Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4318336252', 'doi': 'https://doi.org/10.1002/lipd.12366', 'title': 'Hypoxia increases cellular levels of phosphatidic acid and lysophospholipids in undifferentiated Caco‐2 cells', 'display_name': 'Hypoxia increases cellular levels of phosphatidic acid and lysophospholipids in undifferentiated Caco‐2 cells', 'publication_year': 2023, 'publication_date': '2023-01-28', 'ids': {'openalex': 'https://openalex.org/W4318336252', 'doi': 'https://doi.org/10.1002/lipd.12366', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36708255'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/lipd.12366', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S115623499', 'display_name': 'Lipids', 'issn_l': '0024-4201', 'issn': ['0024-4201', '1558-9307'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101027693', 'display_name': 'Yoshibumi Shimizu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshibumi Shimizu', 'raw_affiliation_strings': ['Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan', 'institution_ids': ['https://openalex.org/I922474255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084072284', 'display_name': 'Keiko Tamiya‐Koizumi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I33858575', 'display_name': 'Nagoya City University', 'ror': 'https://ror.org/04wn7wc95', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I33858575']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Keiko Tamiya‐Koizumi', 'raw_affiliation_strings': ['Department of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I33858575']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051474355', 'display_name': 'Toshihiko Tsutsumi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I11023767', 'display_name': 'Kyushu University of Health and Welfare', 'ror': 'https://ror.org/01banz567', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I11023767']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshihiko Tsutsumi', 'raw_affiliation_strings': ['Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, Nobeoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, Nobeoka, Japan', 'institution_ids': ['https://openalex.org/I11023767']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037909515', 'display_name': 'Mamoru Kyogashima', 'orcid': 'https://orcid.org/0000-0001-7830-7916'}, 'institutions': [{'id': 'https://openalex.org/I157960836', 'display_name': 'Nihon Pharmaceutical University', 'ror': 'https://ror.org/039aamd19', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I157960836']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mamoru Kyogashima', 'raw_affiliation_strings': ['Department of Microbiology and Molecular Cell Biology, Nihon Pharmaceutical University, Saitama, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Molecular Cell Biology, Nihon Pharmaceutical University, Saitama, Japan', 'institution_ids': ['https://openalex.org/I157960836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105465680', 'display_name': 'Reiji Kannagi', 'orcid': 'https://orcid.org/0000-0003-4202-2921'}, 'institutions': [{'id': 'https://openalex.org/I4210096666', 'display_name': 'Institute of Biomedical Sciences, Academia Sinica', 'ror': 'https://ror.org/00tk6s776', 'country_code': 'TW', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096666', 'https://openalex.org/I84653119']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Reiji Kannagi', 'raw_affiliation_strings': ['Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan', 'institution_ids': ['https://openalex.org/I4210096666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045469994', 'display_name': 'Soichiro Iwaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I33858575', 'display_name': 'Nagoya City University', 'ror': 'https://ror.org/04wn7wc95', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I33858575']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Soichiro Iwaki', 'raw_affiliation_strings': ['Department of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I33858575']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082359670', 'display_name': 'Mineyoshi Aoyama', 'orcid': 'https://orcid.org/0000-0002-9976-6465'}, 'institutions': [{'id': 'https://openalex.org/I33858575', 'display_name': 'Nagoya City University', 'ror': 'https://ror.org/04wn7wc95', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I33858575']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mineyoshi Aoyama', 'raw_affiliation_strings': ['Department of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I33858575']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5091525772', 'display_name': 'Akira Tokumura', 'orcid': 'https://orcid.org/0000-0003-2423-228X'}, 'institutions': [{'id': 'https://openalex.org/I75957467', 'display_name': "Yasuda Women's University", 'ror': 'https://ror.org/03c5e1619', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I75957467']}, {'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Akira Tokumura', 'raw_affiliation_strings': ["Department of Pharmacy, Yasuda Women's University, Hiroshima, Japan", 'Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan'], 'affiliations': [{'raw_affiliation_string': "Department of Pharmacy, Yasuda Women's University, Hiroshima, Japan", 'institution_ids': ['https://openalex.org/I75957467']}, {'raw_affiliation_string': 'Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan', 'institution_ids': ['https://openalex.org/I922474255']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5091525772'], 'corresponding_institution_ids': ['https://openalex.org/I75957467', 'https://openalex.org/I922474255'], 'apc_list': {'value': 3450, 'currency': 'USD', 'value_usd': 3450, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.384, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.583529, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 71, 'max': 82}, 'biblio': {'volume': '58', 'issue': '2', 'first_page': '93', 'last_page': '103'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Signalling and Metabolism in Health and Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Signalling and Metabolism in Health and Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12286', 'display_name': 'Mechanosensitive Ion Channels in Physiology and Disease', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lysophosphatidylcholine', 'display_name': 'Lysophosphatidylcholine', 'score': 0.89351225}, {'id': 'https://openalex.org/keywords/lysophosphatidylethanolamine', 'display_name': 'Lysophosphatidylethanolamine', 'score': 0.86097574}, {'id': 'https://openalex.org/keywords/caco-2', 'display_name': 'Caco-2', 'score': 0.67700475}, {'id': 'https://openalex.org/keywords/lysophospholipids', 'display_name': 'Lysophospholipids', 'score': 0.517064}, {'id': 'https://openalex.org/keywords/enterocyte', 'display_name': 'Enterocyte', 'score': 0.48132312}, {'id': 'https://openalex.org/keywords/phospholipase-d', 'display_name': 'Phospholipase D', 'score': 0.4754681}], 'concepts': [{'id': 'https://openalex.org/C2776661833', 'wikidata': 'https://www.wikidata.org/wiki/Q2823281', 'display_name': 'Lysophosphatidic acid', 'level': 3, 'score': 0.96665484}, {'id': 'https://openalex.org/C2778596009', 'wikidata': 'https://www.wikidata.org/wiki/Q410548', 'display_name': 'Lysophosphatidylcholine', 'level': 5, 'score': 0.89351225}, {'id': 'https://openalex.org/C2776909261', 'wikidata': 'https://www.wikidata.org/wiki/Q66000256', 'display_name': 'Phosphatidic acid', 'level': 4, 'score': 0.88059497}, {'id': 'https://openalex.org/C2781112429', 'wikidata': 'https://www.wikidata.org/wiki/Q3269788', 'display_name': 'Lysophosphatidylethanolamine', 'level': 5, 'score': 0.86097574}, {'id': 'https://openalex.org/C193176779', 'wikidata': 'https://www.wikidata.org/wiki/Q5016050', 'display_name': 'Caco-2', 'level': 3, 'score': 0.67700475}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.53125}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4952747}, {'id': 'https://openalex.org/C2779604457', 'wikidata': 'https://www.wikidata.org/wiki/Q1340349', 'display_name': 'Enterocyte', 'level': 3, 'score': 0.48132312}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.47747326}, {'id': 'https://openalex.org/C4733338', 'wikidata': 'https://www.wikidata.org/wiki/Q2792936', 'display_name': 'Lipid metabolism', 'level': 2, 'score': 0.4765618}, {'id': 'https://openalex.org/C6182249', 'wikidata': 'https://www.wikidata.org/wiki/Q700007', 'display_name': 'Phospholipase D', 'level': 3, 'score': 0.4754681}, {'id': 'https://openalex.org/C382228', 'wikidata': 'https://www.wikidata.org/wiki/Q849994', 'display_name': 'Clinical chemistry', 'level': 2, 'score': 0.45397356}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.45354405}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3914675}, {'id': 'https://openalex.org/C2778918659', 'wikidata': 'https://www.wikidata.org/wiki/Q186915', 'display_name': 'Phospholipid', 'level': 3, 'score': 0.34259516}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33478397}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.33393836}, {'id': 'https://openalex.org/C2776330855', 'wikidata': 'https://www.wikidata.org/wiki/Q650187', 'display_name': 'Phosphatidylcholine', 'level': 4, 'score': 0.14194405}, {'id': 'https://openalex.org/C2777882243', 'wikidata': 'https://www.wikidata.org/wiki/Q11090', 'display_name': 'Small intestine', 'level': 2, 'score': 0.11071384}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.09634897}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.09245288}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008246', 'descriptor_name': 'Lysophospholipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010712', 'descriptor_name': 'Phosphatidic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018938', 'descriptor_name': 'Caco-2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008244', 'descriptor_name': 'Lysophosphatidylcholines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008244', 'descriptor_name': 'Lysophosphatidylcholines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/lipd.12366', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S115623499', 'display_name': 'Lipids', 'issn_l': '0024-4201', 'issn': ['0024-4201', '1558-9307'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36708255', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1534992900', 'https://openalex.org/W1569915862', 'https://openalex.org/W1596518827', 'https://openalex.org/W1775749144', 'https://openalex.org/W1967170457', 'https://openalex.org/W1969591932', 'https://openalex.org/W1972426718', 'https://openalex.org/W1978063819', 'https://openalex.org/W1983292390', 'https://openalex.org/W1988967653', 'https://openalex.org/W1990316472', 'https://openalex.org/W1996221314', 'https://openalex.org/W2000809425', 'https://openalex.org/W2001141409', 'https://openalex.org/W2011362522', 'https://openalex.org/W2018957757', 'https://openalex.org/W2030371082', 'https://openalex.org/W2075711199', 'https://openalex.org/W2089779223', 'https://openalex.org/W2123114782', 'https://openalex.org/W2126286238', 'https://openalex.org/W2126767664', 'https://openalex.org/W2134814870', 'https://openalex.org/W2156358891', 'https://openalex.org/W2159315651', 'https://openalex.org/W2161184363', 'https://openalex.org/W2165545940', 'https://openalex.org/W2168526937', 'https://openalex.org/W2259367957', 'https://openalex.org/W2419514907', 'https://openalex.org/W2519481437', 'https://openalex.org/W2589787806', 'https://openalex.org/W2808193471', 'https://openalex.org/W2990571978', 'https://openalex.org/W3003216687', 'https://openalex.org/W3040832352', 'https://openalex.org/W3043469450', 'https://openalex.org/W3093198230', 'https://openalex.org/W3175948189', 'https://openalex.org/W3179741302', 'https://openalex.org/W4224051027', 'https://openalex.org/W4229460325'], 'related_works': ['https://openalex.org/W4318336252', 'https://openalex.org/W4210794065', 'https://openalex.org/W2991588502', 'https://openalex.org/W2765056484', 'https://openalex.org/W2265011503', 'https://openalex.org/W2055995527', 'https://openalex.org/W2039691962', 'https://openalex.org/W2020823395', 'https://openalex.org/W1993906354', 'https://openalex.org/W1589381288'], 'abstract_inverted_index': {'Cancer': [0], 'cells': [1, 25, 60], 'are': [2], 'known': [3], 'to': [4, 33, 64, 81], 'survive': [5], 'in': [6, 58, 68, 96, 104, 108], 'a': [7], 'hypoxic': [8, 48], 'microenvironment': [9], 'by': [10, 75, 83], 'altering': [11], 'their': [12, 18, 102], 'lipid': [13], 'metabolism': [14], 'as': [15, 17], 'well': [16], 'energy': [19], 'metabolism.': [20], 'In': [21], 'this': [22], 'study,': [23], 'Caco-2': [24, 59, 98, 110], 'derived': [26], 'from': [27], 'human': [28], 'colon': [29], 'cancer,': [30], 'were': [31], 'found': [32], 'have': [34], 'elevated': [35], 'intracellular': [36], 'levels': [37, 70], 'of': [38, 56, 71], 'phosphatidic': [39], 'acid': [40, 45], 'and': [41, 73, 78], 'its': [42], 'lysoform,': [43], 'lysophosphatidic': [44], '(LPA),': [46], 'under': [47], 'conditions.': [49], 'Our': [50], 'results': [51], 'suggested': [52], 'that': [53], 'the': [54, 65, 88, 105], 'elevation': [55], 'LPA': [57, 82, 106], 'was': [61], 'mainly': [62], 'due': [63], 'combined': [66], 'increases': [67], 'cellular': [69], 'lysophosphatidylcholine': [72], 'lysophosphatidylethanolamine': [74], 'phospholipase': [76], 'A2': [77], 'subsequent': [79], 'hydrolysis': [80], 'lysophospholipase': [84], 'D.': [85], 'We': [86], 'detected': [87], 'Ca2+': [89], '-stimulated': [90], 'choline-producing': [91], 'activities': [92], 'toward': [93], 'exogenous': [94], 'lysophosphatidylcholines': [95], 'whole': [97], 'cell': [99], 'homogenates,': [100], 'indicating': [101], 'involvement': [103], 'production': [107], 'intact': [109], 'cells.': [111]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4318336252', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-09-26T00:02:16.125440', 'created_date': '2023-01-28'}