Title: PcLecE participates in the antibacterial immune response by specifically inhibiting the proliferation of Enterobacteria
Abstract: Enterobacter infections pose a huge threat to animals, including humans. It is particularly important to develop drugs that specifically inhibit Enterobacter. In the present study, a C-type lectin named PcLecE, which was widely distributed in Procambarus clarkii, could specifically reduce the proportions of Enterobacter and Mycoplasma in the hemolymph. PcLecE showed specific antibacterial activity to Enterobacter in vitro and bacterial clearance activity to Enterobacter in vivo. PcLecE alleviated the intestine damage in crayfish caused by Enterobacter cloacae. PcLecE inhibits its proliferation, promotes its phagocytosis by hemocytes, and improves the survival rate of crayfish under E. cloacae infection. The specific inhibition of Enterobacter by PcLecE might provide new insight into the regulation of immune homeostasis by C-type lectins and the preparation of Enterobacter-specific drugs.
Publication Year: 2023
Publication Date: 2023-03-01
Language: en
Type: article
Indexed In: ['crossref']
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