Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4313890313', 'doi': 'https://doi.org/10.3390/ijms24021288', 'title': 'CXADR: From an Essential Structural Component to a Vital Signaling Mediator in Spermatogenesis', 'display_name': 'CXADR: From an Essential Structural Component to a Vital Signaling Mediator in Spermatogenesis', 'publication_year': 2023, 'publication_date': '2023-01-09', 'ids': {'openalex': 'https://openalex.org/W4313890313', 'doi': 'https://doi.org/10.3390/ijms24021288', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36674801'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms24021288', 'pdf_url': 'https://www.mdpi.com/1422-0067/24/2/1288/pdf?version=1673259247', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1422-0067/24/2/1288/pdf?version=1673259247', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100354598', 'display_name': 'Yang Zhang', 'orcid': 'https://orcid.org/0000-0001-8474-5947'}, 'institutions': [{'id': 'https://openalex.org/I889458895', 'display_name': 'University of Hong Kong', 'ror': 'https://ror.org/02zhqgq86', 'country_code': 'HK', 'type': 'education', 'lineage': ['https://openalex.org/I889458895']}], 'countries': ['HK'], 'is_corresponding': False, 'raw_author_name': 'Yang Zhang', 'raw_affiliation_strings': ['School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China'], 'affiliations': [{'raw_affiliation_string': 'School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China', 'institution_ids': ['https://openalex.org/I889458895']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073321237', 'display_name': 'Wing‐Yee Lui', 'orcid': 'https://orcid.org/0000-0002-3096-1158'}, 'institutions': [{'id': 'https://openalex.org/I889458895', 'display_name': 'University of Hong Kong', 'ror': 'https://ror.org/02zhqgq86', 'country_code': 'HK', 'type': 'education', 'lineage': ['https://openalex.org/I889458895']}], 'countries': ['HK'], 'is_corresponding': True, 'raw_author_name': 'Wing-Yee Lui', 'raw_affiliation_strings': ['School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China'], 'affiliations': [{'raw_affiliation_string': 'School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China', 'institution_ids': ['https://openalex.org/I889458895']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5073321237'], 'corresponding_institution_ids': ['https://openalex.org/I889458895'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 0.304, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.999078, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 79, 'max': 84}, 'biblio': {'volume': '24', 'issue': '2', 'first_page': '1288', 'last_page': '1288'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11495', 'display_name': 'Animal Virus Infections Studies', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1103', 'display_name': 'Animal Science and Zoology'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/blood–testis-barrier', 'display_name': 'Blood–testis barrier', 'score': 0.75898737}, {'id': 'https://openalex.org/keywords/mediator', 'display_name': 'Mediator', 'score': 0.64533013}, {'id': 'https://openalex.org/keywords/knockout-mouse', 'display_name': 'Knockout mouse', 'score': 0.4289565}], 'concepts': [{'id': 'https://openalex.org/C2781068068', 'wikidata': 'https://www.wikidata.org/wiki/Q195614', 'display_name': 'Sertoli cell', 'level': 3, 'score': 0.9470666}, {'id': 'https://openalex.org/C2636012', 'wikidata': 'https://www.wikidata.org/wiki/Q489842', 'display_name': 'Blood–testis barrier', 'level': 4, 'score': 0.75898737}, {'id': 'https://openalex.org/C2779122487', 'wikidata': 'https://www.wikidata.org/wiki/Q281579', 'display_name': 'Germ cell', 'level': 3, 'score': 0.7257257}, {'id': 'https://openalex.org/C123765429', 'wikidata': 'https://www.wikidata.org/wiki/Q36961', 'display_name': 'Spermatogenesis', 'level': 2, 'score': 0.72222847}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6503551}, {'id': 'https://openalex.org/C2107291', 'wikidata': 'https://www.wikidata.org/wiki/Q14886885', 'display_name': 'Mediator', 'level': 2, 'score': 0.64533013}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.58662856}, {'id': 'https://openalex.org/C182704531', 'wikidata': 'https://www.wikidata.org/wiki/Q1364740', 'display_name': 'Knockout mouse', 'level': 3, 'score': 0.4289565}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.26862824}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.25686044}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15351933}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06598449}], 'mesh': [{'descriptor_ui': 'D011991', 'descriptor_name': 'Receptors, Virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013091', 'descriptor_name': 'Spermatogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003384', 'descriptor_name': 'Coxsackievirus Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004770', 'descriptor_name': 'Enterovirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011991', 'descriptor_name': 'Receptors, Virus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012708', 'descriptor_name': 'Sertoli Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012708', 'descriptor_name': 'Sertoli Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013087', 'descriptor_name': 'Spermatids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms24021288', 'pdf_url': 'https://www.mdpi.com/1422-0067/24/2/1288/pdf?version=1673259247', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865082', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36674801', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms24021288', 'pdf_url': 'https://www.mdpi.com/1422-0067/24/2/1288/pdf?version=1673259247', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.44, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 85, 'referenced_works': ['https://openalex.org/W1425683513', 'https://openalex.org/W1564846515', 'https://openalex.org/W1875921292', 'https://openalex.org/W1967939940', 'https://openalex.org/W1974747739', 'https://openalex.org/W1979854824', 'https://openalex.org/W1982408362', 'https://openalex.org/W1983128675', 'https://openalex.org/W1985165311', 'https://openalex.org/W1986538066', 'https://openalex.org/W1990488096', 'https://openalex.org/W1998088031', 'https://openalex.org/W2001070008', 'https://openalex.org/W2003398434', 'https://openalex.org/W2003500813', 'https://openalex.org/W2005127084', 'https://openalex.org/W2005134922', 'https://openalex.org/W2011560862', 'https://openalex.org/W2012820727', 'https://openalex.org/W2014843698', 'https://openalex.org/W2015961726', 'https://openalex.org/W2017001659', 'https://openalex.org/W2021085886', 'https://openalex.org/W2026130605', 'https://openalex.org/W2027264255', 'https://openalex.org/W2027504840', 'https://openalex.org/W2029325021', 'https://openalex.org/W2031066016', 'https://openalex.org/W2035838135', 'https://openalex.org/W2038767318', 'https://openalex.org/W2042400521', 'https://openalex.org/W2042742511', 'https://openalex.org/W2047724121', 'https://openalex.org/W2050015911', 'https://openalex.org/W2051758487', 'https://openalex.org/W2055842243', 'https://openalex.org/W2056891070', 'https://openalex.org/W2058384876', 'https://openalex.org/W2058876649', 'https://openalex.org/W2062855335', 'https://openalex.org/W2073716939', 'https://openalex.org/W2074203697', 'https://openalex.org/W2076373386', 'https://openalex.org/W2078122977', 'https://openalex.org/W2082719475', 'https://openalex.org/W2082823773', 'https://openalex.org/W2083687786', 'https://openalex.org/W2085902727', 'https://openalex.org/W2088830438', 'https://openalex.org/W2092623873', 'https://openalex.org/W2096418924', 'https://openalex.org/W2098845541', 'https://openalex.org/W2101305223', 'https://openalex.org/W2105376199', 'https://openalex.org/W2121555488', 'https://openalex.org/W2125634312', 'https://openalex.org/W2133612168', 'https://openalex.org/W2134208169', 'https://openalex.org/W2137440837', 'https://openalex.org/W2141373945', 'https://openalex.org/W2143952455', 'https://openalex.org/W2145544991', 'https://openalex.org/W2148778055', 'https://openalex.org/W2155267044', 'https://openalex.org/W2158021558', 'https://openalex.org/W2161604884', 'https://openalex.org/W2171399326', 'https://openalex.org/W2208679668', 'https://openalex.org/W2403435068', 'https://openalex.org/W2473586090', 'https://openalex.org/W2520323130', 'https://openalex.org/W2870417857', 'https://openalex.org/W2898706557', 'https://openalex.org/W2924547427', 'https://openalex.org/W2955104655', 'https://openalex.org/W2962057213', 'https://openalex.org/W3033812582', 'https://openalex.org/W3097900553', 'https://openalex.org/W3117103097', 'https://openalex.org/W3139502807', 'https://openalex.org/W4200135473', 'https://openalex.org/W4210504863', 'https://openalex.org/W4210726225', 'https://openalex.org/W4285606907', 'https://openalex.org/W560622854'], 'related_works': ['https://openalex.org/W4313890313', 'https://openalex.org/W4250688937', 'https://openalex.org/W3197180801', 'https://openalex.org/W2097939756', 'https://openalex.org/W2096516625', 'https://openalex.org/W2026456961', 'https://openalex.org/W2014843698', 'https://openalex.org/W1996052294', 'https://openalex.org/W1988629965', 'https://openalex.org/W1625531589'], 'abstract_inverted_index': {'Canonical': [0], 'coxsackievirus': [1], 'and': [2, 18, 24, 34, 37, 47, 71, 111, 131], 'adenovirus': [3], 'receptor': [4], '(CXADR)': [5], 'is': [6, 14, 28, 38], 'a': [7, 63, 96, 132], 'transmembrane': [8], 'component': [9, 82], 'of': [10, 51, 68, 74, 93, 113, 142], 'cell': [11, 84], 'junctions': [12], 'that': [13], 'crucial': [15], 'for': [16, 83], 'cardiac': [17], 'testicular': [19], 'functions': [20], 'via': [21], 'its': [22], 'homophilic': [23], 'heterophilic': [25], 'interaction.': [26], 'CXADR': [27, 52, 94, 114], 'expressed': [29], 'in': [30, 53, 99, 115, 120], 'both': [31], 'Sertoli': [32, 55], 'cells': [33, 36, 46, 56], 'germ': [35, 69], 'localized': [39], 'mainly': [40], 'at': [41], 'the': [42, 90, 109, 136, 140], 'interface': [43], 'between': [44], 'Sertoli-Sertoli': [45], 'Sertoli-germ': [48], 'cells.': [49], 'Knockout': [50], 'mouse': [54], 'specifically': [57], 'impairs': [58], 'male': [59], 'reproductive': [60], 'functions,': [61], 'including': [62], 'compromised': [64], 'blood-testis': [65], 'barrier,': [66], 'apoptosis': [67], 'cells,': [70], 'premature': [72], 'loss': [73], 'spermatids.': [75], 'Apart': [76], 'from': [77], 'serving': [78], 'as': [79, 95, 117, 119], 'an': [80], 'important': [81], 'junctions,': [85], 'recent': [86], 'progress': [87, 106], 'has': [88], 'showed': [89], 'potential': [91], 'roles': [92, 141], 'signaling': [97], 'mediator': [98], 'spermatogenesis.': [100], 'This': [101], 'review': [102, 126], 'summarizes': [103], 'current': [104], 'research': [105], 'related': [107], 'to': [108, 134], 'regulation': [110], 'role': [112], 'spermatogenesis': [116], 'well': [118], 'pathological': [121], 'conditions.': [122], 'We': [123], 'hope': [124], 'this': [125], 'provides': [127], 'some': [128], 'future': [129], 'directions': [130], 'blueprint': [133], 'promote': [135], 'further': [137], 'study': [138], 'on': [139], 'CXADR.': [143]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4313890313', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-12-21T05:30:42.986906', 'created_date': '2023-01-10'}