals.ekb.eg/article_282963_a4ea587db13532e77427403ef0a8f062.pdf', 'source': {'id': 'https://openalex.org/S4210232938', 'display_name': 'Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology', 'issn_l': '2090-0767', 'issn': ['2090-0767', '2090-083X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21608/eajbsc.2023.282963', 'pdf_url': 'https://eajbsc.journals.ekb.eg/article_282963_a4ea587db13532e77427403ef0a8f062.pdf', 'source': {'id': 'https://openalex.org/S4210232938', 'display_name': 'Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology', 'issn_l': '2090-0767', 'issn': ['2090-0767', '2090-083X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/2', 'score': 0.55, 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1521897662', 'https://openalex.org/W1983991097', 'https://openalex.org/W1986709105', 'https://openalex.org/W2026516961', 'https://openalex.org/W2070317848', 'https://openalex.org/W2089970008', 'https://openalex.org/W2140987848', 'https://openalex.org/W2149591934', 'https://openalex.org/W2562403672', 'https://openalex.org/W2730933490', 'https://openalex.org/W2770200125', 'https://openalex.org/W2887745561', 'https://openalex.org/W4240067086'], 'related_works': ['https://openalex.org/W4243758701', 'https://openalex.org/W3151405604', 'https://openalex.org/W3043187607', 'https://openalex.org/W3032012916', 'https://openalex.org/W2793648706', 'https://openalex.org/W2737319532', 'https://openalex.org/W2565797512', 'https://openalex.org/W2050308539', 'https://openalex.org/W2019096591', 'https://openalex.org/W1744006947'], 'abstract_inverted_index': {'The': [0], 'ability': [1], 'of': [2, 7, 19, 59, 72, 82, 91, 123, 132, 146, 184, 188, 192, 213, 231, 237, 243], 'individual': [3, 49, 74, 93, 124, 133, 158, 214], 'and': [4, 9, 15, 25, 64, 84, 86, 106, 114, 137, 169, 215, 220, 240], 'combined': [5, 53, 117, 185, 216], 'extracts': [6, 75, 94, 125, 134], 'ginger': [8, 201, 218], 'persimmon': [10, 102, 222], 'to': [11, 34, 43, 200, 224], 'target': [12, 81, 90, 171], 'BCSCs': [13, 226], 'subpopulation': [14, 40], 'restore': [16], 'the': [17, 52, 57, 80, 89, 120, 129, 144, 182, 190, 211, 229, 235], 'expression': [18, 58, 230], 'tumor': [20], 'suppressive': [21], 'miRNAs,': [22, 127, 233], 'miR-200c,': [23], 'miR-30a': [24], 'miR-128,': [26], 'is': [27, 179], 'evaluated': [28], 'in': [29, 41, 143, 153, 181, 198, 206], 'this': [30, 174], 'study.Combined': [31], 'treatment': [32, 54, 118], 'led': [33], 'decreasing': [35], 'CD44': [36], '+': [37], 'CD24': [38], '-': [39], 'MDA-MB-231': [42], 'a': [44, 70, 150, 163], 'percent': [45], 'lower': [46], 'than': [47], 'both': [48, 73], 'extracts,': [50], 'however,': [51, 173], "didn't": [55], 'affect': [56], 'pluripotency-associated': [60], 'genes,': [61], 'OCT3/4,': [62], 'SOX2': [63], 'NANOG,': [65], 'which': [66, 160], 'are': [67], 'down-regulated': [68], 'as': [69, 79, 88], 'consequence': [71], 'treatment.Bioinformatics': [76], 'predicted': [77], 'DNMT3A': [78], 'miR-200C': [83], 'miR-30a,': [85], 'ABCB9': [87, 115], 'miR-128a.Both': [92], 'exerted': [95], 'an': [96, 107], 'activating': [97, 121, 141], 'effect': [98, 109, 122, 131, 142, 175], 'on': [99, 104, 110, 126, 135, 176], 'miRNAs': [100], '(except': [101], 'extract': [103, 202, 219, 223], 'miR-30a)': [105], 'inhibitory': [108, 130], 'their': [111], 'targets': [112], 'DNMT3a': [113], 'expression.Additionally,': [116], 'keeps': [119], 'decrease': [128, 152], 'ABCB9,': [136], 'reversed': [138], 'it': [139], 'into': [140], 'case': [145, 183], 'DNMT3a.Moreover,': [147], 'we': [148], 'found': [149], 'significant': [151], 'miR-200c': [154, 168], 'promoter': [155], 'methylation': [156, 177, 187], 'after': [157], 'treatments,': [159], 'could': [161], 'represent': [162], 'positive': [164], 'feedback': [165], 'loop': [166], 'between': [167], 'its': [170], 'DNMT3a,': [172], 'status': [178], 'absent': [180], 'treatment.The': [186], 'LINE1,': [189], 'index': [191], 'global': [193], 'DNA': [194], 'methylation,': [195], 'was': [196], 'increased': [197], 'response': [199, 242], 'treatment,': [203], 'predicting': [204], 'increasing': [205], 'genomic': [207], 'stability.Our': [208], 'finding': [209], 'highlighted': [210], 'role': [212], 'aqueous': [217], 'methanolic': [221], 'subdue': [225], 'by': [227], 'modulating': [228], 'tumor-suppressive': [232], 'despite': [234], 'variation': [236], 'molecular': [238], 'genetics': [239], 'epigenetic': [241], 'candidate': [244], 'genes.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4318763294', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}], 'updated_date': '2024-12-26T01:39:58.844295', 'created_date': '2023-02-02'}