Publication Information

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1840], 'gadolinium': [369, 669, 1841], 'enhancement': [370, 1842], '(LGE),': [371], 'presence': [372, 825, 871, 892, 934, 1074], 'ventricular': [375, 396, 567, 673, 678, 682, 700, 1087, 1183, 1548], '(LV)': [376], 'apical': [377, 790, 883], 'aneurysm,': [378, 884], 'systolic': [380, 707], 'dysfunction': [381], '(ie,': [382], 'LV': [383, 785, 879, 1115], 'ejection': [384, 674, 786, 880], 'fraction': [385, 787, 881], '≤50%)': [386], 'have': [387, 918, 981], 'associated': [389, 946, 1080], 'increased': [391, 1028, 1084], 'future': [394, 1264, 1301], 'life-threatening': [395, 1249], 'arrhythmias.': [397], 'According': [398], 'evidence,': [401], 'enhanced': [403, 439], 'version': [404], '2011': [407], 'American': [408, 629, 1413, 1498, 1890], 'Cardiology/American': [411, 1501], 'Heart': [412, 630, 1414, 1502, 1557, 1598, 1854, 1891], 'Association': [413, 1503], '(ACC/AHA)': [414], 'was': [420, 552, 1059, 1079], 'developed': [421], 'then': [423], 'recommended': [424, 741], 'by': [425, 709, 799, 1051, 1163, 1172], '2020': [427, 1481], 'ACC/AHA': [428, 440], 'guidelines': [429, 560, 614, 1176, 1541, 1904], 'choice': [434], 'predicting': [436], 'arrhythmic': [437], 'events.1The': [438], 'algorithm': [441, 551, 577, 900, 1170], 'demonstrated': [442], 'sensitivity': [444], 'identifying': [446], 'high-risk': [447, 524], 'patients.': [448], 'However,': [449, 959, 1099, 1218], 'ability': [451], 'identify': [453, 523], 'low-risk': [454], 'not': [457, 532, 772, 829, 1048, 1129, 1142, 1351, 1404, 1689, 1708, 1721, 1728], 'high,': [458], 'excessive': [463], 'rate.': [466], 'Data': [467], 'International': [470], 'Sarcomeric': [471, 1665], 'Human': [472, 1067, 1666], 'Registry': [474, 1668], 'shows': [475], 'States': [481], 'are': [482, 495, 852, 1231, 1403, 1688, 1697, 1707, 1712, 1720, 1727, 1747], 'more': [483], 'frequently': [484], 'implanted': [485, 502], 'compared': [486, 1118], 'non-US': [490], 'sites,': [491], 'there': [494, 776], 'fewer': [496], 'appropriate': [497, 1320, 1700], 'ICD': [498, 605, 735, 770, 855, 864, 1258, 1271], 'therapy': [499], 'States.3': [506], 'In': [507, 755, 1789], 'contrast,': [508], 'exhibits': [513], 'negative': [516], 'predictive': [517], 'value': [518], 'but': [519], 'fails': [520], 'correctly': [522], 'cases.': [528], 'Moreover,': [529], 'it': [530, 1140], 'does': [531, 1350], 'take': [533], 'into': [534, 831], 'account': [535], 'impact': [537], 'newer': [539], 'markers': [540, 828, 925, 980], 'risk.To': [543], 'overcome': [544], 'these': [545, 1138], 'limitations,': [546], 'discussed': [553], '2022': [558, 1174, 1539], 'ESC': [559, 732, 1175, 1229, 1540], 'management': [563, 1179, 1241, 1544], 'arrhythmias': [568, 1088, 1184, 1549], 'prevention': [571, 622, 739, 1187, 1274, 1552, 1588], 'SCD2': [573], '(Figure).': [574], 'gives': [578, 901], 'central': [580], 'role': [581, 1005], 'statistically': [590], 'capable': [591], 'calculating': [593], 'individual': [595], 'each': [598], 'patient,': [599], 'which': [600, 1070, 1158, 1199, 1210], 'facilitates': [601], 'shared': [602], 'implantation.Download': [606], 'figureDownload': [607], 'PowerPointFigure.': [608], 'Comparison': [609], 'different': [611, 800], 'society': [613, 1359], 'primary': [621, 738, 1273, 1587], 'HCM.': [626], 'AHA/ACC': [627, 1482], 'indicates': [628], 'Association/American': [631], 'Cardiology;': [634, 646], 'BP,': [635], 'blood': [636, 886, 928, 939, 988], 'pressure;': [637], 'CMR,': [638], 'magnetic': [640], 'resonance;': [641], 'ESC,': [642], 'FH': [647], 'HCM,': [648], 'family': [649], 'history': [650], 'hypertrophic': [652, 1492, 1596, 1619, 1660, 1844], 'cardiomyopathy;': [653], 'Risk-SCD,': [655], 'Clinical': [656, 1507, 1873], 'Cardiomyopathy;': [666], 'LGE,': [667, 784, 878], 'enhancement;': [670], 'LVEF,': [671], 'fraction;': [675], 'LVH,': [676], 'hypertrophy;': [679], 'NSVT,': [680], 'nonsustained': [681], 'tachycardia;': [683], 'death.': [688], '*Based': [689], '(': [694], 'https://doc2do.com/hcm/webHCM.html).': [695], '†Usually': [696], '≥15%': [697], 'mass.': [701], '‡Defined': [702], 'failure': [704], 'increase': [706], 'pressure': [708, 887, 929, 940, 989], 'least': [711], '20': [712, 724], 'mm': [713, 725], 'Hg': [714, 726], 'rest': [716], 'peak': [718, 728], 'exercise,': [719, 890], 'or': [720, 789, 1360, 1410], 'fall': [722], 'pressure.As': [729], 'previous': [731], 'guidelines,': [733, 1852], 'placement': [736], 'adult': [743], 'estimated': [747, 759, 842], '≥6%': [752], '(class': [753, 792, 860, 897], 'IIa).': [754], '<4%': [764], '(traditionally': [765], 'considered': [766, 859, 868], 'risk),': [768], 'should': [771, 866, 1677, 1733, 1775], 'placed': [774], 'unless': [775], '≥1': [778, 873], 'major': [779, 1203], 'factor,': [781, 875], 'including': [782, 876], 'significant': [783, 877, 1147], '≤50%,': [788, 882], 'aneurysm': [791], 'IIb).': [793], 'This': [794, 1795], 'recommendation': [796, 1058], 'supported': [798, 1050], 'retrospective': [801], 'studies': [802, 963, 1220], 'show': [804, 1130], 'classified': [807, 836], 'via': [811, 1784], 'because': [822, 1125, 1242], 'incorporated': [830], 'score.For': [834], 'intermediate': [838], '(with': [840], '≥4%': [847], '<6%),': [849], '2': [850], 'recommendations': [851], 'provided:': [853], '(1)': [854], 'may': [857, 1025, 1159, 1254, 1296], 'IIb);': [861], '(2)': [863], 'abnormal': [885, 927, 987], 'response': [888, 930, 941, 990], 'sarcomeric': [894, 936, 1023, 1038, 1077, 1105, 1122], 'pathogenic': [895, 937], 'mutations': [896, 1021], 'IIa).The': [898], 'clinicians': [902], 'ready-to-use': [904], 'solution': [905], 'apply': [907], 'difficult': [909], 'questions': [911], 'regarding': [912, 921], 'stratification.': [915], 'Nevertheless,': [916], 'we': [917, 1017, 1032, 1312], 'concerns': [920], 'specific': [923, 1020], 'exercise': [932, 943, 992, 1278, 1616], 'mutation.Abnormal': [938], 'higher': [949], '≤40': [955], 'years': [956], 'age.': [958], 'absence': [961], 'demonstrating': [964], 'independent': [966], 'association': [967], 'survival': [972], 'analyses4': [973], 'resulted': [982], 'removal': [985], 'routine': [995], 'part': [996], 'estimation.': [1001], 'Furthermore,': [1002], 'complementary': [1004], 'added': [1007], 'unknown.In': [1014], 'addition,': [1015], 'although': [1016], 'acknowledge': [1018], 'genes': [1024], 'confer': [1027], 'believe': [1033], 'inclusion': [1036], 'mutation': [1039, 1078, 1106], 'factor': [1044], 'premature': [1046], 'sufficiently': [1049], 'solid': [1052], 'evidence.': [1053], 'It': [1054], 'seems': [1055], 'results': [1063, 1132], 'SHaRe': [1065], '(Sarcomeric': [1066], 'Registry),5': [1069], 'showed': [1071], '>2-fold': [1083], 'after': [1091], 'controlling': [1092], 'proband': [1094], 'status,': [1095], 'sex,': [1096], 'race.': [1098], 'study,': [1102], 'were': [1107], 'significantly': [1108, 1298], 'younger': [1109], 'had': [1111], 'greater': [1113], 'maximal': [1114], 'wall': [1116], 'thickness': [1117], 'those': [1120, 1406], 'mutation.': [1123], 'authors': [1127, 1348, 1363], 'did': [1128], 'analysis': [1135], 'adjusted': [1136], 'covariates,': [1139], 'possible': [1143], 'exclude': [1145], 'overestimation': [1148, 1253], 'subgroup': [1155], 'patients,': [1157], 'already': [1161], 'covered': [1162], 'actual': [1164], 'estimation': [1166], 'scores.In': [1167], 'conclusion,': [1168], 'tries': [1190], 'fill': [1192], 'US': [1197], 'model,': [1198, 1209, 1321], 'factors,': [1205], 'individualized': [1215], 'calculator.': [1217], 'further': [1219], 'designed': [1221], 'evaluate': [1223], 'performance': [1225], 'required.In': [1232], 'practice,': [1234], 'critical': [1238], 'patient': [1240], 'underestimation': [1244], 'can': [1245], 'lead': [1246], 'unexpected': [1248], 'events;': [1250], 'however,': [1251, 1293], 'result': [1255], 'unnecessary': [1257], 'potential': [1262], 'complications.': [1265], 'decision': [1267], 'place': [1269], 'actuarial': [1277], 'predicted': [1284], 'SCD-': [1287], 'ICD-related': [1289], 'complications': [1290], 'costs;': [1292], 'latter': [1295], 'change': [1297], 'introduction': [1304], 'options.': [1308], 'Therefore,': [1309], 'even': [1310], 'if': [1311], 'seem': [1313], 'getting': [1316], 'closer': [1317], 'how': [1328], 'stratify': [1330], 'continue.Article': [1340], 'InformationThis': [1341], 'article': [1342, 1402, 1681, 1754], 'reflects': [1343], 'views': [1345, 1355], 'necessarily': [1352, 1405], 'represent': [1353], 'scientific': [1358], 'authoritative': [1361], 'body.AcknowledgmentsThe': [1362], 'would': [1364], 'like': [1365], 'thank': [1367], 'Dr': [1368, 1377], 'Marta': [1369], 'Rubino': [1370], '(University': [1371, 1380], 'Vanvitelli")': [1375, 1384], 'Michele': [1378], 'Lioncino': [1379], 'helpful': [1386], 'discussions': [1387], 'topic.Sources': [1390], 'FundingNone.Disclosures': [1392], 'None.FootnotesCirculation': [1393], 'available': [1395], 'www.ahajournals.org/journal/circThe': [1397], 'opinions': [1398], 'expressed': [1399], 'editors': [1409], 'Association.For': [1415], 'Sources': [1416], 'Funding': [1418], 'Disclosures,': [1420], 'see': [1421], 'page': [1422], '283.Correspondence': [1423], '[email protected].': [1458], 'Ommen': [1459], 'SR,': [1460], 'Mital': [1461], 'S,': [1462, 1579, 1807, 1815], 'Burke': [1463], 'MA,': [1464], 'Day': [1465, 1633], 'SM,': [1466, 1634], 'Deswal': [1467], 'A,': [1468], 'Elliott': [1469], 'P,': [1470, 1478, 1529, 1565], 'Evanovich': [1471], 'LL,': [1472], 'Hung': [1473], 'J,': [1474, 1518, 1573, 1805, 1825, 1829], 'Joglar': [1475], 'JA,': [1476], 'Kantor': [1477], 'et': [1479, 1537, 1582, 1651], 'al.': [1480, 1538, 1583, 1652], 'diagnosis': [1486], 'treatment': [1488], 'cardiomyopathy:': [1493, 1661], 'report': [1495], 'Joint': [1504], 'Committee': [1505, 1783], 'Practice': [1508], 'Guidelines.Circulation.': [1509], '2020;': [1510], '142:e558–e631.': [1511], 'doi:': [1512, 1602, 1628, 1672], '10.1161/CIR.0000000000000937LinkGoogle': [1513], 'Scholar2.': [1514], 'Zeppenfeld': [1515], 'K,': 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[1605], 'T,': [1606], 'Raposo': [1607], 'SC,': [1608], 'Brito': [1609], 'Lopes': [1611], 'LR.': [1612], 'Prognostic': [1613], 'relevance': [1614], 'testing': [1617], 'cardiomyopathy.': [1620], 'A': [1621], 'systematic': [1622], 'review.Int': [1623], 'J': [1624], 'Cardiol.': [1625], '339:83–92.': [1627], '10.1016/j.ijcard.2021.06.051CrossrefMedlineGoogle': [1629], 'Scholar5.': [1630], 'Ho': [1631], 'CY,': [1632], 'Ashley': [1635], 'EA,': [1636], 'Pereira': [1639], 'AC,': [1640], 'Cirino': [1643], 'AL,': [1644], 'Fox': [1645], 'JC,': [1646], 'Ware': [1649], 'JS,': [1650], 'Genotype': [1653], 'lifetime': [1655], 'burden': [1656], 'disease': [1658], 'insights': [1662], '(SHaRe).Circulation.': [1669], '2018;': [1670], '138:1387–1398.': [1671], '10.1161/CIRCULATIONAHA.117.033200LinkGoogle': [1673], 'Scholar': [1674], 'eLetters(0)': [1675], 'eLetters': [1676], 'relate': [1678], 'recently': [1682], 'published': [1683, 1722], 'journal': [1686, 1716], 'forum': [1691], 'providing': [1693], 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