Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4315865912', 'doi': 'https://doi.org/10.3390/microorganisms11010203', 'title': 'Metabolic Engineering of Escherichia coli for High-Level Production of (R)-Acetoin from Low-Cost Raw Materials', 'display_name': 'Metabolic Engineering of Escherichia coli for High-Level Production of (R)-Acetoin from Low-Cost Raw Materials', 'publication_year': 2023, 'publication_date': '2023-01-13', 'ids': {'openalex': 'https://openalex.org/W4315865912', 'doi': 'https://doi.org/10.3390/microorganisms11010203', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36677495'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/microorganisms11010203', 'pdf_url': 'https://www.mdpi.com/2076-2607/11/1/203/pdf?version=1673602595', 'source': {'id': 'https://openalex.org/S4210222090', 'display_name': 'Microorganisms', 'issn_l': '2076-2607', 'issn': ['2076-2607'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2076-2607/11/1/203/pdf?version=1673602595', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033446730', 'display_name': 'Mengxue Diao', 'orcid': 'https://orcid.org/0000-0002-2949-1232'}, 'institutions': [{'id': 'https://openalex.org/I4210165264', 'display_name': 'Guangxi Academy of Sciences', 'ror': 'https://ror.org/054x1kd82', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I4210165264']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Mengxue Diao', 'raw_affiliation_strings': ['State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China', 'institution_ids': ['https://openalex.org/I4210165264']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042939085', 'display_name': 'Xianrui Chen', 'orcid': 'https://orcid.org/0000-0001-9525-0034'}, 'institutions': [{'id': 'https://openalex.org/I4210165264', 'display_name': 'Guangxi Academy of Sciences', 'ror': 'https://ror.org/054x1kd82', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I4210165264']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xianrui Chen', 'raw_affiliation_strings': ['State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China', 'institution_ids': ['https://openalex.org/I4210165264']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100337034', 'display_name': 'Jing Li', 'orcid': 'https://orcid.org/0000-0002-9949-1254'}, 'institutions': [{'id': 'https://openalex.org/I150807315', 'display_name': 'Guangxi University', 'ror': 'https://ror.org/02c9qn167', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I150807315']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Li', 'raw_affiliation_strings': ['State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Life Science and Technology College, Guangxi University, Nanning 530004, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Life Science and Technology College, Guangxi University, Nanning 530004, China', 'institution_ids': ['https://openalex.org/I150807315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062101529', 'display_name': 'Yanan Shi', 'orcid': 'https://orcid.org/0000-0002-8037-156X'}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210134982', 'display_name': 'Institute of Microbiology', 'ror': 'https://ror.org/047yhep71', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210134982']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ya’nan Shi', 'raw_affiliation_strings': ['CAS Key Laboratory of Microbial Physiological & Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China'], 'affiliations': [{'raw_affiliation_string': 'CAS Key Laboratory of Microbial Physiological & Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China', 'institution_ids': ['https://openalex.org/I19820366', 'https://openalex.org/I4210134982']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080834198', 'display_name': 'Bo Yu', 'orcid': 'https://orcid.org/0000-0003-3148-0986'}, 'institutions': [{'id': 'https://openalex.org/I4210134982', 'display_name': 'Institute of Microbiology', 'ror': 'https://ror.org/047yhep71', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210134982']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bo Yu', 'raw_affiliation_strings': ['CAS Key Laboratory of Microbial Physiological & Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China'], 'affiliations': [{'raw_affiliation_string': 'CAS Key Laboratory of Microbial Physiological & Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China', 'institution_ids': ['https://openalex.org/I4210134982', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086983724', 'display_name': 'Zhilin Ma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150807315', 'display_name': 'Guangxi University', 'ror': 'https://ror.org/02c9qn167', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I150807315']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhilin Ma', 'raw_affiliation_strings': ['State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Life Science and Technology College, Guangxi University, Nanning 530004, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Life Science and Technology College, Guangxi University, Nanning 530004, China', 'institution_ids': ['https://openalex.org/I150807315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028035588', 'display_name': 'Jianxiu Li', 'orcid': 'https://orcid.org/0000-0003-4777-9712'}, 'institutions': [{'id': 'https://openalex.org/I4210165264', 'display_name': 'Guangxi Academy of Sciences', 'ror': 'https://ror.org/054x1kd82', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I4210165264']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianxiu Li', 'raw_affiliation_strings': ['State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China', 'institution_ids': ['https://openalex.org/I4210165264']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5047503476', 'display_name': 'Nengzhong Xie', 'orcid': 'https://orcid.org/0000-0002-4970-6819'}, 'institutions': [{'id': 'https://openalex.org/I4210165264', 'display_name': 'Guangxi Academy of Sciences', 'ror': 'https://ror.org/054x1kd82', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I4210165264']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Nengzhong Xie', 'raw_affiliation_strings': ['State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China', 'institution_ids': ['https://openalex.org/I4210165264']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5033446730', 'https://openalex.org/A5047503476'], 'corresponding_institution_ids': ['https://openalex.org/I4210165264', 'https://openalex.org/I4210165264'], 'apc_list': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'apc_paid': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'fwci': 0.384, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.583529, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 71, 'max': 82}, 'biblio': {'volume': '11', 'issue': '1', 'first_page': '203', 'last_page': '203'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10932', 'display_name': 'Metabolic Engineering and Synthetic Biology', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10932', 'display_name': 'Metabolic Engineering and Synthetic Biology', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10171', 'display_name': 'Technologies for Biofuel Production from Biomass', 'score': 0.9942, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11663', 'display_name': 'Recombinant Protein Production in Mammalian and Insect Cells', 'score': 0.9768, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/acetoin', 'display_name': 'Acetoin', 'score': 0.9973036}, {'id': 'https://openalex.org/keywords/metabolic-engineering', 'display_name': 'Metabolic Engineering', 'score': 0.4921}, {'id': 'https://openalex.org/keywords/industrial-fermentation', 'display_name': 'Industrial fermentation', 'score': 0.4666106}, {'id': 'https://openalex.org/keywords/enantiomeric-excess', 'display_name': 'Enantiomeric excess', 'score': 0.416331}, {'id': 'https://openalex.org/keywords/strain', 'display_name': 'Strain (injury)', 'score': 0.4151959}], 'concepts': [{'id': 'https://openalex.org/C2777937268', 'wikidata': 'https://www.wikidata.org/wiki/Q223083', 'display_name': 'Acetoin', 'level': 3, 'score': 0.9973036}, {'id': 'https://openalex.org/C100544194', 'wikidata': 'https://www.wikidata.org/wiki/Q41760', 'display_name': 'Fermentation', 'level': 2, 'score': 0.67555416}, {'id': 'https://openalex.org/C206139338', 'wikidata': 'https://www.wikidata.org/wiki/Q192355', 'display_name': 'Raw material', 'level': 2, 'score': 0.6273028}, {'id': 'https://openalex.org/C6350086', 'wikidata': 'https://www.wikidata.org/wiki/Q6822347', 'display_name': 'Metabolic engineering', 'level': 3, 'score': 0.59491557}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.59057283}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4912657}, {'id': 'https://openalex.org/C73401843', 'wikidata': 'https://www.wikidata.org/wiki/Q845523', 'display_name': 'Industrial fermentation', 'level': 3, 'score': 0.4666106}, {'id': 'https://openalex.org/C3141732', 'wikidata': 'https://www.wikidata.org/wiki/Q568761', 'display_name': 'Enantiomeric excess', 'level': 4, 'score': 0.416331}, {'id': 'https://openalex.org/C2778022156', 'wikidata': 'https://www.wikidata.org/wiki/Q576145', 'display_name': 'Strain (injury)', 'level': 2, 'score': 0.4151959}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.34410435}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.33597907}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.33101034}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.27767187}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27665752}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18211937}, {'id': 'https://openalex.org/C146686406', 'wikidata': 'https://www.wikidata.org/wiki/Q898628', 'display_name': 'Enantioselective synthesis', 'level': 3, 'score': 0.1600509}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/microorganisms11010203', 'pdf_url': 'https://www.mdpi.com/2076-2607/11/1/203/pdf?version=1673602595', 'source': {'id': 'https://openalex.org/S4210222090', 'display_name': 'Microorganisms', 'issn_l': '2076-2607', 'issn': ['2076-2607'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867144', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36677495', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/microorganisms11010203', 'pdf_url': 'https://www.mdpi.com/2076-2607/11/1/203/pdf?version=1673602595', 'source': {'id': 'https://openalex.org/S4210222090', 'display_name': 'Microorganisms', 'issn_l': '2076-2607', 'issn': ['2076-2607'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Responsible consumption and production', 'id': 'https://metadata.un.org/sdg/12', 'score': 0.5}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '21868007'}], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1550965069', 'https://openalex.org/W1559992559', 'https://openalex.org/W1969369875', 'https://openalex.org/W1996741098', 'https://openalex.org/W2004870038', 'https://openalex.org/W2017526934', 'https://openalex.org/W2027815076', 'https://openalex.org/W2030951180', 'https://openalex.org/W2034342274', 'https://openalex.org/W2043227293', 'https://openalex.org/W2049788456', 'https://openalex.org/W2063621714', 'https://openalex.org/W2095272743', 'https://openalex.org/W2117529405', 'https://openalex.org/W2130354631', 'https://openalex.org/W2131493394', 'https://openalex.org/W2170774019', 'https://openalex.org/W2170786799', 'https://openalex.org/W2257787929', 'https://openalex.org/W2283794411', 'https://openalex.org/W2382189913', 'https://openalex.org/W2413752983', 'https://openalex.org/W2417386054', 'https://openalex.org/W2529415781', 'https://openalex.org/W2552084879', 'https://openalex.org/W2556603426', 'https://openalex.org/W2593015991', 'https://openalex.org/W2605712730', 'https://openalex.org/W2611072158', 'https://openalex.org/W2748907244', 'https://openalex.org/W2767704799', 'https://openalex.org/W2884913705', 'https://openalex.org/W2915448317', 'https://openalex.org/W3028049812', 'https://openalex.org/W3169612077', 'https://openalex.org/W3202834123', 'https://openalex.org/W3216767965', 'https://openalex.org/W4206964837', 'https://openalex.org/W4213187214', 'https://openalex.org/W4225793119', 'https://openalex.org/W4233470263'], 'related_works': ['https://openalex.org/W4319035191', 'https://openalex.org/W3028049812', 'https://openalex.org/W2964059574', 'https://openalex.org/W2765206790', 'https://openalex.org/W2605712730', 'https://openalex.org/W2347452155', 'https://openalex.org/W2165229869', 'https://openalex.org/W2065453365', 'https://openalex.org/W2051098649', 'https://openalex.org/W1982780844'], 'abstract_inverted_index': {'Acetoin': [0], 'is': [1, 13], 'an': [2, 115], 'important': [3], 'four-carbon': [4], 'platform': [5], 'chemical': [6], 'with': [7, 114, 140], 'versatile': [8], 'applications.': [9], 'Optically': [10], 'pure': [11], '(R)-acetoin': [12, 92, 113, 150], 'more': [14], 'valuable': [15], 'than': [16], 'the': [17, 25, 53, 67, 81, 88, 97, 101, 121, 133, 141], 'racemate': [18], 'as': [19], 'it': [20], 'can': [21], 'be': [22], 'applied': [23], 'in': [24, 120, 128, 137], 'asymmetric': [26], 'synthesis': [27], 'of': [28, 56, 91, 100, 118, 143], 'optically': [29], 'active': [30], 'α-hydroxy': [31], 'ketone': [32], 'derivatives,': [33], 'pharmaceuticals,': [34], 'and': [35, 51, 87], 'liquid': [36], 'crystal': [37], 'composites.': [38], 'As': [39], 'a': [40, 78, 129], 'cytotoxic': [41], 'solvent,': [42], 'acetoin': [43, 54, 70], 'at': [44], 'high': [45], 'concentrations': [46], 'severely': [47], 'limits': [48], 'culture': [49], 'performance': [50], 'impedes': [52], 'yield': [55], 'cell': [57], 'factories.': [58], 'In': [59], 'this': [60, 138, 153], 'study,': [61], 'putative': [62], 'genes': [63], 'that': [64], 'may': [65], 'improve': [66], 'resistance': [68], 'to': [69], 'for': [71, 149], 'Escherichia': [72], 'coli': [73, 107], 'were': [74], 'screened.': [75], 'To': [76], 'obtain': [77], 'high-producing': [79], 'strain,': [80], 'identified': [82], 'acetoin-resistance': [83], 'gene': [84], 'was': [85, 93], 'overexpressed,': [86], 'synthetic': [89], 'pathway': [90], 'strengthened': [94], 'by': [95], 'optimizing': [96], 'copy': [98], 'number': [99], 'key': [102], 'genes.': [103], 'The': [104], 'engineered': [105], 'E.': [106], 'strain': [108], 'GXASR-49RSF': [109], 'produced': [110], '81.62': [111], 'g/L': [112], 'enantiomeric': [116], 'purity': [117], '96.5%': [119], 'fed-batch': [122], 'fermentation': [123], 'using': [124], 'non-food': [125], 'raw': [126], 'materials': [127], '3-L': [130], 'fermenter.': [131], 'Combining': [132], 'systematic': [134], 'approach': [135], 'developed': [136], 'study': [139], 'use': [142], 'low-cost': [144], 'feedstock': [145], 'showed': [146], 'great': [147], 'potential': [148], 'production': [151], 'via': [152], 'cost-effective': [154], 'biotechnological': [155], 'process.': [156]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4315865912', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-09-19T06:30:32.266285', 'created_date': '2023-01-13'}