Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4313442014', 'doi': 'https://doi.org/10.7554/elife.81892', 'title': 'Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome', 'display_name': 'Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome', 'publication_year': 2023, 'publication_date': '2023-01-03', 'ids': {'openalex': 'https://openalex.org/W4313442014', 'doi': 'https://doi.org/10.7554/elife.81892', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36594817'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.81892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.7554/elife.81892', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100405087', 'display_name': 'Dongwon Lee', 'orcid': 'https://orcid.org/0000-0002-1568-2249'}, 'institutions': [{'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}, {'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dongwon Lee', 'raw_affiliation_strings': ['Department of Neuroscience, Baylor College of Medicine', 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital'], 'affiliations': [{'raw_affiliation_string': 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital', 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586']}, {'raw_affiliation_string': 'Department of Neuroscience, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061873666', 'display_name': 'Wu Chen', 'orcid': 'https://orcid.org/0000-0002-7400-0519'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wu Chen', 'raw_affiliation_strings': ['Department of Neuroscience, Baylor College of Medicine', 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}, {'raw_affiliation_string': 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital', 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011186173', 'display_name': 'Heet Naresh Kaku', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Heet Naresh Kaku', 'raw_affiliation_strings': ['Department of Neuroscience, Baylor College of Medicine', 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}, {'raw_affiliation_string': 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital', 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011834523', 'display_name': 'Xinming Zhuo', 'orcid': 'https://orcid.org/0000-0002-1952-7131'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xinming Zhuo', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021805644', 'display_name': 'Eugene S Chao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eugene S Chao', 'raw_affiliation_strings': ['Department of Neuroscience, Baylor College of Medicine', 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}, {'raw_affiliation_string': 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital', 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060703300', 'display_name': 'Armand Soriano', 'orcid': 'https://orcid.org/0009-0009-6619-6281'}, 'institutions': [{'id': 'https://openalex.org/I2800035258', 'display_name': 'Ionis Pharmaceuticals (United States)', 'ror': 'https://ror.org/00t8bew53', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2800035258']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Armand Soriano', 'raw_affiliation_strings': ['Ionis Pharmaceuticals'], 'affiliations': [{'raw_affiliation_string': 'Ionis Pharmaceuticals', 'institution_ids': ['https://openalex.org/I2800035258']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091678165', 'display_name': 'Allen Kuncheria', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Allen Kuncheria', 'raw_affiliation_strings': ['Department of Neuroscience, Baylor College of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015222021', 'display_name': 'Stephanie Flores', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephanie Flores', 'raw_affiliation_strings': ['Department of Neuroscience, Baylor College of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101774559', 'display_name': 'Joo Hyun Kim', 'orcid': 'https://orcid.org/0000-0002-8533-9649'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joo Hyun Kim', 'raw_affiliation_strings': ['Department of Neuroscience, Baylor College of Medicine', 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}, {'raw_affiliation_string': 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital', 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050022186', 'display_name': 'Armando Rivera', 'orcid': 'https://orcid.org/0000-0001-7076-8566'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Armando Rivera', 'raw_affiliation_strings': ['Department of Neuroscience, Baylor College of Medicine', 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}, {'raw_affiliation_string': 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital', 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041605141', 'display_name': 'Frank Rigo', 'orcid': 'https://orcid.org/0000-0001-6467-3309'}, 'institutions': [{'id': 'https://openalex.org/I2800035258', 'display_name': 'Ionis Pharmaceuticals (United States)', 'ror': 'https://ror.org/00t8bew53', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2800035258']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Frank Rigo', 'raw_affiliation_strings': ['Ionis Pharmaceuticals'], 'affiliations': [{'raw_affiliation_string': 'Ionis Pharmaceuticals', 'institution_ids': ['https://openalex.org/I2800035258']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081601379', 'display_name': 'Paymaan Jafar‐Nejad', 'orcid': 'https://orcid.org/0000-0001-5176-739X'}, 'institutions': [{'id': 'https://openalex.org/I2800035258', 'display_name': 'Ionis Pharmaceuticals (United States)', 'ror': 'https://ror.org/00t8bew53', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2800035258']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paymaan Jafar-nejad', 'raw_affiliation_strings': ['Ionis Pharmaceuticals'], 'affiliations': [{'raw_affiliation_string': 'Ionis Pharmaceuticals', 'institution_ids': ['https://openalex.org/I2800035258']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074963804', 'display_name': 'Arthur L. Beaudet', 'orcid': 'https://orcid.org/0000-0003-2083-3192'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arthur L Beaudet', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088145191', 'display_name': 'Matthew S. Caudill', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew S Caudill', 'raw_affiliation_strings': ['Department of Neuroscience, Baylor College of Medicine', 'Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}, {'raw_affiliation_string': 'Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital', 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024073865', 'display_name': 'Mingshan Xue', 'orcid': 'https://orcid.org/0000-0003-1463-8884'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mingshan Xue', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine', 'Department of Neuroscience, Baylor College of Medicine', 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}, {'raw_affiliation_string': 'The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital', 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586']}, {'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'apc_paid': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'fwci': 3.31, 'has_fulltext': False, 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.999941, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '12', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11928', 'display_name': 'Genetic Syndromes and Imprinting', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11928', 'display_name': 'Genetic Syndromes and Imprinting', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10978', 'display_name': 'Prenatal Screening and Diagnostics', 'score': 0.9712, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9654, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/angelman-syndrome', 'display_name': 'Angelman Syndrome', 'score': 0.9961587}, {'id': 'https://openalex.org/keywords/ube3a', 'display_name': 'UBE3A', 'score': 0.9960803}, {'id': 'https://openalex.org/keywords/neurodevelopmental-disorder', 'display_name': 'Neurodevelopmental disorder', 'score': 0.65372103}, {'id': 'https://openalex.org/keywords/knockout-mouse', 'display_name': 'Knockout mouse', 'score': 0.50666386}], 'concepts': [{'id': 'https://openalex.org/C2778691456', 'wikidata': 'https://www.wikidata.org/wiki/Q535364', 'display_name': 'Angelman syndrome', 'level': 3, 'score': 0.9961587}, {'id': 'https://openalex.org/C2777041782', 'wikidata': 'https://www.wikidata.org/wiki/Q14878336', 'display_name': 'UBE3A', 'level': 5, 'score': 0.9960803}, {'id': 'https://openalex.org/C2779388368', 'wikidata': 'https://www.wikidata.org/wiki/Q3450985', 'display_name': 'Neurodevelopmental disorder', 'level': 3, 'score': 0.65372103}, {'id': 'https://openalex.org/C182704531', 'wikidata': 'https://www.wikidata.org/wiki/Q1364740', 'display_name': 'Knockout mouse', 'level': 3, 'score': 0.50666386}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44326174}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.39405409}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.37202853}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.31814414}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.248007}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.20729166}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.07644352}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017204', 'descriptor_name': 'Angelman Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016376', 'descriptor_name': 'Oligonucleotides, Antisense', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012890', 'descriptor_name': 'Sleep', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.81892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904759', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2022.06.18.496687', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2022/06/21/2022.06.18.496687.full.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36594817', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.81892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.77, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320309543', 'funder_display_name': "Texas Children's Hospital", 'award_id': 'Main Street America Fund'}, {'funder': 'https://openalex.org/F4320337346', 'funder_display_name': 'National Institute of Mental Health', 'award_id': 'R01MH117089'}, {'funder': 'https://openalex.org/F4320337359', 'funder_display_name': 'National Institute of Neurological Disorders and Stroke', 'award_id': 'R01NS100893'}], 'datasets': [], 'versions': [], 'referenced_works_count': 65, 'referenced_works': ['https://openalex.org/W1831618129', 'https://openalex.org/W1893871726', 'https://openalex.org/W1977209252', 'https://openalex.org/W1983532821', 'https://openalex.org/W1985513877', 'https://openalex.org/W1985567838', 'https://openalex.org/W1988134422', 'https://openalex.org/W1992577657', 'https://openalex.org/W2016365513', 'https://openalex.org/W2018389173', 'https://openalex.org/W2020538295', 'https://openalex.org/W2023353041', 'https://openalex.org/W2023723856', 'https://openalex.org/W2036322711', 'https://openalex.org/W2041807010', 'https://openalex.org/W2045372468', 'https://openalex.org/W2045819396', 'https://openalex.org/W2064303101', 'https://openalex.org/W2065138462', 'https://openalex.org/W2075059777', 'https://openalex.org/W2076549445', 'https://openalex.org/W2082543557', 'https://openalex.org/W2088707712', 'https://openalex.org/W2089542359', 'https://openalex.org/W2099057097', 'https://openalex.org/W2106822551', 'https://openalex.org/W2112873690', 'https://openalex.org/W2116283958', 'https://openalex.org/W2143860178', 'https://openalex.org/W2155623567', 'https://openalex.org/W2160349581', 'https://openalex.org/W2308611819', 'https://openalex.org/W2402801916', 'https://openalex.org/W2520272104', 'https://openalex.org/W2569493629', 'https://openalex.org/W2580347026', 'https://openalex.org/W2613494796', 'https://openalex.org/W2744804789', 'https://openalex.org/W2886887055', 'https://openalex.org/W2891172641', 'https://openalex.org/W2895927020', 'https://openalex.org/W2910202477', 'https://openalex.org/W2937529266', 'https://openalex.org/W2950649593', 'https://openalex.org/W2995824277', 'https://openalex.org/W3008559558', 'https://openalex.org/W3008711268', 'https://openalex.org/W3082704458', 'https://openalex.org/W3087736452', 'https://openalex.org/W3094331871', 'https://openalex.org/W3118096229', 'https://openalex.org/W3120991859', 'https://openalex.org/W3126915605', 'https://openalex.org/W3128879131', 'https://openalex.org/W3164872599', 'https://openalex.org/W3165105444', 'https://openalex.org/W3168160122', 'https://openalex.org/W3191979850', 'https://openalex.org/W3192696049', 'https://openalex.org/W3199832736', 'https://openalex.org/W3204635266', 'https://openalex.org/W3207642456', 'https://openalex.org/W4220652264', 'https://openalex.org/W4221098892', 'https://openalex.org/W4224680747'], 'related_works': ['https://openalex.org/W4313442014', 'https://openalex.org/W4283164330', 'https://openalex.org/W4247981369', 'https://openalex.org/W3202970859', 'https://openalex.org/W3084233741', 'https://openalex.org/W2995442537', 'https://openalex.org/W2943613942', 'https://openalex.org/W2041807010', 'https://openalex.org/W1973485468', 'https://openalex.org/W1752412230'], 'abstract_inverted_index': {'UBE3A': [0, 19, 33, 46, 62], 'encodes': [1], 'ubiquitin': [2], 'protein': [3, 143], 'ligase': [4], 'E3A,': [5], 'and': [6, 121, 163, 167], 'in': [7, 87, 107], 'neurons': [8, 27], 'its': [9], 'expression': [10, 86], 'from': [11], 'the': [12, 18, 59, 116, 132, 139, 149, 175], 'paternal': [13, 61], 'allele': [14], 'is': [15, 42, 56, 158], 'repressed': [16], 'by': [17, 44, 63, 83, 104], 'antisense': [20, 105], 'transcript': [21], '(': [22], 'UBE3A-ATS': [23, 65], ').': [24], 'This': [25], 'leaves': [26], 'susceptible': [28], 'to': [29, 52, 57, 173], 'loss-of-function': [30], 'of': [31, 74, 128, 134, 141, 152, 178], 'maternal': [32, 45, 75, 111], '.': [34, 66], 'Indeed,': [35], 'Angelman': [36, 54, 96, 129, 156], 'syndrome,': [37], 'a': [38, 91], 'severe': [39], 'neurodevelopmental': [40], 'disorder,': [41], 'caused': [43], 'deficiency.': [47], 'A': [48], 'promising': [49], 'therapeutic': [50, 93, 150], 'approach': [51], 'treating': [53], 'syndrome': [55, 157], 'reactivate': [58], 'intact': [60], 'suppressing': [64], 'Prior': [67], 'studies': [68], 'show': [69], 'that': [70, 101, 148], 'many': [71], 'neurological': [72], 'phenotypes': [73], 'Ube3a': [76, 85, 112, 142], 'knockout': [77, 113], 'mice': [78, 114], 'can': [79], 'only': [80], 'be': [81, 171], 'rescued': [82], 'reinstating': [84], 'early': [88], 'development,': [89], 'indicating': [90], 'restricted': [92], 'window': [94, 151], 'for': [95, 155], 'syndrome.': [97, 130], 'Here,': [98], 'we': [99], 'report': [100], 'reducing': [102], 'Ube3a-ATS': [103], 'oligonucleotides': [106], 'juvenile': [108], 'or': [109], 'adult': [110], 'rescues': [115], 'abnormal': [117], 'electroencephalogram': [118], '(EEG)': [119], 'rhythms': [120], 'sleep': [122, 168], 'disturbance,': [123], 'two': [124], 'prominent': [125], 'clinical': [126, 176], 'features': [127], 'Importantly,': [131], 'degree': [133], 'phenotypic': [135], 'improvement': [136], 'correlates': [137], 'with': [138], 'increase': [140], 'levels.': [144], 'These': [145], 'results': [146], 'indicate': [147], 'genetic': [153], 'therapies': [154], 'broader': [159], 'than': [160], 'previously': [161], 'thought,': [162], 'EEG': [164], 'power': [165], 'spectrum': [166], 'architecture': [169], 'should': [170], 'used': [172], 'evaluate': [174], 'efficacy': [177], 'therapies.': [179]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4313442014', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 2}], 'updated_date': '2025-01-11T01:05:18.720780', 'created_date': '2023-01-06'}