Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4315574008', 'doi': 'https://doi.org/10.3390/brainsci13010126', 'title': 'Consecutive Injection of High-Dose Lipopolysaccharide Modulates Microglia Polarization via TREM2 to Alter Status of Septic Mice', 'display_name': 'Consecutive Injection of High-Dose Lipopolysaccharide Modulates Microglia Polarization via TREM2 to Alter Status of Septic Mice', 'publication_year': 2023, 'publication_date': '2023-01-11', 'ids': {'openalex': 'https://openalex.org/W4315574008', 'doi': 'https://doi.org/10.3390/brainsci13010126', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36672106'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/brainsci13010126', 'pdf_url': 'https://www.mdpi.com/2076-3425/13/1/126/pdf?version=1673427074', 'source': {'id': 'https://openalex.org/S122317144', 'display_name': 'Brain Sciences', 'issn_l': '2076-3425', 'issn': ['2076-3425'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2076-3425/13/1/126/pdf?version=1673427074', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018735097', 'display_name': 'Zhiyun Qiu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210128921', 'display_name': 'The First Affiliated Hospital, Sun Yat-sen University', 'ror': 'https://ror.org/037p24858', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128921']}, {'id': 'https://openalex.org/I4210127074', 'display_name': 'Zhongshan Hospital', 'ror': 'https://ror.org/032x22645', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210127074']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhiyun Qiu', 'raw_affiliation_strings': ['Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210128921', 'https://openalex.org/I4210127074', 'https://openalex.org/I24943067']}, {'raw_affiliation_string': 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102017229', 'display_name': 'Huilin Wang', 'orcid': 'https://orcid.org/0000-0002-3626-6500'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210128921', 'display_name': 'The First Affiliated Hospital, Sun Yat-sen University', 'ror': 'https://ror.org/037p24858', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128921']}, {'id': 'https://openalex.org/I4210127074', 'display_name': 'Zhongshan Hospital', 'ror': 'https://ror.org/032x22645', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210127074']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huilin Wang', 'raw_affiliation_strings': ['Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210128921', 'https://openalex.org/I4210127074', 'https://openalex.org/I24943067']}, {'raw_affiliation_string': 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057852969', 'display_name': 'Mengdi Qu', 'orcid': 'https://orcid.org/0000-0001-5474-0539'}, 'institutions': [{'id': 'https://openalex.org/I4210128921', 'display_name': 'The First Affiliated Hospital, Sun Yat-sen University', 'ror': 'https://ror.org/037p24858', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128921']}, {'id': 'https://openalex.org/I4210127074', 'display_name': 'Zhongshan Hospital', 'ror': 'https://ror.org/032x22645', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210127074']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Mengdi Qu', 'raw_affiliation_strings': ['Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China'], 'affiliations': [{'raw_affiliation_string': 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'institution_ids': ['https://openalex.org/I4210128921', 'https://openalex.org/I4210127074', 'https://openalex.org/I24943067', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020387884', 'display_name': 'Shuainan Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210128921', 'display_name': 'The First Affiliated Hospital, Sun Yat-sen University', 'ror': 'https://ror.org/037p24858', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128921']}, {'id': 'https://openalex.org/I4210127074', 'display_name': 'Zhongshan Hospital', 'ror': 'https://ror.org/032x22645', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210127074']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shuainan Zhu', 'raw_affiliation_strings': ['Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China'], 'affiliations': [{'raw_affiliation_string': 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'institution_ids': ['https://openalex.org/I4210128921', 'https://openalex.org/I4210127074', 'https://openalex.org/I24943067', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100396782', 'display_name': 'Hao Zhang', 'orcid': 'https://orcid.org/0000-0001-5624-9217'}, 'institutions': [{'id': 'https://openalex.org/I4210128921', 'display_name': 'The First Affiliated Hospital, Sun Yat-sen University', 'ror': 'https://ror.org/037p24858', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128921']}, {'id': 'https://openalex.org/I4210127074', 'display_name': 'Zhongshan Hospital', 'ror': 'https://ror.org/032x22645', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210127074']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hao Zhang', 'raw_affiliation_strings': ['Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China'], 'affiliations': [{'raw_affiliation_string': 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'institution_ids': ['https://openalex.org/I4210128921', 'https://openalex.org/I4210127074', 'https://openalex.org/I24943067', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057178472', 'display_name': 'Qingwu Liao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210127074', 'display_name': 'Zhongshan Hospital', 'ror': 'https://ror.org/032x22645', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210127074']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}, {'id': 'https://openalex.org/I4210128921', 'display_name': 'The First Affiliated Hospital, Sun Yat-sen University', 'ror': 'https://ror.org/037p24858', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128921']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qingwu Liao', 'raw_affiliation_strings': ['Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'institution_ids': ['https://openalex.org/I4210127074', 'https://openalex.org/I24943067', 'https://openalex.org/I4210128921', 'https://openalex.org/I157773358']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100382098', 'display_name': 'Changhong Miao', 'orcid': 'https://orcid.org/0000-0003-3516-8308'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210128921', 'display_name': 'The First Affiliated Hospital, Sun Yat-sen University', 'ror': 'https://ror.org/037p24858', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128921']}, {'id': 'https://openalex.org/I4210127074', 'display_name': 'Zhongshan Hospital', 'ror': 'https://ror.org/032x22645', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210127074']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Changhong Miao', 'raw_affiliation_strings': ['Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 210000, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210128921', 'https://openalex.org/I4210127074', 'https://openalex.org/I24943067']}, {'raw_affiliation_string': 'Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai 210000, China', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5100382098'], 'corresponding_institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210128921', 'https://openalex.org/I4210127074', 'https://openalex.org/I24943067'], 'apc_list': {'value': 2000, 'currency': 'CHF', 'value_usd': 2165, 'provenance': 'doaj'}, 'apc_paid': {'value': 2000, 'currency': 'CHF', 'value_usd': 2165, 'provenance': 'doaj'}, 'fwci': 2.551, 'has_fulltext': False, 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.999827, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 92, 'max': 94}, 'biblio': {'volume': '13', 'issue': '1', 'first_page': '126', 'last_page': '126'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T14165', 'display_name': 'Role of TREM-1 and Endocan in Inflammation', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11184', 'display_name': 'Neonatal Brain Injury and Developmental Consequences', 'score': 0.9571, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neuroinflammation', 'display_name': 'Neuroinflammation', 'score': 0.633318}, {'id': 'https://openalex.org/keywords/trem2', 'display_name': 'TREM2', 'score': 0.544631}], 'concepts': [{'id': 'https://openalex.org/C87753298', 'wikidata': 'https://www.wikidata.org/wiki/Q17157137', 'display_name': 'Neuroinflammation', 'level': 3, 'score': 0.9612081}, {'id': 'https://openalex.org/C2779830541', 'wikidata': 'https://www.wikidata.org/wiki/Q1622829', 'display_name': 'Microglia', 'level': 3, 'score': 0.9348397}, {'id': 'https://openalex.org/C2779685842', 'wikidata': 'https://www.wikidata.org/wiki/Q18040973', 'display_name': 'TREM2', 'level': 4, 'score': 0.86143744}, {'id': 'https://openalex.org/C2778754761', 'wikidata': 'https://www.wikidata.org/wiki/Q421804', 'display_name': 'Lipopolysaccharide', 'level': 2, 'score': 0.58779174}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.5266055}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.4467943}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.40961742}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.36037892}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/brainsci13010126', 'pdf_url': 'https://www.mdpi.com/2076-3425/13/1/126/pdf?version=1673427074', 'source': {'id': 'https://openalex.org/S122317144', 'display_name': 'Brain Sciences', 'issn_l': '2076-3425', 'issn': ['2076-3425'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856382', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36672106', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/brainsci13010126', 'pdf_url': 'https://www.mdpi.com/2076-3425/13/1/126/pdf?version=1673427074', 'source': {'id': 'https://openalex.org/S122317144', 'display_name': 'Brain Sciences', 'issn_l': '2076-3425', 'issn': ['2076-3425'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.7, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1834052598', 'https://openalex.org/W1978401253', 'https://openalex.org/W1989063324', 'https://openalex.org/W2010067898', 'https://openalex.org/W2011041653', 'https://openalex.org/W2021988159', 'https://openalex.org/W2058148996', 'https://openalex.org/W2116226263', 'https://openalex.org/W2120443928', 'https://openalex.org/W2123917524', 'https://openalex.org/W2170841408', 'https://openalex.org/W2280404143', 'https://openalex.org/W2523652064', 'https://openalex.org/W2770682151', 'https://openalex.org/W2801885674', 'https://openalex.org/W2894203109', 'https://openalex.org/W2899014689', 'https://openalex.org/W2944565277', 'https://openalex.org/W2955940476', 'https://openalex.org/W2965848053', 'https://openalex.org/W2977662739', 'https://openalex.org/W2986126643', 'https://openalex.org/W3027943973', 'https://openalex.org/W3031532038', 'https://openalex.org/W3048044439', 'https://openalex.org/W3087562324', 'https://openalex.org/W3092520008', 'https://openalex.org/W3126950469', 'https://openalex.org/W3135733909', 'https://openalex.org/W3170190396', 'https://openalex.org/W3212282234', 'https://openalex.org/W4214848460', 'https://openalex.org/W4220852210', 'https://openalex.org/W4226114265', 'https://openalex.org/W4253763355'], 'related_works': ['https://openalex.org/W4385372854', 'https://openalex.org/W4380893801', 'https://openalex.org/W4376648595', 'https://openalex.org/W4360609725', 'https://openalex.org/W4309593279', 'https://openalex.org/W4308968236', 'https://openalex.org/W4283317699', 'https://openalex.org/W4229004030', 'https://openalex.org/W2965172925', 'https://openalex.org/W2763445772'], 'abstract_inverted_index': {'The': [0], 'neuroinflammation': [1, 150], 'of': [2, 12, 44, 57, 63, 68, 74, 83, 120, 128, 173, 223], 'the': [3, 25, 41, 55, 60, 66, 81, 118, 142, 149, 171, 184, 190, 200, 220], 'central': [4], 'nervous': [5], 'system': [6], '(CNS)': [7], 'is': [8, 20, 33, 231], 'a': [9, 84, 232], 'prevalent': [10], 'syndrome': [11], 'brain': [13], 'dysfunction': [14, 140], 'secondary': [15], 'to': [16, 35, 47, 103, 110, 189, 198, 218], 'severe': [17], 'sepsis': [18], 'and': [19, 91, 94, 100, 136, 160, 205], 'regulated': [21, 183], 'by': [22, 88], 'microglia.': [23], 'Triggering': [24], 'receptor': [26], 'expressed': [27], 'on': [28, 59, 146, 157, 162], 'myeloid': [29], 'cells': [30], '2': [31], '(TREM2)': [32], 'known': [34], 'have': [36], 'protective': [37], 'functions': [38], 'that': [39, 212], 'modulate': [40, 215], 'microglial': [42, 185], 'polarization': [43, 61, 122, 204, 221], 'M2': [45, 191], 'type': [46], 'reduce': [48, 170], 'inflammatory': [49], 'responses,': [50], 'thereby': [51, 225], 'improving': [52], 'cognition.We': [53], 'examined': [54], 'effect': [56], 'TREM2': [58, 112, 155, 174, 178, 182, 206, 216, 230], 'state': [62, 119, 222], 'microglia': [64, 121, 203], 'during': [65], 'progression': [67], 'neuroinflammation.': [69, 208, 228, 238], 'After': [70], 'consecutive': [71, 126], 'intraperitoneal': [72], 'injections': [73], 'lipopolysaccharide': [75], 'for': [76, 130, 237], '7': [77, 164], 'days,': [78], 'we': [79, 95, 116], 'evaluated': [80], 'inflammation': [82, 135], 'septic': [85, 143], 'mice': [86, 109], 'model': [87], 'hematoxylin-eosin': [89], '(H&E)': [90], 'electron': [92], 'microscopy,': [93], 'used': [96], 'immunofluorescence': [97], '(IF)': [98], 'assays': [99], 'Western': [101], 'blotting': [102], 'visualize': [104], 'hippocampal': [105], 'sections': [106], 'in': [107, 141, 165, 180, 194, 207], 'C57BL/6': [108], 'assess': [111], 'expression.': [113], 'In': [114], 'addition,': [115], 'analyzed': [117], 'with': [123], 'quantitative': [124], 'RT-PCR.The': [125], 'injection': [127], 'LPS': [129, 168], '4': [131, 159], 'days': [132], 'elevated': [133], 'systemic': [134], 'caused': [137], 'behavioral': [138], 'cognitive': [139], 'model.': [144], 'However,': [145], 'Day': [147, 158, 163], '7,': [148], 'was': [151, 197], 'considerably': [152], 'attenuated.': [153], 'Meanwhile,': [154], 'decreased': [156], 'increased': [161], 'vivo.': [166], 'Consistently,': [167], 'could': [169, 214], 'expression': [172, 179, 217], 'while': [175], 'IFN-β': [176, 213], 'enhanced': [177], 'vitro.': [181], 'M1': [186], "phenotype's": [187], 'conversion': [188], 'phenotype.Our': [192], 'aim': [193], 'this': [195], 'study': [196], 'investigate': [199], 'interconnection': [201], 'between': [202], 'Our': [209], 'results': [210], 'suggested': [211], 'alter': [219], 'microglia,': [224], 'reducing': [226], 'LPS-induced': [227], 'Therefore,': [229], 'novel': [233], 'potential': [234], 'therapeutic': [235], 'target': [236]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4315574008', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}], 'updated_date': '2024-09-16T10:34:11.284609', 'created_date': '2023-01-11'}