Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4317567314', 'doi': 'https://doi.org/10.17179/excli2022-5559', 'title': 'Effects of acute and chronic disease on cell junctions in mouse liver.', 'display_name': 'Effects of acute and chronic disease on cell junctions in mouse liver.', 'publication_year': 2023, 'publication_date': '2023-01-01', 'ids': {'openalex': 'https://openalex.org/W4317567314', 'doi': 'https://doi.org/10.17179/excli2022-5559', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36660194'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36660194', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086007558', 'display_name': 'Raf Van Campenhout', 'orcid': 'https://orcid.org/0000-0002-4340-0210'}, 'institutions': [{'id': 'https://openalex.org/I13469542', 'display_name': 'Vrije Universiteit Brussel', 'ror': 'https://ror.org/006e5kg04', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I13469542']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Raf Van Campenhout', 'raw_affiliation_strings': ['Entity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Entity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium.', 'institution_ids': ['https://openalex.org/I13469542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032135267', 'display_name': 'Bruno Cogliati', 'orcid': 'https://orcid.org/0000-0002-1388-7240'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Bruno Cogliati', 'raw_affiliation_strings': ['School of Veterinary Medicine and Animal Science, Department of Pathology, University of São Paulo, São Paulo, Brazil.'], 'affiliations': [{'raw_affiliation_string': 'School of Veterinary Medicine and Animal Science, Department of Pathology, University of São Paulo, São Paulo, Brazil.', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045862213', 'display_name': 'Mathieu Vinken', 'orcid': 'https://orcid.org/0000-0001-5115-8893'}, 'institutions': [{'id': 'https://openalex.org/I13469542', 'display_name': 'Vrije Universiteit Brussel', 'ror': 'https://ror.org/006e5kg04', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I13469542']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Mathieu Vinken', 'raw_affiliation_strings': ['Entity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Entity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium.', 'institution_ids': ['https://openalex.org/I13469542']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.26, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.499258, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 68, 'max': 79}, 'biblio': {'volume': '22', 'issue': None, 'first_page': '1', 'last_page': '11'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11480', 'display_name': 'Connexins and lens biology', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11480', 'display_name': 'Connexins and lens biology', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11872', 'display_name': 'Barrier Structure and Function Studies', 'score': 0.9823, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10340', 'display_name': 'Hepatitis B Virus Studies', 'score': 0.9806, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adherens-junction', 'display_name': 'Adherens junction', 'score': 0.9914875}], 'concepts': [{'id': 'https://openalex.org/C201508349', 'wikidata': 'https://www.wikidata.org/wiki/Q45173', 'display_name': 'Adherens junction', 'level': 4, 'score': 0.9914875}, {'id': 'https://openalex.org/C177779419', 'wikidata': 'https://www.wikidata.org/wiki/Q1053832', 'display_name': 'Tight junction', 'level': 2, 'score': 0.92486656}, {'id': 'https://openalex.org/C29350253', 'wikidata': 'https://www.wikidata.org/wiki/Q189073', 'display_name': 'Cell junction', 'level': 3, 'score': 0.6822366}, {'id': 'https://openalex.org/C158157758', 'wikidata': 'https://www.wikidata.org/wiki/Q232438', 'display_name': 'Gap junction', 'level': 3, 'score': 0.66932935}, {'id': 'https://openalex.org/C149402561', 'wikidata': 'https://www.wikidata.org/wiki/Q24776048', 'display_name': 'Cadherin', 'level': 3, 'score': 0.65995455}, {'id': 'https://openalex.org/C2776637226', 'wikidata': 'https://www.wikidata.org/wiki/Q6658207', 'display_name': 'Liver injury', 'level': 2, 'score': 0.5331143}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4489783}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.43710136}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4030491}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.338449}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2020081}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.19357127}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.059265107}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36660194', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.72}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1577577364', 'https://openalex.org/W1844303090', 'https://openalex.org/W1964184380', 'https://openalex.org/W1993882745', 'https://openalex.org/W2038430559', 'https://openalex.org/W2038927157', 'https://openalex.org/W2044387031', 'https://openalex.org/W2048992713', 'https://openalex.org/W2050280407', 'https://openalex.org/W2080936785', 'https://openalex.org/W2083034260', 'https://openalex.org/W2107277218', 'https://openalex.org/W2116685646', 'https://openalex.org/W2154589460', 'https://openalex.org/W2167093722', 'https://openalex.org/W2174763143', 'https://openalex.org/W2263973560', 'https://openalex.org/W2283024996', 'https://openalex.org/W2345185607', 'https://openalex.org/W2396447225', 'https://openalex.org/W2401376115', 'https://openalex.org/W2416393131', 'https://openalex.org/W2582913656', 'https://openalex.org/W2623796068', 'https://openalex.org/W2764182566', 'https://openalex.org/W2884399916', 'https://openalex.org/W2898469163', 'https://openalex.org/W2903145923', 'https://openalex.org/W2946542907', 'https://openalex.org/W2948670403', 'https://openalex.org/W2966111839', 'https://openalex.org/W2981912567', 'https://openalex.org/W2990656184', 'https://openalex.org/W3001277415', 'https://openalex.org/W3021630345', 'https://openalex.org/W3037245793', 'https://openalex.org/W3094482057', 'https://openalex.org/W3111167672', 'https://openalex.org/W3113516073', 'https://openalex.org/W3119569234', 'https://openalex.org/W3140442286', 'https://openalex.org/W3180149529', 'https://openalex.org/W3200164005', 'https://openalex.org/W4291020266'], 'related_works': ['https://openalex.org/W4317567314', 'https://openalex.org/W3111167672', 'https://openalex.org/W2792873714', 'https://openalex.org/W2625782423', 'https://openalex.org/W2623796068', 'https://openalex.org/W2298569630', 'https://openalex.org/W2162088887', 'https://openalex.org/W2032637622', 'https://openalex.org/W2004150388', 'https://openalex.org/W1968707758'], 'abstract_inverted_index': {'Cell': [0], 'junctions,': [1, 7], 'including': [2, 30], 'anchoring,': [3], 'occluding': [4], 'and': [5, 15, 45, 80, 87, 104, 121, 128, 130, 150, 158, 180, 194], 'communicating': [6], 'play': [8], 'an': [9], 'indispensable': [10], 'role': [11], 'in': [12, 31, 56, 93, 204], 'tissue': [13], 'architecture': [14], 'homeostasis.': [16], 'Consequently,': [17], 'malfunctioning': [18], 'of': [19, 28, 43, 84, 114, 143, 168, 174], 'cell': [20, 54, 202], 'junctions': [21, 55, 203], 'is': [22], 'linked': [23], 'with': [24, 62], 'a': [25], 'wide': [26], 'range': [27], 'disorders,': [29], 'liver.': [32, 205], 'The': [33, 183], 'present': [34], 'study': [35], 'was': [36, 109, 185], 'set': [37], 'up': [38], 'to': [39], 'investigate': [40], 'the': [41, 115, 123, 131, 144, 151, 188], 'effects': [42, 200], 'acute': [44, 193], 'chronic': [46, 195], 'disease': [47, 197], 'induced': [48], 'by': [49, 70], 'chemical': [50], 'compounds': [51], 'on': [52, 201], 'hepatic': [53], 'mice.': [57], 'Mice': [58], 'were': [59, 91, 138, 161], 'either': [60], 'overdosed': [61], 'paracetamol': [63, 164], 'or': [64, 75], 'repeatedly': [65], 'administered': [66], 'carbon': [67, 169], 'tetrachloride': [68, 170], 'followed': [69], 'sampling': [71], 'at': [72, 187], '24': [73], 'hours': [74], '8': [76], 'weeks,': [77], 'respectively.': [78, 107], 'mRNA': [79, 141, 189], 'protein': [81, 112, 172], 'expression': [82], 'levels': [83, 113, 142, 173], 'adherens,': [85], 'gap': [86, 124], 'tight': [88, 132, 152], 'junction': [89, 117, 125, 133, 146, 153], 'components': [90, 126], 'measured': [92], 'liver': [94, 196], 'using': [95], 'reverse': [96], 'transcription': [97], 'quantitative': [98], 'real-time': [99], 'polymerase': [100], 'chain': [101], 'reaction': [102], 'analysis': [103], 'immunoblot': [105], 'techniques,': [106], 'It': [108], 'found': [110], 'that': [111], 'adherens': [116, 145], 'building': [118, 147], 'blocks': [119], 'β-catenin': [120], 'γ-catenin,': [122], 'Cx26': [127], 'Cx32,': [129, 178], 'constituent': [134, 154], 'zonula': [135, 155], 'occludens': [136, 156], '2': [137, 157], 'decreased,': [139], 'while': [140], 'block': [148], 'E-cadherin,': [149, 175], 'claudin': [159, 181], '1': [160], 'upregulated': [162], 'following': [163], 'overdosing.': [165], 'Repeated': [166], 'administration': [167], 'increased': [171], 'β-catenin,': [176], 'Cx26,': [177], 'Cx43': [179], '1.': [182], 'latter': [184], 'reflected': [186], 'level.': [190], 'In': [191], 'conclusion,': [192], 'have': [198], 'different': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4317567314', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-12-16T02:51:05.524821', 'created_date': '2023-01-21'}